Clinical trials: Cruciate Ligament Injury
Anterior Cruciate Ligament Injuries
The Effects of Knee Extension Constraint Rehabilitation After ACL Reconstruction
To develop new prevention programs for non-contact ACL injuries that do not require additional training time and assistance from a sports medicine professional personnel.
- Trial name
- NCT04464902
- Testing
- brace1, brace2, No Intervention
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee
Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction
The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior…
- Conditions
- Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee, Bone Marrow Aspirate Concentrate, ACL Injury
- Trial name
- NCT06311513
- Testing
- Concentrated Bone Marrow Aspirate Injection, Revision Anterior Cruciate Ligament Reconstruction
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Hospital for Special Surgery, New York
Knee Injuries, Anterior Cruciate Ligament Rupture
Stopping OsteoARthritis After an ACL Tear
By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will…
- Conditions
- Knee Injuries, Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
- Trial name
- SOAR (NCT06195423)
- Testing
- Stop OsteoARthritis (SOAR) program, Living Well after ACLR program
- Where
- 2 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University of British Columbia
Knee Ligament Injury, PCL - Posterior Cruciate Ligament Rupture
Evaluation of Clinical and Radiographic Outcomes of Surgically Treated Multiligamentous Knee Injuries
Multiligament knee injuries are typically caused by high-energy mechanisms and are classified according to the number of ligaments involved using Schenk's classification (Knee Dislocation) into KD 1, KD 2, KD 3, and KD 4.
- Conditions
- Knee Ligament Injury, PCL - Posterior Cruciate Ligament Rupture, PROMs
- Trial name
- MULTI-LIG (NCT06522659)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Istituto Ortopedico Rizzoli
Anterior Cruciate Ligament Injuries, Lower Extremity Problem
Knowledge Translation Intervention for ACL Injury Prevention Program in Youth Soccer
Anterior cruciate ligament (ACL) injuries of the knee are common in youth soccer players, and show an even higher prevalence in female soccer players.
- Trial name
- NCT05442879
- Testing
- Knowledge Translation Intervention, Educational handout
- Where
- United States
- Volunteers
- 671 people, healthy volunteers welcome
- Sponsor
- University of Michigan
ACL Injury
Ultrasound-guided Percutaneous Neuromodulation in Anterior Cruciate Reconstruction
The objective of the study is to demonstrate the efficacy of the ultrasound-guided percutaneous neuromodulation technique in the femoral nerve in patients who underwent surgery for the anterior cruciate ligament.
- Trial name
- NMPeLCA (NCT05606250)
- Testing
- Ultrasound-Guided Percutaneous Neuromodulation
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Universidad Europea de Madrid
Anterior Cruciate Ligament Injury, Knee Joint
ACL Prehabilitation and Functional Outcomes
Anterior cruciate ligament (ACL) rupture is a common knee injury that frequently requires surgical reconstruction and extensive postoperative rehabilitation.
- Trial name
- ACL Prehab fun (NCT07627724)
- Testing
- Preoperative Prehabilitation Program, Standard Preoperative Care
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Beni-Suef University
Knee Injuries
Non- vs Partial Controlled Weightbearing After Multiple Knee Ligament Reconstruction
This is a prospective randomized controlled trial with the purpose to determine if patients undergoing isolated posterior cruciate ligament (PCL) reconstruction, or isolated medial collateral ligament (MCL) reconstruction, or…
- Trial name
- NCT05073276
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Twin Cities Orthopedics
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
The PreOperative Management of Patients Awaiting Anterior Cruciate Ligament Reconstruction
Patient experiences of the NHS ACL treatment pathway are unknown. This study aims to explore patient experiences of anterior cruciate ligament ruptures at three different time points on the patient pathway: (1) 12 participants up…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Rehabilitation
- Trial name
- POP-ACLR (NCT05529511)
- Testing
- Phase 1 - semi-structured interviews, Phase 2 - consensus meeting
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Anterior Cruciate Ligament Injury
Effects of Low-intensity Strength Training With Concomitant Blood Flow Restriction on Pain Perception in Patients With Anterior Cruciate Ligament Surgery
After surgical treatment of a tear of the anterior cruciate ligament, physiotherapeutic exercises are done as standard therapy. This is to achieve a rapid improvement in pain and knee function.
- Trial name
- BFR (NCT06699264)
- Testing
- Blood Flow Restriction Training, Training without BFR
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Praxisklinik Rennbahn AG
Knee Injuries
Establishing the Clinical Significance Values of the Lysholm Knee Score
The goal of this observational study is to learn about patients who will undergo anterior cruciate ligament reconstruction. The main questions it aims to answer are: What is the minimal clinically important difference value of…
- Trial name
- NCT06571227
- Testing
- Anterior cruciate ligament reconstruction
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Kırklareli University
Anterior-cruciate Ligament Knee Injury
Utilization of Rehabilitation Prior to Surgery Among Patients With Anterior-cruciate Ligament Knee Injury
This research aims to assess physiotherapy utilization in the treatment of patients with an anterior-cruciate ligament knee injury, when delivered before their surgery (prehab), and its potential effects on absence from work, and…
- Trial name
- prehab-ACL (NCT05737719)
- Testing
- Rehabilitation before knee surgery (prehab), Post-surgery rehabilitation
- Where
- France
- Volunteers
- 864,000 people
- Sponsor
- Nantes University Hospital
Bone Diseases, Infectious, Musculoskeletal Diseases
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health.
- Conditions
- Bone Diseases, Infectious, Musculoskeletal Diseases, Joint Diseases, Osteoarthritis
- Trial name
- MVMS_MRI (NCT04536103)
- Testing
- MRI
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Xiaojuan Li
Anterior Cruciate Ligament Tear
Bone Marrow Aspirate Concentrate for Anterior Cruciate Ligament Tear Treatment.
A single armed multicenter study enrolling 20 patients using autologous bone marrow aspirate concentrate (which is done under local or general anesthesia to aspirate around 1-2 cc/kg body weight then concentration which is done…
- Trial name
- NCT06353503
- Testing
- autologous bone marrow aspirate concentrate
- Where
- Iraq
- Volunteers
- 20 people
- Sponsor
- abdulmajeed hammadi
Anterior Cruciate Ligament Rupture
Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction
This study will consist of 80 patients ages 18 to 50 at the Emory Orthopaedic and Spine Center who are undergoing Anterior Cruciate Ligament (ACL) reconstruction with a quadriceps tendon autograft or bone patellar tendon bone…
- Trial name
- NCT02189317
- Testing
- Exparel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Anterior Cruciate Ligament Tear
Evaluation of Biocleanse Allografts For ACL Reconstruction
The purpose of this study is to determine the efficacy of patellar tendon allografts that have undergone the BioCleanse™ process.
- Trial name
- NCT00187876
- Testing
- ACL reconstruction control, ACL Biocleanse, surgical
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Florida
ACL Injury
Influence of Combined Double-Bundle ACL Reconstruction With Lateral Retinacular Release to Prevent Patellofemoral Malalignment in Isolated ACL Rupture
Anterior knee pain which might be due to patellofemoral malalignment is an inevitable post operative complication after an ACL reconstruction (ACLR).
- Trial name
- NCT06004297
- Testing
- ACL reconstruction
- Where
- Indonesia
- Volunteers
- 100 people
- Sponsor
- Universitas Indonesia
Anterior Cruciate Ligament Rupture
Evaluation of Tibial and Femoral Tunnel Position After Arthroscopic Reconstruction of the Anterior Cruciate Ligament
The purpose of this study is to evaluate the accuracy of tunnel positions in anterior cruciate ligament reconstruction
- Trial name
- NCT01267435
- Testing
- Anterior cruciate ligament reconstruction
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
ACL Injury
MRI Morphology of Femoral Notch in ACL Injury
This study aims to investigate the association between femoral notch morphology, as assessed by MRI, and the risk of ACL injury
- Trial name
- NCT06707285
- Testing
- MRI
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
ACL Injury, ACL Sprain
Isoinertial Rehabilitation in Recovering Hamstring Strength Following Surgical Anterior Cruciate Ligament Reconstruction
The present experimental study aims to evaluate the effectiveness and tolerability of isoinertial strength training of the hamstrings using machines in patients with ACL-R during the intermediate post-intervention phases.
- Conditions
- ACL Injury, ACL Sprain, ACL Tear, Anterior Cruciate Ligament Rupture
- Trial name
- NCT06063915
- Testing
- Isoinertial training, Strength Training
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Università degli studi di Roma Foro Italico