Clinical trials: DEGLUTİTİON
Tricuspid Regurgitation
Percutaneous Treatment of Tricuspid Valve Regurgitation With the TriCinch System™
The TriCinch System™ is intended for percutaneous treatment of tricuspid regurgitation. It is a percutaneous catheter-based device designed for tricuspid valve repair in order to decrease effective cross-sectional area and…
- Trial name
- PREVENT (NCT02098200)
- Testing
- TriCinch System
- Where
- 14 sites in France, Germany and 2 more
- Volunteers
- 24 people
- Sponsor
- 4Tech Cardio Ltd.
Gastroesophageal Reflux Disease
Anti-reflux Mucosal Ablation Therapy Randomized Sham Control Trial for Gastroesophageal Reflux Disease
The goal of this randomized clinical trial is to investigate the efficacy and safety of antireflux mucosal ablation (ARMA) for patients with refractory gastroesophageal reflux disease (GERD).
- Trial name
- NCT06106100
- Testing
- Antireflux mucosal ablation
- Volunteers
- 68 people
- Sponsor
- Far Eastern Memorial Hospital
Laryngopharyngeal Reflux
Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux
The purpose of this study is to determine whether Lansoprazole 30mg taken twice daily is effective in the treatment of laryngitis due to gastroesophageal reflux.
- Trial name
- NCT00369265
- Testing
- Lansoprazole, Sugar pill
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- American Institute for Voice and Ear Research
Stroke, Dysphagia
Electrical Pharyngeal Stimulation for Dysphagia Therapy in Tracheostomized Stroke Patients
The purpose of this study is to evaluate whether electrical pharyngeal stimulation in addition to standard care can enhance short-term swallow recovery in tracheostomized dysphagic stroke patients and thereby facilitate earlier…
- Trial name
- NCT01956175
- Testing
- Electrical pharyngeal stimulation
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Gastroesophageal Reflux Disease
Diagnostic Value of Flexible Spectral Imaging Color Enhancement (FICE) Plus Probe-based Confocal Laser Endomicroscopy (pCLE) for Minimal Change Esophageal Reflux Disease (MERD) Diagnosis
Gastroesophageal reflux disease (GERD) patients without obvious mucosal break by endoscopy were examined by FICE, followed by confocal. Validity scores for MERD diagnosis were analyzed.
- Trial name
- NCT02336100
- Testing
- Endoscopy (FICE and pCLE)
- Where
- Thailand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Reflux Episodes
TLESR-impedance Study in Patients
The purpose of the study is to compare frequency and content of reflux episodes in patients with gastroesophageal reflux disease.
- Trial name
- NCT00743444
- Testing
- AZD3355
- Volunteers
- 27 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease, GERD
Safety and Efficacy Study of Axid Use in Infants Suffering From Gastroesophageal Reflux Disease (GERD)
The objective of this study is to evaluate the efficacy, acceptability, and safety of Axid Oral Solution versus placebo in the treatment of gastroesophageal reflux disease (GERD) in infants age 30 days up to 1 year.
- Conditions
- Gastroesophageal Reflux Disease, GERD, Heartburn
- Trial name
- NCT00373334
- Testing
- nizatidine (axid)
- Where
- 26 sites in United States
- Volunteers
- 138 people
- Sponsor
- Braintree Laboratories
Dysphagia, Esophageal, Dysphagia, Oral Phase
Post-thyroidectomy Dysphagia: An International Multicentric CONSORT - Compatible RCT
The most common and feared complications of total thyroidectomy are vocal cord paralyses and hypocalcemia. However, post-thyroidectomy dysphagia is not uncommon and has important consequences on the quality of life (QoL).
- Conditions
- Dysphagia, Esophageal, Dysphagia, Oral Phase, Dysphagia Comes and Goes, Thyroiditis
- Trial name
- Dysphagia-TT (NCT04410601)
- Testing
- Total thyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Umraniye Education and Research Hospital
Dysphagia
The Impact of Gastrostomy and Intermittent Oral Tube Feeding on Patients With Dysphagia and Bulbar Palsy After Stroke
The goal of this clinical trial is to compare the differences in quality of life and nutritional status between ischemic stroke patients With Dysphagia and Bulbar Palsy using Intermittent Oro-esophageal Tube and Gastrostomy.
- Trial name
- NCT06637098
- Testing
- routine rehabilitation therapy, Oral tube feeding, Gastrostomy feeding
- Volunteers
- 140 people
- Sponsor
- Babujinaya Cela
Feeding; Difficult, Newborn, Premature Infant Disease
Psychometric Properties of the SMART Feeding Tool
This observational study aims to evaluate the psychometric properties of a new infant feeding tool called "SMART Tool" in the neonatal intensive care unit. The main questions it aims to answer are: 1.
- Conditions
- Feeding; Difficult, Newborn, Premature Infant Disease, Dysphagia of Newborn, Nurse's Role
- Trial name
- NCT05729828
- Where
- 4 sites in United States
- Volunteers
- 76 people
- Sponsor
- Wake Forest University Health Sciences
Head and Neck Cancer
Swallow Exercise as Prophylaxis of Dysphagia After Radiotherapy
Background: Dysphagia is a common side effect after radiotherapy for haed and neck cancer patients. It may be worsened by immobility of the throat during tube feeding. Hypothesis: Exercises may prevent or reduce late dysphagia.
- Trial name
- NCT00332865
- Testing
- Swallowing Exercises
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Valvular Heart Disease Stenosis and Regurgitation
Different Methods of Cardiac MRI in Assessment of Estimated Corrected Ejection Fraction in Valvular Heart Diseases
Comparative study between Phase Contrast , Modified Simpson Rule and Myocardial Strain Analysis methods of Cardiac Magnetic Resonance Imaging in assessment of Corrected Estimated Ejection Fraction in Valvular Heart Disease To…
- Trial name
- NCT05808465
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
GERD, Hiatal Hernia
Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair
This single-blind randomized control study will follow 142 subjects across 7 sites randomized on a 1:1 ratio to compare treatment efficacy and safety between TIF and LNF in GERD patients with hiatal hernia undergoing hernia…
- Trial name
- CTIF (NCT04795934)
- Testing
- LAPAROSCOPIC PARAESOPHAGEAL HIATAL HERNIA REPAIR COMBINED WITH TRANSORAL INCISIONLESS FUNDOPLICATION
- Where
- 7 sites in United States
- Volunteers
- 142 people
- Sponsor
- Mayo Clinic
GORD, Oesophageal Cancer
The Bacterial Composition of the Stomach in Reflux Disease
Gastric and oesophageal (OG) cancer associated with poor long term outcome as overall less than 25% of patients survive for more than 5 years due to late recognition of the disease.
- Conditions
- GORD, Oesophageal Cancer, Oesophageal Reflux, Gastric Cancer
- Trial name
- NCT03835663
- Testing
- No intervention but patients are undergoing an upper GI endoscopy and biopsies for clinical purposes
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Gastroesophageal Reflux
Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux
This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms.
- Trial name
- NCT00231881
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Gastroesophageal Reflux Disease
Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD)
GERD is due to gastric content reflux to esophagus cause symptom and complication including intra-esophagus such as reflux esophagitis, and extra-esophagus such as cough etc.
- Trial name
- NCT01822106
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University Hospital
Ineffective Motility, Diffuse Esophageal Spasms
Reversibility of Dysmotility After Gastric Banding
In the current study we plan to evaluate the effects of the conversion from gastric banding to gastric bypass on esophageal function using combined monitoring.
- Conditions
- Ineffective Motility, Diffuse Esophageal Spasms, Achalasia-Like Dysmotility
- Trial name
- NCT00680030
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Cantonal Hospital of St. Gallen
Stroke, Brain Injury
Use of the Passy Muir Swallowing Self Trainer
The purpose of this study is to develop appropriate training methods and gather participant feedback on their use of the Passy Muir Swallowing Self-Training Device (PMSST).
- Conditions
- Stroke, Brain Injury, Head and Neck Cancer
- Trial name
- NCT02848664
- Testing
- Dysphagia retraining with device
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- James Madison University
Cough, COPD
Acoustic Cough Monitoring for the Management of Patients With Known Respiratory Disease
This study pretends to evaluate the potential use of Hyfe Cough Tracker (Hyfe) to screen for, diagnose, and support the clinical management of patients with respiratory diseases, while enriching a dataset of disease-specific…
- Conditions
- Cough, COPD, GERD, Asthma
- Trial name
- NCT05042063
- Testing
- Hyfe Cough Tracker, Hyfe Air
- Where
- Spain
- Volunteers
- 616 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Gastroesophageal Reflux Disease (GERD)
EFFICACY OF INSPIRATORY MUSCLE TRAINING ASSOCIATED WITH MANUAL TECHNIQUES IN INDIVIDUALS WITH GERD
The objective of this clinical trial is to investigate the efficacy of inspiratory muscle training (IMT) combined with manual techniques for the lower esophageal sphincter (MTLES) and diaphragmatic release (DRT) in patients with…
- Trial name
- GERD (NCT06871163)
- Testing
- inspiratory muscle training, inspiratory muscle training (IMT) combined with manual techniques for the lower esophageal sphincter (MTLES) and diaphragmatic release (DRT), Controle
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal de Pernambuco
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