Clinical trials: Cytomegalovirus
Cytomegalovirus
Cytomegalovirus (CMV) Transmission by Frozen Breast Milk in Preterms
Cytomegalovirus infection threatens preterm infant. We investigated, whether thawed breast milk is a mode of transmission
- Trial name
- NCT00668798
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Haematological Malignancies, CMV Infection
Study of Adoptive Immunotherapy With Donor-derived CMV-specific T Cells for Recipients of Allo-HSCT
The study will test the hypothesis that CMV TCR-transduced T cells, at a specific T-cell dose/kg, can generate a functional CMV immune response post-transplant, where CMV-specific donor T cells cannot be isolated by conventional…
- Trial name
- CMV_TCR-001 (NCT02988258)
- Testing
- CMV-TCR transduced donor-derived T cells
- Where
- 4 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Cytomegalovirus Infection
A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of Cytomegalovirus (CMV) Vaccine mRNA-1647
The main objective of this study is to evaluate the safety, reactogenicity, and immunogenicity of the mRNA-1647 vaccine administered according to a 3-study injection schedule in healthy cytomegalovirus (CMV)-seronegative and…
- Trial name
- NCT05105048
- Testing
- mRNA-1647
- Where
- 3 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Viral Infection, Viral Reactivation
Third Party Viral Specific T-cells (VSTs)
The purpose of this study is to demonstrate that viral specific T-cells (a type of white blood cell) can be generated from an unrelated donor and given safely to patients with viral infections.
- Conditions
- Viral Infection, Viral Reactivation, Infection in an Immunocompromised Host
- Trial name
- NCT02532452
- Testing
- Viral Specific VST Infusion
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cytomegalovirus Retinitis, HIV Infections
A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS Who Cannot Use Ganciclovir
To study the safety and effectiveness of foscarnet in the treatment of AIDS patients who have active infection with cytomegalovirus (CMV) that is causing inflammation of the retina (retinitis).
- Trial name
- NCT00000697
- Testing
- Foscarnet sodium
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Cell Mediated Immunity, Hematopoietic Cell Transplant
The Use of Cytomegalovirus Cell Mediated Immunity to Optimize the Duration of Letermovir Prophylaxis in Hematopoietic Cell Transplant Recipients
The goal of this laboratory research study is to learn if interrupting a patient's letermovir dosing based on their immune system response can help HSC transplant patients avoid post-treatment CMV infections better than taking…
- Trial name
- NCT06639854
- Testing
- Hematopoietic Cell Transplant, Letermovir
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- M.D. Anderson Cancer Center
CMV, Prenatal Diagnosis
Does Normal Brain Imaging Predict Normal Neurodevelopmental Outcome in Fetuses With Proven Cytomegalovirus Infection?
Cytomegalovirus (CMV) is the largest member of the virus family Herpesviridae that infects almost all humans at some point in their lives (Ross, 2004).
- Conditions
- CMV, Prenatal Diagnosis, Ultrasound, MRI
- Trial name
- NCT00872703
- Where
- Israel
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Major Depressive Disorder
ANTIVIRAL TREATMENT OF CYTOMEGALOVIRUS IN DEPRESSION
This study aims to determine whether treatment of CMV positive (CMV+) individuals with major depressive disorder (MDD) with valganciclovir (VGCV) alters neural circuitry, reduces inflammation, and improves depressive behavior and…
- Trial name
- NCT04724447
- Testing
- Valganciclovir
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Cytomegalovirus Infection, Preterm Infants
Clinical Evaluation of Ultrashort-term Heat Inactivation of Cytomegalovirus (CMV) Containing Raw Breast Milk to Prevent CMV-infection of Preterm Infants
To evaluate, in a prospective multicenter study, ultrashort-term heat inactivation for the prevention of Cytomegalovirus (CMV) transmission in preterm infants (<32 weeks gestational age or <1500 g birth weight) under clinical…
- Trial name
- NCT01178905
- Testing
- ultrashort heat inactivation
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
CMV, Lung Transplant Recipient
Combination Letermovir and Standard of Care Antiviral for Enhanced Antiviral Response in Cytomegalovirus Infection in Lung Transplant Recipients
The primary objective of the CLEAR-CMV trial is to evaluate the efficacy of letermovir therapy plus standard of care (SOC) antiviral compared to SOC plus placebo in achieving clearance of CMV viremia by week 3 in lung transplant…
- Trial name
- CLEAR-CMV (NCT07235683)
- Testing
- Letermovir, Valganciclovir/Ganciclovir
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
HIV Infections, CMV Cytomegalovirus Retinitis
Studies of the Ocular Complications of AIDS (SOCA)--HPMPC Peripheral CMV Retinitis Trial (HPCRT)
To test and evaluate the efficacy and safety of intravenous cidofovir (Vistide, previously known as HPMPC) for the treatment of retinitis.
- Trial name
- HPCRT (NCT00000142)
- Testing
- Cidofovir
- Volunteers
- 64 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cytomegalovirus Infection Reactivation
Effect of Letermovir Prophylaxis on CMV-specific Immune Reconstitution Post UCBT
To explore the effect of letermovir prophylaxis on cytomegalovirus-specific immune reconstitution post unrelated cord blood transplantation
- Trial name
- NCT06441669
- Testing
- Letermovir
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Provincial Hospital
Cytomegalovirus (CMV), Anterior Uveitis
Systemic and Topical Antiviral Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes - Trials I and II
The goal of this clinical trial is to compare antiviral treatment strategies for cytomegalovirus (CMV) anterior uveitis - a viral infection causing inflammation inside the front of the eye - in immunocompetent adults aged 18…
- Conditions
- Cytomegalovirus (CMV), Anterior Uveitis, Infectious Uveitis, CMV Infection
- Trial name
- STACCATO I/II (NCT07513623)
- Testing
- Valganciclovir, Ganciclovir (GCV)
- Where
- 6 sites in United States, Taiwan and 1 more
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
CMV
A Study of the Safety and Efficacy of CMX001 for the Prevention of CMV Infection in CMV-seropositive HCT Recipients
This randomized, double-blind, placebo-controlled, parallel group, multicenter study compared the effectiveness of oral brincidofovir (BCV) to placebo for the prevention of cytomegalovirus (CMV) infection in stem cell transplant…
- Trial name
- NCT01769170
- Testing
- Brincidofovir
- Where
- 43 sites in United States, Belgium and 1 more
- Volunteers
- 452 people
- Sponsor
- Jazz Pharmaceuticals
CMV Infection
Prediction of Cytomegalovirus (CMV) Reactivation in Intensive Care Unit (ICU) by Immunological Study
Cytomegalovirus is a herpesviridae whose prevalence in general population is between 50 to 80%. In immunocompetent individuals, CMV remains latent in a number of cells, without any pathological consequence.
- Trial name
- CMV-Réa (NCT02843880)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- AdministrateurDRC
Cytomegalovirus Infection
Efficacy Study of Human Cytomegalovirus (HCMV) Hyperimmune Globulin to Prevent Congenital HCMV Infection
The aim of this trial is to verify, under controlled conditions, the reported efficacy of human cytomegalovirus (HCMV)-specific hyperimmune globulin administration to pregnant women suffering from primary HCMV infection for the…
- Trial name
- CHIP (NCT00881517)
- Testing
- HCMV-specific hyperimmune globulin (Cytotect®)
- Where
- 11 sites in Italy
- Volunteers
- 124 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Kidney Transplant; Complications, CMV
De-novo Initiation of Letermovir vs Valganciclovir for Cytomegalovirus Prophylaxis in AA Kidney Transplant Recipients
This study is being done to compare the effectiveness of de novo Letermovir versus valganciclovir in preventing the development of cytomegalovirus viremia or symptomatic disease in African American kidney transplant recipients…
- Trial name
- NCT06001320
- Testing
- Letermovir 480 mg once daily, Historical/Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Lung Transplant
PREDICT Cytomegalovirus (CMV)
The overall objective of this study is to establish a personalized test to measure individualized cytomegalovirus (CMV) specific immunity in lung transplant recipients in an effort to guide antiviral prophylaxis duration in…
- Trial name
- PREDICT CMV (NCT03300882)
- Testing
- Procedure
- Where
- 4 sites in United States, Canada
- Volunteers
- 84 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Retinitis, Acute Renal Failure
Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration
Cidofovir is an acyclic nucleotide analog with broad-spectrum antiviral activity against herpesviruses. Its potency in inhibiting HCMV has been shown in conventional in vitro studies.
- Trial name
- NCT01866397
- Testing
- Cidofovir pharmacokinetics
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Medical University of Vienna
Cytomegalovirus Infections
Kinetics of Response of Cytomegalovirus With Ganciclovir Treatment Using Quantitative Real-Time PCR
The overall purpose of this research is to develop and use a blood test to better understand how quickly the viral drug ganciclovir works to clear infection with the CMV virus (Cytomegalovirus) when it occurs.
- Trial name
- NCT00004573
- Testing
- ganciclovir
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)