Clinical trials: CtDNA
Lung Cancer
To Establish a Molecular Typing System for Early Diagnosis of Lung Cancer
This topic to take large multicenter study real world, the advanced liquid biopsy will ctDNA methylation detection technique is applied to pulmonary nodules differential diagnosis and early lung cancer screening, validation of…
- Trial name
- NCT05432128
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Singlera Genomics Inc.
Ovarian Cancer
Bespoke ctDNA Assay for Recurrence and Treatment Response Monitoring in Advanced Epithelial Ovarian Cancer
This prospective observational study is to assess the dynamics of circulating tumor DNA (ctDNA) in patients with advanced epithelial ovarian cancer (EOC) undergoing surgery, adjuvant chemotherapy, followed by poly adenosine…
- Trial name
- EOC (NCT05446545)
- Testing
- ND-EOC or platinum-sensitive rEOC
- Where
- China
- Volunteers
- 139 people
- Sponsor
- Fudan University
Neoplasms, Gastrointestinal
The Role of ctDNA, PVT1 and ROS in Diagnosis and Treatment of Gastrointestinal and Hepatobiliary Pancreatic Cancer
This study aims to evaluate the role of ct-DNA, PVT1 and reactive oxygen species (ROS) as biomarkers in the diagnosis, treatment and recurrence monitoring of gastrointestinal and hepatobiliary pancreatic cancer.
- Trial name
- NCT03076502
- Volunteers
- 500 people
- Sponsor
- RenJi Hospital
Non-small Cell Lung Cancer
Furmonertinib Monotherapy and Combination Therapy in Advanced EGFR Mutant NSCLC With Uncleared ctDNA
EGFR mutation positive advanced NSCLC patients with uncleared ctDNA have poor prognosis, whether they can benefit from combination therapy has not been reported.
- Trial name
- FOCUS-C (NCT05334277)
- Testing
- Furmonertinib, Furmonertinib/Pemetrexed/Carboplatin, Furmonertinib/Pemetrexed/Carboplatin/Bevacizumab
- Where
- 26 sites in China
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Epithelial Ovarian Cancer
Plasma ctDNA Detection in Diagnosis of Epithelial Ovarian Cancer.
Epithelial ovarian cancer constitutes one of the most common gynecological malignancies.Because the ovaries lie in the deep pelvic cavity,most ovarian cancer patients are asymptomatic, rendering the majority often diagnosed at an…
- Trial name
- ctDNA_EOC (NCT03155451)
- Testing
- methylation markers screening
- Where
- China
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Metastatic Colorectal Cancer, No Evidence of Disease Status
Predictive Value of ctDNA for NED Status in mCRC and Its Utility in Guiding Therapeutic Intervention
The goal of this clinical trial is to detect the prognostic value of longitudinal monitoring circulating tumor DNA (ctDNA) for no evidence of disease (NED) status in metastatic colorectal cancer (mCRC) patients and its utility in…
- Conditions
- Metastatic Colorectal Cancer, No Evidence of Disease Status, ctDNA Monitoring
- Trial name
- NCT05635630
- Testing
- ctDNA and adjuvant therapy, ctDNA
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Fudan University
Colorectal Cancer
Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays
The study is an observational multicenter evaluation of participants with colorectal cancer (CRC) who will receive longitudinal plasma ctDNA biomarker profiling in addition to their standard-of-care therapy and disease…
- Trial name
- NCT05234177
- Testing
- Observation
- Where
- 20 sites in United States
- Volunteers
- 300 people
- Sponsor
- Tempus AI
Colorectal Cancer, Colon Cancer
BESPOKE Study of ctDNA Guided Therapy in Colorectal Cancer
The BESPOKE CRC study will prospectively enroll patients who have undergone surgery for stage I to IV colorectal cancer (CRC) and who have residual formalin-fixed paraffin-embedded (FFPE) tissue available will provide FFPE and…
- Trial name
- NCT04264702
- Where
- United States
- Volunteers
- 1,788 people
- Sponsor
- Natera, Inc.
Lung Cancer, Non Small Cell Lung Cancer
Trial of ctDNA of Guidance to Determine PostOperative Radiation Therapy
Primary Objective: Evaluate the role of ctDNA positivity in decision making for postoperative therapy for non-small cell lung cancer.
- Conditions
- Lung Cancer, Non Small Cell Lung Cancer, Lung Cancer Recurrent
- Trial name
- PORT (NCT06979661)
- Testing
- Haystack™ ctDNA Assay
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rutgers, The State University of New Jersey
Colorectal Cancer
CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer
The CORRECT - MRD II study will prospectively enroll patients who have undergone complete surgical resection for stage II or III colorectal cancer.
- Trial name
- MRD (NCT05210283)
- Testing
- MRD
- Where
- 32 sites in United States, Canada
- Volunteers
- 1,017 people
- Sponsor
- Exact Sciences Corporation
Prostatic Neoplasms, ctDNA
Prognostic Study of Via Dynamic Change of dT-DNA in Drainage Fluid After Radical Prostatectomy
This study investigates the prognostic value of dynamic changes in Drainage Tumor DNA(dT-DNA) levels found in the peritoneal drainage fluid after radical prostatectomy.
- Trial name
- NCT06707974
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Diffuse Large B-Cell Lymphoma, DLBCL
Study on Predicting Response to Standard First-Line Treatment in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Using ctDNA Combined With PET
This is a prospective, multicenter, multi-cohort study of ctDNA combined with PET for predicting the efficacy of standard first-line therapy for patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL).
- Trial name
- NCT07070648
- Testing
- POLA-R-CHP
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fudan University
Metastatic Breast Cancer
Plasma Circulating Tumor DNA Analyses in ER+ Metastatic Breast Cancer
The purpose of this study is to evaluate whether increased mutant ESR1 allele fraction in plasma ctDNA 3-6 weeks after initiating salvage endocrine therapy is predictive of progression free survival in patients with ER+…
- Trial name
- NCT03161834
- Testing
- Observational
- Where
- United States
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Lung Diseases, Carcinoma, Non-Small-Cell Lung
Atezolizumab Plus Induction Chemotherapy Plus CT-radiotherapy. (APOLO)
Open-label, non-randomized, phase II multi-centre controlled clinical trial. 51 non-resectable stage IIIA-IIIB non-small cell lung cancer patients will be enrolled in this trial to evaluate the efficacy of the treatment…
- Conditions
- Lung Diseases, Carcinoma, Non-Small-Cell Lung, Stage IIIA Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer
- Trial name
- APOLO (NCT04776447)
- Testing
- Carboplatin, Placlitaxel, Atezolizumab
- Where
- 22 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Fundación GECP
Diffuse Large B Cell Lymphoma, Central Nervous System Metastasis
ctDNA and Metabolites in CSF as Early Biomarkers of Secondary CNS Involvement in Diffuse Large B-cell Lymphoma
The study is a prospective clinical study which investigates the use of new diagnostic methods to localize aggressive lymphoma involving the central nervous system(CNS).
- Trial name
- CNSctDNA (NCT04112238)
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Herlev Hospital
Solid Tumor
Identifying MSI Status From ctDNA in Chinese Patients With Refractory Advanced Solid Tumors
This is a molecular epidemiological investigation aiming to identify microsatellite instability status from circulating tumor DNA in Chinese patients with refractory advanced solid tumors.
- Trial name
- IMPACT (NCT03596593)
- Testing
- SPANOM (identifying MSI status from ctDNA)
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Peking University
Endometrial Cancer
Exploring the Potential of ctDNA-MRD for Recurrence Surveillance and Prognostic Evaluation in High-risk Endometrial Cancer
Patients with high-risk endometrial cancer may have MRD after surgical treatment, which is a potential source of follow-up early recurrence and metastasis, and because of its limited resolution, traditional imaging (including…
- Trial name
- NCT06341855
- Testing
- MRD-ctDNA
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Hospital of Jilin University
Pediatric Soft Tissue Sarcoma
Study on Dynamic CtDNA Analysis in Pediatric Soft Tissue Sarcoma
Pediatric soft tissue sarcoma is made up of different subtypes, some of which have distinct genetic alterations. Fusion variants were found in about 43% of bone and soft tissue sarcoma samples.
- Trial name
- NCT05778955
- Testing
- detection and monitoring of cirulating tumor DNA
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-sen University
Carcinoma, Non-Small-Cell Lung
Comparison of Circulating Tumor DNA and Tumor Tissue DNA by Targeted Sequencing in Non-Small Cell Lung Cancer
Conduct a prospective study to compare gene detection by ctDNA with tumor tissue DNA via targeted DNA sequencing in surgical NSCLC patients.
- Trial name
- NCT02645318
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Rectal Cancer
ctDNA-Based Adjuvant Chemotherapy for High-Risk Rectal Cancer
The goal of this clinical trial is to investigate whether adjuvant chemotherapy can prevent disease recurrence in patients with high-risk rectal cancer who have detectable ctDNA after surgery.
- Trial name
- REACT (NCT07188025)
- Testing
- Adjuvant chemotherapy
- Where
- 25 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Erasmus Medical Center