Clinical trials: DNA Sequencing, open to volunteers
Stress Incontinence Female, Pelvic Organ Prolapse
Sequence of Midurethral Sling Placement During Robotic Sacrocolpopexy
This study looks at the best time to place a midurethral sling (MUS), which is a small piece of mesh used to treat stress urinary incontinence (SUI) (leaking urine when you cough, laugh, or exercise).
- Trial name
- NCT07008898
- Testing
- Midurethral sling placed before robotic sacrocolpopexy, Midurethral sling placed after robotic sacrocolpopexy
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Alabama at Birmingham
Cancer, Malignancies Multiple
CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)
This study will collect data on Canadian cancer patients that have uncommon/rare changes in their tumours, such as alterations/rearrangements in the genetic material inside cells - known as deoxyribonucleic acid, or DNA, which…
- Conditions
- Cancer, Malignancies Multiple, Malignant Solid Tumor, Cancer, Therapy-Related
- Trial name
- CARMA-BROS (NCT04151342)
- Testing
- Cancer treatment with tyrosine kinase inhibitors (TKIs) or other molecularly targeted therapeutic agents., Patient-reported outcomes (PROs)
- Where
- 27 sites in Canada
- Volunteers
- 5,500 people
- Sponsor
- University Health Network, Toronto
Infectious Diseases, Immunocompromised Host
Metagenomic Sequencing Across the Infectious Disease Risk and Care Continuum
The AXIS Network is a prospective, multicenter observational registry designed to generate real-world evidence on the use of metagenomic sequencing in clinical practice across a broad range of patient populations, infectious…
- Conditions
- Infectious Diseases, Immunocompromised Host, Opportunistic Infections
- Trial name
- AXIS (NCT07825714)
- Volunteers
- 10,000 people
- Sponsor
- Karius, Inc.
Drug Interaction Research
Clinical Study on Drug Interactions of Flonoltinib Maleate Tablets
This study is a single center, open label, fixed sequence drug interaction study to evaluate the effects of CYP3A4 inhibitor itraconazole and CYP3A4 inducer rifampicin on the pharmacokinetic characteristics of a single oral dose…
- Trial name
- NCT07768111
- Testing
- 75mg Flonoltinib, 100mg Flonoltinib
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chengdu Zenitar Biomedical Technology Co., Ltd
Breast Carcinoma
Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer
This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with hypertension receiving bevacizumab for breast cancer.
- Trial name
- NCT02610413
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 354 people
- Sponsor
- National Cancer Institute (NCI)
Healthy Adult Participants
A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects
This is a Phase 1, fixed-sequence, multiple-dose study in approximately 42 healthy adult participants. The study will be conducted in two parts.
- Trial name
- NCT07881224
- Testing
- Fosmanogepix, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam), Probe substrates (repaglinide, rosuvastatin, and digoxin)
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Hypertension
A Bioequivalence and Safety Study of AJU-C719 and C719R in Healthy Adult Volunteers
To evaluate the bioequivalence and safety of "AJU-C719" and "C719R" in healthy adult subjects.
- Trial name
- NCT07901114
- Testing
- Test Drug, Reference Drug
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- AJU Pharm Co., Ltd.
Healthy Volunteers
A Study of B-3E07 and Forsteo® in Healthy Adult Female Participants
The main aim of the study is to evaluate the pharmacokinetic (PK) biosimilarity of B-3E07 and European Union (EU) - sourced Forsteo® in healthy adult female participants.
- Trial name
- NCT07497503
- Testing
- Forsteo®, B-3E07
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Syneos Health
Neurodevelopmental Disorders, Intellectual Developmental Disorder
High Depth Exome Sequencing on DNA From a Salivary Sample by Mouth Smear.
Despite technological advances, a genetic etiology has been identified in only about 50% to 60% of patients with Neurodevelopmental disorders (NDDs), with a higher diagnostic yield in the syndromic NDD and IDD subgroups.
- Trial name
- SEPASA (NCT07492199)
- Testing
- genetic
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1015-A and Co-administration of BR1015-1 and BR1015-2 Under Fed Conditions
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of BR1015-A and co-administration of BR1015-1 and BR1015-2 in healthy volunteers under fed conditions
- Trial name
- NCT07421388
- Testing
- BR1015-A, BR1015-1, BR1015-2
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Primary Hypercholesterolaemia
A Study to Compare PK Characteristics and Safety Profiles Between AD-228B and AD-2284
Primary endpoint of this study is to evaluate the pharmacokinetic characteristics of AD-228B in healthy subjects.
- Trial name
- NCT06884098
- Testing
- AD-228B, AD-2284
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Chronic Rhinosinusitis (CRS)
Pistacia Lentiscus Oil Nasal Spray With Reduced-Dose Mometasone in Chronic Rhinosinusitis
Chronic rhinosinusitis (CRS) is a persistent inflammatory disease of the nose and sinuses. Medical treatment is mainly based on topical therapies aimed at controlling mucosal inflammation and improving naso-sinus clearance…
- Trial name
- NCT07787494
- Testing
- Mometasone furoate - intranasal application, Bactorinol nasal spray
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Food Effect of KH607 in Chinese Health Participants
A Study to Evaluate the Effect of Food on the Pharmacokinetic Characteristics and Safety Profile of KH607 in Healthy Chinese Participants
This study is a randomized, open-label, 2-period, 2-sequence, crossover food-effect study designed to evaluate the effect of a high-fat meal on the pharmacokinetics of a single oral dose of KH607 tablets in healthy participants…
- Trial name
- NCT07634874
- Testing
- KH607
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Chengdu Kanghong Pharmaceutical Group Co., Ltd.
Rapid Sequence Induction (RSI), Full Stomach
Which Rapid Sequence Induction Technique Should be Used in Urgent Surgery in Children?
The goal of our study is to compare classical Rapid Sequence Induction (RSI) and modified Rapid Sequence Induction (mRSI) in pediatric patients with a full stomach undergoing urgent surgical procedures.
- Conditions
- Rapid Sequence Induction (RSI), Full Stomach, Pediatric
- Trial name
- NCT07428434
- Testing
- Classical Rapid Sequence Induction, Modified Rapid Sequence Induction
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- Tunis University
Ovarian Cancer, Breast Cancer
Clinical Validation of Sophia Genetics Assay
Next-generation sequencing (NGS) technologies have revolutionized the field of genomics, enabling rapid and cost-effective analysis of DNA and RNA .
- Conditions
- Ovarian Cancer, Breast Cancer, Lynch Syndrome, Intestinal Polyposis
- Trial name
- COSMOS (NCT07160010)
- Testing
- Sophia Herditary Cancer Solution
- Volunteers
- 248 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Mixed Dyslipidemia
A Study to Compare to PK Characteristics and Safety Profiles Between PA-111 and PA-111A
Primary endpoint of this study is to evaluate the pharmacokinetic characteristics of PA-111 in healthy subjects.
- Trial name
- NCT06932705
- Testing
- PA-111, PA-111A
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Rapide Sequence Induction, Tracheal Intubation
Pain Assessment During Rapid Sequence Induction
Rapid sequence induction (RSI) is a standard anesthesia technique used in patients at risk of aspiration. Although tracheal intubation following RSI is a frequent and painful procedure, no study has yet evaluated nociception…
- Conditions
- Rapide Sequence Induction, Tracheal Intubation, Nociception, General Anesthesia
- Trial name
- NARSI (NCT07588165)
- Testing
- No Intervention: Observational Cohort
- Where
- Monaco
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Princesse Grace
Pulmonary Nodules
The SEQUENCE Trial
This study will randomize participants undergoing a bronchoscopic biopsy of a peripheral pulmonary nodule for their standard of care to receive robotic-assisted bronchoscopy (RaB) and then staging linear endobronchial ultrasounnd…
- Trial name
- SEQUENCE (NCT06676956)
- Testing
- Linear EBUS first, Robotic-assisted bronchoscopy first
- Where
- 5 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Acute Ischemic Stroke, Endovascular Thrombectomy
Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP)
Acute ischemic stroke (AIS) is a leading cause of mortality and long-term disability worldwide. Among these, stroke caused by large vessel occlusion (LVO) are associated with particularly poor outcomes.
- Conditions
- Acute Ischemic Stroke, Endovascular Thrombectomy, Minocycline, Posterior Circulation
- Trial name
- NCT07594301
- Testing
- Minocycline hydrochloride capsule
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Xiang Luo
Rare Genetic Disease
Exome and Genome Sequencing of DNA Samples, as Required by Specific Research Projects and the Diagnostic Needs of the Gaslini Institute, to Be Performed Within the Framework of the "Joint Genomic Lab" Established Between IGG and IIT
The study involves two centers, only one of which recruits clinical cases. It is funded by the two participating centers according to their respective areas of expertise, in particular through research projects that will make use…
- Trial name
- JL-seq (NCT07877688)
- Where
- Italy
- Volunteers
- 1,950 people
- Sponsor
- Istituto Giannina Gaslini