Clinical trials: Cushing Syndrome
Adrenal Tumor, Primary Aldosteronism
Development of Clinical Evidence for Optimal Management of Adrenal Diseases Based on Real-World Data
This research aims to establish clinical evidence for optimal treatment guidelines for adrenal diseases using real-world data. The approach involves building prospective and retrospective patient registries, which will be…
- Conditions
- Adrenal Tumor, Primary Aldosteronism, Cushing Syndrome, Pheochromocytoma
- Trial name
- NCT06229405
- Where
- South Korea
- Volunteers
- 8,200 people
- Sponsor
- Seoul National University Hospital
Adrenocortical Carcinoma
Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)
This study will investigate the safety and efficacy of Relacorilant in combination with Pembrolizumab for Patients with Adrenocortical Carcinoma which Produces Too Much Stress Hormone (Cortisol).
- Trial name
- NCT04373265
- Testing
- Relacorilant, Pembrolizumab
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Corcept Therapeutics
Nonfunctional Adrenal Cortex Adenoma, Primary Aldosteronism
A Single Center Randomized Controlled Study on the Promotion of Rapid Recovery
The goal of this clinical trial is to exploring the role of tubeless after adrenalectomy surgery. The main questions it aims to answer are: 1. The safety of tubeless laparoscopic adrenalectomy； 2.
- Conditions
- Nonfunctional Adrenal Cortex Adenoma, Primary Aldosteronism, Cushing Syndrome
- Trial name
- NCT06250699
- Testing
- Tubeless laparoscopic adrenalectomy, Drainage tube
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhe Meng
Adrenal Insufficiency, Congenital Adrenal Hyperplasia
Dynamic Hormone Diagnostics in Endocrine Disease
The study will investigate 27 hour profiles of hormones in the subcutaneous tissue of healthy subjects and patients with Addison's, Congenital Adrenal Hyperplasia, Growth Hormone Deficiency, acromegaly, Cushings and Primary…
- Conditions
- Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Cushing Syndrome, Growth Hormone Deficiency
- Trial name
- ultradian (NCT02934399)
- Testing
- 27 hour subcutaneous fluid sampling
- Where
- 4 sites in Greece, Norway and 2 more
- Volunteers
- 528 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Endogenous Cushing Syndrome
Canadian Continuation of Roll-over Study in Patients With Endogenous Cushing's Syndrome
The purpose of this study is to continue the evaluation of long-term safety of osilodrostat in 7 Canadian patients who have already received osilodrostat treatment in a previous Global Recordati-sponsored roll-over study and who…
- Trial name
- ISS-CA-2023 (NCT06131580)
- Testing
- Intervention/Treatment
- Where
- 3 sites in Canada
- Volunteers
- 7 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cushing Syndrome, Metabolic Syndrome
Evaluation of the Severity of Hepatic Fibrosis by Magnetic Resonance Elastography in the Diagnosis of Endogenous Hypercorticism
The main hypothesis of the HEPACORT study is that upon diagnosis of endogenous Cushing's syndrome, significant liver fibrosis may be present, particularly in the most severe forms of Cushing's syndrome.
- Trial name
- HEPACORT (NCT05911620)
- Testing
- Magnetic resonance elastography (MRE)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Central Hospital, Nancy, France
Cushing Syndrome, Pheochromocytoma
Metabolic Myopathy in Endocrinopathy
Endocrine diseases including Cushing's syndrome and phaeochromocytoma/paraganglioma (PPGL) but not Conn's syndrome are associated with muscle wasting and weakness.
- Conditions
- Cushing Syndrome, Pheochromocytoma, Conns Syndrome, Metabolic Myopathy
- Trial name
- LYDIA (NCT05456997)
- Testing
- Muscle biopsy
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Barts & The London NHS Trust
Adrenal Tumor, Adrenal Disease
Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy
The goal of this multicenter, observational, analytic, randomized clinical trial is to analyze the laparoscopic and robot-assisted method in the surgical treatment of patients with adrenal diseases.
- Conditions
- Adrenal Tumor, Adrenal Disease, Adrenal Mass, Adrenalectomy; Status
- Trial name
- NCT06050057
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Olomouc
Adrenal Insufficiency, Cushing Syndrome
Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids
Cortisol is an essential for life hormone secreted in a pulsatile pattern on a diurnal rhythm. Given the complexity of cortisol secretion on a circadian rhythm with pulsations, current methods of cortisol measurement have…
- Conditions
- Adrenal Insufficiency, Cushing Syndrome, Hyperaldosteronism
- Trial name
- SensoCort (NCT06008184)
- Testing
- 24 hours sampling of 4 biological fluids (blood, ISF, sweat and saliva), 24 hours sampling of ISF or sweat (after validating the correlation with blood)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cushing's Syndrome
Retrospective Chart Review Study of Korlym for the Treatment of ACTH Independent Cushing's Syndrome
Chart review study to collect patient data from medical charts of patients who have been treated with Korlym® for the treatment of ACTH independent adrenal Cushing's Syndrome.
- Trial name
- RE-KLAIM (NCT02663609)
- Testing
- No intervention
- Volunteers
- 24 people
- Sponsor
- Corcept Therapeutics
Hypercortisolism
Hypercortisolism and Epicardial Adipose Tissue
Identifying hypercortisolism patients at risk for cardio-vascular events despite biological cure, and determine which patients should be particularly followed.
- Trial name
- Hyper-Cor (NCT02335996)
- Testing
- Blood samples for measuring adiponectin, leptin and omentin plasma, MRI at 3 Tesla
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cushing's Syndrome Cardiomyopathy
Endocrine Cardiomyopathy in Cushing Syndrome: Response to Cyclic GMP PDE5 inhibitOrs
Pathophysiology of Cushing's Syndrome (CS) cardiomyopathy is yet unclear and a specific treatment have not been indicated. It was already demonstrated the positive impact of phosphodiesterase type 5A (PDE5A) inhibition in several…
- Trial name
- ERGO (NCT02611258)
- Testing
- Tadalafil
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Andrea M. Isidori
Endogenous Cushing's Syndrome
Cardiovascular Status in Patients With Endogenous Cortisol Excess (Cushing's Syndrome)
Within this trial, the cardiovascular and mental status as well as the metabolic profiles of patients with endogenous cortisol excess are evaluated.
- Trial name
- CV-CORT-EX (NCT03880513)
- Testing
- Cardiovascular status and quality of life
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Wuerzburg University Hospital
Hypercortisolism, Arterial Hypertension
Cortisol Secretion, Sensitivity and Activity and Hypertension
The goal of this observational study is to evaluate, between patients with arterial hypertension and non hypertensive control group, the prevalence of hidden hypercortisolism the relationship between organ damage and oxidative…
- Trial name
- PRECOR (NCT05766085)
- Testing
- Dexamethasone suppression test
- Where
- Italy
- Volunteers
- 290 people
- Sponsor
- Istituto Auxologico Italiano
Cushing Syndrome, Neoplasms
Effect of Relacorilant on the Pharmacokinetics of the Sensitive P-glycoprotein Substrate Dabigatran Etexilate in Healthy Participants
The primary objective is to determine the effect of relacorilant on the pharmacokinetics (PK) of the sensitive P-glycoprotein (P-gp) substrate dabigatran etexilate.
- Trial name
- NCT05347979
- Testing
- Dabigatran Etexilate, Relacorilant
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Cushing Syndrome
The Circadian Rhythm in CusHing SyndrOme in Active Phase and dUring RemiSsion (TheHOURS)
This is an observational, open, prospective multi-centre study designed to evaluate melatonin and cortisol circadian rhythm, immunological profile and anthropometric parameters in Cushing Syndrome patients during active Remission…
- Trial name
- TheHOURS (NCT03343470)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Roma La Sapienza
Endogenous Cushing's Syndrome
A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome.
This is a double-blind, randomized, placebo-controlled withdrawal and rescue/restoration study in subjects with endogenous Cushing's Syndrome (CS) previously treated with single-arm, open-label levoketoconazole that will assess…
- Trial name
- NCT03277690
- Testing
- Levoketoconazole
- Where
- 45 sites in United States, Bulgaria and 10 more
- Volunteers
- 84 people
- Sponsor
- Cortendo AB
Cushing Syndrome
Appropriate Limit Value for 1 mg DST in Patients With Chronic Renal Failure
In this study, we aimed to determine a specific cut-off value for 1mg DST to prevent false positivity usually seen in CRF patients according to the standard cut-off value of 1.8 mcg/dl.
- Trial name
- NCT05568602
- Testing
- Dexamethasone suppression test
- Where
- Turkey (Türkiye)
- Volunteers
- 1,034 people
- Sponsor
- Marmara University
Cushing Syndrome
Observational Registry on Patients With Endogenous CS to Document Safety and Effectiveness of Ketoconazole.
This is a non-interventional, prospective, multinational, multicentre, observational study, in which data collected are those derived from routine clinical practice via an European registry on CS: ERCUSYN.
- Trial name
- KetoPASS (NCT04872920)
- Where
- 6 sites in Croatia, France and 2 more
- Volunteers
- 200 people
- Sponsor
- HRA Pharma
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia
First-in-human Evaluation of [18F]CETO
Purpose of this clinical phase 1 trial was to determine if para-chloro-2-[18F]fluoroethyletomidate positron emission computed tomography ([18F]CETO-positron emission computed tomography(PET)/computed tomography(CT)) can be used…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia, Adrenal Cushing Syndrome, Non-Secretory Adrenal Adenoma
- Trial name
- NCT05361083
- Testing
- F18CETO
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Uppsala University