Clinical trials: DEGLUTİTİON
Gastro Esophageal Reflux
GERD Treatment With Transoral Incisionless Fundoplication (TIF) Following Hiatal Hernia Surgery
The investigators prospectively studied ninety nine GERD patients following laparoscopic hiatal surgery combined with transoral incisionless fundoplication at two community hospitals.
- Trial name
- GERD (NCT03143608)
- Testing
- Esophyx
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Peter G Mavrelis
Dysphagia, Late Effect of Stroke, Deglutition Disorders
Bio-feedback Treatment for Dysphagic Post-stroke Patients
The primary purpose of the study is to evaluate whether the effect of bio-feedback dysphagia treatment is more effective than a control treatment in post-stroke patients.
- Trial name
- BIO_DYS (NCT03247374)
- Testing
- "ProComp5 Infiniti" Biofeedback, Standard Speech and Language Therapy
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Scleroderma
Probiotics in Patients With Moderate-to-severe Distention/ Bloating From Systemic Sclerosis
Organs of the gastrointestinal tract include the mouth, throat, stomach, intestines, and anus. Patients with scleroderma often have GIT disorders. GIT disorders can be severely debilitating and even life-threatening.
- Trial name
- PRISS (NCT01497743)
- Testing
- Lactobacillus
- Sponsor
- University of Michigan
Achalasia, Gastric Outlet Obstruction
Endoscopic Surgery for Gastrointestinal Disorders: A Multicenter Registry Study
Currently, there is limited multi-center data on endoscopic surgery outcomes in western populations. Evaluation of these measurement would help the investigators compare them to conventional treatment modalities within current…
- Conditions
- Achalasia, Gastric Outlet Obstruction, Gastroparesis, GERD
- Trial name
- NCT05041608
- Testing
- Endoscopic Surgery
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University
Dysphagia
Effects of Age and Age-Related Diseases on Swallowing
The long-term goal of this research program is to advance the treatment of swallowing disorders in elderly adults. This study will identify the impact of an 8-week progressive resistance exercise program for oral muscles on…
- Trial name
- NCT00038350
- Testing
- Lingual Strengthening
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- US Department of Veterans Affairs
Gastroesophageal Reflux Disease, Reflux Esophagitis
The Efficacy of i-Scan for Detecting Reflux Esophagitis
Endoscopy is a widely used modality for the diagnosis and classification of Gastroesophageal reflux disease (GERD), and the extent of esophageal mucosal breaks on endoscopy can be assessed.
- Trial name
- NCT01381991
- Testing
- i-scan
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Konkuk University Hospital
GERD
A New System for GERD Diagnosis and Treatment
This is a pilot study measuring a new diagnosis and treatment system "EAISMLP" in adult patients with gastroesophageal reflux disease (GERD).
- Trial name
- EAISMLP (NCT03600974)
- Testing
- Stretta, Laparoscopic Nissen fundoplication, Probiotic Agent
- Volunteers
- 200 people
- Sponsor
- Capital Medical University
Gastroesophageal Reflux Disease
SThe Effects of Melatonin on GERD Symptoms
We hypothesize that melatonin as compared to PPI and to placebo, improves GERD symptoms by decreasing esophageal acid exposure and esophageal acid sensitivity in GERD.
- Trial name
- NCT00564590
- Testing
- Melatonin, omeprazole
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rabin Medical Center
Dysphagia, Oropharyngeal, Stroke, Ischemic
Combined Conventional Speech Therapy and Functional Electrical Stimulation in Dysphagia Following Stroke
This study will evaluate the effectiveness of conventional speech therapy associated with functional electrical stimulation in patients with dysphagia after ischemic stroke.
- Trial name
- NCT03649295
- Testing
- Functional Electrical Stimulation, Conventional Speech Therapy
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Hospital Geral de Fortaleza
Malnutrition, Sarcopenia
Nutritional Status in Hospitalized Patients Over 65 Years of Age With Mental Disorders
The objective of of this observational study is to evaluate the nutritional status and the prevalence of nutrition-related conditions, as well as dysphagia, among patients aged 65 years and older with mental disorders.
- Conditions
- Malnutrition, Sarcopenia, Obesity, Sarcopenic Obesity
- Trial name
- NutriP-SI65 (NCT07710456)
- Volunteers
- 450 people
- Sponsor
- University Psychiatric Clinic Ljubljana
Gastroesophageal Reflux
Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers
To investigate the effect of citalopram, a selective serotonin reuptake inhibitor, on esophageal sensitivity.
- Trial name
- NCT04355455
- Testing
- Citalopram
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastroesophageal Reflux
Famotidine in Subjects With Non-erosive Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) considered to be associated with mucosal damages in the esophagus and heartburn, which may sometimes interfere with daily activities due likely to reflux of acid gastric contents.
- Trial name
- NCT00141960
- Testing
- Famotidine
- Where
- 7 sites in Japan
- Volunteers
- 480 people
- Sponsor
- Astellas Pharma Inc
Dysphagia, Stroke, Acute
BJH-SDS Validation of the German Translation
The first object of the study is the validation of a translation of the Barnes-Jewish Hospital Stroke Dysphagia Screen with determination of sensitivity, specificity, interrater reliability (especially between different…
- Trial name
- NCT06497790
- Testing
- BJH-SDS Screenint Test, Flexible Endoscopic Evaluation of Swallowing
- Where
- Germany
- Volunteers
- 570 people
- Sponsor
- University of Giessen
Swallowing Disorders
Modelling of Pharyngeal Laryngeal Effectiveness
The purpose of this study is to collect the signals of pharyngeal laryngeal activity through five non-invasive sensors (microphone, accelerometer, surface electromyography (EMG), nasal cannula and oximeter) in order to identify…
- Trial name
- Eph-L (NCT06014710)
- Testing
- Swallowing evaluation
- Where
- 4 sites in France
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis
Comparison of Early Postoperative Outcomes Between Minimally Invasive Valve Surgery Via Right Thoracotomy and Conventional Valve Surgery Via Sternotomy.
This randomized controlled trial aims to compare early postoperative outcomes between Minimally Invasive Valve Surgery (MIVS) via right thoracotomy and Conventional Valve Surgery via median sternotomy in patients undergoing…
- Conditions
- Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis, Aortic Valve Insufficiency, Valvular Heart Disease Stenosis and Regurgitation (Diagnosis)
- Trial name
- NCT07251660
- Testing
- Minimally Invasive Valve Surgery, Conventional Valve Surgery
- Volunteers
- 32 people
- Sponsor
- Chaudhry Pervaiz Elahi Institute of Cardiology
the Correlation Between the Barium Examination and High Resolution Impedance Manometry
The Correlation Between the Barium Examination and High Resolution Impedance Manometry
In many cases, the manometric examination is not feasible because of the pharyngeal sinusitis or pharyngeal torsion. In addition, although previous conventional manometry was used to estimate pharyngeal swallowing, the bolus flow…
- Trial name
- NCT04878588
- Testing
- patients received high resolution impedance manometry
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Reflux, Esophagitis
The Effect of Nexium on Transmucosal Esophageal Leak
In a related study, the investigators have found evidence that patients with Barrett's esophagus have a leak for oral sucrose to leave their upper gastrointestinal tract, enter the blood, and be filtered into urine.
- Conditions
- Reflux, Esophagitis, Barrett's Esophagus
- Trial name
- NCT00216788
- Testing
- Esomeprazole (Nexium) 40 mg/day
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Main Line Health
Dyspepsia, Anemia
The Use of AI to Improve Quality of OGD
Early and accurate recognition of gastrointestinal lesions has implications for public health. The quality of oesophagogastroduodenoscopy (OGD) has great impact on the detection of oesophageal and gastric malignancies.
- Conditions
- Dyspepsia, Anemia, Acid Reflux, Dysphagia
- Trial name
- NCT04883567
- Testing
- The use of artificial intelligence system Cerebro
- Where
- Hong Kong
- Volunteers
- 210 people
- Sponsor
- Chinese University of Hong Kong
Eustachian Tube Dysfunction, Chronic Otitis Media
Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults
This research study measures how well the Eustachian tube works and looks directly at the anatomy of the Eustachian tube in adults who have had tympanostomy tubes surgically inserted into their eardrums because they have been…
- Trial name
- NCT01251432
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Visceral Obesity, Reflux Esophagitis
Adipokines and the Risk of Reflux Esophagitis
We aimed to risk faoctors for GERD and association between visceral obesity, plasma adipoline(leptin, adiponectin, IL-6, TNF-α)and development of reflux esophagitis in healthy Koreans.
- Trial name
- NCT01560598
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital