Clinical trials: Database, open to volunteers
Biliary Atresia
A Prospective Database of Infants With Cholestasis
Biliary atresia, idiopathic neonatal hepatitis, and specific genetic cholestatic conditions are the most common causes of jaundice and hyperbilirubinemia that continue beyond the newborn period.
- Trial name
- PROBE (NCT00061828)
- Where
- 16 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Arbor Research Collaborative for Health
Primary Biliary Cholangitis
National Database on Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a rare, autoimmune, cholestatic liver disease. No data about the disease epidemiology exist in Italy.
- Trial name
- PBC322 (NCT05151809)
- Testing
- Clinical information
- Where
- 55 sites in Italy
- Volunteers
- 6,000 people
- Sponsor
- University of Milano Bicocca
Craniofacial Fibrous Dysplasia
Morbidity in Adults With Craniofacial Fibrous Dysplasia: The CRANIO-DF Study
Fibrous dysplasia is a rare bone disorder in which normal bone is replaced by fibro-osseous tissue. Craniofacial involvement may be associated with substantial morbidity and complex multidisciplinary care.
- Trial name
- NCT07870616
- Testing
- No Intervention: Observational Cohort
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Colon Cancer
A Clinico-biological Database in Cachexia in Patients With Colon Cancer
Creation of a prospective clinico-biological database dedicated to cachexia and undernutrition in order to carry out future research projects, to improve our knowledge of colon cancer and cachexia and to optimize the therapeutic…
- Trial name
- BCBCachexie (NCT05257135)
- Testing
- Biological collection
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Bone Cancer Surgery
Bone Cancer Surgery Prospective Database
According to the Global Burden of Disease Report, the number of cancer patients worldwide is increasing year by year. In 2023, there were a total of 18.5 million newly confirmed cases of malignant tumors worldwide, and it is…
- Trial name
- NCT07669103
- Testing
- Bone cancer surgery
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetes Mellitus
Tübinger Diabetes Mellitus Database (TUEDID)
Diabetes mellitus is a widespread disease with increasing prevalence worldwide. Patients with diabetes can develop multiple late complications such as neuropathy, retinopathy, nephropathy and cardiovascular comorbidities.
- Trial name
- NCT03658512
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may…
- Conditions
- Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Heart Failure, Right Sided, Heart Failure With Mid Range Ejection Fraction
- Trial name
- PREFER-HF (NCT03480633)
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colonic Cancer, Rectal Cancer
Chinese Colorectal Cancer Database
1. To establish the Chinese people's own clinical data database of colorectal cancer, reflecting the law and characteristics of colorectal cancer patients in China. 2.
- Conditions
- Colonic Cancer, Rectal Cancer, Prospective Studies
- Trial name
- CCCD (NCT05434026)
- Where
- China
- Volunteers
- 200,000 people
- Sponsor
- Beijing Friendship Hospital
Self-Help Devices, Long-Term Care
Assistive Device Rental/Purchase, LTC Service Use, and Caregiver Burden in Taiwan
The goal of this observational study is to examine the associations between assistive device approval and acquisition modality (rental or purchase), long-term care service utilization, and family caregiver burden among…
- Conditions
- Self-Help Devices, Long-Term Care, Caregiver Burden, Health Services Research
- Trial name
- NCT07782047
- Where
- Taiwan
- Volunteers
- 161,771 people
- Sponsor
- National Health Research Institutes, Taiwan
Obesity, Metabolic Surgery
Chinese Obesity and MEtabolic Surgery Database (COMES Database)
The purpose of the Chinese Obesity and MEtabolic Surgery Database (COMES Database) is to collect data and examine the long-term effects of metabolic and bariatric surgery on obesity and metabolic disorders in the Chinese…
- Conditions
- Obesity, Metabolic Surgery, Bariatric Surgery, Weight Loss
- Trial name
- COMES (NCT06275061)
- Testing
- Metabolic and Bariatric Surgery
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Jinan University Guangzhou
Congenital Heart Defects
Creation of a French South-Eastern Database and DNA-bank of Congenital Heart Disease to Explore the Genetic Pathways
Congenital heart defects are seen in 0,8% of life births. In France this means more than 5000 newborns per year. The south-east region of France is particularly affected as a result of a higher birth rate and consanguinity, when…
- Trial name
- SEA-HD (NCT02923440)
- Testing
- blood sample
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
External Mechanical Ventilatory Support
Implanted Phrenic Nerve Stimulator Database.
Phrenic nerve stimulation is a neurostimulation technique that allows patients who are dependent on external mechanical ventilatory support to regain their breathing autonomy.
- Trial name
- SPi-REG (NCT03659019)
- Testing
- Quality of life questionnaires
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parathyroid Gland Carcinoma, Parathyroid Gland Atypical Adenoma
Institution of an Italian Multicenter Database of Patients with Parathyroid Carcinoma or Atypical Parathyroid Adenoma
The goal of this observational study is to create, manage and analyze a multicenter national database of patients with parathyroid carcinoma or atypical parathyroid adenoma, aimed at collecting and studying anamnestic…
- Trial name
- NCT06645951
- Where
- 33 sites in Italy
- Volunteers
- 300 people
- Sponsor
- F.I.R.M.O. - Fondazione Italiana Ricerca sulle Malattie dell'Osso - Ente del Terzo Settore
Neoplasm Metastasis
Bone Metastases Database of Patients Treated Surgically for Impending or Pathologic Fracture of Long Bones
The aims of this study are to collect prospective data on the natural history of bone metastases (BMs) and skeleta related events (SREs),
- Trial name
- BMD (NCT03416959)
- Testing
- intramedullary fixation or endoprosthetic reconstruction
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Ortopedico Rizzoli
COPD
Bronchoscopic EmphysemA Treatment in THE NetherLands
Rationale: New bronchoscopic treatments for emphysema have shown promise in clinical trials, improving lung function, exercise capacity and possibly survival and are now being adopted by a number of centres in the Netherlands.
- Trial name
- BREATHE-NL (NCT02815683)
- Where
- 2 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- University Medical Center Groningen
Episodic Migraine, Chronic Migraine
i-NEED: NEw migrainE Drugs Database
Approved by the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) starting in 2018, anti-CGRP monoclonal antibodies (anti-CGRP mAbs) represent the first true revolution in the preventive treatment of…
- Conditions
- Episodic Migraine, Chronic Migraine, Medication Overuse Headache
- Trial name
- i-NEED (NCT07103694)
- Testing
- anti-CGRP monoclonal antibodies, gepants, combination of sumatriptan and naproxen
- Where
- 2 sites in Italy
- Volunteers
- 2,641 people
- Sponsor
- IRCCS San Raffaele Roma
Outpatients With Chronic Heart Failure, Heart Failure Chronic
Biomarker Panel Development for Early Identification of Worsening Heart Failure and Improved Post-acute Care
Heart failure is a complex clinical syndrome with high hospitalization rates and high mortality risks. While N-terminal-pro B-type natriuretic peptide (NT-proBNP) is widely used in clinical practice to assist in diagnosis and…
- Trial name
- NCT07838766
- Volunteers
- 800 people
- Sponsor
- Chang Gung Memorial Hospital
PARKINSON DISEASE (Disorder)
Oculomotor-Pupillary AI Biomarkers in Parkinson's
The goal of this prospective observational study is to investigate whether oculomotor-pupillary abnormalities detected using a novel edge-AI eye-tracking device can serve as objective and quantitative biomarkers for the early…
- Trial name
- NCT07886450
- Testing
- Edge-AI Eye-Tracking Assessment
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Esophageal Disease
The French EsoGastricTumours Data Base
This retrospective study aims at evaluating the outcomes of gastrointestinal stromal tumor after surgery.
- Trial name
- FREGAT (NCT02526095)
- Where
- 31 sites in France
- Volunteers
- 15,000 people
- Sponsor
- University Hospital, Lille
Stomach Neoplasms, Cardia
Institut Paoli Calmettes Cardia Cancer Database
Database of Institut Paoli-Calmettes patients diagnosed with cardia cancer
- Trial name
- NCT02869477
- Testing
- Data collection
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Institut Paoli-Calmettes