Clinical trials: Cystic Fibrosis in Children
Cystic Fibrosis
Respiratory Function at Preschool Age of Children Detected of Cystic Fibrosis in Neonatal Period
The widespread neonatal detection of cystic fibrosis in France since 2002 permits to treat children from birth. New treatments used for young children involve to assess efficacy criteria specific to this population.
- Trial name
- REVOLMUCO (NCT02358798)
- Testing
- 3 years-assessment of respiratory function
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Cystic Fibrosis With Mild to Moderate Lung Disease, CMRI of Lung Perfusion
Sildenafil Trial in Children and Young Adults With CF
Cystic Fibrosis (CF), the most common inherited disease in Caucasians, is characterized by chronic pulmonary inflammation and progressive loss of gas exchange units that eventually results in respiratory failure.
- Conditions
- Cystic Fibrosis With Mild to Moderate Lung Disease, CMRI of Lung Perfusion, Lung Perfusion, Lung Vascularization
- Trial name
- NCT01194232
- Testing
- Sildenafil
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis
Microbiota of the Respiratory Flora in Children With Cystic Fibrosis During the First Year of Life
The goal of this study is characterize the changes in bacterial diversity of the upper respiratory tracts of infants with cystic fibrosis (CF).
- Trial name
- NCT00977158
- Testing
- Throat Swab
- Where
- 2 sites in United States
- Sponsor
- Tufts Medical Center
Cystic Fibrosis in Children
Heart Rate Variability in Children and Adolescents With Cystic Fibrosis
This study aims to assess the effects of a resistance exercise training program on heart rate variability in a group of children and adolescents with cystic fibrosis. The study design is a randomized controlled trial.
- Trial name
- NCT04293926
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Universidad Europea de Madrid
Cystic Fibrosis, Pancreatic Exocrine Insufficiency
Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis
This study will assess the safety and tolerability of pancrelipase delayed release capsules in subjects up to 6 years of age with Pancreatic Exocrine Insufficiency (PEI) due to Cystic Fibrosis.
- Trial name
- NCT00775528
- Testing
- Pancrelipase Delayed Release
- Where
- 12 sites in United States
- Volunteers
- 19 people
- Sponsor
- Solvay Pharmaceuticals
Cystic Fibrosis, Cystic Fibrosis in Children
Feasibility of a Mobile Medication Plan Application in CF Patient Care
This is a pilot, multicenter, prospective, randomized controlled study to evaluate the feasibility of an innovative medication adherence intervention utilizing a web-based, mobile medication management application [MedActionPlan®…
- Trial name
- MAP (NCT03637504)
- Testing
- MedActionPlan®
- Where
- 5 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cystic Fibrosis
Effects of 5-Methyltetrahydrofolate and Vitamin B12 Supplemetation on Red Cell Membrane in Children With Cystic Fibrosis
The purpose of this study is to determine whether 5 - methyltetrahydrofolate and vitamin B12 supplementation can ameliorate cell plasma membrane features in pediatric patients with cystic fibrosis
- Trial name
- NCT00730509
- Testing
- 5-methyltetrahydrofolate and vitamin B12
- Where
- Italy
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Cystic Fibrosis
Web-based Delivery of Effective Treatment for Growth in Cystic Fibrosis
This study will demonstrate feasibility and collect pilot data via a pilot randomized trial of 20 participants on the effectiveness of a web-based delivery system of behavioral plus nutrition intervention for parents of children…
- Trial name
- Be In Charge (NCT01686672)
- Testing
- Web Intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis, Hypoglycemia
Hypoglycemia and Glucagon Response in CF
The goal of this clinical trial is to investigate the etiopathogenesis of isolated hypoglycemia and hypoglycemia with abnormal glucose tolerance in children with Cystic Fibrosis (CF) and to evaluate the role of glucagon and…
- Conditions
- Cystic Fibrosis, Hypoglycemia, Glucagon Deficiency, Pancreatic Insufficiency
- Trial name
- NCT05700604
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Marmara University
Cystic Fibrosis Related Diabetes, Cystic Fibrosis
The Use of Home Oral Glucose Tolerance Test Kit in Screening Cystic Fibrosis Related Diabetes
The aim of this study is to establish if the self-administered electronic Oral Glucose Tolerance Test kit can increase the annual uptake of screening for CFRD in children who are between 10 and 17 years of age with CF.
- Trial name
- HomeOGTT (NCT02703155)
- Testing
- Home Oral Glucose Tolerance Test kit
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Cystic Fibrosis in Children, Cystic Fibrosis
Sinus Disease in Young Children With Cystic Fibrosis
This is a prospective, observational study examining the impact of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators on chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) in young…
- Conditions
- Cystic Fibrosis in Children, Cystic Fibrosis, Chronic Rhinosinusitis (Diagnosis), Olfactory Disorder
- Trial name
- NCT06191640
- Testing
- Ivacaftor or elexacaftor/tezacaftor/ivacaftor
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Cystic Fibrosis (CF)
TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
This is a longitudinal, observational epidemiological study designed to estimate the prevalence of depression, anxiety, and behavior problems in children ages 18 months through 11 years with cystic fibrosis (CF).
- Trial name
- TIDES 2 (NCT07048574)
- Where
- 13 sites in United States
- Volunteers
- 600 people
- Sponsor
- State University of New York at Buffalo
Cystic Fibrosis
Effect of a Family Empowerment Program on Coping, Problem Solving in Parents, and Quality of Life in Children With Cystic Fibrosis
Parents of children with cystic fibrosis (CF) experience high levels of stress and problems. Family empowerment interventions provide important support for many patients with CF and their families.
- Trial name
- NCT03800459
- Testing
- family empowerment program
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Cystic Fibrosis
Leucine-enriched Essential Amino Acid Intake to Optimize Protein Anabolism in Children With Cystic Fibrosis
Malnutrition, including muscle wasting commonly occurs in children with cystic fibrosis (CF), negatively influencing their quality of life and survival.
- Trial name
- NCT01172301
- Testing
- Essential amino acid intake + Leucine vs total AA supplement
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Texas A&M University
Cystic Fibrosis, Abdominal Pain
Rifaximin for Treatment of Bloating in Children and Adults With Cystic Fibrosis
Gastrointestinal symptoms are commonly reported in as much as 65% of people with CF even independent of pancreatic enzyme replacement therapy (PERT) and the most frequent of these symptoms are bloating/distension, flatulence…
- Conditions
- Cystic Fibrosis, Abdominal Pain, Small Bowel Disease
- Trial name
- NCT05408910
- Testing
- Rifaximin 550 MG Oral Tablet [XIFAXAN]
- Sponsor
- Wake Forest University Health Sciences
Cystic Fibrosis (CF)
Machine Learning Prediction of Pulmonary Function in Children With Cystic Fibrosis
Cystic fibrosis is a multisystem genetic disorder characterized by progressive pulmonary impairment and extrapulmonary limitations.
- Trial name
- NCT07770854
- Testing
- Archived Multidimensional Clinical and Functional Assessment Data
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Gazi University
Cystic Fibrosis in Children
Cardiopulmonary Fitness in Children With Cystic Fibrosis Compared to Healthy Children
Cystic fibrosis is the most common severe genetic disease with autosomal recessive transmission in the Caucasian population. Its prognosis has improved considerably since the creation of Cystic Fibrosis centers (CF centers) and…
- Trial name
- VOmuco (NCT06242951)
- Testing
- VO2 max assessment
- Where
- France
- Volunteers
- 345 people
- Sponsor
- University Hospital, Montpellier
Cystic Fibrosis
Backpack Carrying in Children With Cystic Fibrosis
Cystic Fibrosis is a hereditary, chronic respiratory illness. Cystic Fibrosis leads to a progressive decline in lung function. School-aged children with cystic fibrosis experience backpack carrying everyday.
- Trial name
- NCT02700282
- Testing
- Backpack Carrying
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier du Havre
Cystic Fibrosis
Zinc Homeostasis and Kinetics in Children With Cystic Fibrosis (CF)
Zinc deficiency has occasionally been reported in CF, but the need for additional zinc is unclear. We will examine the effect of additional zinc supplements on zinc absorption, zinc excretion, zinc balance and zinc kinetics in…
- Trial name
- NCT00104494
- Testing
- Zinc acetate (20mg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cystic Fibrosis Foundation
Cystic Fibrosis
DPI-Tobra-Kind Cyclops® in Children With Cystic Fibrosis
The goal is to investigate the pharmacokinetic properties of dry powder tobramycin via the Cyclops® at different dosages in children with cystic fibrosis, together with the local tolerability.
- Trial name
- NCT03485456
- Testing
- Tobramycin
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen