Clinical trials: Cryopreservation
Platelet Transfusion Refractoriness
Efficacy and Safety of Autologous Cryopreserved Platelets in Patients With PTR
The purpose of this study is to improve the platelet level of PTR patients; Prevent and improve bleeding; Help patients to successfully through the bone marrow suppression period after chemotherapy; Reduce the overall rate of PTR…
- Trial name
- NCT05761457
- Testing
- Cryopreserved autologous platelet transfusion
- Where
- China
- Volunteers
- 25 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Infertility
Randomized Controlled Trial Comparing Slow-freezing to Vitrification of Oocytes
Preservation of fertility is limited. Current methods include embryo cryopreservation and while still experimental, ovarian cryopreservation.
- Trial name
- NCT00777387
- Testing
- slow-freeze, vitrification
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Platelet Transfusion
Cold Apheresis Platelets in PAS
This is a platelet transfusion study. The purpose of this study is to measure the life span and quality of platelets stored in a refrigerator. Participants will give platelets by apheresis.
- Trial name
- CAPP (NCT02754414)
- Testing
- Apheresis platelet collection, Refrigerated storage of apheresis platelets in PAS/plasma, Infusion of aliquot of autologous radiolabeled platelets
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bloodworks
Trachea Diseases, Tracheal Stenosis
Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices
We used a segment of cryopreserved aorta as a graft for reconstruction for long segment tracheobronchial lesion in human.
- Conditions
- Trachea Diseases, Tracheal Stenosis, Lung Cancer, Tuberculosis; Tracheitis
- Trial name
- NCT04850742
- Testing
- Cryopreserved aorta
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Infertility
pArtiaL zonA pelluciDa Removal by assisteD hatchINg of Blastocysts
The aim of study is to assess the possible impact of assisted hatching on delivery rate after transfer of vitrified-warmed human blastocysts.
- Trial name
- NCT03623659
- Testing
- Laser assisted hatching
- Where
- 2 sites in Italy
- Volunteers
- 700 people
- Sponsor
- IRCCS San Raffaele
Diabetic Foot Infection, Non-healing Wound
Cryopreserved Human Umbilical Cord (TTAX01) for Late Stage, Complex Non-healing Diabetic Foot Ulcers (AMBULATE DFU II)
It is hypothesized that application at 4-week or greater intervals of the human placental umbilical cord tissue TTAX01 to the surface of a well debrided, complex diabetic foot ulcer (DFU) will, with concomitant management of…
- Conditions
- Diabetic Foot Infection, Non-healing Wound, Non-healing Diabetic Foot Ulcer
- Trial name
- NCT04450693
- Testing
- TTAX01, Standard care
- Where
- 16 sites in United States
- Volunteers
- 106 people
- Sponsor
- BioTissue Holdings, Inc
Severe Combined Immunodeficiency Due to ADA Deficiency
Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCID
This is a prospective, non-randomized, single-cohort, longitudinal, single-center, clinical study designed to assess the efficacy and safety of a cryopreserved formulation of OTL-101 (autologous CD34+ hematopoietic…
- Trial name
- NCT03765632
- Testing
- Infusion of autologous cryopreserved EFS-ADA LV CD34+ cells (OTL-101), Busulfan, Peg-Ada
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Graft Versus Host Disease
Cryopreservation of White Blood Cells Before Their UVA Irradiation for Graft Versus Host Disease Treatment
Extracorporeal photopheresis (ECP) is a worldwide recognized treatment of acute and chronic mild to moderate graft versus host disease (GVHD), in second or further line of treatment.
- Trial name
- cryo-ECP (NCT03361254)
- Testing
- cryopreservation
- Volunteers
- 5 people
- Sponsor
- Central Hospital, Nancy, France
Acute Leukemia, Myelodysplastic Syndromes
Cryopreserved MMUD BM With PTCy for Hematologic Malignancies
Multicenter single arm study to assess the safety and efficacy of allogeneic transplantation using cryopreserved bone marrow from deceased MMUD and PTCy, sirolimus and MMF for GVHD prophylaxis.
- Conditions
- Acute Leukemia, Myelodysplastic Syndromes, T-lymphoblastic Lymphoma, Acute Lymphocytic Leukemia
- Trial name
- NCT05170828
- Testing
- Cyclophosphamide, Fludarabine, Total Body Irradiation
- Sponsor
- Ossium Health, Inc.
Non-healing Wound, Non-healing Diabetic Foot Ulcer
Phase 2 Pilot Trial of Subjects With Complex Non-healing Diabetic Foot Ulcers Treated With Standard Care Plus Cryopreserved Umbilical Cord Allograft (TTAX01)
It is hypothesized that application of the human placental umbilical cord tissue TTAX01 to the surface of a well debrided, complex diabetic foot ulcer will, with concomitant management of infection, result in a higher proportion…
- Conditions
- Non-healing Wound, Non-healing Diabetic Foot Ulcer, Diabetic Foot Infection
- Trial name
- NCT03230175
- Testing
- TTAX01, Surgical resection and debridement, Systemic antibiotics
- Where
- 11 sites in United States
- Volunteers
- 32 people
- Sponsor
- BioTissue Holdings, Inc
Oncology, Fertility Issues
Percutaneous Laparoscopy for Ovarian Tissue Cryopreservation.
To compare surgical outcomes of oncologic patients that underwent conventional laparoscopy and percutaneous laparoscopy for cryopreservation of ovarian tissue.
- Conditions
- Oncology, Fertility Issues, Surgery
- Trial name
- NCT05134090
- Testing
- Ovaian tissue explant
- Where
- Italy
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Cryopreservation of Embryos
The Effect of Vitrification Versus Slow Freezing on Day 3: a Randomised Controlled Trial.
Randomized controlled trial (RCT) testing the hypothesis that vitrification is superior to slow freezing.
- Trial name
- NCT02013024
- Testing
- cryopreservation technique
- Where
- Belgium
- Volunteers
- 417 people
- Sponsor
- Sophie Debrock
Ovarian Cancer
Gonadal Dysgenesis Tissue Cryopreservation for Fertility Preservation
The "Gonadal Dysgenesis Tissue Cryopreservation for Fertility Preservation" study is open to a subset of patients with disorders of sex development (DSD) which is associated with the risk of malignancy and a high risk of…
- Trial name
- NCT06518746
- Testing
- Cryopreservation of gonadal tissue
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
ART, Child Development
Cognitive, Emotional, Communicative, and Motor Development in Children Born From IOC
The study focuses on children born after in vitro fertilization (IVF) of cryopreserved oocytes.
- Trial name
- NCT05906966
- Testing
- Phone contact
- Where
- Italy
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
COVID-19 Pneumonia
Treatment of Coronavirus COVID-19 Pneumonia (Pathogen SARS-CoV-2) With Cryopreserved Allogeneic P_MMSCs and UC-MMSCs
Assessment of the clinical effects of infusions of cryopreserved allogeneic multipotent mesenchymal stem cells of the placenta and umbilical cord for COVID-19 patients with acute respiratory distress syndrome.
- Trial name
- NCT04461925
- Testing
- Placenta-Derived MMSCs; Cryopreserved Placenta-Derived Multipotent Mesenchymal Stromal Cells, Antibiotics, Hormones
- Where
- Ukraine
- Volunteers
- 30 people
- Sponsor
- Institute of Cell Therapy
Autologous Platelet-rich Plasma Supplement, Sperm Cryopreservation
The Effects of Autologous Platelet-rich Plasma Supplement During Sperm Cryopreservation on Post-cryopreserved Sperm Quality
Sperm cryopreservation is an essential procedure for male fertility in certain situations, like cancer, vasectomy or other obstructive surgeries, autoimmunity diseases, immunosuppressive therapeutic strategies, or when the male…
- Conditions
- Autologous Platelet-rich Plasma Supplement, Sperm Cryopreservation, Post-cryopreserved Sperm Quality, Semen Analysis
- Trial name
- NCT06258759
- Testing
- autologous platelet-rich plasma supplement, no autologous platelet-rich plasma supplement
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Liver Transplant
Efficacy of Ex-situ Normothermic Perfusion Versus Cold Storage in the Transplant With Steatotic Liver Graft.
Prospective, randomized, controlled clinical trial to determine the overall efficacy of normothermic machine perfusion (NMP) for steatotic liver preservation versus traditional static cold storage (SCS), in 50 liver transplant…
- Trial name
- ORGANOXLAFE (NCT03930459)
- Testing
- Static cold storage (SCS), Normothermic machine perfusion (NMP)
- Where
- Spain
- Volunteers
- 7 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Fertility Preservation, Ovarian Tissue Cryopreservation
Preservation of Ovarian Cortex Tissue in Girls With Turner Syndrome
Rationale: Infertility due is a major concern for girls with Turner syndrome (TS) and their parents. Physicians are often asked about possible options to preserve their fertility.
- Conditions
- Fertility Preservation, Ovarian Tissue Cryopreservation, Turner Syndrome, Live Birth
- Trial name
- NCT03381300
- Testing
- Ovarian tissue cryopreservation
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Cancers
Ovarian Tissue Cryopreservation in Pre-Pubertal (OTC-Pre Pubertal)
The purpose of this study is to safely remove ovarian tissue in pre-pubertal pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.
- Trial name
- NCT05299710
- Testing
- Laparoscopic surgery
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Erin Rowell
Cancer
Oocyte Cryopreservation Study (Egg Banking)
Women of reproductive age who seek to freeze eggs for future pregnancy attempts may be eligible to participate in a study investigating pregnancies that result from frozen eggs.
- Trial name
- NCT02396095
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania