Clinical trials: DEGLUTİTİON
Heartburn, Gastroesophageal Reflux Disease
Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive Heartburn
The purpose of this research study is to determine in heartburn patients with nonerosive disease if detecting the presence of a fragment of the protein e-cadherin in esophageal epithelium or the amount of fragments of e-cadherin…
- Trial name
- NCT01149395
- Testing
- Dexlansoprazole
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
GERD - Gastro-Esophageal Reflux Disease, Anxiety Disorders
Important Correlation Between Anxiety and Reflux Symptoms in Patients With Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is one of the most common gastroenterological disorders with a reported prevalence of 10% to 20% percent in Europe and the USA and less than 5% in Asia.
- Trial name
- NCT06151067
- Testing
- High-Resolution Manometry, Upper-GI endoscopy, pH-Impedance testing
- Where
- Germany
- Volunteers
- 458 people
- Sponsor
- Evangelic Hospital Kalk Cologne
Dysphagia
The Effects of Cold Liquids on the Swallowing Mechanism in Preterm Infants
The purpose of this study is to see if cold liquids improve the swallowing mechanisms in premature infants with swallowing difficulties (dysphagia).
- Trial name
- NCT01863264
- Testing
- Cold Thin Liquid Barium
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Obese Adults
Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity
This study will assess whether a single subcutaneous dose of tirzepatide 7.5 mg , compared with saline placebo, increases total esophageal acid exposure time during a 96-hour wireless pH recording beginning about 48 hours after…
- Trial name
- NCT07893457
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson Disease, Dysphagia
Effortful Swallow Maneuver for Swallowing Impairment in People With Parkinson Disease
Context: Many people with Parkinson Disease (PwPD) experience swallowing difficulties, particularly with food/liquid going down the wrong way or remaining in the throat after swallowing.
- Trial name
- NCT05319795
- Testing
- Effortful Swallow Maneuver
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- University Health Network, Toronto
Head And Neck Cancer
Testing Accountability in Patient Adherence
The goal of this research study is to look for factors that influence whether or not head and neck cancer patients follow the swallowing exercises that they are asked to perform while receiving radiation treatment.
- Trial name
- NCT01844557
- Testing
- Swallowing Exercises, Symptom Inventory, Questionnaires
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- M.D. Anderson Cancer Center
Prosthesis Durability
Hyoid Displacement During Swallowing Function for Completely Edentulous Subjects
To investigate the effect of wearing mandibular implant retained overdentures on superior and anterior hyoid displacement during swallowing process.
- Trial name
- NCT06187181
- Testing
- implant overdenture, videofluroscopy
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Oropharyngeal Dysphagia, Swallowing Disorders
The Effect of Swallowing Exercise and Maneuver Program For Older Adults With Dysphagia in Nursing Home
This clinical trial aimed to evaluate the effectiveness of a structured swallowing exercise and maneuver program for older adults with dysphagia living in a nursing home.
- Conditions
- Oropharyngeal Dysphagia, Swallowing Disorders, Frailty-related Dysphagia, Nursing Homes
- Trial name
- NCT07049471
- Testing
- Swallowing Exercise and Maneuver Program for Older Adults with Dysphagia
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Universitas Indonesia
Functional Dyspepsia, Gastro Esophageal Reflux
Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting
The purpose of this prospective cohort study is to compare upper GI symptoms and endoscopy findings in Canada with Japan and Iran, and correlate this with the upper GI microbiome.
- Conditions
- Functional Dyspepsia, Gastro Esophageal Reflux, Peptic Ulcer, Normal Control
- Trial name
- NCT03868267
- Where
- 3 sites in Canada, Iran and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Hamilton Health Sciences Corporation
Eosinophilic Esophagitis (EoE)
Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)
The goal of this study is to research Dupilumab, an FDA approved medication in treating patients diagnosed with Eosinophilic esophagitis (EoE). The drug works by controlling allergic inflammation of the esophagus.
- Trial name
- NCT06665971
- Testing
- Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Gastroesophageal Reflux Disease
Gastroesophageal Reflux Disease Diagnostic Trial
Gastroesophageal reflux disease (GERD) is a very common condition in clinical practice. In China, GERD affects nearly 150 million patients, whose quality of life are seriously impacted.
- Trial name
- GERDT (NCT06504134)
- Testing
- the Novel Esophageal Cell Collection Device
- Volunteers
- 1,000 people
- Sponsor
- Changhai Hospital
Head and Neck Neoplasms, Deglutition Disorders
EMST in Patients Undergoing CRT for HNCA
This study is a randomized trial examining the impact of expiratory muscle strength training (EMST) on maintenance of safe and efficient oropharyngeal swallow function in persons with cancer of the head and neck (HNCA) undergoing…
- Trial name
- NCT03916809
- Testing
- EMST
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Milwaukee
Gastroesophageal Reflux Disease
Absolute Bioavailability of YH4808 With Accelerator Mass Spectrometry(AMS)-Based Microdose Study
This study aims to determine the absolute bioavailability of YH4808 using simultaneous oral therapeutic- and [14C]-labeled intravenous microdoses.
- Trial name
- NCT02072447
- Testing
- YH4808 PO and [14C]-YH4808 IV
- Where
- South Korea
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cardiovascular Diseases, Dysphagia
Clinical Markers of Dysphagia in Cardiac Surgical Patients
Although dysphagia is a known complication of cardiac surgery, risk factors and sensitive bedside clinical markers of dysphagia have not yet been identified.
- Trial name
- NCT05304416
- Testing
- Fiberoptic Endoscopic Evaluation of Swallowing, Simultaneous FEES and Videofluoroscopy instrumental swallowing exam, Videofluoroscopy instrumental swallowing exam (VFSS)
- Where
- 2 sites in United States
- Volunteers
- 347 people
- Sponsor
- University of Florida
Head and Neck Neoplasms, Xerostomia
Evaluation of Treatment Related Toxicity After Radiotherapy for Head and Neck Cancer
Radiotherapy plays an important role in the curative treatment of head and neck cancer. This treatment however is associated with significant acute and late toxicity with xerostomia and dysphagia severely implicating the…
- Conditions
- Head and Neck Neoplasms, Xerostomia, Deglutition Disorders
- Trial name
- NCT01621048
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastro-esophageal Reflux, Reflux, Gastroesophageal
ARMA (Antireflux Mucosa Ablation) in Patients With Chronic Refractory Reflux Disease
Pilot study of the possible clinical response to anti reflux mucosal ablation in patients with chronic refractory reflux disease
- Trial name
- ARMA (NCT05425771)
- Testing
- Anti Reflux Mucosa Ablation
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Klinikum Garmisch-Patenkirchen
Gastroesophageal Reflux
Study Evaluating Pantoprazole in Adolescents With GERD
The purpose of this study is characterize the PK profile of single and multiple doses of pantoprazole in adolescents aged 12 to 16 years with Gastroesophageal Reflux Disease (GERD).
- Trial name
- NCT00367614
- Testing
- pantoprazole
- Volunteers
- 20 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Gastroesophageal Reflux Disease (GERD)
One-year Clinical Outcomes of Endoscopic Cardia Banding Plication for Refractory Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy
This single-center retrospective cohort study was conducted at the Center for Bariatric and Metabolic Surgery, China-Japan Friendship Hospital, Beijing, China, and is reported in accordance with the STROBE guidelines for…
- Trial name
- NCT07749352
- Testing
- endoscopic cardia banding plication
- Where
- China
- Volunteers
- 47 people
- Sponsor
- China-Japan Friendship Hospital
Dysphagia, Cervical Spinal Cord Injury
Dysphagia After Anterior Cervical Spine Surgery
The purpose of this research project is to investigate the incidence of impaired swallowing (dysphagia) after anterior cervical spine surgery (ACSS) and to study the long-term effect of dysphagia on nutritional status 12 ± 3…
- Trial name
- NCT04855838
- Testing
- Oral neuromuscular training
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Umeå University
Esophageal Achalasia, Esophageal Spasm, Diffuse
Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in Spastic Esophageal Disorders
To compare the efficacy of peroral endoscopic myotomy and Botulinum toxin injection in spastic esophageal disorders.
- Conditions
- Esophageal Achalasia, Esophageal Spasm, Diffuse, Esophageal Motility Disorders
- Trial name
- NCT02663206
- Testing
- peroral endoscopic myotomy, Botulinum toxin injection
- Where
- United States
- Sponsor
- Johns Hopkins University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.