Clinical trials: DNA Damage
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
Supplemental Adjuvants for Intracellular Nutrition and Treatment
Nutritional supplements have an augmentative effect on the outcomes of standard treatment of diabetic macular edema (DME) and Neovascular Age-Related Macular Degeneration (NAMD).
- Trial name
- SAINTS (NCT00893724)
- Testing
- Neutral pills with no medicinal effect, Inosine; Tocopherols, Tocotrienol, CoQ10 combination capsule; Niacinamide SR; Viatmin C; N-acetyl Cysteine; Complete Multivitamin with all minerals, Inosine; Tocopherol, Tocotrienol, CoQ10 combination capsule; Niacinamide; Vitamin C; N-acetyl Cysteine; Complete Multivitamin with all minerals; Minocycline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mid-Atlantic Retina Consultations, Inc.
Triple Negative Breast Cancer, DNA Damage Repair Deficiency
Breast/Cyclosporin A/TNBC (Triple Negative Breast Cancer)
This will be a single arm, non-randomized, pre-surgical clinical trial of women with newly diagnosed triple negative breast cancer with high g-H2Ax (gamma H2AX antibodies) comparing changes in biomarkers from a diagnostic core…
- Trial name
- NCT06246786
- Testing
- Cyclosporin A
- Where
- United States
- Sponsor
- Virginia G. Kaklamani
Cancer, Pancreatic Cancer
9-ING-41 in Patients With Advanced Cancers
GSK-3β is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in…
- Conditions
- Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer
- Trial name
- NCT03678883
- Testing
- 9-ING-41, Gemcitabine - 21 day cycle, Doxorubicin.
- Where
- 66 sites in United States, Belgium and 5 more
- Volunteers
- 350 people
- Sponsor
- Actuate Therapeutics Inc.
COVID-19 Pneumonia
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients
Our aim in this study is to determine the positive effect of stem cell therapy applied on critically ill patients with coronavirus infection on DNA repair genes.
- Trial name
- REPAIR (NCT04898088)
- Testing
- Mesenchymal Stem Cells Transplantation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi
Neoplasms
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors
Background: The drug cisplatin treats certain cancers when given with other chemotherapy drugs. Researchers think combining cisplatin with 2 other drugs could block proteins that support cancer cell growth.
- Trial name
- NCT02723864
- Testing
- Veliparib + VX-970 + Cisplatin
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- National Cancer Institute (NCI)
Neoplasms, Lymphoma
ABT-888 Plus Metronomic Cyclophosphamide to Treat Cancer
Background: Cyclophosphamide (CP) is a drug approved by the Food and Drug Administration for the treatment of certain cancers. It works by causing DNA damage, resulting in cell death, including cancer cells.
- Trial name
- NCT01445522
- Testing
- ABT-888, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- National Cancer Institute (NCI)
Afamelanotide Evaluated as Skin DNA Repair Therapy in Healthy Volunteers
DNA Repair Capacity of Afamelanotide on Ultraviolet Radiation-induced DNA Damage in Healthy Volunteers
This mechanistic study's aim is to assess the DNA damage repair capabilities of afamelanotide in healthy volunteers with skin type I-III following exposure to ultraviolet radiation (UVR)-induced DNA damage.
- Trial name
- NCT05368857
- Testing
- Afamelanotide
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Clinuvel (UK) Ltd.
Occupational Exposure
Assessment of DNA Damage Due to Ionizing Radiation
detection of DNA damage due to occupational exposure to low dose ionizing radiation using comet assay technique and genotyping of certain DNA repair genes to detect inherited polymorphism.
- Trial name
- NCT03240172
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Cytomegalovirus Infections, HIV Infections
Preventing Cytomegalovirus (CMV) Organ Damage With Valganciclovir in People With HIV
Cytomegalovirus (CMV) infection is a common opportunistic infection (OI) in HIV patients. The purpose of this study is to find out whether valganciclovir, an antiviral approved by the FDA for the treatment of CMV in the eye, is…
- Trial name
- NCT00006145
- Testing
- Valganciclovir
- Where
- 57 sites in United States, Puerto Rico
- Volunteers
- 350 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphomas, Solid Tumors
TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas
Background: Methoxyamine hydrochloride (TRC102) is a new cancer treatment drug that may help improve the results of chemotherapy.
- Conditions
- Lymphomas, Solid Tumors, NSCLC, Metastatic Colon Carcinoma
- Trial name
- NCT01851369
- Testing
- TRC102, CT scan, Lomotil
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- National Cancer Institute (NCI)
Obesity, Weight Loss
Oxidative Stress and L-CBMN Cytome Assay in Obese After 3 Weeks VLCD
Obesity leads to physiological imbalance resulting in hyperglycemia, dyslipidaemia and inflammation and can generate systematic oxidative stress through multiple biochemical mechanisms.
- Conditions
- Obesity, Weight Loss, DNA Damage
- Trial name
- NCT05055154
- Testing
- Very low calorie diet
- Where
- Croatia
- Volunteers
- 26 people
- Sponsor
- Special Hospital for Extended Treatment of Duga Resa
Precancerous Condition, Prostate Cancer
Study of Blood Samples From Older Patients at High Risk of Developing Prostate Cancer and From Healthy Male Participants
RATIONALE: Studying samples of blood in the laboratory from patients who are at high risk of developing prostate cancer may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00898274
- Testing
- immunoenzyme technique, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
DNA Damage, Granulosa Cells
Predictive Value of Granulosa Cell DNA Damage in the Success of Assisted Reproductive Technique
Deoxyribonucleic acid (DNA) damage of granulosa cells obtained during oocyte retrieval will be evaluated by flow cytometry with detection of Histone H2A.X and Phosphorylated Gamma H2A.X protein levels in patients with low ovarian…
- Trial name
- NCT05558046
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
DNA Damage, Immune System Disorder
Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation
This is a study to assess the effect of dietary zinc supplementation to mitigate biomarkers of metal toxicity in exposed tribal populations.
- Trial name
- NCT03908736
- Testing
- Zinc Picolinate 15 Mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Oxidative Stress
Xanthohumol and Prevention of DNA Damage
The purpose of this research study is to learn if and in what amount a compound from hops, called xanthohumol (ZAN-tho-HUE-mol), prevents damage to DNA and oxidative stress.
- Trial name
- NCT02432651
- Testing
- 6 mg xanthohumol per day, 12 mg xanthohumol per day, 24 mg xanthohumol per day
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Oxidative Stress, DNA Damage, Radiation Induced
Multi-Nutrient Supplement for Radio-Protection
Exposure to radiation, such as during routine CTs, bone scans, or X-rays, causes oxidative stress which can damage the DNA (your genetic material) within your white blood cells.
- Conditions
- Oxidative Stress, DNA Damage, Radiation Induced, Radiation Exposure
- Trial name
- MNSRP (NCT04781868)
- Testing
- Multi-nutrient supplement
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Kidney Cancer, Leukemia
Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer
RATIONALE: Glutamic acid may help lessen or prevent nerve damage caused by vincristine. It is not yet known whether glutamic acid is more effective than a placebo in preventing nerve damage in patients receiving vincristine for…
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Neurotoxicity
- Trial name
- NCT00369564
- Testing
- glutamic acid
- Where
- 6 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of South Florida
Lung Cancer
Olaparib and Bevacizumab in Relapsed Small Cell Lung Cancer Subjects
This study is a single arm, multi-centre phase II study of olaparib and bevacizumab combination therapy in subjects with relapsed small cell lung cancer (SCLC) as a second or third line (systemic) therapy.
- Trial name
- SUKSES-B2 (NCT04939662)
- Testing
- Olaparib+Bevacizumab to SCLC patients
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Se-Hoon Lee
Occupational Exposure, Genotoxicity
Biomonitoring of Occupationally Populations Exposed to Micro and Nanoplastic
The biomonitoring study aims to evaluate genotoxic damage and other parameters of exposure in different occupational exposed populations that work directly with different plastics.
- Conditions
- Occupational Exposure, Genotoxicity, Damage Dna
- Trial name
- NCT06323603
- Testing
- Micro and nanoplastic
- Where
- 4 sites in Finland, Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ricard Marcos
Prostatic Neoplasms
Analysis of Androgene Receptors Axis and DNA Damage Repair Genes in Patients With Prostate Cancer
In this project, we would like to focus on castration-sensitive prostate cancer (CRPC). This is a highly variable clinical picture with differentiated and burdening symptoms.
- Trial name
- NCT03677414
- Where
- Austria
- Volunteers
- 59 people
- Sponsor
- Medical University of Graz