Clinical trials: DNA
Focus of the Study: DNA Damage Due to Medical Diagnostic X-ray
Impact of Antioxidant Agents on the Number of DNA Double-strand Breaks After Radiation-based Cardiac Examinations
Trial with medicinal products Recent studies revealed that radiation-based procedures in patients may lead to DNA double-strand breaks in human blood lymphocytes.
- Trial name
- NCT01578395
- Testing
- Low-dose radiation exposure, High-dose radiation exposure, No radiation exposure
- Where
- Switzerland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Zurich
DNA Damage, Other Complications Associated With Artificial Fertilization
Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm
The purpose of this study is to find a non-invasive way to discover DNA (deoxyribonucleic acid, which is the genetic material inside your cells) alterations in the sperm's head, in the near future leading us to choose the "good…
- Trial name
- NCT01461395
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Liver Diseases, Hepatitis, Chronic
Epidemiological Study in Children and Adolescents With Chronic Hepatitis B
The purpose of this study is to collect epidemiological data in children and adolescents with chronic hepatitis B(CHB), in particular data on the prevalence of HBeAg positive disease with associated ALT levels , active HBeAg…
- Conditions
- Liver Diseases, Hepatitis, Chronic, Hepatitis, Viral, Human, Hepatitis
- Trial name
- EPIC B (NCT01163240)
- Where
- 86 sites in United States, Argentina and 16 more
- Volunteers
- 1,640 people
- Sponsor
- Novartis Pharmaceuticals
Cockayne Syndrome
Pharmacokinetics and Safety Study of Single and Multiple Oral Doses Prodarsan™ in Patients With Cockayne Syndrome
This study is to compare the exposure of orally administered Prodarsan to the intravenous dosed Osmitrol (10% solution) in Cockayne Syndrome (CS) patients.
- Trial name
- NCT01142154
- Testing
- Prodarsan
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- DNage B.V.
Virus Disease, DNA Virus Infections
The Safety and Immunogenicity of Recombinant Hepatitis B Vaccines in the Health Neonates
The primary safety objective of this study is to assess the safety of 10 mcg recombinant hepatitis B vaccine in the Chinese health neonates.
- Conditions
- Virus Disease, DNA Virus Infections, Hepadnaviridae Infections
- Trial name
- NCT01183611
- Testing
- Experimental recombinant hepatitis B vaccine, HBIG, Active Comparator hepatitis B vaccine, Experimental recombinant hepatitis B vaccine
- Where
- China
- Volunteers
- 1,740 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Patients in Good Health, Types of General Anesthesia
Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery
The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients…
- Conditions
- Patients in Good Health, Types of General Anesthesia, DNA Damage
- Trial name
- NCT00854178
- Testing
- Comparison of two anesthetic drugs
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Mitochondrial Diseases, Diagnosis
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.
Mitochondrial diseases are a heterogeneous group caused by genetic defects in mitochondrial DNA or in nuclear genes. POLG is the most frequently involved gene in mtDNA instability diseases resulting in mtDNA multiple deletion…
- Conditions
- Mitochondrial Diseases, Diagnosis, DNA Mutations
- Trial name
- NCT00831948
- Testing
- mitochondrial DNA mutations diagnosis
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Oxidative DNA Damage
Biological Functions of Carotenoids in Humans
This study will examine the the efficiency fo absorption of major plant pigments, carotenoids, (lutein, beta-carotene and lycopene)and will measure the biological functions of carotenoids in healthy women in response to an 8-week…
- Trial name
- NCT00356252
- Testing
- mixed carotenoids
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tufts University
DNA Virus Infection, Herpesviridae Infections
Prophylaxis With Ganciclovir Improves Graft Survival in Renal Allograft Recipients
Study Phase: IV Study Type: Open-label, multicenter, randomised clinical trial with two arms stratified for an intensified immunosuppressive regimen in patients at high risk for acute rejection.
- Conditions
- DNA Virus Infection, Herpesviridae Infections, Cytomegalovirus Infection
- Trial name
- NCT00373165
- Testing
- Ganciclovir
- Volunteers
- 150 people
- Sponsor
- Lower Saxony Center for Nephrology