Clinical trials: Cystic Fibrosis Lung
Cystic Fibrosis
A Study to Investigate Lung Deposition of Radiolabelled OligoG
OligoG is a new potential treatment which is being developed by AlgiPharma AS (a Norwegian-based company) with an aim to help people with cystic fibrosis in the future.
- Trial name
- NCT01991028
- Testing
- Radiolabelled OligoG CF-5/20 DPI, Radiolabelled OligoG CF-5/20 6% Solution
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- BDD Pharma Ltd
Cystic Fibrosis
Development Of An Innovative Panel of Methods To Measure Intestinal Macronutrient Digestion, Absorption, and Function
Malnutrition is a significant problem in children and adults with Cystic fibrosis (CF). An impaired intestinal digestion and absorption capacity is one of the main factors responsible for the malnutrition in CF.
- Trial name
- NCT01494909
- Testing
- Ensure plus
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Benign Breast Disease, Breast Cancer
Prolactin Receptor and Breast Diseases
Prolactin is known to play an important role in breast development and differentiation. Thus proliferative breast diseases are good models to unravel PRl / PRLR function in proliferative processes.
- Trial name
- Prolacsein (NCT00842465)
- Testing
- blood collection for hormonal status analysis, breast Biopsy or surgery, blood collection
- Where
- France
- Volunteers
- 735 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cystic Fibrosis (CF)
Safety, Tolerability and Efficacy of MP-376 Given for 28 Days to Cystic Fibrosis (CF) Patients
Patients with cystic fibrosis (CF) suffer from chronic infections of the lower respiratory tract that can be caused by one or multiple bacteria, including Pseudomonas aeruginosa, which has been particularly problematic to…
- Trial name
- NCT00677365
- Testing
- MP-376
- Where
- 50 sites in United States, Germany and 1 more
- Volunteers
- 151 people
- Sponsor
- Amgen
Cystic Fibrosis
Airway Clearance Therapy on Hyperpolarized 129Xenon and MRI
This is an observational cohort study building on an existing protocol at our institution recruiting CF patients who are 6-21 years old with one or two copies of the F508del CFTR mutation.
- Trial name
- NCT03593434
- Testing
- hyperpolarized Xenon gas
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis
A Phase 2 Study to Evaluate the Safety, Tolerability, PK and PD of ELX-02 in Cystic Fibrosis Patients With G542X Allele
This is a Phase 2 open-label, dose-escalation study to evaluate the safety, tolerability, PK, and PD of multiple dose levels of SC administered ELX-02 with and without ivacaftor in patients with CF with at least one G542X allele.
- Trial name
- NCT04135495
- Testing
- ELX-02, Ivacaftor
- Where
- 10 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- Eloxx Pharmaceuticals, Inc.
Cystic Fibrosis
Daily Monitoring of Respiratory Symptoms and Spirometry During ETI Treatment in Persons With Cystic Fibrosis.
The goal of this observational study is to provide optimal monitoring and support when initiating ETI treatment in eligible persons with cystic fibrosis (aged 12 y +) and to document on a daily basis, from 72 hours before the…
- Trial name
- NCT05599230
- Testing
- Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- CHC Montlegia
Chronic Rhinosinusitis (Diagnosis)
Xylitol vs Saline Nasal Irrigations in CF-CRS
Cystic fibrosis (CF) is the most common genetic disorder in Belgium, affecting 1 in 2850 children. A defect in the CFTR channel results in increased viscosity of extracellular secretions and decreased mucociliary clearance in the…
- Trial name
- NCT05531630
- Testing
- Nasal rinsing with saline 0.9%, Nasal rinsing with Xylitol
- Where
- Belgium
- Volunteers
- 38 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cystic Fibrosis, Parenthood Status
Health Outcomes of Parents With Cystic Fibrosis
This project will determine the health impact of parenthood on people with cystic fibrosis (CF). The study team will use retrospective data to provide relatively immediate evidence on parenthood's effect on pulmonary health.
- Trial name
- HOPeCF (NCT05829694)
- Testing
- Parental Status
- Where
- 8 sites in United States
- Volunteers
- 956 people
- Sponsor
- University of Pittsburgh
Cystic Fibrosis
Ivacaftor Treatment in 4 Month to 2 Year Old CF Subjects
The purpose of this research study is to determine the effects of clinically prescribed ivacaftor treatment on 4-24 month old children with CF and gating mutations on sleeping energy expenditure, growth status and gut health and…
- Trial name
- NCT03783286
- Testing
- Ivacaftor
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital of Philadelphia
Cystic Fibrosis
Study of Ivacaftor in Cystic Fibrosis Subjects 2 Through 5 Years of Age With a CFTR Gating Mutation
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD), of ivacaftor in children with cystic fibrosis (CF) who are 2 through 5 years of age and have a CF Transmembrane Conductance…
- Trial name
- NCT01705145
- Testing
- Ivacaftor
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 35 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Idiopathic Granulomatous Mastitis, Granulomatous Mastitis
GRAnulomatous MAstitis REGistry Study
Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast condition with unknown cause, affecting approximately 2.4 per 100,000 women aged 20-40 years.
- Trial name
- GRAMAREG (NCT07422870)
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- European Breast Cancer Research Association of Surgical Trialists
Cystic Fibrosis
Behavioral Treatment of Weight Gain in CF
The current study examines the efficacy of two treatments to help children with cystic fibrosis (CF) meet their dietary calorie requirements of 120% to 150% of the recommended daily allowance of energy and the effect of these…
- Trial name
- NCT00006169
- Testing
- Behavioral Treatment
- Where
- 2 sites in United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cystic Fibrosis
Comparing Chest Images From MRI to CT in Patients With Cystic Fibrosis (CF)
The purpose of this research is to learn more about the heart and blood vessels in the lungs of people with cystic fibrosis (CF).
- Trial name
- NCT01860872
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis
Efficacy and Safety Study of Inhaled Glutathione in Cystic Fibrosis Patients
The majority of cystic fibrosis (CF) patients die from a progressive pulmonary disease.Airway inflammation plays a major role for the pathogenesis of CF lung disease, and ultimately leads to lung destruction.
- Trial name
- NCT00506688
- Testing
- reduced glutathione sodium salt, 0.9% normal saline (control)
- Where
- 14 sites in Germany
- Volunteers
- 153 people
- Sponsor
- Mukoviszidose Institut gGmbH
Cystic Fibrosis
Concerns of Children Whose Parents Have Cystic Fibrosis
As more and more patients with cystic fibrosis (CF) become parents, we have studied parenting concerns in this serious chronic disease in a first study (MucoPar) which is ongoing.
- Trial name
- MUCOKIDS (NCT04702386)
- Testing
- Focus groups, Individual interviews
- Where
- 2 sites in France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cystic Fibrosis
Regional Monitoring of CF Lung Disease
The main reason for this research study is to learn more about some new tests that are being developing for patients with Cystic Fibrosis (CF) to measure changes in the lungs.
- Trial name
- NCT06339593
- Testing
- Airway-clearance vest, Hyperpolarized Xe129
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis
Inspiratory Muscle Training in Individuals With Cystic Fibrosis
Cystic fibrosis is a genetic disease that affects some organs of the human body. Among them, the lungs tend to be the most affected due to the accumulation of mucus in the airways, which in addition to avoiding the passage of…
- Trial name
- NCT03737630
- Testing
- Inspiratory muscle training
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Cystic Fibrosis
A Randomized-Controlled Trial of Inhaled Hypertonic Saline (7%) to Evaluate the Lung Clearance Index
The Lung Clearance Index (LCI) is a non invasive measure of lung function that is more sensitive than FEV1. It can be used to measure lung function in children younger than 6 years of age.
- Trial name
- NCT02276898
- Testing
- Hypertonic Saline 7%
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis
Novel Therapeutic Approaches for Treatment of CF Patients With W1282X Premature Termination Codon Mutations
Based on previous clinical findings, the investigator hypothesize that ivacaftor will have synergistic effects with drugs that facilitate truncated but partially active W1282X CFTR protein processing (tezacaftor) in patients with…
- Trial name
- NCT03624101
- Testing
- Symdeko, Ivacaftor and Symdeko
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham