Clinical trials: Cytokine Levels
Periodontitis, Adult, Smoking
Impact of Smoking on Salivary Interleukin (IL)-39, IL-41, IL-1β, TNF-α Levels in Periodontal Disease
The goal of this observational study is to evaluate if the measurement of salivary Interleukin (IL)-39, IL-41, IL-1Beta(β), and Tumor necrosis factor-alpha (TNF-α) levels can aid in the early diagnosis of periodontitis in…
- Conditions
- Periodontitis, Adult, Smoking, Periodontal Diseases
- Trial name
- NCT06528522
- Testing
- Clinical Measurements and Saliva Sample Collection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Systemic Lupus Erythematosus
Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with a relatively high mortality and morbidity rate, especially in developing countries such as Indonesia.
- Trial name
- NCT05430087
- Testing
- Observe the clinical outcome and inflammatory cytokines levels in patients with systemic lupus erythematosus (SLE) after being supplemented with Cholecalciferol (Vitamin D3) and Curcumin-Piperine.
- Where
- Indonesia
- Volunteers
- 45 people
- Sponsor
- Saiful Anwar Hospital
Liver Cirrhosis
Cytokines and the Risk of Infection in Liver Cirrhosis
The aim of this study is to test whether the oscillation of cytokine concentrations in serum is able to predict the development of infection in patients with liver cirrhosis.
- Trial name
- CLC-2009 (NCT00857181)
- Where
- Austria
- Volunteers
- 150 people
- Sponsor
- Medical University of Graz
Pulpitis - Reversible, Occlusal Caries
Evaluation of Cytokines Level as an Indicator of Pulp Inflammation and Its Relation to the Success Rates of Pulpotomy in Primary Molars Affected With Proximal Versus Occlusal Decay
pulpotomy will be done I primary molars with occlusal or proximal decay and level of cytokines will be measured as an indicator for pulp inflammation levels
- Conditions
- Pulpitis - Reversible, Occlusal Caries, Proximal Caries
- Trial name
- NCT07171229
- Testing
- Pulpotomy, Measuring Cytokines level
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Cairo University
Retina, Regional Blood Flow
Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans.
Oxidative stress, which refers to cellular damage caused by reactive oxygen intermediates, has been implicated in many disease processes, especially age-related disorders.
- Conditions
- Retina, Regional Blood Flow, Endotoxin, Escherichia Coli
- Trial name
- NCT00431691
- Testing
- vitamin and mineral supplement, Escherichia coli Endotoxin (LPS), 100% O2
- Where
- Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cortisol Excess, Stress, Psychological
Effects of "Vitamin N" Nature Immersion Therapy on Stress Levels in Health Care Workers in the City of Bogotá
Recent studies on health personnel in Colombia have evidenced the considerable increase in the levels of stress and anxiety, among other psychological disorders, as a product of the COVID-19 pandemic that is being experienced…
- Conditions
- Cortisol Excess, Stress, Psychological, Anxiety, Epigenetic Disorder
- Trial name
- NCT05315388
- Testing
- Immersion therapy in nature - Vitamin N
- Where
- Colombia
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Jeadran N. Malagón-Rojas
Ocular Rosacea, Dry Eye
Efficacy of IPL Treatment of Dry Eye and Ocular Rosacea
Dry eye disease (DED) is a common condition that causes ocular discomfort and reduces visual acuity. The two categories of DED are evaporative dry eye and aqueous deficient dry eye.
- Trial name
- NCT03194698
- Testing
- Intense Pulsed Light Treatment (IPL), Meibomian Gland Expression
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Ulcerative Colitis (UC)
An Exploration of the Relationship Between Serum Cytokine Levels and the Clinical Efficacy of Vedolizumab
It is uncertain the relationship between serum cytokine levels and the clinical efficacy of vedolizumab in the treatment of ulcerative colitis.
- Trial name
- NCT06855862
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Fibromyalgia Syndrome
Study of Indoleamine 2,3-dioxygenase Activity, Serum Levels of Cytokines, BDNF, BH4 and Mirtazapine Efficacy in Fibromyalgia Syndrome
This study aims to investigate the anti-nociceptive biogenic amine (serotonin [5-hydroxytryptamine; 5-HT], norepinephrine [NE], dopamine [DA], and their metabolites) status, and serum levels of cytokines, BDNF and BH4 in Thai…
- Trial name
- NCT00919295
- Testing
- mirtazapine
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Acne Vulgaris
Gene Polymorphisms, Skin Barrier, and Inflammation in Acne
This study investigated the relationship between Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) gene polymorphisms and acne pathogenesis.
- Trial name
- NCT07069075
- Testing
- MMP-2 Gene Polymorphism (rs243865) Analysis, TIMP-2 Gene Polymorphism (rs8179090) Analysis
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hong Zhang
Renal Failure, Sleep Disorder
The Relationship Between Sleep Disorders and Cytokine Levels Among Hemodialysis and Peritoneal Dialysis Patients
Sleep disorders are common in patients with end-stage renal disease on both hemodialysis and peritoneal dialysis and are associated with significant medical, psychological and social disturbances.
- Conditions
- Renal Failure, Sleep Disorder, Hemodialysis, Peritoneal Dialysis
- Trial name
- NCT00172471
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Diabetic Macular Edema
Mean Visual Acuity Changes Following Five Injections of Aflibercept
Diabetic Macular Edema is a serious ocular consequence of poorly controlled diabetes. Even though significant research has been done to clarify the pathogenesis of DME, a clear causal pathway of the complication is of yet…
- Trial name
- NCT02645266
- Testing
- Aflibercept Injection [Eylea]
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- McMaster University
Diabetes Mellitus, Type 2
The Effect of Single Probiotic on Metabolic Control in Type 2 Diabetes
Recent studies indicate that dysbiosis of intestinal microbiota and low grade inflammation are important pathogenic determinants of type 2 diabetes (T2DM), which has increased in epidemic size over the last 20 years.
- Trial name
- NCT05066152
- Testing
- Lactobacillus rhamnosus GG (ATCC 53103)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Osteoarthritis, Knee
Changes in Cytokine Levels After Dextrose Injection in Stage IV Knee Osteoarthritis
Twenty participants with severe arthritis will be enrolled. For the first week participants will either be injected with dextrose or just have fluid withdrawn for testing.
- Trial name
- NCT03400631
- Testing
- Dextrose 0, Aspiration 0, Dextrose 1
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Fisiatria y Traumatología
Heart; Dysfunction Postoperative, Cardiac Surgery, Cytokine Release Syndrome
Study of the Clinical Scoring System and Cytokines for Prediction of Inflammatory Response in Major Surgery
Cardiac surgery with cardiopulmonary bypass (CPB) and hepatic surgery are major operations, associated with a systemic inflammatory response syndrome.
- Trial name
- NCT01353157
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Khon Kaen University
Type 1 Diabetes, Type 2 Diabetes
Comparison of Th1 Cytokine Levels Between Type 1 and Type 2 Diabetes
Recent reports show increased prevalence of obesity in patients with type 1 diabetes (T1DP)s while some studies stated that patients with type 2 diabetes (T2DPs) have islet cell auto-antibodies.
- Trial name
- NCT02860611
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Postoperative Pain
Rectus Sheath Block: Postoperative Analgesia and Proinflammatory Cytokines
Good quality of postoperative analgesia would lead to attenuate or prevent the adverse effects on the common functions of the immune system.
- Trial name
- NCT03074097
- Testing
- Bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
NMO Spectrum Disorder, Azathioprine Adverse Reaction
Monitoring of Azathioprine Metabolite Concentrations and Cytokine Levels in Neuromyelitis Optica Spectrum Disorder
Background: The pathogenesis of NMOSD has been linked to the cytokines interleukins (IL) -6, NOD-, LRR-and pyrin domain-containing 3 (NLRP3) and IL-18 that contribute to development of inflammatory reactionsmay.
- Trial name
- NCT05896605
- Testing
- Azathioprine
- Where
- China
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Periodontal Treatment, Cytokines
Non-surgical Periodontal Treatment and Periostin Levels
Two different studies were planned from the recruited samples. The aim of these studies was to investigate the effect of non-surgical periodontal treatment on the inflammatory markers levels in serum and gingival crevicular fluid…
- Trial name
- NCT05535049
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Periodontal Diseases
TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases
This study aimed to investigate gingival crevicular fluid (GCF) and salivary hypoxia inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-α) levels in different…
- Trial name
- NCT03558906
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University