Clinical trials: Deep Brain Stimulation
Alzheimer Disease
ADvance II Study: DBS-f in Patients With Mild Alzheimer's Disease
The primary efficacy objective of this study is to test the hypothesis that DBS-f stimulation (ON) will slow cognitive and functional progression of AD, as compared to no stimulation (OFF), by measuring baseline…
- Trial name
- NCT03622905
- Testing
- DBS-f On, DBS Off
- Where
- 21 sites in United States, Canada and 1 more
- Volunteers
- 74 people
- Sponsor
- Functional Neuromodulation Ltd
Parkinson's Disease (PD)
Coordinated Reset Deep Brain Stimulation
The study will explore the viability of an alternative/novel programming strategy in Deep Brain Stimulation (DBS) for patients with Parkinson's Disease (PD).
- Trial name
- RESET-DBS (NCT03732898)
- Testing
- Novel Programming (nDBS), Conventional Programming (cDBS)
- Where
- 2 sites in Germany
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Parkinson's Disease
Automated Parkinson's Disease (PD) Motor Symptom Assessment for Deep Brain Stimulation (DBS) Programming
The purpose of this study is to evaluate the utility of a portable motion sensor-based system designed to assist with deep brain stimulation (DBS) programming sessions for Parkinson's disease patients.
- Trial name
- NCT01429220
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Parkinson Disease, Idiopathic
Investigating Adaptive Deep Brain Stimulation in Parkinson's Disease Management
The goal of this prospective, multi-center, randomized, double-blind, crossover clinical trial is to evaluate the effectiveness and safety of adaptive DBS (aDBS) and conventional DBS (cDBS) delivered through the AlphaDBS system…
- Trial name
- ADVENT (NCT06891781)
- Testing
- Deep Brain Stimulation
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Newronika
Spinal Cord Stimulation, Deep Brain Stimulation
Implantable Systems Performance Registry
The Implantable Systems Performance Registry (ISPR) was developed to evaluate the long-term reliability and performance of market-released Medtronic Neuromodulation infusion and stimulation products.
- Conditions
- Spinal Cord Stimulation, Deep Brain Stimulation, Drug Infusion (Implantable Pumps), Sacral Neuromodulation
- Trial name
- ISPR (NCT00959296)
- Testing
- Various
- Where
- 50 sites in United States, Austria and 5 more
- Volunteers
- 10,981 people
- Sponsor
- MedtronicNeuro
Epilepsy
Medtronic Deep Brain Stimulation (DBS) Therapy for Epilepsy Post-Approval Study (EPAS)
The purpose of this post-approval study is to further evaluate the long-term safety and effectiveness of Medtronic DBS therapy for epilepsy on seizure reduction in newly implanted participants through 3 years of follow-up.
- Trial name
- EPAS (NCT03900468)
- Testing
- Activa™ PC and Percept™ PC Neurostimulation Systems
- Where
- 8 sites in United States, Czechia
- Volunteers
- 29 people
- Sponsor
- MedtronicNeuro
Opioid Addiction
PINS Stimulator System for Deep Brain Stimulation of the Nucleus Accumbens to Treat Severe Opioid Addiction
The purpose of this study is to verify efficacy and safety of a bilateral deep brain stimulation (DBS) of the Nucleus accumbens (NAc) as a treatment option for severe opioid addiction.
- Trial name
- NCT02282072
- Testing
- Deep brain stimulation：PINS Stimulation System
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Dystonia
Vercise™ DBS Dystonia Prospective Study
To compile characteristics of real-world outcomes of Boston Scientific Corporation's commercially approved VerciseTM Deep Brain Stimulation (DBS) Systems for the treatment of dystonia.
- Trial name
- NCT02686125
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 36 sites in Belgium, Canada and 10 more
- Volunteers
- 300 people
- Sponsor
- Boston Scientific Corporation
Parkinson Disease
Deep Brain Stimulation (DBS) for Parkinson's Disease International Study
To gather data on DBS Therapy effectiveness in different geographic populations.
- Trial name
- REACH-PD (NCT02937688)
- Testing
- Medtronic DBS Therapy for Parkinson's disease
- Where
- 15 sites in Brazil, China
- Volunteers
- 212 people
- Sponsor
- MedtronicNeuro
Parkinson Disease
NeuroGlove PD Study Clinical
Safety and Feasibility of Peripheral Sensory Stimulation of the Hand in the Treatment of Parkinson's Disease
- Trial name
- NCT06578273
- Testing
- NeuroGlove
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- NeuroGlove LLC
Parkinson Disease, Essential Tremor
Deep Brain Stimulation (DBS) Retrospective Outcomes Study
The primary objective of this study is to characterize real-world clinical outcomes of Deep Brain Stimulation (DBS) using retrospective review of de-identified patient records.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT03664609
- Testing
- Deep Brain Stimulation
- Where
- 20 sites in United States, Belgium and 4 more
- Volunteers
- 5,000 people
- Sponsor
- Boston Scientific Corporation
Tremor, Action Tremor
Deep Brain Stimulation (DBS) for the Suppression of Tremor
The purpose of the proposed study is to demonstrate the safety and efficacy of the ANS Totally Implantable Deep Brain Stimulation System in the VIM nucleus of the thalamus implanted for the treatment of tremor due to essential…
- Conditions
- Tremor, Action Tremor, Essential Tremor, Tremor, Limb
- Trial name
- NCT02087046
- Testing
- ANS Totally Implantable Deep Brain Stimulation System
- Where
- 12 sites in United States
- Volunteers
- 127 people
- Sponsor
- Abbott Medical Devices
Parkinson Disease
An Open-label Clinical Trial to Compare the Safety and Effectiveness of Adaptive Versus Conventional Deep Brain Stimulation
The clinical trial aims to evaluate the safety and effectiveness of bilateral subthalamic nucleus (STN) and Globus Pallidus internus (GPi) deep brain stimulation (DBS) with the AlphaDBS IPG System when programmed in adaptive…
- Trial name
- ADVENT (NCT05262348)
- Testing
- adaptive DBS delivered through AlphaDBS IPG System, conventional DBS delivered through AlphaDBS IPG System
- Sponsor
- Newronika
Parkinson's Disease
Satisfaction Survey on PINS Stimulator System for Patients With Parkinson's Disease
This study will be done because the investigators would like to evaluate product satisfaction of two PINS products (product A, product B) that are to evaluate the effectiveness of rechargeable and non-rechargeable Deep Brain…
- Trial name
- NCT02251808
- Where
- China
- Volunteers
- 612 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Machado Joseph Disease (SCA3)
The Influence of Deep TMS on Cerebellar Signs in Patients With Machado Joseph Disease
To test the effects of low frequency deep rTMS using the novel HCERMJD-coil on cerebellar deficits in patients with SCA3 and to establish its safety in this population.
- Trial name
- NCT02039206
- Testing
- Deep TMS
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Brainsway
Parkinson Disease, Movement Disorders
Deep Brain Stimulation to Treat Symptoms of Parkinson's Disease
The purpose of this study is to evaluate the safety and efficacy of bilateral stimulation of the subthalamic nucleus (STN) of the brain when using the ANS Totally Implantable Deep Brain Stimulation System as an adjunctive…
- Trial name
- NCT00552474
- Testing
- Libra Deep Brain Stimulation System
- Where
- 15 sites in United States
- Volunteers
- 136 people
- Sponsor
- Abbott Medical Devices
Idiopathic Parkinson Patients
MRI Compatible and Long-term LFP Recordable Deep Brain Stimulation on PD Patients
Deep Brain Stimulation represents the golden standard for surgical treatment of Parkinson's disease (PD), but it is not optimally effective for controlling every motor sign and adverse events are not so infrequent.
- Trial name
- NCT02937727
- Testing
- 3T MRI compatible and LFP recordable G106R of Beijing Pins medical.
- Where
- 3 sites in China
- Volunteers
- 10 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Parkinson Disease
directSTIM Deep Brain Stimulation System Study
The purpose of this study is to obtain clinical outcome data on safety and effectiveness of the directSTIM DBS system when used on-label, according to the instructions for use.
- Trial name
- NCT04329676
- Testing
- Deep Brain Stimulation
- Where
- 6 sites in Germany
- Volunteers
- 62 people
- Sponsor
- Aleva Neurotherapeutics SA
Essential Tremor
directSTIM™ Deep Brain Stimulation System Post-Market Clinical Follow-up Study on Essential Tremor
This is a prospective, multi-center, single arm post-market clinical follow-up study. The present study investigates a product authorized on the European market that will be used per its intended use, and all procedures involved…
- Trial name
- NCT05795218
- Testing
- Deep Brain Stimulation
- Where
- 5 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Aleva Neurotherapeutics SA
Obesity
PINS Stimulator System for Deep Brain Stimulation to Treat Obesity
The purpose of this clinical study is to verify the long term effecacy and safety of a bilateral deep brain stimulation (DBS) produced by Beijing PINS Medical Co., Ltd. as a treatment option for patients with obesity.
- Trial name
- NCT02254395
- Testing
- Deep Brain Stimulation
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Beijing Pins Medical Co., Ltd