Clinical trials: Damage Control
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer
Bevacizumab may reduce CNS side effects caused by radiation therapy. This randomized phase II trial is studying how well bevacizumab works in reducing CNS side effects in patients who have undergone radiation therapy to the brain…
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Meningioma, Adult Anaplastic Oligodendroglioma
- Trial name
- NCT00492089
- Testing
- bevacizumab, magnetic resonance imaging, quality-of-life assessment
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Cerebral Palsy, Spastic, Physical Therapy
Effect of Botulinum Toxin Type A Associated With Physical Therapy on Children With Spastic Cerebral Palsy
Purpose: The aim of this study was investigate the effects of botulinum toxin type A (BoNT-A) associated with physical therapy on the functional capacity of children with spastic cerebral palsy (CP).
- Conditions
- Cerebral Palsy, Spastic, Physical Therapy, Botulinum Toxin
- Trial name
- NCT03704155
- Testing
- Botulinum toxin type A, Physical Therapy
- Volunteers
- 24 people
- Sponsor
- University of Nove de Julho
Cerebral Palsy
Contralaterally Controlled FES for Hand Opening in Hemiplegic Cerebral Palsy
This is a pilot randomized controlled trial of an intervention to improve arm function in children ages 6 to 17 with cerebral palsy and upper limb hemiparesis.
- Trial name
- NCT02925455
- Testing
- Contralaterally-controlled functional electrical stimulation, Hand therapy video games
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- MetroHealth Medical Center
Injuries, Spinal Cord, CVA (Cerebrovascular Accident)
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
Comparing the efficacy of Intracthecal Baclofen dose between the Prometra II and Medtronic SynchroMed II for patients with spasticity and with current a current SyncroMed II pump needing replacement.
- Conditions
- Injuries, Spinal Cord, CVA (Cerebrovascular Accident), Traumatic Brain Injury, MS (Multiple Sclerosis)
- Trial name
- NCT04530955
- Testing
- Prometra II Programmable Pump - Flowonix Medical
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Culicchia Neurological Clinic
Cerebral Palsy
Bike Skills Training for Children With Cerebral Palsy
An assessor blinded multi-centre randomized controlled trial will be conducted in which 60 participants will be randomized to either a novel task-specific approach to training bike skills or a parent-led home program comparison…
- Trial name
- CPBIKERCT (NCT03003026)
- Testing
- Novel task-specific bike skills training program, Parent-led home-based bike skills training program
- Where
- 2 sites in Australia
- Volunteers
- 62 people
- Sponsor
- Murdoch Childrens Research Institute
Cerebral Palsy
The Role of Pilates, Plyometrics, and Their Combination for Children With Unilateral Cerebral Palsy
This study was conducted to compare the effect of Pilates-based core strengthening (PsCS) and plyometric-based muscle loading (PlyoML) and their combination on postural control, balance, and mobility in children with unilateral…
- Trial name
- NCT05429281
- Testing
- Pilates-based Core Strengthening Exercises, Plyometric-based Muscle Loading Exercises, Combined Pilates and Plyometrics
- Where
- Saudi Arabia
- Volunteers
- 81 people
- Sponsor
- Cairo University
Cerebral Palsy
Effects of Intensive Upper and Lower Limbs Motor Control Therapy in Cerebral Palsy Children
The aim of the study is to determine the effetiveness of the intensive upper and lower limbs therapy to improve the funtional outcomes and to minimize ther energetic spendings during funtional activities in Cerebral Palsy…
- Trial name
- NCT03521427
- Testing
- Intensive bimanual therapy, Intensive neurodevelopmental therapy
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- University of Alcala
Patients in Minimally Conscious State After a Severe Brain Injury
tDCS on Precuneus in MCS: Repeated Stimulations
In this study researchers will apply transcranial direct current stimulation (tDCS) for 5 consecutive days in chronic patients in minimally conscious state (MCS).
- Trial name
- NCT02702362
- Testing
- transcranial direct current stimulation
- Volunteers
- 33 people
- Sponsor
- Hangzhou Normal University
Cerebral Palsy
Intensive Somatosensory Camp for Manual Function and Participation in Children With Unilateral Cerebral Palsy
This study will evaluate whether an intensive day camp that combines somatosensory and motor training for the affected upper limb improves hand function and participation in children with unilateral cerebral palsy more than an…
- Trial name
- CAMPUSENS (NCT07487857)
- Testing
- Somatosensory-Motor Intensive Camp, Motor-Only Intensive Camp
- Volunteers
- 26 people
- Sponsor
- University of Castilla-La Mancha
Ischemia Reperfusion Injury
Protecting Autologous Free Flaps From Ischemia/Reperfusion Damage With Cold Storage.
Reconstructive microsurgery allows autologous transplantation of flaps. The procedure causes temporary ischemia. The absence of perfusion and the post-anastomosis reperfusion causes ischemia/reperfusion (I/R) damage and an…
- Trial name
- PAFFIRD (NCT06523920)
- Testing
- University of Wisconsin solution + cold storage, Unperfused free flap under warm ischemia
- Volunteers
- 90 people
- Sponsor
- University of Cagliari
Cerebral Palsy, Spastic
Altered Back Geometry and Mobility Function After Backward Walking Training in Children With Cerebral Palsy
PURPOSE: To assess the effect of backward walking training on back geometry and mobility function in children with hemiparetic cerebral palsy through a comparative analysis with forward walking training.
- Trial name
- NCT04981964
- Testing
- Exercise training
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Cairo University
Cerebral Palsy (CP)
Core Stability Exercises vs Hippotherapy for Spastic Cerebral Palsy
Cerebral palsy is associated with impaired balance and trunk control, which affect functional mobility and independence. This randomized clinical trial compares the effects of core stability exercises versus hippotherapy, both…
- Trial name
- NCT07851701
- Testing
- core stability exercises, hippotherapy
- Where
- Pakistan
- Volunteers
- 49 people
- Sponsor
- Riphah International University
Cerebral Palsy, Spastic, Hemiplegic Cerebral Palsy
Upper Limb Somatosensory Discrimination Therapy and Dose-matched Motor Therapy in Children and Adolescents With Unilateral Cerebral Palsy
A randomized, controlled, and evaluator-blinded trial will be carried out to investigate the effects of 8 weeks of upper limb somatosensory discrimination therapy compared to an equal dose of motor therapy on sensorimotor…
- Trial name
- NCT06006065
- Testing
- Upper limb somatosensory discrimination therapy, Upper limb motor therapy
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Hilde Feys
Cerebral Palsy, Cognitive Orientation
The Effect of the CO-OP Approach for Children With Cerebral Palsy
In the literature, despite the reported positive findings of the Cognitive Orientation to daily Occupational Performance (CO-OP) approach, studies in this area have been limited and it is stated that studies involving more sample…
- Trial name
- NCT04308200
- Testing
- CO-OP approach, NDT
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- ZEYNEP KOLİT
Cerebral Palsy, Upper Extremity Dysfunction
Construct Validity and Reliability SCUES
The aim of the study was to determine construct validity, discriminant validity and intra- and interrater reliability of the Selective Control of the Upper Extremity Scale (SCUES).
- Trial name
- NCT03600597
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Gazi University
Cerebral Palsy, Exercise
A Feasibility Randomised Controlled Trial of an Online Exercise Programme for Adults With Cerebral Palsy
Adults with cerebral palsy (CP) often face challenges in accessing exercise programmes that are appropriate for their needs. Barriers such as limited mobility, a lack of tailored options, and restricted access to physiotherapy…
- Conditions
- Cerebral Palsy, Exercise, Adults, Fitness
- Trial name
- NCT06983782
- Testing
- Exercise and education programme, control group
- Where
- Ireland
- Volunteers
- 47 people
- Sponsor
- Royal College of Surgeons, Ireland
Cerebral Palsy
Allogeneic UCB Therapy With EPO in Children With CP
This randomized controlled study aims to evaluate the efficacy and safety of allogeneic umbilical cord blood therapy combined with erythropoietin for children with cerebral palsy.
- Trial name
- NCT01991145
- Testing
- Umbilical Cord Blood therapy, Erythropoietin alfa, Rehabilitation
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- MinYoung Kim, MD, PhD
Rheumatoid Arthritis
A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate
This 3 arm study assessed the efficacy of rituximab (MabThera®/Rituxan®) in the prevention of progression of structural joint damage in participants with active rheumatoid arthritis who had an inadequate clinical response to…
- Trial name
- SCORE (NCT00578305)
- Testing
- Rituximab, Methylprednisolone, Methotrexate
- Where
- 60 sites in Argentina, Brazil and 17 more
- Volunteers
- 185 people
- Sponsor
- Hoffmann-La Roche
Cerebral Palsy
A Study Protocol for an Online Intervention to Promote School Engagement
Cerebral Palsy (CP) is a neurological, non-progressive, and permanent developmental disorder that mainly affects movement and posture, with a prevalence of 3 to 4 children per 1000 live births.
- Trial name
- NCT04247516
- Testing
- Online-intervention group I (IGI), Online-intervention group II (IGII)
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- University of Minho
Age-related Macular Degeneration
Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON)
This was a 64-week randomized, double-masked, multi-center, active-controlled, two-arm study in patients with neovascular age related macular degeneration (nAMD) who have not previously received anti- vascular endothelial growth…
- Trial name
- TALON (NCT04005352)
- Testing
- Brolucizumab 6 mg, Aflibercept 2 mg
- Where
- 118 sites in United States, Argentina and 18 more
- Volunteers
- 734 people
- Sponsor
- Novartis Pharmaceuticals