Clinical trials: Death, Cardiac
Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death
Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection…
- Conditions
- Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death, Ventricular Arrhythmia, Implantable Cardioverter Defibrillator (ICD)
- Trial name
- CARVTOP-ICD (NCT06964464)
- Testing
- Metoprolol Succinate, Carvedilol
- Where
- 13 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Rochester
Arrhythmia, Cardiovascular Diseases
Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
To compare conventional treatment of congestive heart failure (CHF) with two experimental interventions: amiodarone and an implantable cardioverter-defibrillator (ICD).
- Conditions
- Arrhythmia, Cardiovascular Diseases, Death, Sudden, Cardiac, Heart Diseases
- Trial name
- NCT00000609
- Testing
- amiodarone, defibrillators, implantable
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke, Acute Cerebrovascular Accident
Radiofrequency and Cryoablation of the Posterior Wall of the Left Atrium
Atrial fibrillation (AF) is the cause of 20% of strokes, and the risk of stroke in a person suffering from this arrhythmia increases by 5 times.
- Conditions
- Stroke, Acute Cerebrovascular Accident, Transient Ischemic Attack, Death
- Trial name
- NCT06253000
- Testing
- Cryoablation, Radiofrequency ablation
- Where
- Russia
- Volunteers
- 158 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Sinus Rhythm, Atrial Fibrillation
Prevention of Stroke and Sudden Cardiac Death by Recording of 1-Channel Electrocardiograms
Single-channel electrocardiograms (lead I of 12-lead surface ECG; 30 seconds) will be collected from subjects/patients at 11 clinical centers in Germany to train an Artificial Intelligence in the automatic diagnosis of regular…
- Conditions
- Sinus Rhythm, Atrial Fibrillation, Atrial Premature Complexes, Ventricular Premature Complexes
- Trial name
- PRICE (NCT04637230)
- Testing
- Electrocardiogram analysis by Artificial Intelligence
- Where
- Germany
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- A-Rhythmik GmbH
Sudden Cardiac Death, Cardiac Arrest
Experience From the Italian S-ICD Registry
The purpose of this registry is to collect data on implant parameters, early, mid and long-term clinical effectiveness of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) therapies in order to better understand how to…
- Conditions
- Sudden Cardiac Death, Cardiac Arrest, Ventricular Arrythmia, Implantable Cardiac Defibrillator
- Trial name
- ELISIR (NCT04373876)
- Testing
- Subcutaneous Implantable Cardioverter Defibrillator
- Where
- 18 sites in France, Germany and 2 more
- Volunteers
- 500 people
- Sponsor
- Luigi Sacco University Hospital
Cardiovascular Disease
Cardiovascular Inflammation Reduction Trial
The Cardiovascular Inflammation Reduction Trial (CIRT) is a randomized clinical trial investigating whether taking low-dose methotrexate reduces heart attacks, strokes, or death in people with type 2 diabetes or metabolic…
- Trial name
- CIRT (NCT01594333)
- Testing
- Methotrexate
- Where
- 470 sites in United States, Canada and 1 more
- Volunteers
- 4,786 people
- Sponsor
- Brigham and Women's Hospital
Sudden Cardiac Death, End Stage Renal Disease
T-Wave Alternans in Dialysis Patients
Sudden cardiac death due to arrhythmia is the leading cause of death in end-stage renal disease (ESRD) patients treated with hemodialysis (HD).
- Trial name
- NCT00621426
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Sudden Cardiac Death
The International SubcutaneouS Implantable Cardioverter Defibrillator Registry (iSuSI)
The entirely subcutaneous implantable defibrillator (S-ICD) (Emblem, Boston Scientific, Marlborough, MA, USA) was introduced as a new therapeutic alternative to the conventional transvenous ICD in 2009 and implantations are…
- Trial name
- iSuSI (NCT05390047)
- Where
- Germany
- Volunteers
- 4,000 people
- Sponsor
- University of Luebeck
Heart Diseases, Ventricular Arrhythmia
Prognostic Significance of T Wave Alternans
To evaluate whether T Wave Alternans can predict ventricular arrhythmias and sudden cardiac death (SCD) in a prospective epidemiologic natural history study.
- Conditions
- Heart Diseases, Ventricular Arrhythmia, Ventricular Fibrillation, Death, Sudden, Cardiac
- Trial name
- NCT00006501
- Testing
- ECG
- Where
- United States
- Volunteers
- 549 people
- Sponsor
- Columbia University
Ventricular Arrythmias
Home-Monitoring in Implantable Cardioverter Defibrillator (ICD) Patients
The purpose of this study is to investigate the cost-effectiveness and effectiveness of remote-monitoring compared to standard care in patients with implantable cardioverter defibrillator.
- Trial name
- Monitor-ICD (NCT00787683)
- Testing
- Home-monitoring provided by LUMAX ICD device and CardioMessenger II
- Where
- 13 sites in Germany
- Volunteers
- 416 people
- Sponsor
- F. Mueller-Riemenschneider
Long QT Syndrome, Sudden Cardiac Death
Electromechanical Profiling of the Long-QT Syndrome (LQTS)
High-resolution, non-invasive electromechanical mapping in genotyped long-QT syndrome patients and healthy controls at baseline and during smart provocation.
- Conditions
- Long QT Syndrome, Sudden Cardiac Death, Ventricular Tachycardia
- Trial name
- EMLoQ (NCT04074122)
- Testing
- Adenosine and epinephrine, isoprenaline provocation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Schizophrenia, Schizoaffective Disorder
Changes in Heart Rhythms Associated With Antipsychotic Drug Treatment
This study is being done to look at the electrical activity of the heart. This study will help decide whether taking recordings for a 24-hour period gives more useful information than recording it for a few seconds in a doctor's…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT00538122
- Testing
- 24 Holter Monitor Recording
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University
Arrhythmogenic Cardiomyopathy, PKP2-ACM
Long-term Follow-up Study of Gene Therapy for Arrhythmogenic Cardiomyopathy Due to a Plakophilin-2 Pathogenic Variant
The primary objective of this Phase 1/2 long-term follow-up (LTFU) study is to assess the long-term safety and tolerability of LX2020 for the treatment of arrhythmogenic cardiomyopathy (ACM) due to a plakophilin-2 gene (PKP2)…
- Conditions
- Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
- Trial name
- GRIT-PKP2 (NCT07050160)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lexeo Therapeutics
Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest
Epinephrine Dose: Optimal Versus Standard Evaluation Trial
The objective of this randomized controlled trial is to evaluate whether a low cumulative dose of epinephrine ("low dose") is non-inferior to a standard cumulative dose of epinephrine ("standard dose") with respect to survival to…
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest, Ventricular Fibrillation, Ventricular Tachycardia-Pulseless
- Trial name
- EpiDOSE (NCT03826524)
- Testing
- Epinephrine
- Where
- 9 sites in Canada
- Volunteers
- 1,250 people
- Sponsor
- Unity Health Toronto
Cardiac Ion Channelopathy
Post-mortem Genetic Testing
This is a prospective observational study to examine the incidence of cardiac ion channelopathies in unexplained still births.
- Trial name
- NCT01120886
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Thayyil, Sudhin
Kidney Failure, Chronic
Lung Water by Ultrasound Guided Treatment in Hemodialysis Patients (The Lust Study).
Volume overload is a leading risk factor for death and cardiovascular events in end stage renal disease patients maintained on chronic dialysis, particularly in those with myocardial ischemia and heart failure which represent a…
- Trial name
- LUST (NCT02310061)
- Testing
- Extra-vascular lung water measurements by ultrasound (LW-US), Standard protocol of fluid management in hemodialysis
- Where
- 19 sites in France, Germany and 7 more
- Volunteers
- 383 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Sudden Cardiac Death, Myocardial Infarction
Digital MEDIcal TWIN for the Prediction of Arrhythmic Sudden Cardiac Death After a Myocardial Infarction
TWIN-SCD STEMI is a multicentric prospective, non-randomized pilot study designed to establish a multiparametric model for predicting life-threatening ventricular arrhythmias in patients experiencing their first myocardial…
- Trial name
- TWIN-SCD STEMI (NCT07527494)
- Testing
- Programmed ventricular stimulation, Cardiac CT scan
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Bordeaux
Heart Failure, Systolic
Patient and Physician Survey Determinants of Appropriate ICD Utilization
To better understand the reasons for underutilization of defibrillator therapy in selected populations, the investigators propose a study to assess heart failure patient knowledge and attitudes toward device therapy.
- Trial name
- NCT01514773
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Todd M Koelling, MD
Acute Myocardial Infarction, Ventricular Tachycardia
Acute Cardiovascular Events Triggered by COVID-19-Related Stress
The current COVID19 pandemic has afflicted almost the whole globe. The stress related to the pandemic, not the direct virus-related injury, can be potentially associated with acute cardiovascular events due to a large list of…
- Conditions
- Acute Myocardial Infarction, Ventricular Tachycardia, Sudden Cardiac Death, Stroke, Acute
- Trial name
- JoCORE (NCT04368637)
- Where
- 5 sites in Jordan
- Volunteers
- 50 people
- Sponsor
- Jordan Collaborating Cardiology Group
End-stage Renal Disease
A Study of Thymoglobuline® Induction Therapy in Adult Recipients of Donated After Cardiac Death Kidney Transplant
Primary Objective: To investigate the efficacy of the standard dose of Thymoglobuline® induction therapy for preventing acute rejection (AR) after transplantation among recipients of Donated after Cardiac Death (DCD) kidney…
- Trial name
- START-DCD (NCT03099122)
- Testing
- Rabbit Anti-thymocyte Immunoglobulin, Tacrolimus, Methylprednisolone
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Sanofi