Clinical trials: Deafness Neurosensory
Severe Sudden Sensorineural Hearing Loss
Efficacy of SENS 401 in Subjects With Severe or Profound Sudden Sensorineural Hearing Loss
Primary objective of the study is to assess the efficacy of SENS-401 on hearing loss in comparison to placebo at the end of the 4-week treatment period
- Trial name
- AUDIBLE-S (NCT03603314)
- Testing
- SENS-401
- Where
- 26 sites in Bulgaria, Canada and 8 more
- Volunteers
- 115 people
- Sponsor
- Sensorion
CNS Infection, Inner Ear Hearing Loss
CNS Infections Effect on the Inner Ear
Study on patients with CNS infections.
- Conditions
- CNS Infection, Inner Ear Hearing Loss, Vestibular Abnormality, Inner Ear Inflammation
- Trial name
- NCT03715569
- Testing
- Vestibular function, OAE/WBT, Biomarker
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Sudden Deafness, Sudden Sensorineural Hearing Loss
The Role of Migraine Prophylaxis Agent Topiramate in Treating Patients With Sudden Sensorineural Hearing Loss
Migraine and sudden sensorineural hearing loss(SSNHL) are two related disorders. A systemic steroid is usually used to treat SSNHL but the role of migraine prophylaxis medication remained unknown. Mehdi Abouzari et al.
- Trial name
- NCT05403229
- Testing
- Topiramate, Systemic Steroids
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Chang Gung Memorial Hospital
Sensorineural Hearing Loss, Tinnitus
ACEMg Hearing Preservation, Tinnitus and Hyperacusis Relief
ACEMg (Soundbites) is a neuroprotectant supplement designed to block the initiating biological events in the inner ear leading to inner ear hearing loss, sensorineural hearing loss, SNHL, which accounts for more than 90% of all…
- Conditions
- Sensorineural Hearing Loss, Tinnitus, SNHL, Inner Ear Hearing Loss
- Trial name
- OTISRWD (NCT06477354)
- Testing
- ACEMg
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Keep Hearing, Inc.
Hearing Loss, High-Frequency
High Frequency ABR
This study is looking at a method called 'ABR', which measures the electrical activity in the brain (brain waves) when we hear sounds.
- Trial name
- NCT06161857
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cardiff and Vale University Health Board
Sensorineural Hearing Loss (Disorder)
Single-sided Deafness and Cochlear Implants
As the left and right hemisphere are specialized for different auditory tasks, the proposed study aims at demonstrating different consequences of right or left-sided deafness for the affected individual.
- Trial name
- NCT01749592
- Testing
- cochlear implant
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Vestibular Vertigo, Sudden Hearing Loss
Vestibular Prognosis Assessment of ISSNHL With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids
Idiopathic sudden sensorineural hearing loss (ISSNHL) is a complicated hearing impairment with unclear etiology and unsatisfying treatment effects.
- Trial name
- NCT03974867
- Testing
- Prednisone 5Mg Tab, Methylprednisolone 40 mg
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Sensorineural Hearing Loss, Vertigo
Gastrodin Acupoint Injection for Sensorineural Hearing Loss With Vertigo
Sensorineural hearing loss (SNHL) accompanied by vertigo is a significant clinical challenge. Current conventional treatments often offer limited efficacy.
- Trial name
- NCT07283562
- Testing
- Gastrodin Injection, Conventional Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Hospital of Hebei Medical University
Hearing Impairment, Sensorineural Hearing Loss, Bilateral
Hearing Aid Noise Reduction in Pediatric Users Pilot Study (Oticon Pilot Study)
The purpose of this study is to evaluate the efficacy of OpenSound Navigator (OSN), a hearing aid speech-enhancement algorithm developed by Oticon, as treatment for pediatric hearing aid users.
- Trial name
- NCT04469946
- Testing
- Oticon OpenSound Navigator speech enhancement algorithm
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hearing Loss, Bilateral, Sensorineural Hearing Loss
Effectiveness of P02 Digital Hearing Aids
To test the effectiveness of body-worn, digital hearing aids, model 02 which is developed by the National Electronics and Computer Technology Center, Thailand.
- Trial name
- P02 (NCT01902914)
- Testing
- Hearing Aids Evaluation
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Khon Kaen University
Hearing Loss, Sensorineural Hearing Loss
Quality Control of CE-Certified Phonak Hearing Aids - 2018_28
Phonak Hearing Systems pass through different development and study stages. At an early stage, feasibility studies are conducted to investigate new algorithms, features and functions in an isolated manner.
- Trial name
- NCT03718975
- Testing
- Successor of Phonak Audéo B90, Phonak Audéo B90
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- Sonova AG
Bilateral Sensorineural Hearing Loss
Noise Reduction With Hearing Aids
The purpose of this study is to use an optimized version of the SEDA algorithm (SEDA-HA) for hearing aids to evaluate the benefit for listeners with varying degrees of hearing loss in realistic environments and evaluate its…
- Trial name
- NCT07700043
- Testing
- Speech Enhancement using Decomposition Approach-Hearing Aid (SEDA-HA) algorithm, Hearing aid (HA) prototype with SEDA-HA algorithm
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Hearing Loss
Littlears Auditory Questionnaire: Validation Study in CI Children
The LittlEARS Auditory Questionnaire is designed to assess the development of the auditory behavior in children during the first two (hearing) years.
- Trial name
- LittlEars (NCT00785707)
- Where
- 5 sites in United States
- Volunteers
- 31 people
- Sponsor
- Med-El Corporation
Hearing Loss, Sensorineural
Fludrocortisone for Sudden Hearing Loss
The standard of care treatment of sudden hearing loss uses a type of steroid called glucocorticoid. Examples of glucocorticoids are prednisone, methylprednisolone and dexamethasone.
- Trial name
- NCT01186185
- Testing
- Fludrocortisone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Sudden Loss of Hearing
Bed Rest for Idiopathic Sudden Sensorineural Hearing Loss
sudden sensorineural hearing loss: idiopathic in most cases 5-20/100,000 new cases annually in the U.S no establishes pathogenesis treated with oral steroids in most cases ~50% improvement in hearing levels bed rest - acceptable…
- Trial name
- NCT00416143
- Testing
- bed rest, prednisone - oral corticosteroid 1mg/kg/D for 1 week
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Sudden Sensorineural Hearing Loss
Video HIT in Sudden Sensorineural Hearing Loss
The function of the vestibular system among patients with Sudden Sensori Neural Hearing Loss will be evaluted using the video Head Impulse Test
- Trial name
- NCT04224909
- Testing
- Video Head Impulse Test
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Ototoxic Hearing Loss
Intratympanic N-Acetylcysteine for Prevention of Cisplatin-induced Ototoxicity.
Although many intratympanic agents have been attempted, N-Acetylcysteine (NAC) appears to be the most promising and is a powerful, commonly used anti-oxidant.
- Trial name
- NCT04291209
- Testing
- N-Acetyl Cysteine
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hearing Loss, Sudden
Establishment of a Trans-round Window Inner Ear Continuous Drug Delivery System for the Treatment of Severe-to-profound Sudden Sensorineural Hearing Loss
The investigators enrolled patients with total sudden deafness who had failed treatment with systemic combined intra-dural hormone injections.
- Trial name
- NCT05455398
- Testing
- Surgical treatment of round window niche enlargement via round window for inner ear drug delivery, Drum chamber drug injection
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sudden Sensorineural Hearing Loss
Oral Statins and Protection From Hearing Loss
A small clinical trial for idiopathic sudden sensorineural hearing loss (ISSNHL). Will the addition of an oral statin to the standard treatment (oral methylprednesolone and the salvage therapy of intratympanic dexamethasone)…
- Trial name
- NCT04826237
- Testing
- Statin, methylprednisolone, dexamethasone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Sudden Sensorineural Hearing Loss
Evaluation of Oral Corticosteroid Therapy in Idiopathic Sudden Unilateral Hearing Loss.
Context: Idiopathic Sudden Sensorineural Hearing Loss (ISSHL) is a rapid-onset, sensorineural hearing loss of unknown etiology. It is one of the most common ENT emergencies, with spontaneous recovery occurring in 32% to 65% of…
- Trial name
- ECOSUB (NCT07067801)
- Testing
- prednisone - oral corticosteroid 1mg/kg/D for 1 week
- Where
- France
- Volunteers
- 430 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon