Clinical trials: Crystal Arthropathies
Gout
Safety and Pharmacodynamics of SEL-212 (Pegsiticase + SEL-110) in Subjects With Elevated Blood Uric Acid Levels
This Study will first evaluate the safety and pharmacokinetics of a single intravenous dose of SEL-110, a nanoparticle containing rapamycin, in subjects with elevated blood uric acid levels.
- Trial name
- NCT02648269
- Testing
- SEL-110, SEL-212, SEL-037
- Where
- 6 sites in United States
- Volunteers
- 63 people
- Sponsor
- Selecta Biosciences, Inc.
Gout Initiating Urate-loweringUrate-lowering Therapy
The Remote Monitoring of Gout Study
The goal of this clinical trial is to: compare a new digital self-management treatment strategy to usual care, for patients with gout receiving urate lowering therapy in specialist healthcare.
- Trial name
- ReMonit Gout (NCT06822933)
- Testing
- Urika, Nurse-led follow-up with telephone consultations.
- Where
- Norway
- Volunteers
- 168 people
- Sponsor
- Diakonhjemmet Hospital
Calcifying Shoulder Tendinitis
Effectiveness of ECA Cream on Calcifying Shoulder Tendinitis
This pilot trail aims to assess the effectiveness of ECA cream in the treatment of calcifying shoulder tendinitis in terms of: 1. Reduction or removal of shoulder calcifications 2. Functional improvements 3.
- Trial name
- ECA (NCT02986035)
- Testing
- ECA cream
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Consorci Sanitari del Maresme
Primary Osteoarthritis, Secondary Osteoarthritis
Clinical and Radiological Outcomes of Medacta Shoulder System
This is a post-marketing surveillance on Medacta Shoulder System
- Conditions
- Primary Osteoarthritis, Secondary Osteoarthritis, Rotator Cuff Tear Arthropathy, Rheumatoid Arthritis Shoulder
- Trial name
- NCT03547947
- Testing
- Medacta Shoulder System
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Osteo Arthritis Shoulders, Proximal Humeral Fracture
Reverse Total Shoulder Arthroplasty: A Data Analysis on Patients Undergoing Reverse Total Shoulder Arthroplasty
The purpose of this study is to evaluate reverse total shoulder arthroplasty patients preoperative objective measurements and operative objective measurements to determine if there is any effect to postoperative outcomes.
- Conditions
- Osteo Arthritis Shoulders, Proximal Humeral Fracture, Rotator Cuff Tear, Rotator Cuff Tear Arthropathy
- Trial name
- rTSA (NCT03617107)
- Testing
- reverse total shoulder arthroplasty
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Orthopaedic Research & Innovation Foundation
Type2Diabetes, Hypertension
Digital Care for Holistic Health in Older Adults With Diabetes and Multimorbidity
The purpose of this study was to explore the effectiveness of the "Digital Care Community Common Good" program in improving disease control indicators, self-management abilities, depression, and quality of life among patients…
- Conditions
- Type2Diabetes, Hypertension, Dyslipidemia, CKD
- Trial name
- NCT07310849
- Testing
- Digital Care Community Common Good Program, Usual Care
- Where
- Taiwan
- Volunteers
- 169 people
- Sponsor
- Chang Gung University of Science and Technology
Rotator Cuff Tears, Rotator Cuff Tear Arthropathy
Retrovertion Assesment and Study in Elderly Patients With Reverse Total Shoulder Arthroplasty
Determine the optimal degree of retroversion (0-30º) to obtain the best rotational mobility, both internal and external, of the shoulder after implanting a reversed sghoulder arthroplasty (Comprehensive system), and analyze the…
- Trial name
- NCT06316050
- Testing
- humeral retroversion
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Consorci Sanitari de Terrassa
Gout, Arthritis
A Nurse Led Patient Management Programme to Improve Outcomes in Gout
This study evaluates the addition of a structured nurse led patient management programme to standard of care in gout patients. Half of the patient will receive the nurse led programme in addition to standard of care and the other…
- Conditions
- Gout, Arthritis, Crystal Arthropathy
- Trial name
- BONUS (NCT03345186)
- Testing
- nurse led plus standard of care
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- University Hospital, Basel, Switzerland
Gout
Single and Multiple Dose Study in Japanese
This study will explore the safety, tolerability, and serum uric acid lowering effect of lesinurad in healthy Japanese males to allow comparison with the Western population.
- Trial name
- NCT01744379
- Testing
- Lesinurad
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ardea Biosciences, Inc.
Nephritis, Interstitial, Chronic Renal Failure
Hereditary Tubulointerstitial Nephritis
The aim of this study is to identify families with hereditary chronic tubulointerstitial renal diseases , characterize the phenotype and screen for mutations in known genesis (UMOD, REN, TCF2, NPHP1).
- Conditions
- Nephritis, Interstitial, Chronic Renal Failure, Gout, Renal Cysts
- Trial name
- NTIH (NCT01312727)
- Testing
- Blood and urine sample collections
- Where
- France
- Volunteers
- 225 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gouty Arthritis
Real-life Study of the Characteristics of Patients Treated With Ilaris® (Canakinumab) for Gouty Arthritis in France
This was a non-interventional, retrospective, cross-sectional, descriptive study, conducted on the National Health Data System (Système National des Données de Santé, SNDS).
- Trial name
- NCT05964946
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Novartis Pharmaceuticals
Gout
Validation Study of Physical Measurement of Tophi
The purpose of this study is to determine the inter- and intra-rater reproducibility of direct physical measurement of tophus nodules in subjects with gout.
- Trial name
- NCT00175006
- Testing
- Measurement of Tophi to validate procedure
- Volunteers
- 13 people
- Sponsor
- Takeda
Hyperuricemia
ALLN-346 Single Ascending Dose (SAD) Study in Healthy Volunteers
The purpose of this study is to evaluate the safety of ALLN-346 in healthy volunteers, in this first in human, single ascending dose study. ALLN-346 is an enzyme that degrades urate in the gastrointestinal tract.
- Trial name
- SAD (NCT04236219)
- Testing
- ALLN-346
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Allena Pharmaceuticals
Rotator Cuff Tear Arthropathy
the Effect of Core Stability on Hand Functions
Determining the factors affecting hand function after upper limb injuries is very important for maintaining independence in daily living activities.
- Trial name
- NCT06105398
- Testing
- clinical evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Gülçe İrem Yalçınkaya
Gout
Pegylated Recombinant Mammalian Uricase (PEG-uricase) as Treatment for Refractory Gout
The purpose of this study is to determine whether PEG-uricase (a chemically modified recombinant mammalian enzyme that degrades uric acid) is effective in controlling hyperuricemia in patients with chronic gout, who cannot…
- Trial name
- NCT00111657
- Testing
- Pegloticase
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- John Sundy
Primary Osteoarthritis, Secondary Osteoarthritis
Clinical and Radiological Outcomes of Medacta Shoulder System FR
This is a post-marketing surveillance on Medacta Shoulder System
- Conditions
- Primary Osteoarthritis, Secondary Osteoarthritis, Rotator Cuff Tear Arthropathy, Rheumatoid Arthritis Shoulder
- Trial name
- NCT05926622
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Gouty Arthritis
Oral Huzhang Granules for Acute Gouty Arthritis
We designed this study as a double-blind, randomized, controlled clinical trial. The aim of the study is to evaluate the clinical efficacy, safety and control of recurrence rate of acute gouty arthritis
- Trial name
- NCT04462666
- Testing
- Huzhang granule, Etoricoxib
- Volunteers
- 267 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Rheumatoid Arthritis (RA, Ankylosing Spondylitis
Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic Diseases
Rheumatic diseases are chronic inflammatory conditions that can lead to long-term tissue damage and increased cardiovascular and metabolic risk.
- Conditions
- Rheumatoid Arthritis (RA, Ankylosing Spondylitis, Psoriatic Arthritis, Reactive Arthritis (ReA)
- Trial name
- NCT07329556
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bursa City Hospital
Hyperuricemia, Gout
Safety, Tolerability and Pharmacokinetic/Pharmacodynamic Characteristics of LC350189
This will be a dose block-randomized, double-blind, active and placebo controlled, single and multiple dosing, dose-escalation study to evaluate tolerability, safety and pharmacokinetic / pharmacodynamic characteristics.
- Trial name
- NCT01361646
- Testing
- LC350189
- Where
- South Korea
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Rotator Cuff Tear Arthropathy
The Effects of Platelet Rich Plasma on the Integrity of Rotator Cuff Repair
The purpose of this study was to determine the effect of platelet-rich fibrin matrix (PRFM) augmentation to at-risk arthroscopic rotator cuff repairs on healing rates and functional outcome scores.
- Trial name
- NCT01424969
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Utah