Clinical trials: Cytology
Thyroid Nodule, Thyroid Cancer
Clinical Validation of a Molecular Signature to Detect Cancer in Thyroid Nodules With Indeterminate Cytology
1. Principal objective: The primary objective of this study is to validate the diagnostic performance of a Dx15 molecular test based on molecular transcriptomic signatures previously identified in distincts cohorts of samples to…
- Trial name
- CITHY (NCT02225509)
- Testing
- FNA biopsy for thyroid nodule(s)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Diaxonhit
Gastric Adenocarcinoma, Carcinomatosis
A Phase II Study of Perioperative Paclitaxel in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology
To learn about the effects of paclitaxel and gastrectomy (surgery to remove all or part of the stomach) on improving outcomes in patients with gastric cancer.
- Trial name
- NCT05977998
- Testing
- Paclitaxel, Dexamethasone, Diphenhydramine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Solitary Pulmonary Nodule, Biopsy, Fine-Needle
iNod System Human Feasibility Assessment
The purpose of this study is to demonstrate feasibility to access, visualize, and obtain specimens adequate for cytology of lung lesions in subjects with suspected lung cancer when using the iNod System.
- Trial name
- iNod (NCT02832284)
- Testing
- iNod System
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Boston Scientific Corporation
Bile Duct Stricture, Malignancy
Performance of FISH for the Diagnosis of Malignant Biliary Strictures in Thai Patients
Fluorescence in situ hybridization (FISH) has improved the diagnostic performance of cytology for evaluation of malignant biliary strictures in the US and Europe.
- Trial name
- NCT02442167
- Volunteers
- 101 people
- Sponsor
- Mayo Clinic
Rhinitis, Allergic, Nasal Allergy
Mometasone Furoate Nasal Spray in Italian Children
Objective Seasonal allergic rhinitis (SAR) is a common disease in childhood and characterized by type 2 inflammation, bothersome symptoms, and impaired quality of life (QoL).
- Conditions
- Rhinitis, Allergic, Nasal Allergy, Allergy Pollen, Nasal, Cytology
- Trial name
- NCT05301647
- Testing
- Nasal cytology, The validated Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ), Total symptom score (TSS)
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Bladder Cancer
Urine Cytology and Utility in Bladder Recurrence
Review bladder cancer patients and form a database in regards to urine cytology.
- Trial name
- NCT00971256
- Volunteers
- 10 people
- Sponsor
- Corewell Health East
Stomach Neoplasm
Treatment Strategy for Stage IV Gastric Cancer with Positive Peritoneal Cytology As the Only Non-curable Factor
Gastric cancer with positive is defined as stage IV disease in 7th AJCC/UICC TNM staging system. Controversy exists on the treatment of this part of patients.
- Trial name
- Cy-plus (NCT02969122)
- Testing
- standard gastrectomy with D2 lymphadenectomy, hyperthermic intraperitoneal chemotherapy, Extensive intraperitoneal lavage
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Peking University
Urothelial Carcinoma (UC), Upper Tract Urothelial Carcinoma
Non-invasive Urinary Genomics-Based Risk Assessment for Early Urothelial Carcinoma Diagnosis
This is a two-stage, prospective, single-center observational diagnostic accuracy study evaluating noninvasive urine testing for the detection of urothelial carcinoma (UC).
- Conditions
- Urothelial Carcinoma (UC), Upper Tract Urothelial Carcinoma, UTUC, Bladder Cancer (BC)
- Trial name
- NCT07614594
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Henan Provincial People's Hospital
High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion
Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities
The goal of this clinical trial is to learn if an investigational vaginal suppository therapy works to treat low-grade cervical lesions (ASC-US and LSIL) associated with high-risk human papillomavirus (hr-HPV) infection in women.
- Conditions
- High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion, ASC-US, HPV Infection
- Trial name
- NCT07572396
- Testing
- EGCG and Quinine Sulfate Vaginal Suppository
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- Amplexd Therapeutics, Inc.
Pterygium, Dry Eye
Using Impression Cytology to Observe the Cytological Changes of Ocular Surface Cells in Various Ocular Surface Disorders
Currently, due to the advantage of noninvasive, localized, rapid, painless and easily repeatable of impression specimens, the technique is an ideal method of investigating ocular surface disorders when the diagnosis is not…
- Conditions
- Pterygium, Dry Eye, Tumor
- Trial name
- NCT01387971
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Fine Needle Aspiration Cytology, Thyroid Diseases
Accuracy of FNAC in Thyroid Nodules Compared to to Surgical Specimen : QOC Experience
Thyroid gland diseases are the second most common endocrine disease following diabetes mellitus(1). Thyroid nodules are common disorders with a prevalence ranged from 4 to 7% in adult population, 5%-30% are malignant…
- Trial name
- Thyroid FNAC (NCT05521594)
- Testing
- Fine Needle Aspiration Cytology
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Qena Oncology Center
Asthma
Cell Biology of Steroid Resistant Asthma
The hypothesis is that patients who demonstrate steroid resistant asthma by showing little or no improvement in lung function after a course of oral steroids have different cellular responses to steroids than patients who are…
- Trial name
- NCT00361920
- Testing
- prednisone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Jewish Health
Multiple Myeloma
Characterization of Corneal Epithelial Changes in Participants Treated With Belantamab Mafodotin
This study will be available to any participant who has received or is currently receiving belantamab mafodotin treatment through either a clinical trial, an access program, or a physician prescription.
- Trial name
- NCT04549363
- Testing
- Belantamab mafodotin
- Where
- 6 sites in United States
- Volunteers
- 16 people
- Sponsor
- GlaxoSmithKline
COPD, Asthma,ACO
Diagnostic Value of Sputum Cytology in Asthma-COPD Overlap
The aim of this study is to evaluate the diagnostic value of sputum cell counts in differentiation between asthma, COPD and ACO.
- Trial name
- NCT04056364
- Testing
- sputum cytology
- Volunteers
- 150 people
- Sponsor
- Assiut University
Cervical Cancer Screening, HIV Infections
Anal HPV Infection and Abnormal Cytology in HIV-infected Women
The population of HIV infected women seen at Boston Medical Center may have a higher frequency of anal cytologic and histologic abnormalities than what is reported for the non-HIV infected population.
- Trial name
- NCT00933140
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Medical Center
Cervical Dysplasia
A Comparison of Immediate Treatment of CIN1 With Cryotherapy and 12 Month Cytology Follow up in HIV Seropositive Women
Based on the high incidence of cervical cancer and high grade dysplasia and increased progression and incomplete treatment of CIN2 and 3 in South Africa, we propose to study the effect of cryotherapy among HIV-positive women…
- Trial name
- NCT02250716
- Testing
- cryotherapy
- Where
- South Africa
- Volunteers
- 480 people
- Sponsor
- University of Witwatersrand, South Africa
Thyroid Nodule
Comparison Between Combined Scoring of Bethesda Cytology and TIRADS Ultrasound With Histopathology in Thyroid Nodule
A thyroid nodule is a discrete lesion within the thyroid gland that is radiologically distinct from the surrounding thyroid parenchyma. Most thyroid nodules are benign, with only 10% to 15% harboring cancer.
- Trial name
- TIRADS (NCT06391021)
- Where
- Nepal
- Volunteers
- 42 people
- Sponsor
- Tribhuvan University, Nepal
Parotid Neoplasm, Parotid Cancer
Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology for Parotid Gland Neoplasms
Parotid gland tumors are mostly treated surgically, but the extent of parotidectomy is decided upon preoperative work-up information.
- Trial name
- NCT03849482
- Testing
- Multiparametric Magnetic Resonance Imaging, Fine Needle Aspiration Cytology, Clinical Evaluation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Davide Di Santo
Rare Diseases, Aniridia
Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
The cross-sectional observational clinical study related to rare eye diseases is a multi-center study in which the hypothesis is that neurokinin 1 receptor and/or substance P expression is increased in REDs associated with…
- Conditions
- Rare Diseases, Aniridia, Neurotrophic Keratopathy, Limbal Stem Cell Deficiency
- Trial name
- NCT06412718
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Oral Cancer, Diagnoses Disease
Exfoliated Cytology in Detection of Oral Premalignant and Malignant Lesions
Micronuclei have been used since 1937 as an indicator of genetic toxic exposure due to their association with chromosomal alterations.
- Trial name
- NCT04955197
- Testing
- exfoliated cytology
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University