Clinical trials: Decompressive Craniectomy
Intracranial Hemorrhages
Decompressive Craniectomy Combined With Hematoma Removal to Treat ICH
Decompressive craniectomy has been reported for the treatment of patients with intracerebral hemorrhage. But no prospective randomised controlled trials have yet been undertaken to confirm its effect.The purpose of the study is…
- Trial name
- CARICH (NCT02135783)
- Testing
- Decompressive Craniectomy, non-Decompressive Craniectomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southwest Hospital, China
Bone Defects, Decompressive Craniectomy and Cranioplasty
Cranioplasty Using Titanium Mesh vs Bone Cement
The aim of this study is: To compare the surgical outcomes between titanium mesh and bone cement in cranioplasty. To assess the complication rates associated with each material.
- Conditions
- Bone Defects, Decompressive Craniectomy and Cranioplasty, Cranioplasty
- Trial name
- NCT06662903
- Testing
- Cranioplasty with Titanium mesh, Cranioplasty with bone cement
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Osman Hassan Osman Zafraan
Ischemic Stroke, Decompressive Craniectomy
Craniectomy Protocol
The objective of this protocol is to evaluate the quality of life and functional disability in the long term (2 years after craniectomy) in subject's victims of malignant Sylvien stroke who received a decompressive craniotomy in…
- Trial name
- NCT01990014
- Where
- 4 sites in France
- Volunteers
- 62 people
- Sponsor
- Nantes University Hospital
Hypertension Intracranial
Decompressive Craniectomy for Severe Traumatic Brain Injury in Children With Refractory Intracranial Hypertension
Severe traumatic brain injury (TBI) is the leading cause of mortality and severe disability in the pediatric population. The prognosis of these patients depends on the severity of the initial lesions but also on the effectiveness…
- Trial name
- RANDECPED (NCT03766087)
- Testing
- decompressive craniectomy
- Where
- France
- Sponsor
- Fondation Lenval
Brain Injuries
The DECRA Trial: Early Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury
This is a multi-centre randomised trial to evaluate the effect of early decompressive craniectomy on neurological function in patients with severe traumatic brain injury.
- Trial name
- NCT00155987
- Testing
- Early decompressive craniectomy
- Where
- Australia
- Volunteers
- 155 people
- Sponsor
- National Trauma Research Institute
Traumatic Brain Injury, Subdural Hematoma
Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury
Cerebral edema is seen heterogenous group of neurological disease states that mainly fall under the categories of metabolic, infectious, neoplasia, cerebrovascular, and traumatic brain injury disease states.
- Conditions
- Traumatic Brain Injury, Subdural Hematoma, Cerebral Contusion, Head Injury
- Trial name
- NCT01605357
- Testing
- Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium)
- Sponsor
- Massachusetts General Hospital
Brain Edema
Swiss Prospective Autologous Bone Flap Resorption Study
The complications after reimplantation of cryoconserved autologous bone flaps are reported inhomogeniously in the literature. Especially the incidence of bone flap resorption varies from 0% to about 30%.
- Trial name
- SPARS (NCT02320955)
- Testing
- Reimplantation of cryoconserved bone flap
- Where
- 2 sites in Switzerland
- Volunteers
- 88 people
- Sponsor
- University of Zurich
Ischemic Stroke, Acute, Malignant Cerebral Edema
Expansion-floating Craniotomy for the Treatment of Malignant Cerebral Edema Caused by Acute Ischemic Stroke
This clinical study investigates Expansion-floating Craniotomy (EC), a novel surgical technique for treating life-threatening malignant cerebral edema following large hemispheric infarction (commonly known as massive stroke).
- Trial name
- ECAIS (NCT07195786)
- Testing
- Expansion-floating Craniotomy, decompressive craniectomy, drug conservative therapeutic
- Volunteers
- 356 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Traumatic Brain Injuries, Intracranial Hypertension
Effectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain Injury
Traumatic brain injury (TBI) patients often exhibit an increase in their intracranial volume due to blood collection or brain tissue edema.
- Trial name
- E-SPACE-TBI (NCT06776614)
- Testing
- Decompressive Craniectomy, Expansion Craniotomy
- Volunteers
- 292 people
- Sponsor
- Meditech Foundation
Severe Traumatic Brain Injury
Cisternostomy Vs Decompressive Craniectomy for Severe Traumatic Brain Injury
The objective of this clinical study is to compare the outcomes of two neurosurgical interventions, Cisternostomy and Decompressive Craniectomy (DC), for the management of severe Traumatic Brain Injury (TBI), assessed using the…
- Trial name
- NCT06363474
- Testing
- Decompressive Craniectomy, Cisternostomy
- Volunteers
- 190 people
- Sponsor
- University of Health Sciences Lahore
Subarachnoid Hemorrhage, Aneurysmal
Trial of Prophylactic Decompressive Craniectomy for Poor-grade Aneurysmal Subarachnoid Hemorrhage
Decompressive craniectomy has been reported for the treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH). But no prospective randomised controlled trials have yet been undertaken to confirm its effect.The purpose…
- Trial name
- NCT02995928
- Testing
- Decompressive craniectomy, Best medical treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tang-Du Hospital
Head Injury Trauma
Decompressive Craniectomy Following Trauma
A prospective clinical trial on trauma patients with increased intracranial pressure(ICP) applied for decompressive craniectomy to lower ICP
- Trial name
- NCT04574349
- Testing
- Decompressive craniectomy
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Traumatic Brain Injury, Middle Cerebral Artery Stroke
Intracranial Pressure After Decompressive Craniectomy
Observational study to investigate the natural course of intracranial pressure (ICP) after decompressive craniectomy (DC) using long-term telemetric ICP monitoring.
- Conditions
- Traumatic Brain Injury, Middle Cerebral Artery Stroke, Intracranial Hemorrhages, Intracranial Hypertension
- Trial name
- NCT03364634
- Testing
- Intracranial pressure monitoring
- Volunteers
- 17 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Skull Defect
Prospective Observational Study on Comprehensive Effects of PEEK Cranioplasty and Titanium Cranioplasty After DC（RECEPT-DC）
The objective of this trial is to scientifically evaluate the efficacy of PEEK cranioplasty and titanium cranioplasty. The primary objective is to compare the rate of implant failure (defined as infection, implant exposure and…
- Trial name
- NCT05416684
- Where
- China
- Volunteers
- 358 people
- Sponsor
- RenJi Hospital
Intracranial Pressure Increase
Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Descompressive Craniectomy.
This is a single centre, observational study with a medical device which has Conformité Européenne (CE) marking. The aim of the study is to demonstrate that patients with malignant middle cerebral artery infarction (M-MCA) show…
- Trial name
- NCT03221959
- Testing
- Medical Device Vittamed 205
- Volunteers
- 48 people
- Sponsor
- Kienzler Jenny
Traumatic Brain Injury, Decompressive Craniectomy
Study on the Efficacy of Long-term Drainage of Subdural Effusion After Decompressive Craniectomy
Drilling or puncture drainage is commonly used in TBI patients with subdural effusion following decompressive craniectomy who fail to respond to conservative treatment, but there is no exact regulation or guideline recommendation…
- Conditions
- Traumatic Brain Injury, Decompressive Craniectomy, Subdural Effusion
- Trial name
- NCT06391203
- Testing
- Long-term Drainage, Short-term Drainage
- Where
- China
- Volunteers
- 160 people
- Sponsor
- RenJi Hospital
Epidural Hematoma, Brain Herniation
Prospective Randomized Evaluation of Decompressive Ipsilateral Craniectomy for Traumatic Acute Epidural Hematoma
Although craniotomy provides a more complete evacuation of the acute epidural hematoma, there are insufficient data to support specific surgical treatment method.
- Conditions
- Epidural Hematoma, Brain Herniation, Decompressive Craniectomy, Craniotomy
- Trial name
- PREDICT-AEDH (NCT04261673)
- Testing
- Decompressive Craniectomy, Craniotomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RenJi Hospital
Acquired Brain Injury, Traumatic Brain Injury
Connectivity in Cranioplasty
An Exploratory Interventional study to assess the effects of cranioplasty on brain network connectivity, neuropsychological and motor functioning in patients with severe acquired brain injury with pre-, post-cranioplasty and 6…
- Conditions
- Acquired Brain Injury, Traumatic Brain Injury, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT05440682
- Testing
- CP group
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Azienda Usl di Bologna
Traumatic Brain Injury
ICP Threshold After Decompressive Craniectomy
Severe traumatic brain injury (sTBI) is a critical disease of public health importance. Increased intracranial play a significant role in the secondary injury of TBI. Reducing the ICP is helpful in reducing the mortality of sTBI.
- Trial name
- NCT06083792
- Volunteers
- 240 people
- Sponsor
- Tang-Du Hospital
Stroke, Acute
aICP Measurement in Patients With Cerebral Artery Infarction / aICP MCA Infarction
Space-occupying, malignant middle cerebral artery (M-MCA) infarctions are still one of the most devastating forms of ischemic stroke, with a mortality of up to 80% in untreated patients.
- Trial name
- aICPStroke (NCT03641963)
- Testing
- Vittamed 205 Non-invasive intracranial pressure (ICP) meter
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Kantonsspital Aarau