Clinical trials: Death, Cardiac
Atrial Fibrillation (AF), Stroke
Comparative Evaluation of the Efficacy and Safety of High-Power Short-Duration Radiofrequency Ablation and Standard Low-Power Ablation in Catheter Treatment of Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and represents one of the leading causes of cardiovascular morbidity and mortality.
- Conditions
- Atrial Fibrillation (AF), Stroke, Acute Cerebrovascular Accident, Atrial Fibrillation Recurrent
- Trial name
- NCT07728539
- Testing
- Technique of radiofrequency ablation using very high-power short-duration ablation parameters, Technique of radiofrequency ablation using low-power settings
- Where
- Russia
- Volunteers
- 196 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Wolff-Parkinson-White Syndrome, Sudden Cardiac Death
Stress ECG Test for the Evaluation of the Risk of Sudden Cardiac Death in a Paediatric Cohort With WPW Pattern
Patients with preexcitation are at risk for sudden cardiac death. The pathogenesis is a rapid antegrade conduction of atrial fibrillation over the accessory pathway to the ventricle resulting in ventricular fibrillation.
- Conditions
- Wolff-Parkinson-White Syndrome, Sudden Cardiac Death, Risk Stratification
- Trial name
- NCT03207373
- Testing
- Stress test (ECG)
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Christian Balmer
Sudden Cardiac Arrest
Research on Attitudes, Confidence, and Practical Skills in Performing Cardiopulmonary Resuscitation and Automated External Defibrillation After Completing a Course Based on the European Resuscitation Council Model
Research on attitudes, confidence, and practical skills in performing cardiopulmonary resuscitation and automated external defibrillation after completing a course based on the European Resuscitation Council model
- Trial name
- RACE-CPR (NCT07331831)
- Where
- Bulgaria
- Volunteers
- 656 people, healthy volunteers welcome
- Sponsor
- First Three Minutes Foundation
Coronary Artery Disease, Cardiac Death
BioFreedom QCA Study in CAD Patients
This study aims to demonstrate that the BioFreedom™ Cobalt Chromium Drug Coated Stent is non-inferior to the market authorized BioFreedom™ Stainless Steel Stent with respective to efficacy and shows a similar safety profile.
- Conditions
- Coronary Artery Disease, Cardiac Death, Myocardial Infarction
- Trial name
- BioFreedomQCA (NCT03307213)
- Testing
- BioFreedom™ CoCr Biolimus A9™ stent, BioFreedom™ SS Biolimus A9™ stent
- Where
- 2 sites in Denmark, Spain
- Volunteers
- 200 people
- Sponsor
- Biosensors Europe SA
Cardiac Resynchronisation Therapy (CRT), Heart Failure
Conduction System Pacing vs. Biventricular Pacing for Cardiac Resynchronization Therapy
The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular…
- Conditions
- Cardiac Resynchronisation Therapy (CRT), Heart Failure, Conduction System Pacing
- Trial name
- Nordic-CSP (NCT07492979)
- Testing
- HIS or LBBB -CRT, Conventional BiV-CRT
- Where
- 5 sites in Denmark, Finland and 2 more
- Volunteers
- 1,100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sleep Apnea, Sudden Cardiac Death
European Sleep Apnea and Sudden CArdiac Death ProjEct
The objective of ESCAPE-SCD Study is assessment of the effect of sleep apnea on sudden cardiac death risk and cardiovascular outcomes in patients with ischemic cardiomyopathy.
- Conditions
- Sleep Apnea, Sudden Cardiac Death, Heart Failure, Ischemic Cardiomyopathy
- Trial name
- ESCAPE-SCD (NCT02506166)
- Testing
- Positive Airway Pressure Therapy
- Volunteers
- 900 people
- Sponsor
- University Hospital Olomouc
Arrhythmia
Effects of Docosahexaenoic Acid (DHA) on Heart Rate Variability in Elderly Patients
The purpose of this study is to test the hypothesis that dietary supplementation with an algal source of docosahexaenoic acid (DHA) can improve the heart rate variability in elderly patients.
- Trial name
- NCT00749307
- Testing
- Docosahexaenoic acid (DHA)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Campus Bio-Medico University
Channelopathies, Brugada Syndrome
Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies
Patients with cardiac channelopathies needing restorative dental treatment will be included in two sessions of the study, using local dental anesthetic: lidocaine 2% with epinephrine and lidocaine 2% without vasoconstrictor.
- Conditions
- Channelopathies, Brugada Syndrome, Long QT Syndrome, Ventricular, Tachycardia
- Trial name
- SLDAPCC (NCT03182777)
- Testing
- Dental restorative procedure
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo General Hospital
Heart Failure, Heart Failure With Reduced Ejection Fraction
CRTd Responders Optimization
Suboptimal optimization of atrio-ventricular (AV) and inter-ventricular (VV) timings could affect the clinical response of CRTd in T2DM patients.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Cardiac Death
- Trial name
- NCT04547244
- Testing
- echocardiographic optimization of CRTd
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Campania Luigi Vanvitelli
Shock, Death
Polish Nationwide Register of Hospitalized Patients in Cardiac Intensive Care Units
Cardiac Intensive Care Units (CICUs) provide care for a diverse patient population. Understanding the clinical characteristics, analysis of treatment modalities, and prognosis of patients hospitalized in the CICU are important to…
- Conditions
- Shock, Death, Cardiac Intensive Care Unit, Treatment Complication
- Trial name
- POL-CICU (NCT06371677)
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Fetal Distress, Perinatal Asphyxia
Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings
The PRISM pilot feasibility study consists of two phases to determine: 1) to delivery practices, rates of primary and secondary outcomes, and feasibility of enrollment rates, and 2) to assess the feasibility and acceptability of…
- Conditions
- Fetal Distress, Perinatal Asphyxia, Birth Asphyxia, Stillbirth
- Trial name
- PRISM (NCT05946681)
- Where
- Zambia
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Heart Failure
Heart Transplantation Using Normothermic Regional Perfusion Donation After Circulatory Death
Normothermic regional perfusion (NRP) utilizes Extracorporeal Membrane Oxygenation (ECMO) or cardiopulmonary bypass to reperfuse the heart and other organs in situ after isolation and ligation of the cerebral vessels.
- Trial name
- NCT04284319
- Testing
- DCD Heart Transplantation Using NRP
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Death, Sudden, Cardiac
Genomics of Sudden Cardiac Arrest
Sudden cardiac arrest (SCA) is a sudden, unexpected loss of heart function. It is a leading cause of death, and more than 400,000 people in the United States die each year as a result of SCA.
- Trial name
- GenSCA (NCT00661128)
- Where
- United States
- Volunteers
- 14,862 people
- Sponsor
- University of Washington
Brugada Syndrome Type 1
Rhythmic Risk of Type 1 Brugada Syndrome and Pulmonary Infundibulum Mapping
Brugada syndrome has been described as the association of a right bundle block with ST segment elevation on the V1 to V3 electrocardiogram in patients with a structurally normal heart.
- Trial name
- SB-CARTO (NCT03572881)
- Testing
- Endocardial mapping
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Arrythmia, Cardiac, Sudden Cardiac Death
Arrhythmia in Hemodialysis Patients
Patients receiving dialysis for kidney failure suffer from very high rates of sudden cardiac death due to abnormal heart rhythms and perfusion defects associated with HD treatment.
- Conditions
- Arrythmia, Cardiac, Sudden Cardiac Death, Hemodialysis
- Trial name
- NCT04036695
- Testing
- Reveal LINQ insertable cardiac monitoring system
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sudden Cardiac Arrest
HS Students Mandatory Universal Student Instruction in CPR Appraised Learning- Is the Mandate Working?
This study will help to provide better input to state health and education departments to improve the processes for CPR education.
- Trial name
- NCT04493970
- Testing
- High School Students Survey
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Sudden Death, Ventricular Tachycardia
Skin Sympathetic Nerve Activity and Cardiac Arrhythmia
Sympathetic tone is important in cardiac arrhythmogenesis. The simultaneous recording of sympathetic nerve activity (SNA) and electrocardiogram (ECG) was obtained by invasive method.
- Conditions
- Sudden Death, Ventricular Tachycardia, Persistent Atrial Fibrillation
- Trial name
- SKNA (NCT04918303)
- Testing
- SKNA recording
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Tetralogy of Fallot, Ventricular Tachycardia
Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot
Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability…
- Conditions
- Tetralogy of Fallot, Ventricular Tachycardia, Sudden Cardiac Death
- Trial name
- NCT05236153
- Testing
- Electroanatomic substrate mapping
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Post-extrasystolic Potentiation (PESP), Ventricular Tachycardia
Post-Extrasystolic Potentiation as a Predictor of Ventricular Arrhythmias
Background: Patients at increased risk for sudden cardiac death (SCD) may receive an implantable cardioverter defibrillator (ICD).
- Trial name
- A PRIORY (NCT03631303)
- Testing
- Cardiac stimulation through the device leads
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Amsterdam UMC, location VUmc
Cardiomyopathy (Ischemic or Non-Ischemic)
Data Analysis and Evaluation of the Incidence of Life-threatening Ventricular Arrhythmias in Patients with Newly Diagnosed Cardiomyopathies of NICM or MI/CAD Origin PROTECTED from SCD by a WCD
SCD-PROTECT is an epidemiological, observational, multicenter study to assess the incidence of sudden cardiac arrest/death (SCA/SCD) in patients with newly diagnosed non-ischemic cardiomyopathy or with myocardial…
- Trial name
- SCD-PROTECT (NCT06883383)
- Where
- Germany
- Volunteers
- 19,598 people
- Sponsor
- Hannover Medical School