Clinical trials: Deep Brain Stimulation
Obsessive Compulsive Disorder
Deep Brain Stimulation for Obsessive Compulsive Disorder (OCD PMCF)
The purpose of the study is to monitor the safety and performance of Reclaim® Deep Brain Stimulation (DBS) Therapy in patients with chronic, severe, treatment-resistant Obsessive Compulsive Disorder.
- Trial name
- NCT01135745
- Testing
- Reclaim® Deep Brain Stimulation
- Where
- 8 sites in Belgium, Germany and 5 more
- Volunteers
- 32 people
- Sponsor
- MedtronicNeuro
Parkinson's Disease
CUSTOM-DBS: Current Steering to Optimize Deep Brain Stimulation
The objective of the study is to compare different deep brain stimulation (DBS) settings using the commercially approved Boston Scientific Neuromodulation Vercise system.
- Trial name
- CUSTOM-DBS (NCT01896115)
- Testing
- Vercise DBS settings
- Where
- 10 sites in United States, Austria and 3 more
- Volunteers
- 40 people
- Sponsor
- Boston Scientific Corporation
Parkinson's Disease
Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
The purpose of this study is to evaluate the safety and effectiveness of Boston Scientific's Vercise Deep Brain Stimulation (DBS) system in the treatment of patients with with advanced, levodopa-responsive bilateral Parkinson's…
- Trial name
- INTREPID (NCT01839396)
- Testing
- Deep Brain Stimulation
- Where
- 22 sites in United States
- Volunteers
- 313 people
- Sponsor
- Boston Scientific Corporation
Stroke
Electrical Stimulation of the Dentate Nucleus for Upper Extremity Hemiparesis Due to Ischemic Stroke
This clinical trial will evaluate if Deep Brain Stimulation (DBS) is safe for the treatment of stroke and will help understand if DBS improves motor recovery for patients who continue to have significant impairment.
- Trial name
- EDEN (NCT02835443)
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Enspire DBS Therapy, Inc.
Parkinson's Disease
Retrospective, Non-significant Risk, Deep Brain Stimulation (DBS) Care Management Software Feasibility Study
To evaluate DBS device settings and match with the features of the DBS care management software.
- Trial name
- DBS (NCT01750242)
- Testing
- Medtronic DBS system
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- MedtronicNeuro
Parkinson Disease
Automated Deep Brain Stimulation Programming Using Functional Mapping
Participants will undergo DBS programming guided by the DBS-Expert system and by a clinician per standard care.
- Trial name
- DBS-Expert (NCT02765282)
- Testing
- Algorithm based programming using Kinesia-based assessment
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Parkinson's Disease
Deep Brain Stimulation Effects Study
The purpose of this study is to provide proof-of-concept that the test product can perform as intended in an intra-operative setting and the responses to the test product are perceivable in a person.
- Trial name
- NCT01098565
- Testing
- Study device HFR0001
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- MedtronicNeuro
Parkinson's Disease (PD), Deep Brain Stimulation
A Study of Buntanetap in Participants With PD
This study will examine the long-term safety of buntanetap in participants with PD. This will be a 36-month open-label safety study. This study will be conducted with two cohorts.
- Trial name
- NCT07284784
- Testing
- buntanetap/posiphen
- Where
- 27 sites in United States
- Volunteers
- 500 people
- Sponsor
- Annovis Bio Inc.
Parkinson Disease
DiSCERN: Advanced PD Therapy Candidacy and Evaluation System
To collect data to develop models that identify when patients with advanced Parkinson's disease (PD) are not responding well to their current therapy and may be ready to consider advanced therapy and when patients receiving…
- Trial name
- DiSCERN (NCT05351580)
- Testing
- DiSCERN
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Parkinson Disease
Clinical Evaluation of the Infinity Deep Brain Stimulation System
The purpose of this post-market study is to characterize the clinical performance of the Infinity Deep Brain Stimulation (DBS) system, including the Implantable Pulse Generator (IPG), directional DBS leads, extensions, iPad…
- Trial name
- PROGRESS (NCT02989610)
- Testing
- Omnidirectional stimulation, Directional stimulation
- Where
- 41 sites in United States, Australia and 6 more
- Volunteers
- 234 people
- Sponsor
- Abbott Medical Devices
Deep Brain Stimulation, Parkinson Disease
Visualization of the STN and GPi for DBS
The purpose of the study is to determine if using SIS System for DBS planning results in less distance between the planned target location and the actual implanted lead location than DBS planning without SIS System.
- Trial name
- VISION (NCT05774041)
- Testing
- SIS System
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Surgical Information Sciences Inc.
Parkinson's Disease
Effectiveness and Safety of Directional Deep Brain Stimulation for Parkinson's Disease
The purpose of this study is to demonstrate the safety and effectiveness of the PINS Deep Brain Stimulation (DBS) system, including the G107R/G107 IPG, L305/L306 directional leads, E204 extensions and related system components.
- Trial name
- NCT05992701
- Testing
- Directional deep brain stimualtion
- Where
- 9 sites in China
- Volunteers
- 26 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Depressive Disorder, Major, Unipolar Depression
Deep Brain Stimulation for Major Depressive Disorder
This study is designed as a prospective, multi-centered, double-blind, randomized, controlled 12-month pivotal study to evaluate the safety and efficacy of the ANS Libra® Deep Brain Stimulation System for patients with major…
- Trial name
- NCT00617162
- Testing
- Deep Brain Stimulation, Libra Deep Brain Stimulation System
- Where
- 13 sites in United States, Canada and 1 more
- Volunteers
- 125 people
- Sponsor
- Abbott Medical Devices
Parkinson's Disease, Tremor
Pilot Study for Automated Deep Brain Stimulation Programming
The clinical utility of deep brain stimulation (DBS) for the treatment of movement disorders such as Parkinson's disease has been well established; however, there is a great disparity in outcomes among DBS recipients due to…
- Conditions
- Parkinson's Disease, Tremor, Bradykinesia
- Trial name
- NCT02046863
- Testing
- Automated Programming
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Epilepsy
SANTE - Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy
The purpose of this research is to study the safety and effectiveness of bilateral stimulation of the anterior nucleus of the thalamus as adjunctive therapy for reducing the frequency of seizures in adults diagnosed with epilepsy…
- Trial name
- NCT00101933
- Testing
- Medtronic DBS Therapy for epilepsy
- Volunteers
- 157 people
- Sponsor
- MedtronicNeuro
Stroke, Acute, Venous Thromboembolism
GEKO Venous Thromboembolism Prevention Study
This multicentre, randomised geko™ venous thromboembolism (VTE) prevention study will prospectively collect clinical data on VTE occurrences in immobile patients after stroke, who will be randomised, on a 1:1 allocation, to…
- Conditions
- Stroke, Acute, Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT05476913
- Testing
- geko™ device
- Where
- 18 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- Firstkind Ltd
Dystonia
A Randomized Controlled Trail Comparing Subthalamic and Pallidal Deep Brain Stimulation for Dystonia
The purpose of this study was to compare the subthalamic nucleus(STN) with the globus pallidus internus(GPi) as a stimulation target for deep brian stimulation(DBS) for medically refractory dystonia.
- Trial name
- NCT02263417
- Testing
- Deep Brain Stimulation (DBS) of Gpi, Deep Brain Stimulation (DBS) of STN
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Parkinson Disease
Study to Characterize Acute and Chronic Directional Aspects of Deep Brain Stimulation
The primary objective is to characterize the programming effects of Boston Scientific Vercise™ PC System using the DBS Directional Lead for bilateral STN DBS for the treatment of Parkinson's disease in acute and chronic settings.
- Trial name
- DIRECT-DBS (NCT02835274)
- Testing
- BSC Deep Brain Stimulation System with Directional Lead
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 12 people
- Sponsor
- Boston Scientific Corporation
Parkinson Disease
Adaptive Deep Brain Stimulation (aDBS) Study (Early Adapter) Part II
The purpose of the study is to evaluate the efficacy of aDBS (preferred mode, single or dual threshold) vs standard continuous DBS (cDBS) in decreasing Total Electrical Energy Delivered (TEED).
- Trial name
- NCT07106242
- Testing
- Adaptive DBS, cDBS
- Where
- 2 sites in Japan
- Volunteers
- 25 people
- Sponsor
- MedtronicNeuro
Alzheimer's Disease
Deep Transcranial Magnetic Stimulation for Treatment of Alzheimer's Disease
The primary objective of this trial is to assess the ability of Transcranial Magnetic Stimulation with H coil to prefrontal cortex , with an addition of cognitive brain training, to improve cognitive performance in patients with…
- Trial name
- NCT01179373
- Testing
- TMS, H coil
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Brainsway