Clinical trials: Decision-making
Pregnancy - Prenatal Testing
Informed Choice Regarding Invasive Prenatal Testing
This study will compare the effectiveness of two interventions to help women make informed choices about whether or not to undergo an invasive procedure (amniocentesis or chorionic villus sampling) for prenatal testing.
- Trial name
- NCT00514553
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Impulsive Behavior, Suicidal Impulses
tDCS Applied to the OFC: Effects on Decision-Making and Impulse Control
In this study the investigators aim to assess whether transcranial direct current stimulation (tDCS; a safe and non-invasive method for modulating the activity of specific brain regions) when applied over the orbitofrontal cortex…
- Trial name
- NCT01805401
- Testing
- Transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Medical Termination of Pregnancy
Decision-making Regarding the Possibility of Medical Termination of Pregnancy
The aim of this study is to improve professional practices by better understanding parents who face the choice of medical termination of pregnancy.
- Trial name
- DEFIMEG (NCT05202639)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Hospices Civils de Lyon
Suicidal Ideation, Circadian Rhythm Disorders
Mind After Midnight
This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts.
- Conditions
- Suicidal Ideation, Circadian Rhythm Disorders, Sleep Deprivation, Sleep Wake Disorders
- Trial name
- MaM (NCT07438912)
- Testing
- Sleep Pressure Manipulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona
Healthy, Alcohol Use Disorder (Mild vs. Moderate to Heavy)
Modification of Pavlovian and Instrumental Learning in Human Addiction
The project aims at investigating modifications of environmental factors (i.e. cues and stress) relevant for learning mechanisms in addictive disorders.
- Trial name
- NCT04032587
- Testing
- Modified training version of the Approach / Avoidance Task (AAT, see Wiers et al., 2011), Mindfulness-based interventions (e.g. body scan)
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Palatal Neoplasms, Lip Neoplasm
Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making
Objectives Validate the OncAlert® RAPID Test by demonstrating that NPV > (1 -prevalence). Evaluate the independent and associated contribution of readily available clinical variables including age, race, gender, HPV status…
- Conditions
- Palatal Neoplasms, Lip Neoplasm, Gingival Neoplasms, Leukoplakia, Oral
- Trial name
- NCT03239834
- Testing
- OncAlert
- Where
- 26 sites in United States
- Volunteers
- 893 people
- Sponsor
- Vigilant Biosciences, Inc.
Quality of Life, Behavior
Breathing and Decision-Making
The study aims to investigate how slow breathing with prolonged exhalation (i.e., ProlEx breathing) modulates decision-making under risk in healthy participants.
- Conditions
- Quality of Life, Behavior, Stress, Psychological
- Trial name
- ProlEx-MRI (NCT05936684)
- Testing
- Breathing with prolonged exhalation (ProlEx) during risky decision-making, Normal breathing (Eupnea/Control) during risky decision-making
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Pertussis
Assessing Contacts' Decision Making on Reducing the Risk of Pertussis Transmission to Newborns Through Immunisation
This study aims to establish an effective method to inform parents or close relatives of newborns about the risk of pertussis transmission to newborns and the advantages offered by the cocooning strategy (vaccinating those who…
- Trial name
- NCT01890447
- Testing
- Web-based survey questionnaire
- Where
- 9 sites in Italy, Spain
- Volunteers
- 676 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obstructive Sleep Apnea, Adherence
Effort-based Decision-making and CPAP Adherence
Obstructive sleep apnoea is the most common sleep disorder in general population, and is often associated with cognitive deficit, mood disorders, hypertension, diabetes mellitus, excessive daytime somnolence, nicturia and an…
- Trial name
- NCT04557293
- Testing
- Continuous Positive Airway Pressure (CPAP) treatment
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Pelvic Organ Prolapse
Testing a Decision Aid for Women With Urogenital Prolapse
Development of a decision aid for women with urogenital prolapse followed by an intervention with use of the decision aid to investigate the effect on the perceived shared decision making in the clinical consultations.
- Trial name
- NCT03706716
- Testing
- decision aid developed for pelvic organ prolapse
- Where
- 3 sites in Denmark
- Volunteers
- 82 people
- Sponsor
- University of Southern Denmark
Schizophrenia
Oxytocin and Social Decision Making in Schizophrenia
schizophrenia patients and healthy volunteers will be included. Subjects who meet the inclusion and exclusion criteria for the study will be recruited.
- Trial name
- NCT04176835
- Testing
- Oxytocin nasal spray
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Healthy Volunteers, Motivation
Neural Bases of Motivation
Effort-based decisions are essential in daily life but strongly impaired in apathy across various brain disorders. Now, significant research to unveil the neural causes of apathy is needed.
- Conditions
- Healthy Volunteers, Motivation, Action
- Trial name
- MOTIVACTION (NCT07251816)
- Testing
- Cortico-cortical paired-associative stimulation (ccPAS), Bifocal transcranial alternating current stimulation (tACS), Combining transcranial temporal interference stimulation (tTIS) and oscillatory TMS
- Where
- France
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Acute Heart Failure, Emergencies
Risk Stratification Using MEESSI-AHF Scale in ED and Impact on AHF Outcomes
Evaluate the impact the application of the MESSI-AHF scale (a risk stratification scale specifically derived and validated in patients diagnosed with acute heart failure, AHF) in decision making (admission vs.
- Trial name
- MEESSI (NCT05919225)
- Testing
- Risk stratification before decision-making about patient hospitalization or discharge
- Where
- 19 sites in Spain
- Volunteers
- 3,200 people
- Sponsor
- Hospital Clinic of Barcelona
Suicide, Attempted
The Choice of a Violent Suicidal Means: a MRI Study With Computational Modeling of Decision-making
The study authors hypothesize a combination of cognitive, brain structural, brain functional and brain connectivity impairments in Suicide Attempters compared to Patient Controls and Healthy Controls, with deficits more marked in…
- Trial name
- SUICIDE_DECIDE (NCT05230043)
- Testing
- Algometer test, functional MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Traumatic Brain Injury
Evaluation of the Abbott i-STAT TBI Biomarker Test
According to the Centers for Disease Control and Prevention, approximately 200,000 hospitalizations occurred in 2020 related to Traumatic Brain Injury (TBI), which does not include many TBIs treated only in emergency departments…
- Trial name
- NCT06766435
- Testing
- i-STAT TBI Test
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Strep Pharyngitis, Pneumonia
Evidence Based Decision Making: Integrating Clinical Prediction Rules
Clinical prediction rules (CPRs) are frontline decision aids that help physicians make evidence-based, cost-effective decisions that benefit their patients.
- Trial name
- iCPR and EHR (NCT01386047)
- Testing
- Integrated Clinical Prediction Rule (iCPR)
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Breast Cancer, Survivorship
Shared Decision Making in Surveillance for Distant Metastasis in Breast Cancer
In this study, clinical impacts of shared decision making between physicians and patients in strategy of surveillance for asymptomatic patients who ended the primary treatments on quality of life would be investigated
- Conditions
- Breast Cancer, Survivorship, Quality of Life
- Trial name
- SMART-FU (NCT04862078)
- Testing
- Shared decision making, Usual care
- Where
- South Korea
- Volunteers
- 368 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma (HCC)
AI Multitask Model for HCC Treatment
We will integrate multi-modal cardiac data via an AI multitask framework to develop and validate concurrent models for liver function, treatment prognosis, and microvascular invasion (MVI) prediction in hepatocellular carcinoma.
- Trial name
- NCT07157085
- Testing
- Comprehensive treatment
- Where
- China
- Volunteers
- 7,000 people
- Sponsor
- Sun Yat-sen University
Regret
Impact of Anticipated Regret Incorporation Into Patient Decision Aids
The purpose of this study is to investigate the impact of incorporating "anticipated regret " into standard patient decision aids.
- Trial name
- NCT02563808
- Testing
- Standard Decision Aid, Post-surgical Regret Decision Aid
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
DME, Retinal Vein Occlusion (RVO)
AI vs. Physician for Anti-VEGF Decision-Making: An RCT
We developed an artificial intelligence system, called QiLin, which was designed to assist anti-VEGF treatment decisions in retinal diseases.
- Conditions
- DME, Retinal Vein Occlusion (RVO), Neovascular (Wet) Age-Related Macular Degeneration
- Trial name
- NCT07328776
- Testing
- QiLin-assisted, physician only, without QiLin assisted
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine