Clinical trials: D-dimer
Adnexal Torsion
Role of Preoperative D-dimer Levels in the Diagnosis of Adnexal Torsion
Adnexal torsion is the fifth most common gynecologic emergency. Thirty percent of all cases of adnexal torsion occur in females younger than 20 years.
- Trial name
- NCT06324565
- Testing
- D-Dimer test
- Where
- 9 sites in Austria, Italy and 1 more
- Volunteers
- 130 people
- Sponsor
- IRCCS Burlo Garofolo
Pulmonary Embolism
Breath Analysis Technique to Diagnose Pulmonary Embolism
A pulmonary embolism (PE) is a blockage in one of the arteries of the lungs, and is usually caused by a traveling blood clot. The D-dimer blood test is currently used to diagnose PEs, but it is not always accurate for individuals…
- Trial name
- NCT00368836
- Testing
- BreathScreen PE
- Where
- United States
- Volunteers
- 475 people
- Sponsor
- Wake Forest University Health Sciences
Venous Thromboembolism, Anticoagulants
Apixaban for Extended Anticoagulation (APIDULCIS)
The study aims at optimizing the long-term and extended management of patients with a first episode of venous thromboembolism (proximal deep vein thrombosis with or without pulmonary embolism) (VTE).
- Trial name
- APIDULCIS (NCT03678506)
- Testing
- Apixaban
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Arianna Anticoagulazione Foundation
Deep Vein Thrombosis, D-dimer
Age-adjusted D-dimer Cutoff Levels to Rule Out Deep Vein Thrombosis: a Prospective Outcome Study
Prospective validation of an age-adjusted D-dimer cut-off to rule out deep vein thrombosis (DVT)
- Trial name
- ADJUST-DVT (NCT02384135)
- Testing
- Three-month thromboembolic risk in patient with D-dimer levels between the usual cut-off and the age-adjusted cut-off
- Where
- 15 sites in Canada, France and 1 more
- Volunteers
- 3,300 people
- Sponsor
- University Hospital, Geneva
Thrombosis, Thrombus Formation
Study in an Ex-vivo Thrombosis Model With Human Umbilical Vein Endothelial Cells (HUVEC)-Perfusion
Evaluation of fibrin and platelet deposition on a human umbilical endothelial cell surface in perfusion chamber experiments using human whole blood.
- Conditions
- Thrombosis, Thrombus Formation, Thrombus Stability
- Trial name
- HUVEC (NCT01020110)
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
COVID -19
C Reactive Protein in Home Quarantined Coronavirus Disease 2019 (COVID -19) Patients.
During the peak of the second COVID -19 wave, the hospitals were over-crowded. Many COVID -19 positive patients had to stay at home and reach out to their family physicians for guidance.
- Trial name
- NCT04935515
- Testing
- Oral Antibiotic, Antihistamine, Anti-inflammatory, Multivitamins, Oral low dose steroid, Intravenous Antibiotics with Low dose steroid.
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Manimarane Arjunan, MD,DM (Cardiology)
Cerebral Venous Thrombosis
The Role of Factor XIII Activation Peptide and D-dimer Values for the Diagnosis of Cerebral Venous Thrombosis (CVT)
The investigators aim to assess the overall accuracy of D-dimer values and FXIII activation peptide (FXIII-AP), using a newly developed ELISA test, to exclude CVT in patients with clinical suspicion of CVT.
- Trial name
- NCT00924859
- Testing
- ELISA Test
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 401 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Valve Heart Disease, Anticoagulants; Increased
Randomized Evaluation of D-dimer Guiding dUration of Oral antiCoagulation thErapy
Guidelines recommended that patients with bioprosthetic heart valves (BHV) only need 6 months oral anticoagulation therapy after operation.
- Trial name
- REDUCE (NCT03885180)
- Testing
- Warfarin Sodium
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Wuhan Asia Heart Hospital
Deep Vein Thrombosis
Systematic Machine Learning Algorithm for Rapid Thrombosis Detection
The goal of this clinical trial is to compare the use of a machine learning-based algorithm and point-of-care D-dimer to laboratory D-dimer and compression ultrasound to exclude deep vein thrombosis in the under extremities in…
- Trial name
- DVT-SMART (NCT06842446)
- Testing
- POC D-dimer, POC ultrasound, Machine learning model
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Ostfold Hospital Trust
Deep Vein Thrombosis of Lower Limb, Lower Extremity Deep Venous Thrombosis Recurrent
Optimal Duration of Anticoagulation in Deep Venous Thrombosis
Prospective cohort study aimed at optimizing the duration of anticoagulant treatment in patients at their first episode of proximal deep venous thrombosis (DVT) of the lower extremities, whose pathogenesis is either unknown…
- Trial name
- MORGAGNI (NCT01285661)
- Testing
- Sodium warfarin
- Where
- Italy
- Volunteers
- 584 people
- Sponsor
- University of Padova
Aortic Dissection
Aortic Dissection Detection Risk Score Plus D-dimer in Suspected Acute Aortic Dissection
Acute aortic dissection (AD) is a deadly, difficult to diagnose disease presenting with an array of common and unspecific symptoms.
- Trial name
- ADvISED (NCT02086136)
- Where
- 6 sites in Brazil, Germany and 2 more
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Neovascular Age-related Macular Degeneration
Blood Coagulation Parameters in Patients Receiving Intravitreal Aflibercept for Age-related Macular Degeneration
This study aims to evaluate coagulation parameters in treatment naive patients with neovascular age-related macular degeneration (AMD).
- Trial name
- NCT03509623
- Testing
- Blood sampling through direct peripheral venous puncture
- Where
- Greece
- Volunteers
- 47 people
- Sponsor
- University Hospital of Patras
Deep Vein Thrombosis, Point of Care Ultrasound
Two-Site Compression POINt-OF-CARE Ultrasonography for DVT
Introduction Undiagnosed deep vein thrombosis (DVT) can lead to significant morbidity and mortality, including death from DVT-associated massive pulmonary embolism (PE).
- Trial name
- NCT03056196
- Testing
- point of care ultrasound
- Volunteers
- 500 people
- Sponsor
- Jewish General Hospital
Pregnancy
Coagulation Parameters During Pregnancy in Amniotic Fluid
Amniotic fluid embolism is a rare devastating thromboembolic event, which is probably caused by the entrance of amniotic fluid (AF) to the maternal circulation.
- Trial name
- NCT00458666
- Where
- Israel
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Deep Vein Thrombosis, Pulmonary Embolism
D-dimer to Select Patients With First Unprovoked Venous Thromboembolism Who Can Have Anticoagulants Stopped at 3 Months
The purpose of this study is to determine if the risk of recurrent venous thromboembolism (VTE) after stopping therapy is low and acceptable in patients with a first unprovoked proximal deep vein thrombosis (DVT) or pulmonary…
- Trial name
- DODS (NCT00720915)
- Testing
- Discontinue anticoagulant therapy (Negative d-dimer), Continue on anticoagulant therapy (positive d-dimer)
- Where
- 13 sites in United States, Canada and 2 more
- Volunteers
- 410 people
- Sponsor
- McMaster University
Gall Stone Disease, Polyp
Comparison of Coagulation Factors During Laparoscopic Cholecystectomy
Pneumoperitoneum is formed with CO2 during laparoscopic abdominal operations. Effect of pneumoperitoneum on coagulation factors is not well known.
- Trial name
- NCT02568852
- Testing
- Combined anaesthesia, General anaesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Lütfiye Nuri Burat Government Hospital
Pneumonia, Sepsis
Effects of Lumbrokinase DLBS1033 on D-Dimer, Interleukin-6, and Clinical Outcomes in Patients With Pneumonia and Sepsis
Pneumonia is a lung infection that can cause serious complications, especially when accompanied by sepsis. Sepsis can trigger excessive inflammation and abnormal blood clotting, potentially leading to organ damage and delayed…
- Conditions
- Pneumonia, Sepsis, Blood Coagulation Disorders
- Trial name
- NCT07892794
- Testing
- DLBS1033
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Sebelas Maret
Covid-19 With Positive RT-PCR
Incidence of Acute Pulmonary Embolism in Covid-19 Patients on CT Angiography and Relationship to D-dimer Levels
Reports of acute pulmonary embolism (APE) associated with COVID-19 have emerged in the literature. For example, Chen et al. described 25 pulmonary CT angiograms examinations from 1008 COVID-19 patients; 10 were positive for…
- Trial name
- COVID-APE (NCT04373486)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Strasbourg, France
Venous Thromboses, Colorectal Cancer
The Correlation of a D-dimer Testing Protocol With Venous Thromboembolism in Surgical Colorectal Patients
The purpose of this study is to evaluate the use of a D-dimer based protocol to screen for thrombotic events in colorectal surgical patients.
- Conditions
- Venous Thromboses, Colorectal Cancer, Diverticular Diseases, Crohn Disease
- Trial name
- NCT05246943
- Testing
- D-dimer and lower limb venous duplex
- Sponsor
- The University of Texas Medical Branch, Galveston
Deep Vein Thrombosis
Selective D-Dimer Testing Compared With Uniform D-Dimer Testing in the Diagnosis of Deep Vein Thrombosis (SELECT)
The purpose of this study is to compare two diagnostic interventions to improve the way D-dimer blood testing (MDA D-dimer) is used to diagnose first time symptomatic deep vein thrombosis.
- Trial name
- SELECT (NCT00157677)
- Testing
- D-dimer testing
- Where
- 5 sites in Canada
- Volunteers
- 1,727 people
- Sponsor
- McMaster University