Clinical trials: Decompensated Heart Failure
Heart Failure
Voice Analysis for Monitoring Patients With Heart Failure
This observational study involves ADHF patients at two sites in the United States and Germany. After informed consent and screening assessments, participants will perform daily voice recordings during their hospital stay, from…
- Trial name
- VAMP-HF (NCT06566911)
- Where
- 2 sites in United States, Germany
- Volunteers
- 70 people
- Sponsor
- Noah Labs
Renal Insufficiency, Congestive Heart Failure
Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency
The purpose of the current study is to assess the safety and tolerability of intravenous tonapofylline.
- Trial name
- TRIDENT-1 (NCT00709865)
- Testing
- tonapofylline
- Where
- 189 sites in United States, Argentina and 16 more
- Volunteers
- 420 people
- Sponsor
- Biogen
Heart Failure With Reduced Ejection Fraction
Daily Ambulatory Remote Monitoring System For Post-Dischage Management Of ADHF
Background: Despite the advances in pharmacological management of heart failure (HF), the associated mortality and re-hospitalization for HF remain poor.
- Trial name
- DAVID-HF (NCT03072693)
- Testing
- Home-based remote heart failure management, Home-based physiological parameter recording only
- Where
- Hong Kong
- Volunteers
- 876 people
- Sponsor
- The University of Hong Kong
Congestive Heart Failure, Heart Failure
Heart Failure Event Advance Detection Trial
Patients who are admitted with acutely decompensated heart failure and are receiving intravenous diuretics will be recruited to undergo testing using the Indicor Device.
- Conditions
- Congestive Heart Failure, Heart Failure, Decompensated Heart Failure
- Trial name
- HEADstart (NCT04223271)
- Testing
- Indicor
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Vixiar Medical, Inc.
Decompensated Heart Failure
Vericiguat in Decompensated Cardiac Failure: Clinical Insights on Addition to Guidelines Derived Medical Therapy-VERCIG Trial
This study will compare the outcomes of Vericuguat and placebo in patient with decompensated heart failure . This study will carry out after approval from IERB.
- Trial name
- NCT07444398
- Testing
- Vericiguat tablet, Sacubitril / Valsartan
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Khawaja Danish Ali
Heart Failure, Acupuncture
The Effect and Safety of Low-level Laser Therapy in Acute Decompensated Heart Failure Patients.
The advantages of laser acupuncture are a non-invasive, painless, low risk of infection and high safety. Laser acupuncture as a treatment tool has the following advantages1.Painless, 2.
- Trial name
- NCT04383080
- Testing
- Acupuncture, Low-level laser therapy
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- National Yang Ming Chiao Tung University Hospital
Heart Failure; With Decompensation
Smart SCALEs With Bioimpedance Analysis for Treatment Guidance in Decompensated Heart Failure
In this trial the measurement of whole body water will be compared to the standard method of measuring the body weight as treatment guidance in patients with decompensated heart failure.
- Trial name
- SCALE HF (NCT03288701)
- Testing
- Seca medical Body Composition Analyser 515
- Where
- Switzerland
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Acute Decompensated Heart Failure, Acute Kidney Injury
Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study
AKINESIS is a clinical study to assess the utility of blood and urine NGAL tests in predicting worsening kidney function in patients who present with acute heart failure (AHF) and who are treated with diuretics.
- Trial name
- AKINESIS (NCT01291836)
- Where
- 13 sites in United States, Greece and 5 more
- Volunteers
- 930 people
- Sponsor
- Alere San Diego
Congestive Heart Failure (CHF)
Recombinant Human Relaxin for the Treatment of Decompensated CHF
Two doses of relaxin will be compared to placebo for the treatment of patients with decompensated CHF
- Trial name
- NCT00406575
- Testing
- Recombinant human relaxin (rhRlx)
- Where
- 2 sites in Russia
- Volunteers
- 11 people
- Sponsor
- Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies
Heart Decompensation, Heart Failure, Congestive
Pilot Study for the Evaluation of the Safety and Performance of the RenaSense System in Hospitalized Acute Decompensated Heart Failure Patients
The study is intended to verify the safety and assess the performance of up to 3-days treatment protocol with the RenaSense System in ADHF patients.
- Conditions
- Heart Decompensation, Heart Failure, Congestive, Renal Insufficiency
- Trial name
- NCT02324400
- Testing
- RenaSense Stimulation
- Where
- 3 sites in Israel
- Volunteers
- 36 people
- Sponsor
- Nephera Ltd.
Symptomatic Decompensated Congestive Heart Failure, Congestive Heart Failure in Acute Coronary Syndrome
A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure.
The purpose of this study is to compare the hemodynamic (blood flow) and clinical effects of the study drug, Natrecor (nesiritide, a recombinant form of the natural human peptide normally secreted by the heart in response to…
- Trial name
- NCT00270374
- Testing
- nesiritide
- Volunteers
- 498 people
- Sponsor
- Scios, Inc.
Systemic Inflammatory Response Syndrome, Distributive Shock
Peripheral Venous Analysis (PIVA) for Predicting Volume Responsiveness and Fluid Status
The aim of this study is to determine the effects of fluid alternations, hemodynamic changes, mechanical ventilation, pharmacologic agents, positional changes, and comorbidities on the Peripheral Intravenous waveform Analysis…
- Conditions
- Systemic Inflammatory Response Syndrome, Distributive Shock, Hypotension and Shock, Decompensated Congestive Heart Failure
- Trial name
- PIVA (NCT03407287)
- Testing
- Peripheral Intravenous Analysis (PIVA), Standard of care invasive vascular monitoring, Standard noninvasive vascular monitoring
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Vanderbilt University Medical Center
Acute Heart Failure
Heart Failure Hospital Readmissions and Physical Therapy
This is a dissertation study which is divided into three different studies in order to answer the main research question (Study 3).
- Trial name
- NCT03517514
- Testing
- Physical Therapy service
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- The Methodist Hospital Research Institute
Acute Decompensated Heart Failure
Prognostic Factors of Patients With ADHF
To explore the prognostic indicators for patients with ADHF
- Trial name
- NCT04390919
- Testing
- elevated monocyte count
- Volunteers
- 362 people
- Sponsor
- Chongqing Medical University
Acute Heart Failure, Congestive Heart Failure
Clinical Evaluation of the TRVD™ System in ADHF
A prospective, multi-national, open-label clinical study which is conducted to asses the safety, feasibility and performance of the TRVD™ System in hospital-admitted patients with Acute Decompensated Heart Failure (ADHF) and…
- Conditions
- Acute Heart Failure, Congestive Heart Failure, Heart Failure, Congestive
- Trial name
- TRVD (NCT03621436)
- Testing
- TRVD Therapy
- Where
- 3 sites in Belgium, Croatia and 1 more
- Volunteers
- 13 people
- Sponsor
- Magenta Medical Ltd.
Heart Decompensation
Study of the Sudden Heart Failure Participant Population in the US
An observational study using data from a large US electronic health record database to find participants hospitalized with ADHF who do not have a concurring heart attack
- Trial name
- NCT03566264
- Testing
- Non-Interventional
- Where
- 2 sites in United States
- Sponsor
- Bristol-Myers Squibb
Cardiogenic Shock
Comparison of ARNI to Alternate Oral Vasodilator Therapies in Patients With Low Cardiac Output
This is a prospective, randomized, non-blinded, single-center efficacy study of acutely decompensated heart failure patients with reduced ejection fraction (HFrEF), low cardiac index (<2.2) as determined by pulmonary artery…
- Trial name
- PARAVLO-HF (NCT04206865)
- Testing
- Sacubitril-Valsartan, Standard Oral Vasodilators
- Where
- United States
- Sponsor
- The Cleveland Clinic
Heart Failure, Congestive, Heart Decompensation
A Study to Develop Additional Safety and Clinical Experience With NATRECOR hBNP (Nesiritide) in the Treatment of Patients With Worsening Congestive Heart Failure Who Require Inpatient Intravenous Therapy With Medications That Influence the Tone and Caliber of Blood Vessels
The purpose of this safety study is to evaluate NATRECOR® hBNP (a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure), in subjects with worsening congestive heart failure…
- Trial name
- NCT00271557
- Testing
- nesiritide
- Volunteers
- 305 people
- Sponsor
- Scios, Inc.
Acute Decompensated Heart Failure
Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus Ultrafiltration
The CRUF trial is a prospective randomized monocentric trial comparing different impact of diuretics versus ultrafiltration on renal congestion, plasma refill rate, echocardiographic filling pressures, neurohormonal activation…
- Trial name
- CRUF (NCT01138683)
- Testing
- ultrafiltration, diuretics
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Ghent
Acute Decompensated Heart Failure, Fluid Overload
A Feasibility Study on Ultrafiltration and Blood Volume Measurements
The objective of this feasibility study is to characterize the performance of the Aquadex FlexFlow® System with the hematocrit (HCT) feature in conjunction with Daxor's blood volume analyzer (BVA-100).
- Trial name
- NCT04241718
- Testing
- Aquadex FlexFlow System and BVA-100
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Nuwellis, Inc.