Clinical trials: Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF)
Evaluation of FlowMod System While Intermittently Partially Occluding Vena Cava Blood Flow in Subjects With ADHF
FLOW-HF will assess the impact of intermittent partial occlusion of the SVC and/or IVC, the cardiac filling pressure and the difference of effects between the two occlusion locations (SVC and IVC) using the FlowMod flow…
- Trial name
- FLOW-HF (NCT07810335)
- Testing
- FlowMod System in subjects with acute decompensated heart failure (ADHF)
- Where
- 4 sites in Georgia, Uzbekistan
- Volunteers
- 30 people
- Sponsor
- FlowMod, Inc.
Heart; Decompensation, Congestive
The Safety and Feasibility of the eLym™ System
The goal of this feasibility study is to evaluated the safety and performance of the WhiteSwell eLym System in the treatment of fluid overload or congestion in adult patients with Acute Decompensated Heart Failure (ADHF).
- Trial name
- DELTA-HF (NCT05747196)
- Testing
- WhiteSwell eLym System
- Where
- 11 sites in Georgia, Poland and 1 more
- Volunteers
- 70 people
- Sponsor
- WhiteSwell, Limited
Heart Failure, Transplant; Failure, Heart
Shear Wave Elastography
In individuals needing a left ventricular assist device (LVAD), right heart failure (RHF) is a serious complication post-surgery, associated with worsened outcomes including mortality.
- Conditions
- Heart Failure, Transplant; Failure, Heart, Decompensated Heart Failure, Fibrosis, Liver
- Trial name
- NCT04493346
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Baylor Research Institute
Congestive Heart Failure(CHF), Pleural Effusion Due to Congestive Heart Failure
DRAIN: DRainage in Acute Decompensated Heart faIlure With Pleural effusioNs
The goal of this study is to assess if removal of fluid around the lungs (pleural effusion) by a routine procedure called as thoracentesis is helpful to decrease shortness of breath in hospitalized patients with congestive heart…
- Trial name
- DRAIN-IT (NCT07419360)
- Testing
- Thoracentesis
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Albany Medical College
Acute Decompensated Heart Failure, COPD Exacerbation
Use of ΔIVC for Early Diagnosis of AHF in AECOPD
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05327374
- Testing
- calculation of the inferior vena cava collapsibility index
- Where
- 3 sites in Tunisia
- Volunteers
- 401 people
- Sponsor
- University of Monastir
Acute Heart Failure, Low Cardiac Output Syndrome
Exogenous Ketones for Acutely Decompensated HEart Failure
This study will evaluate whether supplementation of exogenous ketones in patients with severe left ventricular dysfunction and acutely decompensated heart failure requiring inotropic therapy would improve the patient's…
- Conditions
- Acute Heart Failure, Low Cardiac Output Syndrome, Hemodynamic Instability, Ketosis
- Trial name
- KADHEF (NCT04698005)
- Testing
- 25g Ketone monoester without added salts
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Acute Decompensated Heart Failure
The Hemodynamic Effects of SGLT2i in Acute Decompensated Heart Failure
The main purpose of this study is to observe hemodynamic effects of initiating sodium-glucose co-transporter 2 inhibitors (SGLT2i) in patients admitted to the intensive care unit (ICU) with acute decompensated heart failure.
- Trial name
- NCT05346653
- Testing
- SGLT2i, No SGLT2i
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Chicago
Acute Decompensated Heart Failure, Cytokine Storm
Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart Failure
Assess the anti-inflammatory effects of short-term Copaxone therapy on patients with acute decompensated heart failure. Trial Design An open-label, randomized, prospective trial of patients hospitalized due to acute…
- Conditions
- Acute Decompensated Heart Failure, Cytokine Storm, Inflammatory Response, Heart Failure
- Trial name
- Copaxone (NCT06003972)
- Testing
- Copaxone, guideline directed medical therapy (GDMT)
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- Hadassah Medical Organization
Acute Decompensated Heart Failure
Point Of Care With Serial NT-proBNP Measurement in Patients With Acute Decompensation of Heart Failure
The goal of this study is to explore whether the availability of serial NT-proBNP measurements together with safety parameters such as electrolytes and creatinine may influence treatment decision in patients with acute…
- Trial name
- NCT04471610
- Testing
- Serial measurements of NT-pro BNP, potassium, sodium, and creatinine every second business day
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Heart Failure With Reduced Ejection Fraction
Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event
To explore two modalities of treatment initiation (Pre-discharge, and Post-discharge) with LCZ696 in HFrEF patients following stabilization after an ADHF episode.
- Trial name
- TRANSITION (NCT02661217)
- Testing
- LCZ696
- Where
- 152 sites in Argentina, Belgium and 17 more
- Volunteers
- 1,002 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure NYHA Class I, Heart Failure NYHA Class II
Future Patient - Telerehabilitation of Heart Failure Patients
The idea behind the Future Patient research project is to develop a telerehabilitation program and tools for patients with heart failure.
- Conditions
- Heart Failure NYHA Class I, Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
- Trial name
- NCT03388918
- Testing
- Telerehabilitation
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Aalborg University
Acute Decompensated Heart Failure
RAAS Optimization for Acute CHF Patients
Holding ACEI/ARBs during initial 72 hours of admission with acute decompensated heart failure may help preserve renal function with a lesser decline in GFR.
- Trial name
- ROAD-HF (NCT03695120)
- Testing
- Change of treatment plan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Florida
Pulmonary Hypertension
European Registry of Acutely Decompensated Pulmonary Arterial Hypertension
Acute decompensation of pulmonary hypertension (PH) is associated with a very unfavorable short-term prognosis. However, the development of circulatory support techniques and the possible use of emergency transplantation in…
- Trial name
- PHAROS Acute (NCT06923917)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HEART FAILURE
Randomized Double-blind Trial to Study the Benefit of Colchicine in Patients With Acutely Decompensated Heart Failure
Heart failure (HF) is a chronic disease associated with multiple acute decompensations, which are the main cause of hospital admission above 65 years and two thirds of the high costs associated with the disease.
- Trial name
- COLICA (NCT04705987)
- Testing
- Colchicine 0.5 MG
- Where
- Spain
- Volunteers
- 279 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Cardiogenic Shock, Ventricular Arrythmia
Innovative Technologies for the Treatment of Pulmonary and Heart Failure
The purpose of the program. Formulation of new treatments for heart and pulmonary failure through using organ-replacing technologies.
- Conditions
- Cardiogenic Shock, Ventricular Arrythmia, Cardiac Arrest With Successful Resuscitation, Sepsis
- Trial name
- NCT05090930
- Testing
- HA330 - Jafron Biomedical Co., Ltd., China - extracorporeal hemocorrection, CytoSorb (CytoSorbents Corp., USA) - an extracorporeal cytokine adsorber
- Where
- Kazakhstan
- Volunteers
- 100 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan
Heart Failure, Decompensated Heart Failure
Use of Point-of-Care Ultrasound (POCUS) to Reduce Hospital Length of Stay in Patients With Heart Failure ( POCUSHF )
This study will evaluate whether using bedside ultrasound (also called Point-of-Care Ultrasound or POCUS) can help improve the care of hospitalized patients with decompensated heart failure.
- Conditions
- Heart Failure, Decompensated Heart Failure, Hospital Length of Stay
- Trial name
- POCUSHF (NCT06965712)
- Testing
- Point-of-Care Ultrasound (POCUS)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Florida International University
Cardiorenal Syndrome
Accuracy of Urinary NGAL in Predicting CardioRenal Syndrome in Acute Heart Failure at Emergency - CYNDERELA-HF Study
Rationale: Heart Failure (HF) elevated prevalence in Brasil and the world; 20-30% AHF patients develop CardioRenal Syndrome (CRS) type 1; Worsening Renal Failure (WRF) is a prognostic marker of mortality in Acute HF;NGAL is a…
- Trial name
- CYNDERELA-HF (NCT01364636)
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Pro-Cardiaco Hospital
Heart Failure
Fluid and Salt Restriction in Decompensated Heart Failure Patients
The non-pharmacological measures that are widely practiced and recommended for HF patients, such as salt and water restriction, specially at moments of disease decompensation, still lack clearer evidence of their therapeutic…
- Trial name
- NCT01133236
- Testing
- Salt and fluid restriction
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Decompensated Heart Failure, Volume Overload
Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR)
This clinical research study is being conducted in multiple hospitals in Belgium and approximately 519 patients with acute decompensated heart failure are expected to participate.
- Trial name
- Advor (NCT03505788)
- Testing
- Acetazolamide
- Where
- Belgium
- Volunteers
- 519 people
- Sponsor
- Ziekenhuis Oost-Limburg
Acute Decompensated Heart Failure (ADHF)
ExCR's Effects and Safety in Vulnerable ADHF Patients
Exercise-based cardiac rehabilitation has become a key component of the comprehensive care system for patients with stable heart failure (HF).
- Trial name
- NCT06795737
- Testing
- Exercise rehabilitation, Conventional rehabilitation
- Where
- China
- Volunteers
- 88 people
- Sponsor
- YE Jing