Clinical trials: Deafness
Cystic Fibrosis, Sensorineural Hearing Loss
Evaluation of the High Frequency Digit Triplet Test in Cystic Fibrosis
The purpose of this study is to find out whether the High Frequency Digit Triplet test can be used to screen patients with cystic fibrosis for hearing loss in conditions of health and pulmonary exacerbation.
- Trial name
- 3D-CF (NCT02252601)
- Testing
- HFDT test, Pure tone Audiogram
- Where
- 3 sites in United Kingdom
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hearing Loss
Validation and Evaluation of the French Version of a Hearing Loss Screening Questionnaire in Adults Aged 60 Years Old and More
Nowadays in France, there is no organized screening of the hearing loss in the elderly; however, it is a very common disease and simples tests to perform to detect it exist.
- Trial name
- VF DEPIST 60 (NCT04159428)
- Testing
- HHIE-S survey score
- Where
- France
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Hearing Loss, Bilateral Sensorineural, Progressive
Quality Control of CE-Certified Phonak Hearing Aids - 2017_13
A methodical evaluation of new CE-labelled Phonak Hearing Systems is intended to be conducted on hard of participants with a hearing loss to grant quality control prior to product launch.
- Trial name
- NCT03131557
- Testing
- Line extension of the Phonak Audéo B product family, Phonak Audéo B
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Sonova AG
Cochlear Implant, Sensorineural Hearing Loss
The Effect of Anatomy-based Fitting on the Perception of Speech in Noise and Music in Single-sided Deaf Cochlear Implant Users
The present study evaluates the effect of anatomy-based fitting on speech perception in noise and music perception in newly implanted single-sided deaf (SSD) CI recipients.
- Conditions
- Cochlear Implant, Sensorineural Hearing Loss, Single Sided Deafness
- Trial name
- NCT07703800
- Testing
- Anatomy-based fitting, Default fitting
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Deafness; Perception, Bilateral
Plasticity and Cross-modal Interactions in Profoundly Deaf Adults
The aim of this study is to evaluate cerebral asymmetry for face processing in a group of profoundly deaf participants and a group of hearing controls by the mean of fMRI measure.
- Trial name
- PLASMODY (NCT02632214)
- Testing
- fMRI measure
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
GJB2-mediated Hearing Loss, GJB2 Gene Mutation
Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss
Skylark Bio is conducting a study of an investigational new drug called SKY-GJB2 and its delivery device, the SKY-CAT. SKY-GJB2 is a gene therapy that is being developed to treat children who have hearing loss due to changes in…
- Conditions
- GJB2-mediated Hearing Loss, GJB2 Gene Mutation, DFNB1A
- Trial name
- SONIX (NCT07627971)
- Testing
- SKY-GJB2
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Skylark Bio Inc.
Hearing Loss, High-Frequency
Hybrid Cochlear Implants in Severe to Profound Adults, Children, and Adolescents
The purpose of this study is to determine if adults and children with residual low-pitch hearing in the severe hearing loss range can develop improved speech perception by combining their residual acoustic hearing with electrical…
- Trial name
- NCT01975571
- Testing
- Cochlear® Nucleus™ Hybrid L24, Cochlear® Nucleus™ Hybrid S12
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bruce J Gantz
Hearing Loss
Body Mass Index and Audiology Function
Obesity may directly or indirectly lead to hearing loss
- Trial name
- NCT03172663
- Testing
- pure tone audiometry
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hearing Impairment, Sensorineural Hearing Loss, Bilateral
Hearing Aid Noise Reduction in Pediatric Users Pilot Study (Oticon Pilot Study)
The purpose of this study is to evaluate the efficacy of OpenSound Navigator (OSN), a hearing aid speech-enhancement algorithm developed by Oticon, as treatment for pediatric hearing aid users.
- Trial name
- NCT04469946
- Testing
- Oticon OpenSound Navigator speech enhancement algorithm
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Total Unilateral Deafness, Unilateral Partial Deafness
Cochlear Implantation for Treatment of Single-sided Deafness
This is a research study to determine whether a cochlear implantation (CI) device can improve hearing in people who are deaf in one ear (known as single-sided deafness).
- Trial name
- NCT02532972
- Testing
- Med-el MAESTRO Cochlear Implant with Flex 28 electrode array
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Dr. Daniel Lee
Tympanic Membrane Perforation
Efficacy of Platelet Enriched Plasma in Preventing Surgery for Patients With Chronic Tympanic Membrane Perforation
By doing this study, researchers hope to find out if platelet rich plasma (PRP) can heal holes in the eardrum as an alternative to surgery.
- Trial name
- NCT03837665
- Testing
- Platelet Rich Plasma
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Kansas Medical Center
Deafness
Development of a Deaf Child With a Cochlear Implant.
Cochlear implantation enables profoundly deaf children to acquire speech and develop their understanding of spoken language. However, there are significant interindividual differences in the results obtained with the implant.
- Trial name
- DECCODES (NCT02539901)
- Testing
- Evaluation of the detection of non-linguistic sounds, Free hearing test categorization, Early Social Communication Scale (ECSP)
- Where
- France
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Secretory Otitis Media, Acute Otitis Media
The Effect of Early Non-Surgical Treatment of Children With Middle Ear Effusion on the Hearing
Secretory otitis media (SOM) or middle ear effusion is a common finding after acute otitis media (AOM). It is usually associated with 5-15 deci Bells hearing loss.
- Trial name
- NCT02549612
- Testing
- Moniri Otovent
- Volunteers
- 80 people
- Sponsor
- Vastra Gotaland Region
Cochlear Implant, Severe to Very Severe Sensorineural Hearing Loss
Epidemiological Survey on the Current Status of Cochlear Implantation in China
Cochlear implantation is an effective intervention for patients with severe to very severe sensorineural hearing loss. By the beginning of 2026, the total number of cochlear implants in China was about 180000.
- Trial name
- NCT07821281
- Testing
- Cochlear Implant
- Volunteers
- 180,000 people
- Sponsor
- Chinese PLA General Hospital
Bone Conduction, Hearing Loss, Conductive
Post-market Evaluation of the Transition From the Baha Connect System to the Osia System in Adult Bone Conduction Implant Recipients
The goal of this interventional study is to confirm the safety and performance of the latest generation Osia System and to examine its benefits compared to the Baha Connect System in adults with mixed or conductive hearing loss…
- Conditions
- Bone Conduction, Hearing Loss, Conductive, Hearing Loss, Mixed
- Trial name
- OSIRIS (NCT07130136)
- Testing
- Cochlear™ Osia® System, Cochlear™ Baha® System
- Where
- 3 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Cochlear
Hearing Loss
Clinical Applications for Time-Compressed Speech Tests
The purpose of this study is to determine the effects of age-related cognitive changes on hearing aid benefit based on hearing aid compression time constants.
- Trial name
- NCT00371839
- Testing
- Audiological Evaluation
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Psychological Resilience and Disaster Preparedness
Psychological Resilience and Disaster Preparedness
Given our geographical location, there is always the possibility of encountering a disaster at any moment. It is a well-known fact that families with children who have special needs face a series of challenges throughout their…
- Trial name
- disaster (NCT06542081)
- Testing
- Descriptive information form, psychological resilience scale and disaster preparedness scale were completed by the parents of hearing impaired children.
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Head and Neck Cancer, Ototoxicity
Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal…
- Conditions
- Head and Neck Cancer, Ototoxicity, Radiation Toxicity
- Trial name
- NCT01216800
- Testing
- adjuvant therapy, assessment of therapy complications, quality-of-life assessment
- Where
- United Kingdom
- Volunteers
- 84 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Hearing Loss, Hearing Abnormality
Optimisation of Hearing Aid Fitting
This study aims to explore if objective brain responses to speech stimuli (words and running speech) can be used to evaluate hearing aid fitting in adults.
- Trial name
- NCT03279367
- Testing
- Objective speech response detection
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Southampton
Hearing Loss
Three-dimensional Perception of Sounds in Military with Acoustic Trauma
Spatial hearing capacities of soldiers with acoustic trauma are evaluated in ENT consultations with routine tests (i.e. tonal audiometry, voice audiometry).
- Trial name
- SPHEAR (NCT05468567)
- Testing
- SPHERE protocol : Spatial hearing performances test, French Matrix Test : audiology test of speech in noise perception, SSQ15 questionnaire of life : (The Speech, Spatial and Other Qualities of Hearing Scale)
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon