Clinical trials: Cystectomy
Bladder Cancer, Cystostomy; Complications
Evaluation of Naloxegol in the Prevention of POI After Cystectomy
Postoperative ileus (POI) is defined as a transient reduction of bowel motility that prevents effective transit of bowel content and tolerance of oral intake following surgical interventions, especially after radical cystectomy.
- Trial name
- ANTAGOCYST (NCT04219046)
- Testing
- Naloxégol oxalate
- Sponsor
- Institut Paoli-Calmettes
Bladder Cancer
Comprehensive Geriatric Assessment for Perioperative Optimization in Cystectomy
Patients with muscle-invasive bladder cancer are often older and multimorbid, thus in an increased risk of perioperative mortality and morbidity in relation to radical cystectomy (RC).
- Trial name
- COMPETENCE (NCT05679557)
- Testing
- Perioperative geriatric assessment and intervention
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Aarhus University Hospital
Surgical Procedure, Unspecified
3D Versus 2D Laparoscopic Ovarian Cystectomy
This is a prospective randomized study involving 80 patients. All participates will be given written information on 3D laparoscopy.
- Trial name
- NCT02775344
- Testing
- Three dimension laparoscopy
- Where
- Hong Kong
- Volunteers
- 83 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Pulmonary Complications, Inflammatory Response
Intraoperative PEEP Optimization: Effects on Postoperative Pulmonary Complications and Inflammatory Response
The purpose of this prospective randomized controlled trial is to determine the effects of intraoperative lung protective mechanical ventilation using an individual optimal PEEP value on postoperative pulmonary complications and…
- Trial name
- NCT02931409
- Testing
- Optimal PEEP, Standard PEEP
- Where
- 2 sites in Hungary
- Volunteers
- 40 people
- Sponsor
- Péterfy Sándor Hospital
Bladder Urothelial Carcinoma
A Study of Radiation Therapy and Cemiplimab With or Without Fianlimab In People With Bladder Cancer
The researchers are doing this study to find out whether stereotactic body radiation therapy (SBRT) in combination with immunotherapy (cemiplimab with or without fianlimab) before cystectomy is an effective and safe treatment for…
- Trial name
- NCT07414992
- Testing
- Stereotactic body radiotherapy, Cemiplimab, Cemiplimab and Fianlimab
- Where
- 7 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Invasive Bladder Cancer Stage II
Neoadjuvant Rapamycin in Patients Undergoing Radical Cystectomy
This study aims to evaluate the effects of rapamycin directly on bladder tumors and the effects of rapamycin on the immune system of patients with bladder cancer.
- Trial name
- NCT01827618
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Fluid Retention Tissue
Comparison of Liberal and Restrictive Fluid Management on the Endothelial Glycocalyx in Radical Cystectomy
The aim of this study is to compare the effect of the liberal and restrictive fluid treatments which are routinely performed in major urological surgeries in the perioperative period on ANP release and the endothelial glycocalyx…
- Trial name
- NCT04780490
- Testing
- liberal fluid management, restrictive fluid management
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Istanbul University
Post-operative Delirium
Postoperative Delirium in Patients Undergoing Radical Cystectomy
In this study, post-operative delirium will be measured in patients undergoing surgery for bladder resection, and associated microRNA biomarkers will be evaluated in patients considered delirious and non-delirious after surgery.
- Trial name
- NCT03132168
- Testing
- Assessments, Blood Draw, Standardized Anesthetic Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Anxiety, Hemodynamic Instability
Effect of Acupressure Applied Before Cystectomy on Preoperative Anxiety Level
This randomized controlled study evaluates the effect of acupressure application on the anxiety level patients undergoing cystectomy surgery.
- Trial name
- NCT05325307
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mersin University
Muscle-Invasive Bladder Carcinoma, Bladder Cancer
Bladder Preservation or Cystectomy for MIBC
In this research study, investigators will assess whether it is feasible to use information from the genes of a tumor combined with evaluation of the tumor response to systemic therapy to determine if bladder sparing…
- Conditions
- Muscle-Invasive Bladder Carcinoma, Bladder Cancer, Urothelial Carcinoma
- Trial name
- NCT07821177
- Testing
- Gemzar, Cisplatin, Adrucil
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dana-Farber Cancer Institute
Bladder Cancer
Endo-GIA Versus Endowrist Stapler in Intracorporeal Urinary Diversion in Robotic Assisted Radical Cystectomy
The study is a randomized clinical trial (RCT) including patients undergoing robotic assisted cystectomy with intracorporeal ileal conduit at four large university hospitals in Denmark.
- Trial name
- EGIAES (NCT03385798)
- Testing
- Endowrist, Endo-GIA
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Jørgen Bjerggaard Jensen
Urothelial Cancer, Urinary Bladder Neoplasms
Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309)
This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together as a bladder preservation approach to treat patients with muscle invasive bladder cancer.
- Trial name
- NCT07566156
- Testing
- Enfortumab vedotin, Conventional Radiotherapy, Hypofractionated Radiotherapy
- Where
- 26 sites in United States, Canada and 2 more
- Volunteers
- 390 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Stage III Bladder Cancer, Stage IV Bladder Cancer
Surgery With or Without Postoperative Intensity Modulated Radiation Therapy in Treating Patients With Urothelial Bladder Cancer
This randomized phase II trial studies the side effects and how well postoperative intensity modulated radiotherapy works after surgery in treating patients with urothelial bladder cancer.
- Trial name
- NCT02316548
- Testing
- Intensity-Modulated Radiation Therapy
- Where
- 127 sites in United States, Canada and 1 more
- Volunteers
- 14 people
- Sponsor
- NRG Oncology
Bladder Cancer
Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol
To determine if Alvimopan during open or robotic radical cystectomy with urinary diversion results in quicker return of bowel function (GI-2 recovery = time to upper [first toleration of solid food] and lower [first bowel…
- Trial name
- NCT03216525
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Brigham and Women's Hospital
Cancer, Bladder, Cystostomy; Complications
Outcome of Perioperative Immune Enhancing Nutrition in Patients Undergoing Radical Cystectomy
The aim of this study is to evaluate the outcome of perioperative immune-nutrition with glutamine, arginine and fish oil in patients undergoing radical cystectomy as regards to enhancement of healing, increasing immunity and…
- Trial name
- NCT05822518
- Testing
- Neo-mune powder (otsuka pharmaceutical), Dipeptiven solution (Fresenius Kabi pharmaceutical)
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Menoufia University
Bladder Cancer
Information Needs and Supportive Rehabilitation Over Time in Patients Undergoing Cystectomy in Bladder Cancer
Bladder cancer is one of the diseases that can affect the urinary tract. Globally, it is the tenth most common cancer, with an incidence rate of 9.5 per 100,000 persons per year for men and 2.4 for women.
- Trial name
- CaRe (NCT07180121)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Linkoeping University
Bladder Cancer, Transitional Cell Carcinoma of the Bladder
Prostate Capsule Sparing Cystectomy and Nerve-sparing Radical Cystoprostatectomy in Men With Bladder Cancer
Bladder cancer is the 4th most common cancer amongst men. If bladder cancer invades the muscle of the bladder or fails local treatments, surgical removal of the bladder (cystectomy) with creation of a new bladder from intestine…
- Trial name
- SPARC (NCT01824329)
- Testing
- Prostate capsule sparing cystectomy, Nerve sparing cystectomy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Patients Undergoing Transurethral Prostate or Cystectomy Under Spinal Anesthesia
Respiratory Measurement Using Infrared Camera and Electrical Impedance Tomography for Sedation in Patients Undergoing TURP/TURB Under Spinal Anesthesia
Tidal volume may be the most important technical indicator for ventilation. Measuring tidal volume can be used as an indicator of how effective a patient's gas exchange is, and can also be used as a predictive indicator to…
- Trial name
- NCT05591469
- Testing
- IR Camera, Electrical Impedance Tomography
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Ovarian Cysts
Ovarian Reserve After Ovarian Hemostasis by Floseal Matrix
Laparoscopy has become the gold standard for the surgical treatment of benign ovarian cysts and is usually performed by stripping the ovarian cyst wall, followed by bleeding control of the ovarian wound ground using bipolar…
- Trial name
- NCT01857466
- Testing
- Floseal, Bipolar coagulation
- Where
- 3 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- CHA University
Endometrioma, Endometriosis
Laparoscopic Therapy of Endometrioma: Sclerotherapy vs Cystectomy in Patients With Unfinished Reproductive Plans
The aim of this prospective randomized study is to compare laparoscopic sclerotherapy to cystectomy in following: AMH dynamics, endometrioma recurrence, complications, pregnancy rate, assisted reproduction methods success rate…
- Trial name
- NCT05801523
- Testing
- laparoscopic ethanol sclerotherapy, laparoscopic cystectomy of endometrioma
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Institute for the Care of Mother and Child, Prague, Czech Republic