Clinical trials: Crying
Crying, Fussy Infant (Baby)
An In-home Observational Study to Compare Infant Crying and Fussing Parameters Documented by the LENA Recorder With Those Documented Via Parental E-diaries
This is a in-home observational study of 12 healthy term infants of ≤15 weeks of age to compare infant crying and fussing parameters documented by the LENA recorder with those documented via parental e-diaries
- Trial name
- LENUS (NCT03390348)
- Testing
- LENA Recorder
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Pain
Effect of Using White Noise, Embracing and Facilitated Tucking in Newborns
This study was conducted to evaluate the effect of using white noise, embracing and facilitated tucking on physiological parameters, crying duration and pain during heel lance blood sampling in healthy newborns.
- Trial name
- NCT04837326
- Testing
- Heel Lance Blood Sampling in Facilitated Tucking Position, Heel Lance Blood Sampling When the Infant is Embraced by the Mother, Heel Lance Blood Sampling Using White Noise
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ordu University
Infantile Colic
The Effect of Probiotics in Infantile Colic
Academic, independent, non-commercial, multicenter study sponsored by the Department of Translational Medical Sciences (DISMET), University of Naples Federico II.
- Trial name
- CSUB0214 (NCT07894445)
- Testing
- Probiotic: L. reuteri DSM 17938 + BG-R46, total 2 × 10⁸ CFU/day
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Federico II University
Gastrointestinal, Colic
Safety and Effect of L. Reuteri on Biomarkers of Inflammation in Healthy Infants With Colic
This protocol is a study of the effects of Lactobacillus reuteri in 45 healthy infants with colic. The study is being conducted in order to prove treatment dose with probiotic (Lactobacillus reuteri) in a clinical setting is safe…
- Trial name
- NCT01849991
- Testing
- Lactobacillus reuteri
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Preterm, Chronobiology
The Effect of Oral Feeding Model With a Chronobiological Approach in Neonates
The ideal food for healthy term babies as well as preterm babies and sick term babies is breast milk. There are many studies showing that the composition of breast milk can vary from mother to mother, according to the baby's…
- Conditions
- Preterm, Chronobiology, Human Milk/Breastfeeding, Bottle Feeding
- Trial name
- NCT06821672
- Testing
- Chronobiological Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Newborn
The Effect of White Noise and Pacifier Applications on Pain and Crying Time
The objective of the study was to determine the effect of white noise and pacifier applications on pain and crying time in newborns during painful interventions. The research was planned experimentally.
- Trial name
- NCT06535061
- Testing
- white noise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
Infantile Colic
Effects of Vivatlac Baby on Crying Behavior of Colicky Babies
Open trial with two parallel arms, assessing the effects of Simethicone and Vivatlac Baby in babies diagnosed for infantile colic.
- Trial name
- NCT04487834
- Testing
- Simethicone Solution, Vivatlac Baby
- Where
- 2 sites in Poland
- Volunteers
- 87 people
- Sponsor
- The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz
Multiple Sclerosis
Safety and Efficacy of AVP-923 for Pseudobulbar Affect in Multiple Sclerosis Patients
Pseudobulbar Affect is a condition characterized by frequent episodes of laughing and crying out of proportion. Other terms used to describe this condition include emotional lability, emotionalism, emotion incontinence, emotional…
- Trial name
- NCT00050232
- Testing
- AVP-923
- Where
- 20 sites in United States
- Volunteers
- 96 people
- Sponsor
- Avanir Pharmaceuticals
Nasal Congestion, Nursing
Effects of Different Nasal Irrigation Methods on Pain Level, Crying and Procedure Times in Nasal Congestion in Infants
This study aimed to evaluate the effects of different nasal irrigation (NI) methods for relieving nasal obstruction on pain, crying and procedure times, and physiologic parameters in infants with acute upper respiratory tract…
- Trial name
- NCT06691620
- Testing
- Nasal irrigation with isotonic saline, Nasal irrigation with hypertonic saline, Nontraumatic nasopharyngeal aspiration
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Neonatal Tongue-tie, Maternal Nipple Pain Upon Breastfeeding
Use of Topical Benzocaine for Analgesia in Lingual Frenotomy of the Newborn
Frenotomy of tongue-tie is commonly performed to resolve breastfeeding difficulties, eg maternal nipple pain and infant's latching difficulties. The procedure carries minor discomfort for the infants.
- Conditions
- Neonatal Tongue-tie, Maternal Nipple Pain Upon Breastfeeding, Neonatal Latch Difficulties
- Trial name
- NCT01274247
- Testing
- Topical Benzocaine
- Where
- Israel
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Infantile Colic
Clinical Trial of L. Reuteri in Infantile Colic 2017
RCT to evaluate the safety and efficacy of Lactobacillus reuteri DSM 17938 to significantly reduce the duration of crying time and fussines in infants from 15days to 4 months of age with colic, feed with human milk (30% sample)…
- Trial name
- Colic2017 (NCT03360253)
- Testing
- L. reuteri DSM 17938 in drops
- Where
- Mexico
- Volunteers
- 244 people
- Sponsor
- Innovacion y Desarrollo de Estrategias en Salud
Infant Sleep and Crying
Effects of Two Swaddling Techniques on Infant Sleep, Crying, and Maternal Comfort
The goal of this clinical trial is to learn how two different safe swaddling techniques affect sleep duration, crying duration, and maternal comfort in infants aged 1-4 months and their mothers.
- Trial name
- NCT07868380
- Testing
- Hip-Healthy Swaddling, Midline Flexion Swaddling
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Izmir University of Economics
Colic, Infantile
Effect of Probiotic Limosilactobacillus Reuteri (L. Reuteri) on Crying Time in Infants With Colic
This is a double-blind, multi-center, randomized, placebo-controlled, parallel-group study in infants with colic with the primary objective to evaluate crying time.
- Trial name
- NCT05512234
- Testing
- L. reuteri
- Where
- 3 sites in Ireland, Mexico and 1 more
- Volunteers
- 102 people
- Sponsor
- BioGaia AB
Crying
Feeding Intervention for Infants With Crying
The purpose of the study is to assess if infants who have excessive crying and fussing have less of these symptoms when fed a formula containing a probiotic compared to those fed a standard infant formula.
- Trial name
- NCT01017991
- Testing
- Milk based infant formula with probiotic, Milk based infant formula
- Where
- 9 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Recurrent Crying Spells
Recurrent Crying Spells in Cerebral Palsy
This is a study of recurrent crying spells in Spastic Cerebral Palsy patients and their treatment.
- Trial name
- RCSCPSQ (NCT01955655)
- Testing
- Baclofen
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Sathbhavana Brain Clinic
Excessive Crying, Prolonged Pain
Assessment of Prolonged Pain in Infants With Excessive Crying: Contribution of Infrared Thermal Imaging - The NEOTHERM Pilot Study
NEOTHERM is a multicenter, prospective, observational pilot study examining whether infrared thermal imaging (ITI) can contribute to the assessment of prolonged pain in infants with excessive crying.
- Trial name
- NEOTHERM (NCT07693179)
- Where
- 3 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Denis
Mitral Regurgitation
Mitral Splay Sign, Its Mechanism and Association With Severity of Regurgitation
To study echocardiography splay sign in mitral regurgitation and its association with mitral regurgitation severity and doppler band artifact ('seagull cry').
- Trial name
- NCT06152315
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- ITMO University
Ophthalmia Neonatorum
Prevalence of Conjunctivitis and Indentification of Risk Factors With and Without Prophylactic Antibiotic Treatment in Neonates
The French guidelines for the use of Rifamycine eye drops in delivery room to prevent neonatal conjunctivitis have been actualized.
- Trial name
- CRY-NOT (NCT03528915)
- Testing
- Rifamycine treatment, whithout Rifamycine treatment
- Where
- France
- Volunteers
- 881 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Amyotrophic Lateral Sclerosis
Safety/Efficacy of AVP-923 in the Treatment of Emotional Lability (Uncontrolled Crying & Laughing) in Patients With ALS
The purpose of this study is to compare and evaluate the safety of AVP-923 (dextromethorphan/quinidine) for the treatment of emotional lability in ALS patients.
- Trial name
- NCT00021697
- Testing
- AVP-923
- Where
- 17 sites in United States
- Volunteers
- 100 people
- Sponsor
- Avanir Pharmaceuticals
Colic, Inflammation
Effect of Lactobacillus Rhamnosus GG (LGG) on Infant Colic
This study will compare 2 currently marketed formulas in healthy full term babies: Nutramigen A+ (a hypoallergenic formula) and Nutramigen-Enflora (hypoallergenic formula with Lactobacillus GG (LGG)) during 3 months of formula…
- Trial name
- LGG (NCT01279265)
- Testing
- Nutramigen with Enflora, Nutramigen A+
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston