Clinical trials: Decompensated Heart Failure
Heart Failure, Acute Decompensated Heart Failure
Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
This is a prospective, multi-center, single-arm, early feasibility study that aims to evaluate the safety of the Impella BTR™ in adult patients requiring left-ventricular hemodynamic support, and to evaluate the effectiveness of…
- Trial name
- BTR EFS (NCT05291884)
- Testing
- Impella BTR
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Abiomed Inc.
Acute Decompensated Heart Failure
Effects of In-Hospital Cardiac Rehabilitation and Manual Lymphatic Drainage in Acute Decompensated Heart Failure
Heart failure is a major global health issue requiring effective interventions to enhance patients' physical function and quality of life.
- Trial name
- NCT07095764
- Testing
- Manual Lymphatic Drainage, Cardiac Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Izmir Bakircay University
Acute Decompensated Heart Failure (ADHF)
Levosimendan in Acute Decompensated Heart Failure
Acute decompensated heart failure (ADHF) is one of the major causes of hospitalization and mortality worldwide. Despite advances in medical treatments, managing ADHF remains complex, especially in high-risk populations.
- Trial name
- NCT07262723
- Testing
- Levosimendan, Standard care
- Where
- 6 sites in Bangladesh
- Volunteers
- 332 people
- Sponsor
- Chittagong Medical College
Acute Decompensated Heart Failure, Heart Failure, Diastolic
Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure
This clinical trial aims to compare the efficacy and safety of acetazolamide versus metolazone as adjunctive treatments to standard therapy in patients with acute decompensated heart failure (ADHF).
- Conditions
- Acute Decompensated Heart Failure, Heart Failure, Diastolic, Heart Failure, Systolic
- Trial name
- NCT07199088
- Testing
- Acetazolamide, Metolazone
- Where
- Pakistan
- Volunteers
- 320 people
- Sponsor
- University of Health Sciences Lahore
Acute Decompensated Heart Failure, Acute Heart Failure
SVC Occlusion in Subjects With Acute Decompensated Heart Failure
Safety and performance evaluation of the preCARDIA System for patients with ADHF.
- Conditions
- Acute Decompensated Heart Failure, Acute Heart Failure, Congestive Heart Failure, Heart Diseases
- Trial name
- VENUS-HF (NCT03836079)
- Testing
- preCARDIA system
- Where
- 17 sites in United States
- Volunteers
- 60 people
- Sponsor
- Abiomed Inc.
Heart Failure, Decompensated Heart Failure
Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure
The goal of this clinical trial is to test whether using Bioimpedance Analysis (BIA) can help manage fluid levels in patients with heart failure who are admitted to the hospital with worsening symptoms.
- Trial name
- BIO-HF (NCT07173426)
- Testing
- Bioimpedance analysis
- Where
- United Kingdom
- Volunteers
- 255 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Heart Failure, Arrhythmia
BIO|CONCEPT.BIOMONITOR-HF Collect Clinical Data From Heart Failure Patients Using BIOMONITOR Devices With a Study Specific Research Software
[Plain language]: Heart failure (HF) patients often experience irregular heartbeats, known as arrhythmias. Atrial fibrillation (AF) is common among HF patients and can worsen their condition, leading to strokes and higher death…
- Conditions
- Heart Failure, Arrhythmia, Decompensated Heart Failure, Atrial Fibrillation
- Trial name
- NCT06989580
- Testing
- BIOMONITOR IV with study software
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 300 people
- Sponsor
- Biotronik SE & Co. KG
Acute Decompensated Heart Failure
EACH-ADHF: Early Comprehensive Rehabilitation in Patients With ADHF
EACH-ADHF: Early Comprehensive Rehabilitation in patients with ADHF study is a multi-center, parallel-group, randomized controlled trial designed to evaluate the effects of the early comprehensive rehabilitation including…
- Trial name
- EACH-ADHF (NCT06161987)
- Testing
- Early comprehensive rehabilitation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Guangdong Provincial People's Hospital
Acute Decompensated Heart Failure, Acute Myocardial Infarction
Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations
Health literacy is the ability to access, understand, evaluate and apply information in order to communicate with health professionals and understand health instructions but also, promote, maintain and improve health throughout…
- Trial name
- ILIADE (NCT03951467)
- Testing
- Interventional educational toolkit specific to low Health Literacy patients, designed with patients and health professionals.
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Acute Decompensated Heart Failure, Obstructive Sleep Apnea
Motivational Enhancement - Acute Decompensated Heart Failure and OSA
A feasibility randomized controlled trial will be conducted with a 6-month follow up to: Examine the impact of early intensive telemedicine motivational enhancement (TIME) vs standard of care on PAP adherence (n=40/group) and…
- Conditions
- Acute Decompensated Heart Failure, Obstructive Sleep Apnea, Motivational Enhancement, PAP Adherence
- Trial name
- NCT04752462
- Testing
- Telemedicine Intensive Motivational Enhancement
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The Cleveland Clinic
Acute Decompensated Heart Failure (ADHF)
Bedside Ultrasound-guided Volume Management and Discharge Timing for Patients With Heart Failure During Hospitalization: A Randomized Controlled Trial
Brief Summary of the POCUS-HF Study The goal of this clinical trial is to determine whether using bedside ultrasound (POCUS) to guide fluid management and discharge timing can improve outcomes for hospitalized heart failure (HF)…
- Trial name
- NCT07046169
- Testing
- Ultrasound-Guided Volume Assessment and Decongestion Strategy (UVADS), clinical assessment
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Pan He
Hemolysis Intravascular, Acute Decompensated Heart Failure
HEMolysis in a Percutaneous Axial Flow LVAD, Effects of Pentoxifylline in a Randomized Controlled Trial
Temporary mechanical circulatory support devices are increasingly used for short-term support in patients with decompensated cardiogenic shock. Recently, a new axial flow pump has become widely available with the Impella System.
- Trial name
- NCT04391231
- Testing
- Pentoxifylline Oral Product
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Acute Decompensated Heart Failure
Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF
The objective of this interventional study is to evaluate the safety and functional performance of the Nephronyx System in patients with ADHF, presenting clinical signs of volume overload and compromised response to diuretics.
- Trial name
- NCT05759806
- Testing
- Nephronyx system (Perfuser)
- Where
- 4 sites in Israel
- Volunteers
- 10 people
- Sponsor
- Nephronyx LTD
Cardiogenic Shock, Acute Decompensated Heart Failure
SURPASS Impella 5.5 Study
A multi-center, prospective \& retrospective, observational single-arm study of the clinical outcomes up to one year collected from electronic health records of patients which have undergone standard of care implantation of…
- Trial name
- NCT05100836
- Testing
- Impella 5.5
- Where
- 15 sites in United States
- Volunteers
- 1,017 people
- Sponsor
- Abiomed Inc.
Heart Failure, Decompensated Heart Failure
A Prospective, Observational, Single Centre Study to Assess the Feasibility of the Data Harvested by the Acorai Intracardiac Pressure Monitoring (ICPM) System in Predicting Prognosis in Patients Discharged From Hospital After Treatment for Acute Decompensated Heart Failure
Acorai is developing the Acorai Heart Monitor, a handheld electronic device for monitoring pressures inside the heart in a non-invasive manner, by placing the device on the chest of a patient.
- Trial name
- NCT06397833
- Testing
- Acorai ICPM system
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Acute Decompensated Heart Failure
EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System (FASTR-EU)
The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve DMS system to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure…
- Trial name
- FASTR-EU (NCT06362668)
- Testing
- Reprieve Decongestion Management System, Diuretic (furosemide, bumetanide, torsemide, hydrochlorothiazide, and/or acetazolamide)
- Where
- 2 sites in Netherlands, Poland
- Volunteers
- 12 people
- Sponsor
- Reprieve Cardiovascular, Inc
Acute Decompensated Heart Failure (ADHF)
ExCR's Effects and Safety in Vulnerable ADHF Patients
Exercise-based cardiac rehabilitation has become a key component of the comprehensive care system for patients with stable heart failure (HF).
- Trial name
- NCT06795737
- Testing
- Exercise rehabilitation, Conventional rehabilitation
- Where
- China
- Volunteers
- 88 people
- Sponsor
- YE Jing
Cardiorenal Syndrome, Heart Failure
Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure
The purpose of this study is to assess the feasibility, safety and effectiveness of VExUS guided organ decongestion compared to standard of care in patients hospitalized with acute decompensated heart failue (ADHF).
- Conditions
- Cardiorenal Syndrome, Heart Failure, Acute Kidney Injury, Acute Decompensated Heart Failure
- Trial name
- VExOUS-ADHF (NCT06714409)
- Testing
- VExUS guided decongestion
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
Acute Decompensated Heart Failure, Fluid Overload
A Feasibility Study on Ultrafiltration and Blood Volume Measurements
The objective of this feasibility study is to characterize the performance of the Aquadex FlexFlow® System with the hematocrit (HCT) feature in conjunction with Daxor's blood volume analyzer (BVA-100).
- Trial name
- NCT04241718
- Testing
- Aquadex FlexFlow System and BVA-100
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Nuwellis, Inc.
Acute Myocardial Infarction, Acute Decompensated Heart Failure (ADHF)
Noninvasive Assessment of Pulmonary Fluid Levels by Remote Dielectric Sensing Technology to Improve Cardiac InsUfficieney During Ischemia-Reperfusion and Clinical Outcomes in MyocArdiaL Infarction
To explore whether a ReDS-guided strategy for AMI patients with cardiac insufficiency following coronary flow reperfusion is superior to routine care for improving outcomes.
- Trial name
- NATURAL (NCT06671067)
- Testing
- Remote dielectric sensing system
- Where
- 6 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai 10th People's Hospital