Clinical trials: DEGLUTİTİON
Gastro-oesophageal Reflux Disease
LINX vs Fundoplication
Reflux disease can severely impact upon quality-of-life and lead to complications, including ulceration of the oesophagus. It is often controlled with self-help measures and medication. However, sometimes surgery is recommended.
- Trial name
- GOLF (NCT07093359)
- Testing
- Laparoscopic or robotic LINX procedure, Laparoscopic or robotic fundoplication
- Where
- 5 sites in United Kingdom
- Volunteers
- 460 people
- Sponsor
- University of Oxford
Dysphagia, OSA
Obstructive Sleep Apnea (OSA), Oral Frailty, Dysphagia, Continuous Positive Airway Pressure (CPAP)
The purpose of this study is to evaluate the effects of the CPAP treatment on oral frailty and dysphagia among OSA patients.
- Conditions
- Dysphagia, OSA, CPAP
- Trial name
- NCT05977296
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
the Correlation Between the Barium Examination and High Resolution Impedance Manometry
The Correlation Between the Barium Examination and High Resolution Impedance Manometry
In many cases, the manometric examination is not feasible because of the pharyngeal sinusitis or pharyngeal torsion. In addition, although previous conventional manometry was used to estimate pharyngeal swallowing, the bolus flow…
- Trial name
- NCT04878588
- Testing
- patients received high resolution impedance manometry
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Hyperparathyroidism
Swalqol in Primary Hyperparathyroidism
Swallow related quality of life before and after parathyroidectomy will be evaluated in patients with primary hyperparathyridism.
- Trial name
- NCT03968510
- Testing
- parathyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Uşak University
Esophageal Dysmotility
Esophageal Dysmotility - Prospective Study Evaluating Methods for Esophageal Dilation
The purpose of the study is to prospectively evaluate the most effective treatment of esophageal dysmotility that alleviates symptoms of dysphagia and improves quality of life.
- Trial name
- NCT03604523
- Testing
- Dilation by Balloon, Dilation by Semi-rigid Savary
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Massachusetts, Worcester
Pilates Exercise, Gastro Esophageal Reflux
Effects of Clinical Pilates Exercises on Symptoms, Posture, Balance and Quality of Life in GERD
This randomized, single-blind, parallel-group clinical trial investigates whether a six-week supervised clinical Pilates exercise program improves reflux symptom severity, postural alignment, dynamic balance, sleep quality…
- Trial name
- NCT07573280
- Testing
- Usual Daily Activity (No Exercise Intervention), Supervised Clinical Pilates Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Istinye University
Esophageal Achalasia
Per Oral Endoscopic Myotomy (POEM) and Prolonged Dilatation (PRD) for Achalasia
Achalasia is an esophageal motility disorder, which leads to clinical symptoms such as dysphagia, regurgitation, chest pain and consecutive weight loss.
- Trial name
- POETA (NCT02518542)
- Testing
- Endoscopic intervention A, Endoscopic intervention B, Endoscopic intervention C
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Gastroesophageal Reflux Disease (GERD)
Assessment of the Role of Tegaserod Therapy in the Management of Gastroesophageal Reflux Disease (GERD) Symptoms in Patients With Incomplete Response to Proton Pump Inhibitors (PPIs).
Study to assess the effects of tegaserod added to PPI therapy in the resolution of heartburn and regurgitation in patients with incomplete relief from PPIs .
- Trial name
- NCT00171483
- Testing
- Tegaserod
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Novartis
Gastroesophageal Reflux Disease
Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients
This study is designed to evaluate the efficacy and tolerability of ilaprazole relative to that of esomeprazole in healing erosive esophagitis and resolving accompanying symptoms of GERD.
- Trial name
- NCT02860624
- Testing
- 10 mg ilaprazole, 40mg esomeprazole
- Volunteers
- 550 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Diabetes Mellitus, Type 2, Anesthesia
Investigation of the Evolution of Gastric Emptying by Gastric Ultra Sonography in Patients Treated With GLP-1 Receptor Agonists on a 7 Days Pausing Period.
Glucagon-like-peptide-1 is a hormone released by the gut enteroendocrine cells. Its secretion occurs after each meal to enable production of insulin and inhibits the production of glucagon to lower after meal glycemia.
- Conditions
- Diabetes Mellitus, Type 2, Anesthesia, Pulmonary Aspiration of Gastric Contents
- Trial name
- NCT06388213
- Testing
- Gastric Ultrasonography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Gastroesophageal Reflux Disease
Prevalence of Gastroesophageal Reflux Disease in Primary Care Patients With Upper Gastrointestinal Symptoms
The purpose of this study is to provide data on the gastroesophageal reflux disease (GERD) prevalence as percentage of patients with upper gastrointestinal (GI) symptoms that are identified with GERD using the Gerd-Q…
- Trial name
- NCT01020890
- Where
- 12 sites in Bulgaria
- Volunteers
- 2,210 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
A Study of Nexium (Esomeprazole) 40 mg Once Daily in Subjects With Symptoms of Gastroesophageal Reflux Disease (GORD) After Treatment With a Full Dose of Proton Pump Inhibitor (PPI)
The purpose of this study is to assess how patients with gastro-oesophageal reflux disease (heartburn) who are currently receiving treatment with a proton pump inhibitor but are still experiencing symptoms will benefit from a…
- Trial name
- NEON (NCT00734097)
- Testing
- Esomeprazole 40 mg, Physical Exam, Quality of Life Questionnaires
- Where
- 10 sites in Argentina, Chile and 2 more
- Volunteers
- 314 people
- Sponsor
- AstraZeneca
GERD, Cough
Ablation of Esophageal Inlet Patches in Patients Referred for Bravo pH-Testing
Patients with suspected extra-esophageal manifestations of gastro-esophageal reflux disease (GERD), such as cough, hoarseness, and globus, are often referred for pH testing.
- Conditions
- GERD, Cough, Metaplasia
- Trial name
- NCT05131932
- Testing
- Endoscopic ablation of inlet patch
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Dysphagia, Swallowing Disorder
SURE Trial: Swallowing Ultrasound Reliability Evaluation Trial
This study aims to explore the reliability of using ultrasonography (US) for the assessment of swallowing function in patients with dysphagia.
- Trial name
- NCT07098767
- Testing
- ultrasound evaluation, Fiberoptic endoscopic evaluation of swallowing (FEES)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
GERD
Twenty-Four Hour Combined Multi-Channel Impedance and pH Ambulatory Monitoring: Impedance Reflux Episodes of Patients On and Off Proton Pump Inhibitor Therapy
The purpose of this study is to determine the effects of proton pump inhibitors (PPIs) on the total number of reflux episodes in the distal esophagus measured by impedance in patients with and without gastroesophageal reflux…
- Trial name
- NCT01710800
- Testing
- Esomeprazole
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Gastroesophageal Reflux Disease, Apnea Infants
Gastroesophageal Reflux and Cardiorespiratory Problems
Cardiorespiratory and gastroesophageal reflux events often coexist in infants in Neonatal Intensive Care Unit (NICU) thus leading to drugs over-prescription and delayed discharge.
- Conditions
- Gastroesophageal Reflux Disease, Apnea Infants, Desaturation of Blood, Bradycardia
- Trial name
- CR-GER (NCT03053609)
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- University of Turin, Italy
Barrett Esophagus, Gastroesophageal Reflux
Novel Imaging Techniques in Barrett's Esophagus
Primary Aim: In patients with endoscopically suspected BE, compared to standard endoscopy, novel techniques (NBI and AFI) with target biopsies will Detect more patients with intestinal metaplasia Detect more areas of high grade…
- Trial name
- NCT00576498
- Testing
- NBI-AFI imaging, Standard Endoscopy
- Where
- 3 sites in United States, Netherlands
- Volunteers
- 130 people
- Sponsor
- Midwest Biomedical Research
Imaging Data Collection From Dynamic Swallowing MRI in Healthy Volunteers, Create Operating Algorithms
Transposition of Dynamic MRI Data From Healthy Subjects to an in Vitro Swallowing Simulator
Swallowing is a complex process, involving a very fine synchronization of the pharyngo-larynx, with respiration, under the control of the central nervous system and numerous peripheral effectors.
- Conditions
- Imaging Data Collection From Dynamic Swallowing MRI in Healthy Volunteers, Create Operating Algorithms, Apply the Imaging Data of MRI to a Swallowing Simulator
- Trial name
- SWALL-E (NCT05178108)
- Testing
- Real-time MRI of swallowing
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Gastro-Esophageal Reflux, Fundoplication
Health, Economic Analysis and Clinical Aspects of Patients With Neurological Disabilities in Enteral Nutrition With Dedicated Formula. The Role of Nissen's Fundoplication in the Management of Gastroesophageal Reflux
Nutritional difficulties are common in children with neurodisabilities and can be associated with malnutrition and gastrointestinal diseases, such as gastro-esophageal reflux disease (GERD) and constipation.
- Trial name
- NCT05068089
- Testing
- Nissen fundoplication, Enteral nutrition
- Where
- Italy
- Volunteers
- 360 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Dysphagia, Dysphonia
Dysphagia and Dysphonia Outcomes in SARS CoV-2 (COVID-19) Infection (DYADS Study)
This study examines the presence, severity and natural history of dysphagia and dysphonia in the post-extubation and severely unwell COVID-19 patient.
- Conditions
- Dysphagia, Dysphonia, Subglottic Stenosis, Voice Disorders
- Trial name
- DYADS (NCT04584658)
- Testing
- Fibreoptic Endoscopic Evaluation of Swallowing (FEES), Videofluoroscopy, Dysphagia Handicap Index (DHI)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
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