Clinical trials: Cytoreductive Surgery
LMS - Leiomyosarcoma, Uterine Leiomyosarcoma
CytoreductiveSurgery & HIPEC w/Gemcitabine+Chemotherapy w/Dacarbazine in Uterine Leiomyosarcoma
The purpose of this study is to find out if giving a dose of heated chemotherapy in the abdomen immediately after surgery that is done to remove uterine leiomyosarcoma type of cancer will help lower the risk of the cancer coming…
- Trial name
- NCT04727242
- Testing
- Gemcitabine, Dacarbazine, Cytoreductive Surgery
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Ovarian Cancer
Secondary Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Recurrent Mucinous Ovarian Cancer (HI-MOC Study)
The primary objective is to estimate overall survival after secondary cytoreductive surgery and HIPEC for women with recurrent primary mucinous ovarian cancer
- Trial name
- NCT05123807
- Testing
- Cytoreductive surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Peritoneal Metastases
Perioperative Immunonutrition for Patients Undergoing CRS and HIPEC
Patients with peritoneal disease commonly present with symptoms of abdominal distension and subacute intestinal obstruction. This results in poor oral intake leading to these patients often presenting in a malnourished state.
- Trial name
- NCT03430128
- Testing
- IMPACT immunotherapy, ENSURE
- Where
- Singapore
- Volunteers
- 70 people
- Sponsor
- National Cancer Centre, Singapore
Incisional Hernia
Prophylactic Mesh in Cytoreductive Surgery
Evaluate the effectiveness of mesh reinforcement in high-risk patients to prevent incisional hernia.
- Trial name
- NCT03953365
- Testing
- Prophylactic Mesh
- Volunteers
- 66 people
- Sponsor
- Hospital Universitario Fundación Alcorcón
Metastatic Cancer, Foregut Carcinoid Tumor
Study Comparing Standard of Care Chemotherapy With/ Without Sequential Cytoreductive Surgery for Patients With Metastatic Foregut Cancer and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid Levels
This study is designed for participants who have cancer of the upper gastrointestinal (GI) tract such as cancer of the esophagus, stomach, duodenum (the initial portion of your small intestine), pancreas, bile duct…
- Conditions
- Metastatic Cancer, Foregut Carcinoid Tumor, Gastric Adenocarcinoma, Gallbladder Adenocarcinoma
- Trial name
- NCT04931420
- Testing
- Standard of Care Chemotherapy, Video-Assisted Thoracic Surgery (VATS), Lobectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Carcinomatosis, Peritoneal
Inferior Epigastric Lymp Node (IELN) Basin as a Possible Systemic Metastatic Pathway of Ovarian Peritoneal Metastases
The IELN basin could represent a primary LN relay for systemic metastatic dissemination in patients with OPM. This newly described lymphatic pathway of metastatic dissemination of OPM may be involved in certain presentations of…
- Trial name
- OvEpiLyPath (NCT06237582)
- Testing
- epigastric lymph node biopsy
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Jules Bordet Institute
Carcinoma of the Appendix, Colorectal Cancer
Thalidomide in Treating Patients Who Have Undergone Surgery and Chemotherapy for Cancer That Has Spread Throughout the Abdomen Due to Colorectal Cancer or Appendix Cancer
RATIONALE: Thalidomide may stop the growth of tumor cells by blocking blood flow to the tumor. Giving thalidomide after surgery and chemotherapy may kill any remaining tumor cells.
- Trial name
- NCT00310076
- Testing
- thalidomide, surgery
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Wake Forest University Health Sciences
Advanced Ovarian Cancer
Efficacy and Safety of Tranexamic Acid in Cytoreductive Surgery for Ovarian Cancer
Tranexamic acid has been used in surgery for more than 30 years. It's effect on reducing bleeding and blood transfusing has been demonstrated. In our hospital, the amount of cytorsductive surgery for ovarian cancer is big.
- Trial name
- NCT04360629
- Testing
- Tranexamic Acid, normal saline
- Where
- China
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Jun Zhang
Ovarian Cancer, Fallopian Tube Carcinoma
Study of Acute Normovolemic Hemodilution (ANH) in People With Ovarian Cancer Who Are Having Cytoreductive Surgery
Participants will be scheduled for primary cytoreductive surgery as part of their standard care. Before surgery, participants will be assigned by chance to a study group.
- Conditions
- Ovarian Cancer, Fallopian Tube Carcinoma, Ovarian Carcinoma, Peritoneal Carcinoma
- Trial name
- NCT06290193
- Testing
- Acute Normovolemic Hemodilution/ANH
- Where
- 7 sites in United States
- Volunteers
- 86 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stomach Neoplasm
Cytoreductive Surgery Combined With HIPEC and Chemotherapy for Gastric Cancer With Peritoneal Metastasis
This study evaluates the survival benefit and safety of cytoreductive surgery(CRS) combined with HIPEC and chemotherapy in gastric cancer with peritoneal metastasis.
- Trial name
- NCT03023436
- Testing
- Cytoreductive surgery, Hyperthermic Intraperitoneal Chemotherapy, Fluoropyrimidine
- Where
- 13 sites in China
- Volunteers
- 220 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Ovarian Neoplasms
Laparoscopic Interval Cytoreductive Surgery in Advance Ovarian Cancer
This is a study that aims to demonstrate the non-inferiority of minimally invasive surgery versus open surgery, as an approach for patients with advanced ovarian cancer who received neoadjuvant chemotherapy, giving them the…
- Trial name
- NCT06883409
- Testing
- Interval Cytoreduction Surgery
- Where
- Mexico
- Volunteers
- 33 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Myeloproliferative Neoplasms
Selinexor Monotherapy for Cytoreduction in BCR::ABL1-Negative Myeloproliferative Neoplasms
Myeloproliferative neoplasms are chronic blood cancers in which the bone marrow produces too many blood cells. Patients with Philadelphia chromosome-negative myeloproliferative neoplasms, including polycythemia vera, essential…
- Trial name
- NCT07626021
- Testing
- Selinexor
- Volunteers
- 15 people
- Sponsor
- Zhongshan Hospital (Xiamen), Fudan University
Peritoneal Carcinomatosis
Longitudinal Study of CRS/HIPEC for Peritoneal Carcinomatoses
Longitudinal Study of the Effect of Cytoreductive Surgery and HIPEC in Patients With Peritoneal Carcinomatoses
- Trial name
- CRS/HIPEC (NCT04108936)
- Where
- 2 sites in Germany
- Volunteers
- 250 people
- Sponsor
- University of Regensburg
Peritoneal Carcinomatosis
Representation of the Body for Patients With Cancer
The project aims to understand better how patients live the event of cancer and live its consequences on their bodily representations.
- Trial name
- CORCAN (NCT01560533)
- Testing
- Interviews
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Primary Aldosteronism
Baxdrostat and Molecular Imaging of Adrenal Cytoreduction in Primary Aldosteronism
The goal of this clinical trial is to find out whether treatment with baxdrostat changes aldosterone-producing activity in the adrenal glands of people with primary aldosteronism.
- Trial name
- EliXir (NCT07800858)
- Testing
- baxdrostat
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Queen Mary University of London
Ovarian Cancer Stage III, Ovarian Cancer Stage IV
Predicting Outcome of Cytoreduction in Advanced Ovarian Cancer
PREDAtOOR is a pilot study and this study aims at improving the selection of the best treatment strategy for patients with advanced ovarian cancer by using Camera Vision (CV) to predict outcomes of cyto reduction at the time of…
- Trial name
- PREDAtOOR (NCT06017557)
- Testing
- Artificial Intelligence
- Where
- Italy
- Volunteers
- 151 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Peritoneal Surface Malignancies
The Intraoperative Physiologic Changes of Patients Under Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Cytoreductive Surgery; Prospective Observational Study
The most popular surgical treatment of peritoneal cancer is the type known as hyperthermic intraperitoneal chemoperfusion (HIPEC), a type of cytoreductive surgery for which a significantly high survival rate has been demonstrated…
- Trial name
- NCT02325648
- Testing
- HIPEC cytoreductive surgery
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Cytoreductive Surgery
Does Serum Procalcitonin Levels Predict Sepsis in Patients Undergoing Cytoreductive Surgery
Serum procalcitonin levels will be considerably higher, for a longer period of time, in patients who develop sepsis compared to patients with SIRS or those who have an uncomplicated post-surgical recovery.
- Trial name
- NCT02189434
- Testing
- Serum procalcitonin lab draws
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eastern Regional Medical Center
Peritoneal Diseases
ERAS® Guidelines Validation of CRS With or Without HIPEC
Enhanced recovery after surgery (ERAS®) pathways have been shown to considerably reduce complications, length of stay and costs after most of surgical procedures by standardised application of best evidence-based perioperative…
- Trial name
- NCT05185791
- Testing
- Pre-ERAS® phase (current clinical practice), Post-ERAS® implementation phase
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 288 people
- Sponsor
- Hospices Civils de Lyon
Peritoneal Carcinoma, Ovarian Cancer
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Carcinomatosis From Ovarian Cancer (Cyto-chip 2)
Epithelial ovarian carcinoma (EOC) is one of the main cause of death from cancer in women in the Western world. It is often diagnosed at an advanced stage and the disease remains confined to the peritoneal cavity for much of its…
- Trial name
- Cyto-chip 2 (NCT03931304)
- Testing
- Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy procedure
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Hospices Civils de Lyon