Clinical trials: Cryopreservation
Primary Infertility, Secondary Infertility
LANDA Embryo Freezing Technique.
The aim of this study is to track the outcome from the patients who had embryo cryopreservation as part of their Advanced Reproductive Technology (ART) treatment at West Coast Fertility Centers.
- Conditions
- Primary Infertility, Secondary Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- Freezing (NCT01271400)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- West Coast Fertility Centers
Infertility, Preimplantation Genetic Screening
Investigating the Cryopreserved Blastocyst's ImplantatiOn Potential After Genetic Screening
This is a two-arm parallel group randomized controlled trial at the Department of Reproductive Medicine at Ghent University Hospital.
- Trial name
- BIOPS (NCT03173885)
- Testing
- Preimplantation Genetic Screening
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University Hospital, Ghent
Malaria
Sanaria™ PfSPZ Challenge Vaccine
This study will randomize 30 healthy adult participants to one of three cohorts comprised of six groups of 5 individuals per group to simultaneously receive PfSPZ Challenge via the ID route.
- Trial name
- NCT01546389
- Testing
- Sanaria™ PfSPZ Vaccine, Chloroquine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
In Vitro Fertilization
Follow-up Protocol on the Outcome of Frozen-thawed Embryo Transfer Cycles From Clinical Trial P05690 (P05711)
Clinical trial objective is to collect the outcome of Frozen-Thawed Embryo Transfer (FTET) cycles performed after the embryos are cryopreserved in the base study P05690 in order to estimate the cumulative pregnancy rate for each…
- Trial name
- NCT00702546
- Testing
- corifollitropin alfa, recFSH (follitropin alfa), gonadatropin releasing hormone (GnRH) antagonist ganirelix
- Volunteers
- 102 people
- Sponsor
- Organon and Co
In Vitro Fertilization
Corifollitropin Alfa Application in PCOS Patients
Corifollitropin alfa, single dose administered sustains multiple follicular development for 7 days. However, It may induce ovarian hyperstimulation syndrome (OHSS), especially in high responder women such as patients of…
- Trial name
- NCT02215135
- Testing
- Corifollitropin alfa
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Spina Bifida; Fetus, Myelomeningocele
Cryopreserved Human Umbilical Cord as a Meningeal Patch in Fetoscopic Spina Bifida Repair
The objective is to test the efficacy of a laparotomy-assisted fetoscopic surgical approach to cover spina bifida spinal cord developmental defects using cryopreserved human umbilical cords (NEOX Cord 1K®) as a meningeal and skin…
- Conditions
- Spina Bifida; Fetus, Myelomeningocele, Myeloschisis
- Trial name
- HUC-FICS (NCT06042140)
- Testing
- NEOX Cord 1K applied fetoscopically
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Osteoarthritis
Cryopreserved Human Meniscus Transplantation
The purpose of this study is to determine the long-term survivorship and clinical outcomes of all cryopreserved meniscus transplants performed by Dr. Frank Noyes.
- Trial name
- NCT02319811
- Testing
- Cryopreserved meniscus transplants
- Volunteers
- 76 people
- Sponsor
- Cincinnati Sportsmedicine Research and Education Foundation
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination
The reconstitution of a functioning immune system after allogeneic stem cell transplantation takes months to years. Particularly memory B-lymphocytes reconstitute poorly with the current conditioning regimes.
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia, Non Hodgkin's Lymphoma
- Trial name
- B-cell therapy (NCT02007811)
- Testing
- allogeneic donor derived B-lymphocytes
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Infertility
Safety and Efficacy of Freezing and Thawing of Human Eggs in Assisted Reproductive Technology
The purpose of this study is to determine the effectiveness of the ViaCell's product media for freezing and thawing human eggs for future use in assisted reproductive technology.
- Trial name
- NCT00451009
- Testing
- Viacell's product Media Kits
- Where
- 4 sites in United States
- Sponsor
- ViaCell
Diamond Blackfan Anemia
Mobilization of Stem Cells With G-CSF for Collection From Patients With Diamond-Blackfan Anemia
This study will provide information needed to develop more effective treatments for patients with Diamond-Blackfan anemia (DBA). Current treatments include steroids, such as prednisone, and blood transfusions.
- Trial name
- NCT00011505
- Testing
- G-CSF, Leukapheresis
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Non Union Fracture, Metaphyseal Fibrous Defect
Allogenic Mesenchymal Stem Cell for Bone Defect or Non Union Fracture
Mesenchymal stem cell (MSC) is one kind of stem cell which is gained form adult tissue. Although MSC derived from autogenic bone marrow are proven to help regeneration in non union fracture and long bone defect, the aspiration…
- Trial name
- AMSC (NCT02307435)
- Testing
- MSC
- Where
- 2 sites in Indonesia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Fertility Preservation
Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or…
- Trial name
- HOLIDAY (NCT07225660)
- Testing
- OCP pause
- Where
- 3 sites in United States
- Volunteers
- 394 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Infertility Assisted Reproductive Technology
From a Single Child to Family Planning
This monocentric retrospective cohort study aims to investigate reproductive behavior and subsequent family-building outcomes in couples who achieved a first live birth through assisted reproductive technology (ART) at a…
- Trial name
- FromSich (NCT07458165)
- Volunteers
- 5,852 people
- Sponsor
- Istituto Clinico Humanitas
Determine Effectiveness of Theraskin in the Treatment of DFU and VLU
Clinical Trial to Examine Effectiveness of a Human Allograft for Treatment of DFU and VLU
Retrospective clinical study of 188 patients to examine effectiveness of human cryopreserved allograft in the treatment of diabetic foot ulcers and venous leg ulcers
- Trial name
- NCT03999281
- Testing
- Human Allograft (Theraskin)
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Solsys Medical LLC
Azoospermia or Severe Oligozoospermia, Infertility
Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue
This is a pilot clinical trial to evaluate the feasibility and outcome of autologous transplantation of immature testicular tissue cryopreserved during childhood as a method of fertility preservation for prepubertal boys in case…
- Conditions
- Azoospermia or Severe Oligozoospermia, Infertility, Autologous Transplantation
- Trial name
- TESTIGRAFT (NCT07542626)
- Testing
- autologous transplantation of cryopreserved testicular tissue
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Herpes Simplex Dendritic Keratitis
Evaluating Adjunctive Cryopreserved Amniotic Membrane Treatment in Herpes Simplex Dendritic Keratitis
To prospectively evaluate the effectiveness of Prokera Slim in adults with primary or recurrent herpetic epithelial keratitis in terms of visual function, corneal opacity, time to resolution, cost of care, number of patient…
- Trial name
- NCT04598282
- Testing
- Prokera Slim, Standard of Care
- Where
- United States
- Sponsor
- Oregon Health and Science University
Fertility Preservation
FSH and LH Versus FSH Alone for Ovarian Stimulation in Non-hormone Sensitive Onco-fertility Patients
Fertility preservation has been performed before the initiation of cancer therapy as cancer therapy is known to be toxic for ovarian function.
- Trial name
- NCT06227949
- Testing
- Luveris
- Volunteers
- 140 people
- Sponsor
- Ellen Greenblatt
Infertility
Oocyte Cryopreservation: Slow Cooling Versus Vitrification Techniques on Oocyte Survival
Oocyte cryopreservation has been studied for many years without much success in refining a method that has consistent, reliable results in producing viable embryos and clinical pregnancies.
- Trial name
- NCT00602966
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- UConn Health
Sperm Cryodamage
Effect of PRP in Donor Semen During Cryoprervation
Sperm cryopreservation allows the preservation of sperm biological function for long periods of time for later use in assisted reproductive techniques (ART).
- Trial name
- PRP (NCT07504575)
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI Alicante
Oocyte Cryopreservation
Paired Non-inferiority Study Comparing Overture Semi-automated Vitrification System ("DaVitri") to Standard Manual Process for Clinical Pregnancy Outcomes
This study will recruit 260 female recipients (and up to a maximum of 130 donors). This study is a sequel to the protocol CP-DV-000-GEN-003, entitled, "NON-INFERIORITY STUDY COMPARING OVERTURE SEMI-AUTOMATED VITRIFICATION SYSTEM…
- Trial name
- NCT06853418
- Testing
- Oocyte Cryopreservation
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Overture Life