Clinical trials: Cystic Fibrosis in Children
Non Cystic Fibrosis Bronchiectasis in Children
The Efficacy of Azithromycin in Treating Children With Non Cystic Fibrosis Bronchiectasis
Bronchiectasis is characterized by a permanent and abnormal dilatation of a part of the bronchial tree. An accumulation of mucus in the respiratory tract ensues, resulting in frequent bacterial infections and eventual destruction…
- Trial name
- AZI-STOP (NCT02531984)
- Testing
- Azithromycin
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cystic Fibrosis
Choline Nutrition in Children With Cystic Fibrosis (CF)
Cystic Fibrosis (CF) is a complex disease with a wide range of clinical problems. Despite enzyme replacement therapy, children with cystic fibrosis (CF) may still have problems absorbing some nutrients.
- Trial name
- NCT00686361
- Testing
- Choline supplementation
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of British Columbia
Primary Sclerosing Cholangitis, Inflammatory Bowel Disease
NPDT Evaluation in Children With CFTR and (PSC)
The investigators hypothesize that PSC in children is associated with mutations and functional changes of the cystic fibrosis (CF) gene.
- Trial name
- NPD (NCT00179439)
- Testing
- nasal potential difference testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Non-cystic Fibrosis Bronchiectasis
Procalcitonin as a Marker of Severity of Non-cystic Fibrosis Bronchiectasis in Children
The aim of this study is to evaluate the role of procalcitonin in bronchoalveolar lavage as a biomarker for assessment of severity of non-CF bronchiectasis in children in correlation with other markers (functional and…
- Trial name
- NCT06352944
- Testing
- procalcitonin
- Volunteers
- 30 people
- Sponsor
- Assiut University
Cystic Fibrosis
Efficacy and Safety of 28 or 56 Day Treatment for Pseudomonas Aeruginosa in Children With Cystic Fibrosis
This study assessed time to recurrence of infection with Pseudomonas aeruginosa following treatment of the initial infection with tobramycin nebuliser solution.
- Trial name
- ELITE (NCT00391976)
- Testing
- Tobramycin solution for inhalation 300 mg
- Volunteers
- 123 people
- Sponsor
- Novartis
Pseudomonas Infection
Cipro Inhaler for Cystic Fibrosis Children Ages 6-12
Ciprofloxacin PulmoSphere Inhalation Powder appears to be an effective and adequate antibiotic treatment for cystic fibrosis patients with P. aeruginosa colonisation.
- Trial name
- NCT00910351
- Testing
- Ciprofloxacin (Cipro, BAYQ3939)
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- Bayer
Cystic Fibrosis, Cystic Fibrosis in Children
Program Of Exercises During The Hospitalization Of Children And Adolescents With Cystic Fibrosis
The objective of this study was to evaluate the effect of a physical exercise program on the functional capacity of children and adolescents with cystic fibrosis hospitalized at the Hospital de Clínicas of Porto Alegre (HCPA)…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis in Children, Cystic Fibrosis Pulmonary Exacerbation, Cystic Fibrosis With Exacerbation
- Trial name
- NCT03273959
- Testing
- Exercise protocol
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cystic Fibrosis, Glucose Metabolism Disorders
One Year Glargine Treatment in CFRD Children and Adolescents
Glargine treatment can improve the clinical features in Cystic Fibrosis patients affected by glucose derangements
- Trial name
- NCT00483769
- Testing
- Glargine
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Federico II University
Cystic Fibrosis
Study of Total Energy Expenditure in Infants and Children With Moderate to Severe Cystic Fibrosis
OBJECTIVES: I. Compare the resting energy expenditure using respiratory calorimetry in infants and children with moderate to severe cystic fibrosis versus age matched healthy controls. II.
- Trial name
- NCT00006273
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Cystic Fibrosis
Choline Nutrition in Children With Cystic Fibrosis
Cystic fibrosis (CF) is the most common lethal, inherited disorder among Caucasians. Choline is an essential vitamin and as a methyl donor is critically needed to support the normal metabolism.
- Trial name
- NCT01070446
- Testing
- Vitamin: Choline Bitartrate (2-hydroxyethyl) trimethylammonium salt 1:1
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cystic Fibrosis
Effects of a Telerehabilitation Approach in Children With Cystic Fibrosis
Patients with cystic fibrosis aged 6-13 will be recruited and randomized into two groups: one will receive telerehabilitation sessions including postural, breathing and high-intensity interval training exercises and one will be…
- Trial name
- NCT04683809
- Testing
- Telerehabilitation
- Volunteers
- 30 people
- Sponsor
- Marmara University
Cystic Fibrosis
Evaluation of the Lung Clearance Index
The purpose of this study is to determine the efficacy of a non invasive method of detecting the pulmonary disease in order to initiate treatment against cystic fibrosis as soon as possible.
- Trial name
- LCI (NCT02342951)
- Testing
- Lung clearance index determination
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cystic Fibrosis
The Role of Oral Glutathione on Growth Parameters in Children With Cystic Fibrosis
The purpose of this randomized, placebo-controlled (Phase II) study will be to further evaluate the effects of oral glutathione on growth in children with CF.
- Trial name
- GROW (NCT03020719)
- Testing
- Oral Glutathione
- Where
- 18 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Cystic Fibrosis
Virtual Reality for the Reduction of Pain During Venipuncture in Children With CF
Children with Cystic fibrosis (CF) have to undergo several needle-related procedures during outpatient visits or hospital stay. It is common for children with CF to display distress and behavioural problems during invasive…
- Trial name
- VRAP (NCT02802839)
- Testing
- Virtual Reality
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Florence
Cystic Fibrosis in Children
Use of a Portable Spirometer in Pediatric Patients With Cystic Fibrosis at the Nancy CHRU: Feasibility Study
Respiratory diseases (asthma, cystic fibrosis, COPD…) need for the diagnosis and the follow-up the use of pulmonary function tests.
- Trial name
- SPIROMUCO (NCT04837911)
- Testing
- Spirobank Smart
- Volunteers
- 35 people
- Sponsor
- Central Hospital, Nancy, France
Cystic Fibrosis, Pseudomonas Aeruginosa
Safety of AZLI in Children With Cystic Fibrosis (CF) and Chronic Pseudomonas Aeruginosa in the Lower Airways
This was an open-label, multicenter study in children ≤ 12 years of age with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa (PA) infection in the lower airways using three 28-day courses of Aztreonam for Inhalation…
- Trial name
- PALS (NCT01404234)
- Testing
- AZLI
- Where
- 29 sites in United States, France and 4 more
- Volunteers
- 61 people
- Sponsor
- Gilead Sciences
Cystic Fibrosis in Children
Detection of Unsuspected Small Airways Obstruction in Cystic Fibrosis
Goal is to physiologically detect unsuspected small airways obstruction in children and adults with treated heterozygous and homozygous cystic fibrosis.
- Trial name
- NCT03839992
- Testing
- spirometry
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Gelb, Arthur F., M.D.
Cystic Fibrosis in Children, Cystic Fibrosis Gastrointestinal Disease
Intestinal Inflammation in CF Patients
Cystic Fibrosis (CF) is a disease that affects salt and water transport in multiple organs. Many CF patients suffer from abdominal pain and this could be due to intestinal inflammation.
- Conditions
- Cystic Fibrosis in Children, Cystic Fibrosis Gastrointestinal Disease, Cystic Fibrosis
- Trial name
- NCT04392544
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis, Pseudomonas Aeruginosa
Cross Transmissions of Pseudomonas Aeruginosa Between Children From a Same Cystic Fibrosis Center.
Cystic fibrosis is the most common hereditary autosomal recessive disease in the Caucasian population. The diseases is caused by a mutation of the gene coding for the CFTR protein (Cystic fibrosis transmembrane conductance…
- Conditions
- Cystic Fibrosis, Pseudomonas Aeruginosa, Cross Infection
- Trial name
- PAPED (NCT03910920)
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Queen Fabiola Children's University Hospital
Cystic Fibrosis
Comparison of 2 Treatment Regimens for Eradication of P Aeruginosa Infection in Children With Cystic Fibrosis
Treatment of new Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) can postpone chronic infection. Aim of the study: compare 2 Pa eradication regimens in children with new Pa infection.
- Trial name
- CCTOBI (NCT01400750)
- Testing
- oral ciprofloxacin plus inhaled colistin, TOBI
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven