Clinical trials: Deep Brain Stimulation
Parkinson's Disease (PD)
Phase I Clinical Study of NouvNeu001 Injection for the Treatment of Moderate-to-Advanced Parkinson's Disease in Patients Who Have Previously Undergone Deep Brain Stimulation or Deep Brain Nucleus Lesioning Surgery
This clinical trial is designed to evaluate the safety, tolerability and preliminary efficacy of a single injection of NouvNeu001 (Human Dopaminergic Progenitor Cells Injection) in patients with Parkinson's Disease who have…
- Trial name
- NCT07550374
- Testing
- NouvNeu001 injection
- Where
- China
- Volunteers
- 10 people
- Sponsor
- iRegene Therapeutics Co., Ltd.
Parkinson Disease, Freezing of Gait
Use of CereGate Therapy for Freezing of Gait in PD
A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed with Parkinson's Disease.
- Conditions
- Parkinson Disease, Freezing of Gait, Deep Brain Stimulation
- Trial name
- NCT05292794
- Testing
- CereGate Software; BSN cDBS Programmer; BSN Burst Programmer
- Where
- 7 sites in United States
- Volunteers
- 41 people
- Sponsor
- CereGate Inc.
Parkinson Disease
LFP Beta aDBS Feasibility Study
The purpose of this study is to use local field potentials as control signals for adjusting DBS stimulation settings under varying patient states and to assess patient outcomes.
- Trial name
- NCT03446833
- Testing
- The LFP Beta aDBS System
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- MedtronicNeuro
Parkinson Disease
Cartesia eXTend 3D Study
The purpose of the study is to document patient outcomes including effectiveness for Boston Scientific Corporation's Vercise Cartesia 16-contact Directional Lead(s) (X/HX) with Deep Brain Stimulation (DBS) systems for the…
- Trial name
- eXTend 3D (NCT04577651)
- Testing
- 16-contact Directional Deep Brain Stimulation
- Where
- 10 sites in Germany, Netherlands and 1 more
- Volunteers
- 58 people
- Sponsor
- Boston Scientific Corporation
Parkinson's Disease
BradyXplore Phase II: Bradykinesia Feature Extraction System
Study objectives are to improve motion sensor algorithms for measuring bradykinesia in the clinic and the home, evaluate test-retest reliability of motion sensor algorithms for measuring bradykinesia compared to clinician raters…
- Trial name
- NCT02358876
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Parkinson Disease
Closed Loop Programming Evaluation Using External Responses for Deep Brain Stimulation
The objective of this study is to evaluate the performance of novel DBS programming methods compared to traditional programming methods.
- Trial name
- CLOVER (NCT03037398)
- Testing
- Vercise Deep Brain Stimulation System
- Where
- 3 sites in Germany
- Volunteers
- 69 people
- Sponsor
- Boston Scientific Corporation
Parkinson's Disease
Post Market (Libra/LibraXP System) Deep Brain Stimulation (DBS) Parkinson's Disease Study
The objective of this study is to evaluate the effectiveness of Deep Brain Stimulation as an adjunctive treatment for reducing some of the symptoms of advanced, levodopa-responsive Parkinson's disease that are not adequately…
- Trial name
- NCT01352819
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 21 people
- Sponsor
- Abbott Medical Devices
Stroke, Upper Extremity Paresis
Pilot/Pivotal Study of DBS+Rehab After Stroke
The RESTORE Stroke Study will evaluate the safety and effectiveness of DBS+Rehab for treating arm weakness and reduced function after a stroke.
- Trial name
- RESTORE (NCT05701280)
- Testing
- Deep Brain Stimulation, Rehabilitation
- Where
- 9 sites in United States
- Volunteers
- 202 people
- Sponsor
- Enspire DBS Therapy, Inc.
Parkinson Disease
Post Market (Brio™ System) Deep Brain Stimulation (DBS) PD Study
The objective of this study is to evaluate the effectiveness of a rechargeable Deep Brain Stimulation as an adjunctive treatment for reducing some of the symptoms of advanced, levodopa-responsive Parkinson's disease that are not…
- Trial name
- NCT01218919
- Sponsor
- Abbott Medical Devices
Dystonia
Efficacy and Safety of DBS in Patients With Primary Dystonia
The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) for primary dystonia.
- Trial name
- NCT03017586
- Testing
- Beijing Pins Medical Co., Ltd. Deep Brain Stimulator
- Where
- 7 sites in China
- Volunteers
- 72 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Essential Tremor
Boston Scientific Registry of Deep Brain Stimulation for Treatment of Essential Tremor (ET)
To compile characteristics of real-world outcomes for Boston Scientific Corporation's commercially approved Deep Brain Stimulation (DBS) Systems, when used according to the applicable Directions for Use, for the treatment of…
- Trial name
- NCT04032470
- Testing
- Deep Brain Stimulation Systems (DBS)
- Where
- 20 sites in Austria, Belgium and 7 more
- Volunteers
- 500 people
- Sponsor
- Boston Scientific Corporation
Idiopathic Parkinson's Disease
Vercise Implantable Stimulator for Treating Parkinson's Disease
The purpose of this study is to document patient outcomes, including effectiveness, safety, and health economic data, for the Boston Scientific implantable deep brain stimulation (DBS) Vercise™ system for bilateral stimulation of…
- Trial name
- VANTAGE (NCT01221948)
- Testing
- Deep Brain Stimulation
- Where
- 7 sites in Austria, France and 4 more
- Volunteers
- 53 people
- Sponsor
- Boston Scientific Corporation
Depressive Disorder, Major
European Deep Brain Stimulation (DBS) Depression Study
To evaluate the effects of two different programming settings of deep brain stimulation (DBS) in the subgenual white matter (Brodmann Area 25 WM) as an adjunctive treatment for treatment resistant Major Depressive Disorder…
- Trial name
- NCT01331330
- Testing
- Deep Brain Stimulation
- Where
- 5 sites in France, Israel and 1 more
- Volunteers
- 9 people
- Sponsor
- Abbott Medical Devices
Parkinson's Disease, Essential Tremor
Evaluation of Directional Stimulation During the Implantation of Deep Brain Stimulation (DBS) Leads
The purpose of this study is to provide proof-of-concept that directional stimulation, in an intraoperative setting, is perceivable in a subject and is different from omnidirectional stimulation.
- Trial name
- NCT01764815
- Testing
- directSTN Acute lead connected to external neurostimulator
- Where
- Switzerland
- Volunteers
- 13 people
- Sponsor
- Aleva Neurotherapeutics SA
Parkinson Disease
IPG Replacement Study (PREFERENCE-H)
This post-marketing evaluation has been designed to consistently investigate the subject's preference when switching from a Medtronic® constant voltage or constant current device to a St Jude Medical Infinity™ or St Jude Medical…
- Trial name
- PREFERENCE-H (NCT02963259)
- Testing
- SJM Infinity™ DBS IPG or SJM Brio™ DBS IPG system
- Where
- 14 sites in United States, Germany and 1 more
- Volunteers
- 17 people
- Sponsor
- Abbott Medical Devices
Parkinson's Disease With Deep Brain Stimulation
Parkinstep: Automated PD Gait and Balance Assessment for Optimizing DBS
Changes in deep brain stimulation (DBS) settings can have a delayed effect on gait function, which makes it impractical to optimize DBS for gait parameters in the clinic.
- Trial name
- NCT02080572
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Parkinson Disease, Deep Brain Stimulation
Validation of HaGuide Software Module Accuracy in Mapping STN Boundaries in Parkinson's Disease Patients Who Underwent DBS Procedure
HaGuide version 1.0 (Neuro-Omega Ltd.) is a software module add-on to the FDA cleared Neuro-Omega System (K123796). It was designed to facilitate the use of Neuro-Omega's system by automatically mapping visually the depth of STN…
- Trial name
- NCT03363724
- Testing
- HaGuide version 1.0 software module
- Volunteers
- 103 people
- Sponsor
- Alpha Omega Engineering Ltd.
Parkinson Disease
Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease
The purpose of the study is to demonstrate the safety and effectiveness of adaptive DBS (aDBS) for Parkinson's disease.
- Trial name
- ADAPT-PD (NCT04547712)
- Testing
- Adaptive DBS
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 85 people
- Sponsor
- MedtronicNeuro
Parkinson Disease
Safety and Efficacy of Adaptive DBS Vs Conventional DBS in Patients With Parkinson's Disease
This is an exploratory study to preliminary assess safety and efficacy of an adaptive Deep Brain Stimulation (DBS) closed-loop method in patients with PD.
- Trial name
- NCT03422757
- Testing
- adaptive Deep Brain Stimulation, conventional Deep Brain Stimulation
- Where
- 4 sites in Italy
- Volunteers
- 6 people
- Sponsor
- Newronika
Parkinson's Disease
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
The purpose of this registry is to compile characteristics of world-wide outcomes for the use of Boston Scientific's commercially available Vercise DBS System in the treatment of Parkinson's disease.
- Trial name
- NCT02071134
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 87 sites in United States, Argentina and 13 more
- Volunteers
- 1,500 people
- Sponsor
- Boston Scientific Corporation