Clinical trials: Cystic Fibrosis Pulmonary Exacerbation
Cystic Fibrosis, Impaired Glucose Tolerance
Cystic Fibrosis (CF) Exacerbation and Insulin Treatment
The purpose of the study is to evaluate whether insulin treatment during pulmonary exacerbation (PE) in patients with Cystic Fibrosis (CF)and normoglycemia improves their short term outcome by normalizing the glycemic profile and…
- Conditions
- Cystic Fibrosis, Impaired Glucose Tolerance, Pulmonary Exacerbation
- Trial name
- NCT01149005
- Testing
- novorapid / humalog short acting insulin, Novo Rapid Insulin (Novonordisk)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Cystic Fibrosis Pulmonary Exacerbation
Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis
The aim objective is to identify markers of bacterial, viral and fungal pulmonary dysbiosis, associated with the occurrence of exacerbation in patients followed for cystic fibrosis.
- Trial name
- DYSBIOSE-CF (NCT03569904)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Cystic Fibrosis
MUCOviscidose EXacerbation Outils Connectés Education Thérapeutique
Early detection of pulmonary exacerbations (PEx) in Cystic Fibrosis (CF) patients is important to quickly trigger treatment and reduce respiratory damage.
- Trial name
- MucoExocet (NCT03304028)
- Testing
- Connected Devices for 3 months, Educationnal Intervention, Connected Devices for 12 months
- Where
- 7 sites in France
- Volunteers
- 36 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Exacerbation Copd, Bronchiectasis
Efficacy of Roflumilast on Exacerbations in Patients With Non-cystic Fibrosis Bronchiectasis
Roflumilast compare with placebo for decrease infected exacerbation in non-cystic Bronchiectasis
- Conditions
- Exacerbation Copd, Bronchiectasis, Lung Function Decreased
- Trial name
- NCT04122547
- Testing
- Roflumilast
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Prince of Songkla University
Cystic Fibrosis
Cystic Fibrosis Blood Neutrophils
The purpose of this prospective study is to analyze function and phenotype of blood neutrophils in cystic fibrosis patients and the impact of Pseudomonas aeruginosa chronic infection, treatment with CFTR modulators and acute…
- Trial name
- MUCO-PNN (NCT04970225)
- Testing
- 1 blood sample, 2 blood samples
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cystic Fibrosis
OPTIMIZing Treatment for Early Pseudomonas Aeruginosa Infection in Cystic Fibrosis
The purpose of this trial is to compare the effects of treatment with tobramycin solution for inhalation (TIS) with and without azithromycin in people with cystic fibrosis (CF) age 6 months to 18 years who have early isolation of…
- Trial name
- OPTIMIZE (NCT02054156)
- Testing
- azithromycin, Tobramycin solution for inhalation
- Where
- 45 sites in United States
- Volunteers
- 221 people
- Sponsor
- Bonnie Ramsey
Cystic Fibrosis
Mucin in Sputum of CF During Pulmonary Exacerbation
The purpose of this study is to determine whether mucin is increased during pulmonay exacerbations in adult patients with cystic fibrosis (CF).
- Trial name
- NCT00202072
- Where
- 2 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Philipps University Marburg
Cystic Fibrosis-related Diabetes, Cystic Fibrosis Pulmonary Exacerbation
Sensor Augmented Pump (SAP) Therapy for Inpatient CFRD Management
This research proposes a pilot study using the combination of continuous glucose monitor (CGM) and insulin pump therapy, also known as sensor augmented pump (SAP) therapy, for cystic fibrosis related diabetes (CFRD) management in…
- Conditions
- Cystic Fibrosis-related Diabetes, Cystic Fibrosis Pulmonary Exacerbation, Cystic Fibrosis in Children
- Trial name
- NCT03939065
- Testing
- Sensor Augmented Pump Therapy, Standard of Care with CGM
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Cystic Fibrosis, Primary Ciliary Dyskinesia
Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia
The objective of this study is to compare the lower airways inflammatory response to infection/pulmonary exacerbation among children known to have Primary Ciliary Dyskinesia (PCD) with children known to have Cystic Fibrosis (CF)…
- Trial name
- NCT01155115
- Testing
- Sputum Collection, Pulmonary Function Testing, Exhaled Nitric Oxide
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis
Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF) Subjects
Cystic fibrosis (CF) lung disease is characterized by chronic bacterial colonization and recurrent infection of the airways. Lowering the airway surface liquid (ASL) salt concentration has been shown to increase activity of salt…
- Trial name
- NCT00928135
- Testing
- Xylitol, Hypertonic saline
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Joseph Zabner
Cystic Fibrosis
Assessment of Cystic Fibrosis Lung Involvement With UTE Pulse Sequences
Non-invasive assessment of lung involvement is a crucial issue for the follow-up of cystic fibrosis patients. Currently, CT is the method of reference to evaluate and quantify the lung morphological changes in cystic fibrosis…
- Trial name
- MucoIRM (NCT02449785)
- Testing
- MR measurements of lung morphological changes in cystic fibrosis (Avanto dot, Siemens), CT measurements of lung morphological changes in cystic fibrosis
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux