Clinical trials: D-dimer
Tracheostomy, Characteristics Disease
Early SARS-CoV-2 Tracheostomy
Objective of this case series was to evaluate the characteristics of early COVID-19 tracheostomy and its effect on laboratory parameters.
- Conditions
- Tracheostomy, Characteristics Disease, Metabolic Disturbance
- Trial name
- NCT05520957
- Testing
- Tracheostomy
- Where
- Bosnia and Herzegovina
- Volunteers
- 17 people
- Sponsor
- Cantonal Hospital Zenica
Coronary Artery Disease, Percutaneous Coronary Intervention
NOAC Therapy Guided by PARIS Risk Score and D-dimer in Patients With ACS After PCI
The goal of this clinical trial is to compare short-term Triple Antithrombotic Therapy (DAPT + Rivaroxaban) followed by DAPT with standard DAPT in selected ACS patients with high ischemic risk.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome
- Trial name
- NCT05638867
- Testing
- Aspirin + Clopidogrel + Rivaroxaban, Aspirin + Clopidogrel
- Where
- China
- Volunteers
- 3,944 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Aortic Syndrome
Integrated Diagnostic Algorithm for Acute Aortic Syndromes
Observational, prospective, multicentre, international, non-profit, investigator-driven, outcome and diagnostic accuracy study performed in Emergency Departments.
- Trial name
- PROFUNDUS (NCT04430400)
- Testing
- integrated diagnostic algorithm
- Where
- 12 sites in Brazil, Germany and 3 more
- Volunteers
- 3,023 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
ECMO, Mplementation of a Veno-venous VV or Veno-arterial VA
EVOLUTION OF D-DIMER AS A MARKER OF BLEEDING RISK ON ECMO
ECMO (extracorporeal membrane oxygenation) is a life-saving device, used in intensive care to treat severe respiratory or cardiac failure. However, it carries a high risk of serious life-threatening bleeding.
- Conditions
- ECMO, Mplementation of a Veno-venous VV or Veno-arterial VA, INTENSIVE CARE
- Trial name
- ECMOstase2 (NCT07039513)
- Testing
- Blood sampling collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Covid-19
Clinical Trial on the Efficacy and Safety of Bemiparin in Patients Hospitalized Because of COVID-19
The 2019 coronavirus disease (Covid-19) is a new disease caused by the SARS-CoV2 virus of which many things are not yet known. Among others, there is a need to define the best therapeutic strategy to treat Covid-19, improving…
- Trial name
- NCT04420299
- Testing
- Bemiparin
- Where
- 2 sites in Spain
- Volunteers
- 81 people
- Sponsor
- Fundación de investigación HM
Atrial Fibrillation
D-Dimer-based Indication for Transesophageal Echocardiography to Exclude Left Atrial Thrombus Before Cardioversion of Non-anticoagulated Atrial Fibrillation: A Multicenter Belgian Study
This trial aims at evaluating the number of thromboembolic events post cardioversion in patients receiving a direct current cardioversion with either prior transesophageal echocardiography or D-Dimer (DD) analysis.
- Trial name
- CARDDI-BEL (NCT04784039)
- Testing
- Transesophageal echocardiography, D-Dimer analysis
- Volunteers
- 1,368 people
- Sponsor
- AZ Sint-Jan AV
Deep Vein Thrombosis
Destiny: D-dimer. Investigating D-dimer Levels Using Point-of-Care (POC) Testing at Primary Care.
DESTINY D-Dimer is an observational feasibility study, and a collaboration between the University of South Wales and Cwm Taf Morgannwg University Health Board (CTMUHB). The study is based at St.
- Trial name
- Destiny (NCT05109260)
- Testing
- Point-of-Care Immunoassay device
- Where
- 2 sites in United Kingdom
- Volunteers
- 244 people
- Sponsor
- University of South Wales
Pulmonary Embolism, D-dimer
Emergency Medicine Pulmonary Embolism Testing Multicentre Study
It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although the…
- Conditions
- Pulmonary Embolism, D-dimer, Diagnosis
- Trial name
- EMPET (NCT06320236)
- Testing
- Adjust-Unlikely
- Where
- 4 sites in Canada
- Volunteers
- 4,000 people
- Sponsor
- Dr. Kerstin de Wit
Atrial Fibrillation, Stroke
Colchicine in Atrial Fibrillation to Prevent Stroke
The purpose of this study is to determine the feasibility of performing a randomized controlled trial to investigate the efficacy of an anti-inflammatory drug, colchicine, at reducing well validated markers of thrombosis…
- Trial name
- CIAFS-1 (NCT02282098)
- Testing
- Colchicine
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Population Health Research Institute
Anticoagulation Reversal
Study of PER977 Administered to Subjects With Steady State Edoxaban Dosing and Re-anticoagulation With Edoxaban
This study will evaluate the establishment of anticoagulation ("re-anticoagulation") of subjects with edoxaban following reversal by PER977 and will identify a dose regimen of PER977 that reverses the effects of edoxaban for up…
- Trial name
- NCT02207257
- Testing
- PER977, Edoxaban
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc.
D-Dimer as an Early Detector of Pulmonary Embolism
Correlation Between Computer Tomography Angiography and D-Dimer Level for the Diagnosis of Pulmonary Embolism
A blood sample was taken before starting the patients on any thrombolytic treatment. The positivity threshold for D-Dimer was above 250 ng/ml. CTPA was performed after performing blood sampling.
- Trial name
- NCT05862220
- Testing
- D-Dimer vs CTPA
- Where
- United Arab Emirates
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Zulekha Hospitals
Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients
Potential Role of Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients: Impact of Ferretin and D -Dimer.
2.1 Study the role of NLRP3 inflammasome in COVID-19 patients. 2.2 Study the gene expression of NLRP3 and IL-1β in blood samples of COVID-19 patients and compare to apparently healthy subjects.
- Trial name
- NCT06080750
- Testing
- Quantitative Real Time Polymerase chain reaction (qRT-PCR), ELISA and colorimeter
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pulmonary Embolism
Age-adjusted D-dimer Cut-off Levels to Rule Out Pulmonary Embolism
Suspected pulmonary embolism (PE) is a frequent clinical problem and remains a diagnostic challenge. The diagnostic approach of PE relies on sequential diagnostic tests, such as plasma D-dimer measurement, multi-slice computed…
- Trial name
- ADJUST (NCT01134068)
- Testing
- Evaluation of a modified DD cut-off to rule out PE
- Where
- 4 sites in France, Netherlands and 1 more
- Volunteers
- 3,306 people
- Sponsor
- Marc Righini
Coronavirus Disease (COVID)19
D-dimer Adjusted Versus Therapeutic Dose Low-molecular-weight Heparin in Patients With COVID-19 Pneumonia
evaluation of the efficacy and safety of D-dimer adjusted heparin versus therapeutic dose heparin in patients with COVID-19 Pneumonia.
- Trial name
- NCT04584580
- Testing
- low-molecular-weight heparin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Coronary Artery Disease, Percutaneous Coronary Intervention
Study of the Long-term Effects of P2Y12 Inhibitor Monotherapy and Coagulation Markers After Percutaneous Coronary Angioplasty.
Patients who undergo percutaneous coronary intervention (PCI) are commonly treated with antiplatelet therapy to prevent stent thrombosis and recurrence of events.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndromes, Antiplatelet Therapy
- Trial name
- HI-TECH 2 (NCT07582835)
- Testing
- Clopidogrel, Ticagrelor, Prasugrel
- Where
- Switzerland
- Volunteers
- 355 people
- Sponsor
- Cardiocentro Ticino
Pneumonia
Observation and Treatment of Pulmonary Microthrombosis in Childhood Pneumonia With Elevated D-dimer
Objective 1. Master the clinical feathers, imaging features and laboratory diagnosis characteristics and economic costs of children pneumonia with higher D-dimer: 1.
- Trial name
- NCT04778917
- Testing
- Low-Molecular-Weight Heparins Calcium Injection
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Capital Institute of Pediatrics, China
Venous Thromboses, Ischemic Stroke
OsciPulse D-dimer Efficacy Trial
The purpose of this study is to assess the safety and efficacy of the OsciPulse System in reducing serum d-dimer levels in hospitalized ischemic stroke patients.
- Trial name
- NCT05389488
- Testing
- OsciPulse system, Flowtron ACS900
- Where
- United States
- Sponsor
- OsciFlex LLC
Placenta Accreta Spectrum, Placenta Previa
Hematological and Coagulation Markers in Predicting Placenta Accreta Spectrum in Placenta Previa
Placenta accreta spectrum (PAS) is a serious pregnancy complication where the placenta attaches too deeply into the wall of the uterus.
- Trial name
- NCT07826247
- Volunteers
- 130 people
- Sponsor
- Assiut University
Emergency Department, Non-specific Complaints
The Safe Fast Track Study
Emergency departments (ED) internationally are treating an increasing number of patients. Most require hospital services but some could be better cared for on alternative pathways. D-dimer has some unique properties.
- Trial name
- SafeFT (NCT06219486)
- Testing
- D-dimer
- Where
- 2 sites in Denmark
- Volunteers
- 1,538 people
- Sponsor
- Odense University Hospital
Chronic Urticaria
Antiplatelet Therapy in Chronic Urticaria
This study compares the combination of antiplatelets and antihistamine versus antihistamine alone for the treatment of chronic spontaneous urticaria
- Trial name
- NCT06268470
- Testing
- Desloratadine plus cilostazol and dipyridamole, Desloratadine
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Chulalongkorn University