Clinical trials: DEGLUTİTİON
Cerebral Palsy
The Pediatric Eating Assessment Tool
There is no dysphagia spesific and patient/parent centered outcome instrument in the pediatric population. The purpose of this investigation is to develop the Pediatric version of the Eating Assessment Tool (PEDI-EAT-10) and…
- Trial name
- NCT02909127
- Testing
- SWALLOWING EVALUATION, The Functional Independence Measure, The PEDI-EAT-10
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Gastro Esophageal Reflux
A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-212-A and AD-2121
Primary endpoint of this study is to evaluate the pharmacokinetic and pharmacodynamic characteristics of AD-212-A in healthy subjects.
- Trial name
- NCT06025773
- Testing
- Lansoprazole 15 mg, Lansoprazole 15mg/Calcium carbonate 600mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Deglutition Disorders, Intensive Care Unit Syndrome
Removal of Nasogastric Feeding Tube Post Extubation in ICU : a Prospective Randomized Trial
Post-extubation dysphagia (PED) is a frequent but still underestimated condition in the intensive care units (ICU). In the international literature, the manifestations and consequences of PED lead to intra- and post-intensive…
- Conditions
- Deglutition Disorders, Intensive Care Unit Syndrome, Swallowing Disorder, Feeding or Eating Disorder
- Trial name
- FIRST (NCT05795569)
- Testing
- Nasogastric Tube removal during extubation, Yale Swallow Protocol, Classif Nasogastric Tube Management
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Non-Erosive Gastro-Esophageal Reflux Disease, Gastroesophageal Reflux Disease (GERD)
Evaluation of the Clinical Course of NERD and Assessment of the Esophageal Mucosa Resistance
GERD is characterized by a high prevalence (about 13.3%) and is associated with a deterioration in the quality of life, as well as an increased risk of esophageal adenocarcinoma and a rise in the number of refractory cases.
- Trial name
- NCT07174882
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Gastro-oesophageal Reflux Disease
LINX vs Fundoplication
Reflux disease can severely impact upon quality-of-life and lead to complications, including ulceration of the oesophagus. It is often controlled with self-help measures and medication. However, sometimes surgery is recommended.
- Trial name
- GOLF (NCT07093359)
- Testing
- Laparoscopic or robotic LINX procedure, Laparoscopic or robotic fundoplication
- Where
- 5 sites in United Kingdom
- Volunteers
- 460 people
- Sponsor
- University of Oxford
Neurogenic Dysphonia, Neurogenic Dysphagia
Neurogenic Dysphonia/Dysphagia Registry
The Neurogenic Dysphonia/Dysphagia Registry is designed to be purely observational (i.e. non-interventional, exploratory). Patient data collected from the registry is expected to be consistent with any information which can be…
- Trial name
- StrongVoice (NCT02493491)
- Where
- 12 sites in United States
- Volunteers
- 146 people
- Sponsor
- Merz North America, Inc.
Polymyositis, Dermatomyositis
Efficacy and Tolerability of BAF312 in Patients With Polymyositis and Dermatomyositis
This study determined the efficacy, safety, tolerability and the PK profile of BAF312, a novel immunomodulator, in polymyositis and dermatomyositis patients who were not responsive to traditional immunosuppressive and/or…
- Trial name
- NCT01148810
- Testing
- BAF312
- Where
- 6 sites in United States, Czechia and 3 more
- Volunteers
- 18 people
- Sponsor
- Novartis Pharmaceuticals
Deglutition Disorders
Evaluation of Dysphagia by 6-chnnel Surface Electromyography
The natural process of aging affects a few very specific timing parameters such as swallow reaction time and hyoid one movement velocity. Many swallow timing and bolus transit parameters appear to be unaffected by aging.
- Trial name
- NCT03494361
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Esophageal Atresia
Respiratory Complications of Operated Esophageal Atresia in Children
The respiratory complications of esophageal atresia have already been identified. They are mainly related to tracheomalacia linked to the esophageal malformation, and are aggravated by frequently associated gastroesophageal…
- Trial name
- ATRESIA (NCT05527873)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Strasbourg, France
Achalasia
POEM Anterior Versus Posterior Approach
Per-oral endoscopic myotomy (POEM) is an incisionless procedure used to treat esophageal achalasia, performed by GI endoscopist without cutting any surface of the human body.
- Trial name
- NCT02454335
- Testing
- Peroral Endoscopic Myotomy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University
Cough
Esophageal Motility in Reflux Induced Cough
To determine whether contraction abnormalities in the esophagus plays a role in gastroesophageal reflux induced cough, and thus cough severity in patients with chronic cough.
- Trial name
- NCT02492126
- Testing
- Citric Acid
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Mayo Clinic
Upper Esophageal Sphincter Relaxing Pressure
Swallowing Evaluation by HRIM in Patients With Cervical Spondylosis
patients with cervical spondylolysis may have swallowing or eating difficulty. In this study, we will use high resolution impedance manometry to evaluate these patients' detailed swallowing mechanisms.
- Trial name
- NCT05713968
- Testing
- patients with EAT-10 higher than 3 or frailty questionnaire higher than 2 examined by HRIM, patients with EAT-10 lower than 3 or frailty questionnaire lower than 2
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
GERD, Gastroesophageal Reflux
Compassionate Use of Domperidone for Refractory Gastroparesis
The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesophageal reflux disease (GERD) who have failed all the standard…
- Conditions
- GERD, Gastroesophageal Reflux, Gastroparesis
- Trial name
- NCT04699591
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jose Cocjin
Gastroesophageal Reflux Disease
Diaphragmatic Myofascial Release in Gastroesophageal Reflux Disease
This study is a double blinded randomized clinical trial with two arms which aims to study the effects of diaphragmatic myofascial release in patients with gastroesophageal reflux disease (GERD).
- Trial name
- GERD (NCT03299985)
- Testing
- Diaphragmatic myofascial release
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Cardenal Herrera University
Thymidine Kinase 2 (TK2)
A RETROspective Study of Patients With TK2d
This is a medical chart review study to collect information for patients who have been taking pyrimidine nucleosides for treatment of TK2 deficiency.
- Trial name
- RETRO (NCT03701568)
- Testing
- dC/dT
- Where
- 8 sites in United States, Israel and 1 more
- Volunteers
- 38 people
- Sponsor
- Zogenix MDS, Inc.
Thyroid Carcinoma
A Study Into the Effect of Seprafilm in Open Total Thyroidectomy
The investigators intend to determine the role of Seprafilm, a popular anti-adhesive agent in minimising internal adhesion formation in the neck after thyroid surgery and therefore reduce swallowing discomfort experienced by…
- Trial name
- NCT01865838
- Testing
- Seprafilm (Sanofi, USA)
- Where
- 2 sites in Singapore
- Volunteers
- 19 people
- Sponsor
- National Cancer Centre, Singapore
Dysphagia, Swallowing Disorder
The Effects of Bilateral Cerebellar rTMS on Cortical Function
Swallowing function is controlled by two swallowing centres (one on each half of the brain). There is a dominant and non-dominant swallowing centre.
- Trial name
- NCT03831789
- Testing
- Cerebellar targeted rTMS
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manchester
GERD
Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
This study is a randomised, double-blind, parallel-group and placebo controlled study comparing the efficacy of esomeprazole 40 mg orally qd vs. placebo and esomeprazole 20 mg orally qd vs.
- Trial name
- NCT00241540
- Testing
- Esomeprazole
- Where
- 119 sites in United States, Belgium and 4 more
- Volunteers
- 808 people
- Sponsor
- AstraZeneca
Multi Drug Resistant, Dysphagia
Evaluation of the Variation of the Intestinal Microbiota and the Integrity of the Intestinal Barrier in Patients With M.D.R. Germ-induced Pneumonia Undergoing Enteral Nutrition
The study aims to evaluate the effects of enteral nutrition in subjects with MDR on the intestinal microbiota
- Trial name
- NCT06485791
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease
The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis
The primary aim of this study was to determine the proportion of patients with esophageal eosinophilic infiltration that have objective (measurable) evidence of gastroesophageal reflux disease (GERD).
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease, EE, GERD
- Trial name
- NCT00728481
- Testing
- Esomeprazole, Budesonide
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Mayo Clinic
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