Clinical trials: DEGLUTİTİON
Deglutition, Physiology
Metaplasticity in Human Pharyngeal Motor Cortex
The purpose of the study is to determine the effects of giving 2 doses of brain stimulation through repetitive transcranial magnetic stimulation (rTMS) on swallowing neurophysiology (brain function) in healthy adults.
- Trial name
- NCT03705936
- Testing
- rTMS
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Gastroesophageal Reflux Disease
Comparison of Laparoscopic Nissen Versus Thal Fundoplication in Children
Laparoscopic fundoplication is increasingly performed in paediatric surgery. Many types of fundoplication are performed, each has advantages and disadvantages.
- Trial name
- NCT01027975
- Testing
- laparoscopic Nissen/laparoscopic Thal
- Where
- United Kingdom
- Sponsor
- Oxford University Hospitals NHS Trust
Obesity, Gastro Esophageal Reflux Disease
Effect of Routine Anterior Crural Repair in De-Novo Gastroesophageal Reflux After Laparoscopic Sleeve Gastrectomy
The purpose of the study is to evaluate the superiority of anterior crural repair during sleeve gastrectomy over no repair in decreasing the incidence of gastroesophageal reflux disease.
- Trial name
- NCT04884074
- Testing
- Standard Sleeve Gastrectomy plus Anterior Crural Repair, Standard sleeve gastrectomy (SSG, the control group)
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Stroke
Reflexive Coughing Force in Severe Aspirators
To assess coughing force during reflex coughing test in those with severe dysphagia and severe aspiration and compare them to than those with stroke patients with no signs of dysphagia/aspiration.
- Trial name
- NCT02080988
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Recessive Dystrophic Epidermolysis Bullosa, Dysphagia
Treatment of Dysphagia in Patients With Dystrophic Epidermolysis Bullosa With Budesonide: a Retrospective Bicentric Study Nice - Paris St Louis / Necker (EBUDE Study)
Budesonide is an anti-inflammatory medication that works by decreasing the immune system's overreaction. In the treatment of eosinophilic esophagitis, especially with Jorveza or a preparation made in a pharmacy, it reduces the…
- Conditions
- Recessive Dystrophic Epidermolysis Bullosa, Dysphagia, Esophageal Stenosis
- Trial name
- EBUDE (NCT07684105)
- Testing
- The retrospective data collected will be entered into an eCRF and then analyzed centrally
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Type III Achalasia, EGJ Outflow Obstruction With Spastic/Hypercontractile Features
PREcision MEDicine In Achalasia (PREMEDIA) - Cohort
The goal of this observational study is to learn about how the doctor decides how long to cut t the esophageal muscle during Per-Oral Endoscopic Myotomy (POEM) in patients with difficulty swallowing due to certain conditions.
- Conditions
- Type III Achalasia, EGJ Outflow Obstruction With Spastic/Hypercontractile Features, Jackhammer Esophagus, Distal Esophageal Spasm
- Trial name
- PREMEDIA (NCT07293689)
- Where
- 16 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Speech and Language Disorder, Speech Therapy
Providing Speech Therapy Awareness in Private Schools
There has been limited research in the area of speech and language therapy awareness in Pakistan. The study aims to assess the efficacy of providing speech therapy awareness in private schools through a pre-post model.
- Conditions
- Speech and Language Disorder, Speech Therapy, Speech Delay, Swallowing Disorder
- Trial name
- NCT04505696
- Testing
- Speech-Language Pathology Presentation
- Where
- Pakistan
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Paraesophageal Hernia
Short Esophagus in Type II-IV Hiatus Hernia
Background: The existence, diagnosis and treatment of short esophagus is one of the controversies of the past which has recently re-emerged.
- Trial name
- SEHH (NCT01587859)
- Testing
- laparoscopic surgery
- Where
- 2 sites in Italy
- Volunteers
- 34 people
- Sponsor
- University of Bologna
Niemann-Pick Disease, Type C
Adrabetadex to Treat Niemann-Pick Type C1 (NPC1) Disease
Due to different study designs, the sponsor separated Part C into this separate registration (NCT04958642), leaving Parts A/B in NCT02534844.
- Trial name
- NCT04958642
- Testing
- Adrabetadex
- Where
- 30 sites in United States, Australia and 7 more
- Volunteers
- 66 people
- Sponsor
- Mandos LLC
Achalasia
Assessing the Efficacy of Steroid Treatment of Achalasia
Would systemic steroids be an effective treatment in early variants of achalasia?
- Trial name
- NCT01903486
- Testing
- Apo-Prednisone Cordorol, Detasone - Prednisone
- Sponsor
- Mayo Clinic
Dysphagia
Clinical and Instrumental Assessment Tools for Neurogenic Dysphagia: Translation and Validation
This study aims to translate and validate Italian versions of several clinical assessment tools for patients with neurogenic dysphagia.
- Trial name
- Val_Dysphagia (NCT07549724)
- Testing
- dysphagia assessment
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Cerebral Palsy (CP)
Scooter Board Activities on Neck Control and Dysphagia in Children With Cerebral Palsy
This study is a randomized control trial exploring the therapeutic effects of scooter board activities on neck control and dysphagia in children with cerebral palsy (CP).
- Trial name
- NCT06477224
- Testing
- Scooter Board Activities, Routine Physical Therapy
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Periodontitis, Periodontal Diseases
Evaluation of the Impact of Periodontitis and Its Treatment on Swallowing Functions and Oral Quality of Life
The objective of this single-center prospective study is to evaluate the impact of periodontal treatment on masticatory performance in patients with periodontitis.
- Conditions
- Periodontitis, Periodontal Diseases, Quality of Life
- Trial name
- FI-PAROCROC (NCT07651579)
- Testing
- Functionnal test
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Clermont-Ferrand
Deglutition Disorders
A New Ultrasound Score for Swallowing Disorders Diagnosis in Difficult-to-wean Tracheostomised Patients
Swallowing Disorders (SD) is commonly observed in intensive care unit (ICU) patients. Disruption to the upper airway by way of a tracheostomy may lead to physiological and/or biomechanical changes to the swallow, thereby…
- Trial name
- SHUBACA (NCT06630013)
- Where
- 4 sites in France
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Hopital Forcilles
Gastro-esophageal Reflux Disease (GERD)
FODMAPs and Refractory GERD
The aim of this study is to determine the effects of a low Fermentescible Oligosaccharides Disaccharides Monosaccharides and Polyols (FODMAP) diet in patients with documented refractory GERD on proton pump inhibitor (PPI) therapy.
- Trial name
- EFFORR (NCT02471989)
- Testing
- Low-FODMAP diet, GERD diet
- Where
- 6 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Bordeaux
Postoperative Sore Throat, Bronchoscopy
Dexmedetomidine Nasal Spray and Postoperative Sore Throat After Bronchoscopy
The goal of this observational study is to learn whether dexmedetomidine nasal spray is associated with a lower risk of postoperative sore throat in adult patients who underwent bronchoscopy under general anesthesia.
- Conditions
- Postoperative Sore Throat, Bronchoscopy, Hoarseness, Dysphagia
- Trial name
- NCT07894224
- Testing
- Dexmedetomidine Nasal Spray, standard general anesthesia
- Where
- China
- Volunteers
- 4,400 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Hernia, Hiatal
Laparoscopic Repair of Giant Hiatal Hernias With Nitinol-framed Lightweight Polytetrafluoroethylene Mesh
This study is prospective randomized trial enrolling at least 50 participants which compares efficacy and safety of two alternative methods of laparoscopic hiatal repair for giant (i.e.
- Trial name
- GIANT (NCT01780285)
- Testing
- Nitinol-framed lightweight PTFE mesh for hiatal repair, Partially absorbable lightweight mesh for hiatal repair
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Odessa National Medical University
GERD
A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
Background: Gastroesophageal reflux disease (GERD), which affects at least 20% of adult Americans, may be especially common and severe in Veteran patients.
- Trial name
- NCT01265550
- Testing
- Nissen fundoplication, baclofen, Desipramine
- Where
- 15 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Gastroesophageal Reflux
Practice and Patient Compliance on the PPI (Proton Pump Inhibitors) Treatment of Gastroesophageal Reflux in South Korea
The purpose of this study is to examine the treatment profile of approximately 1,000 adult patients with gastroesophageal reflux who begin raberpazole sodium treatment for 4 months, and assess patients' adherence to the study…
- Trial name
- NCT01018160
- Testing
- Rabeprazole Sodium
- Volunteers
- 1,197 people
- Sponsor
- Janssen Korea, Ltd., Korea
Gastroesophageal Reflux
Study to Evaluate the Pharmacokinetics and Safety of Dexlansoprazole in Pediatric Subjects With Symptomatic Gastroesophageal Reflux Disease
The purpose of this study is to assess the pharmacokinetics and safety of dexlansoprazole, once daily (QD), in pediatric subjects with symptomatic Gastroesophageal Reflux Disease.
- Trial name
- NCT01045096
- Testing
- Dexlansoprazole
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- Takeda
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