Clinical trials: Cryotherapy
Postoperative Pain
The Effect of Intermittent Cryotherapy Exposure on Patients' Quality of Recovery After Surgery
"Cryotherapy", or cold therapy, can include the use of gel packs, ice bags, ice baths, whole body chambers, and cold aerosol sprays.
- Trial name
- ICE (NCT04564963)
- Testing
- Cryotherapy
- Where
- 3 sites in Canada
- Volunteers
- 196 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cryotherapy Effect, Burn Scar
Observation of the Comfort and Efficacy of CO2 Laser Combined With Cryo 6 for Burn or Linear Scars.
To investigate the effect of 10,600 nm CO2 laser combined with Zimmer Cryo 6 forced cold air device on the comfort and efficacy of patients with burn scars or post-operative linear scars, and to provide a safer, more effective…
- Conditions
- Cryotherapy Effect, Burn Scar, Scar; Previous Cesarean Section
- Trial name
- NCT05555602
- Testing
- Cold-air cooling
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kaiyang Lv, MD-PhD
Kidney Neoplasms
Tracking Renal Tumors After Cryoablation Evaluation
TRACE is an observational, open-label, single-arm, multi-center registry of subjects who have undergone renal lesion cryoablation per their physician's standard of care.
- Trial name
- TRACE (NCT01117779)
- Testing
- Cryoablation
- Where
- 7 sites in United States
- Volunteers
- 246 people
- Sponsor
- Boston Scientific Corporation
Barrett's Esophagus
A Dose-Optimization Study for the Initial Treatment of Dysplastic Barrett's Esophagus With trūFreeze™ Spray Cryotherapy
The primary objective of this study is to determine the percentage segment regression after spray cryotherapy in a dose-escalation study performed in patients with dysplastic Barrett's Esophagus (BE) using trūFreeze™ spray…
- Trial name
- DOSE (NCT01845454)
- Testing
- trūFreeze™ Spray Cryotherapy
- Where
- 6 sites in United States
- Volunteers
- 36 people
- Sponsor
- CSA Medical, Inc.
Verruca Vulgaris
A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin
The purpose of the study was to see if liquid nitrogen, a commonly used treatment for warts, is more effective if it is used alone, or if it is more effective if combined with cantharidin, a topical treatment also commonly used…
- Trial name
- NCT01084824
- Testing
- Liquid nitrogen and cantharidin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- North Idaho Dermatology
Paronychia, Epidermal Growth Factor Receptor Inhibitor
The Efficacy of Topical Timolol Combined With Cryotherapy in EGFR Inhibitors-induced Paronychia - a Double-blinded, Intrapatient Left-to-right Controlled Study
Background: EGFR inhibitors (EGFRi) have been used to treat a wide variety of cancers nowadays. One of the major side effects of EGFRi is paronychia, which was not fatal but may caused huge negative impact on patient's daily…
- Trial name
- NCT05165082
- Testing
- Timolol maleate 0.5% ophthalmic solution, Cryotherapy with liquid nitrogen
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Taipei Medical University WanFang Hospital
External Genital Warts
Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment
External Genital Warts (EGW) are the most common sexually transmitted disease associated with more than 30 types of the Human Papillomavirus (HPV). Cryotherapy is an effective method of EGW treatment.
- Trial name
- NCT02147353
- Testing
- Sinecatechins 15% Ointment, Cryotherapy alone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy
Prevention of Oral Mucositis After Using Chamomile Oral Cryotherapy Versus Oral Cryotherapy in Pediatric Cancer Patients Receiving Chemotherapy.
oral mucositis is a painful situation that significantly affects patients' quality of life with the severe cases being associated with ulcerated mucosa and secondary infection which may lead to life-threatening sepsis.Chamomile…
- Trial name
- NCT03605186
- Testing
- Chamomile oral cryotherapy, Oral cryotherapy
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Actinic Keratoses
Efficacy and Safety of Cryotherapy Versus 5-Fluorouracil in the Treatment of Actinic Keratosis
The goal of this clinical trial is to compare the effectiveness and safety of two treatments-cryotherapy and 5-Fluorouracil (5-FU)-for actinic keratosis, a common skin condition caused by long-term sun exposure.
- Trial name
- NCT06461442
- Testing
- Cryotherapy, 5Fluorouracil
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of California, Davis
Chronic Rhinitis
ClariFix Rhinitis RCT
A randomized, sham-controlled, single-blind study of cryotherapy as a treatment for chronic rhinitis.
- Trial name
- CR RCT (NCT04154605)
- Testing
- ClariFix cryotherapy
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- Stryker Instruments
Prostate Cancer
Phase I Clinical Trial of Cryoimmunotherapy Against Prostate Cancer
20 patients with invasive castration resistant prostate cancer and radiologically verified metastases will be enrolled into the Phase I Clinical Trial. The trial is a dendritic cell based immunotherapy.
- Trial name
- CryoIT (NCT02423928)
- Testing
- Dendritic cell based cryoimmunotherapy, Cyclophosphamide, ipilimumab
- Where
- Norway
- Volunteers
- 18 people
- Sponsor
- Alden Cancer Therapy II
Periapical Diseases
Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit RCT
A total of 60 patients presenting with single-rooted teeth exhibiting symptomatic apical periodontitis were subjected to a randomized allocation into two groups of 30 each.
- Trial name
- NCT07598188
- Testing
- Saline 0.9% (1.5-2.5°C)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Islamabad Medical and Dental College
Kidney Neoplasms
Cryaoablation Assisted Partial Nephrectomy a Non Ischemic Approach
Patients with renal masses eligible to partial nephrectomy often require arterial ischemia to control or prevent blood loss during this surgical procedure.
- Trial name
- RCAPN (NCT05218811)
- Testing
- Cryoablation Assisted Partial Nephrectomy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Urological Research Network, LLC
Actinic Keratosis
Imiquimod 3.75% Cream in Combination With Cryotherapy in the Treatment of Hypertrophic Actinic Keratoses
Actinic keratoses (AK) are common cutaneous lesions associate with chronic ultraviolet radiation exposure. While most authorities consider AK as a pre-malignant lesion, some consider it as an incipient squamous cell carcinoma…
- Trial name
- NCT01229319
- Testing
- Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Frankel, Amylynne, M.D.
Proximal Tibia Fracture
The Efficacy and Cost Effectiveness of Preoperative and Postoperative Cryotherapy in Proximal Tibia Fractures
Consenting patients with proximal tibia fractures will be randomized to 10 degree or 21 degree cryotherapy sleeves. Time to discharge and complications will be monitored.
- Trial name
- ARCTIC CAT (NCT01104831)
- Testing
- Cryotherapy, Room temperature cuff
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Cryotherapy Effect, Irreversible Pulpitis
Cryotherapy Efficacy During Pulp Therapy of the Mandibular First Permanent Molars in Children
The aim of the study is to assess the efficacy of cryotherapy application on the success of inferior alveolar nerve block (IANB) in reducing pain during pulp therapy of the mandibular first permanent molars with irreversible…
- Conditions
- Cryotherapy Effect, Irreversible Pulpitis, Pain
- Trial name
- NCT05441995
- Testing
- Cryotherapy
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Minia University
Breast Neoplasms, Prostate Cancer
Evaluation of the Cryotherapy in the Prevention of Nails Toxicity Induced by Taxotere® in Breast or Prostate Cancer
Taxotere® can induce nails changes like dyschromia, hematoma, lines of Beau-Reil (signing the stop of the epithelial proliferation), abscess, or pain.
- Conditions
- Breast Neoplasms, Prostate Cancer, Nail Diseases
- Trial name
- CRYO1 (NCT00925418)
- Testing
- Frozen Glove
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Institut Paoli-Calmettes
Lentigo, Solar Lentigo
Interventional, Monocentric, Double-blind Randomized Category 2b Study Evaluating the Evaluation of the Tolerance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post -Inflammatory Hyperpigmentation (Pih)) on the Face
The goal of this clinical trial is to compare the 2 different prototype of cytoselectivecryotherapy devices (name of the devices : CRYONOVE) use in brown spots on the face of subject from different ethnicities.
- Conditions
- Lentigo, Solar Lentigo, Post Inflammatory Hyperpigmentation
- Trial name
- CS5_10 (NCT06361251)
- Testing
- CRYONOVE (EC14_4osc), CRYONOVE (EC05osc)
- Where
- South Africa
- Volunteers
- 30 people
- Sponsor
- Cryonove Pharma
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of Preoperative Cold Therapy on Early Postoperative Outcomes in Total Knee Arthroplasty
This prospective, single-center, randomized controlled trial investigates the effects of preoperative cold therapy on early postoperative outcomes in patients undergoing unilateral primary total knee arthroplasty (TKA).
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Cryotherapy, Postoperative Pain Management
- Trial name
- NCT07134283
- Testing
- Preoperative and Postoperative Cold Therapy with Gel Cold Pack, Postoperative Cold Therapy with Gel Cold Pack
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people
- Sponsor
- Ankara City Hospital Bilkent
Cutaneous Warts
Intralesional Bleomycin Versus Cryotherapy for Treatment of Cutaneous Warts
The purpose of the study was to determine the efficacy of intralesional bleomycin in comparison to cryotherapy on participants having cutaneous warts.
- Trial name
- NCT05023408
- Testing
- Bleomycin Injection, Cryotherapy
- Where
- Pakistan
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre