Clinical trials: Deep Brain Stimulation, open to volunteers
Neuro-Degenerative Disease
3T MRI in Patients With Deep Brain Stimulation (DBS)
Deep brain stimulation (DBS) is an established treatment for advanced Parkinson's disease, medically refractory tremor, dystonia and obsessive compulsive disorder.
- Trial name
- NCT03153670
- Testing
- fMRI
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University Health Network, Toronto
Parkinsons Disease, Deep Brain Stimulation
Udall Project 1 Aim 4
By defining the strength and direction of connectivity patterns at rest and during movement across the basal ganglia-thalamocortical (BGTC) network we will characterize the role of individual circuits in motor performance and…
- Trial name
- NCT05568199
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Parkinson Disease, Essential Tremor
Motor Network Physiology
The brain networks controlling movement are complex, involving multiple areas of the brain. Some neurological disorders, like Parkinson's disease (PD) and essential tremor (ET), cause abnormalities in these brain networks.
- Trial name
- NCT04957095
- Testing
- Apomorphine Injectable Solution, Subcortical Stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Texas Southwestern Medical Center
Subjective Cognitive Decline, Alzheimer Disease
Using Artificial Intelligence to Detect Early Signs of Alzheimer's Disease in People With Memory Concerns
AHEAD is a prospective, longitudinal, risk-stratified single-arm interventional study enrolling 300 patients with Subjective Cognitive Decline (SCD) at IRCCS San Raffaele Hospital, Milan, Italy.
- Conditions
- Subjective Cognitive Decline, Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- AHEAD (NCT07652931)
- Testing
- High-frequency Transcranial Magnetic Stimulation (TMS), Digital Cognitive Training, Structured Physical Exercise
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
Disorders of Consciousness
REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study
The RE-CONNECT study is an early feasibility study to establish the safety, feasibility, and efficacy of two central thalamic deep brain stimulation targets in patients with chronic disorders of consciousness.
- Trial name
- NCT07228286
- Testing
- Deep brain stimulation (DBS) electrode implantation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Samuel Snider, MD
Essential Tremor
The STEREO-DBS ET Study: 7-Tesla MRI Brain Network Analysis for Deep Brain Stimulation in Essential Tremor
Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for the patients with advanced essential tremor, despite optimal pharmacological treatment.
- Trial name
- STEREO-ET (NCT05909839)
- Testing
- 7T MRI network analysis for deep brain stimulation in essential tremor
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Freezing of Gait, Parkinson Disease
DBS and Levodopa for Treating Freezing of Gait in Parkinson's Disease
Freezing of gait (FoG) is a complex symptom of Parkinson's disease (PD) that cause falls and disability in PD patients, heavily affect patients' autonomy and quality of life.
- Trial name
- NCT06316232
- Testing
- STIM ON plus, MED ON plus
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Istituto delle Scienze Neurologiche di Bologna
Essential Tremor
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor.
- Trial name
- TRaNCE (NCT06293638)
- Testing
- Alcohol, Alprazolam, Cold Therapy
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Parkinson Disease
Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain…
- Trial name
- NCT04715984
- Testing
- Neurophysiology recordings, Neural stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Cognitive Decline, Alzheimer Disease
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
This study aims to explore a non-invasive way to improve memory and slow cognitive decline in older adults by enhancing sleep quality.
- Conditions
- Cognitive Decline, Alzheimer Disease, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
- Trial name
- NCT06669546
- Testing
- Phase-locked auditory stimulation (PLAS)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Parkinson Disease, Movement Disorders
Cognitive Decline Following Deep Brain Stimulation
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS.
- Trial name
- NCT05822388
- Testing
- Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Parkinson's Disease (PD)
Investigating Basal Ganglia-Cortical Physiology During Sleep and Its Modulation by Adaptive Deep Brain Stimulation in Parkinson Disease
This is an interventional study of a cohort of patients with PD treated with DBS, and already utilizing adaptive DBS (dual threshold mode).
- Trial name
- NCT07808346
- Testing
- adaptive DBS (aDBS)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease
Effects of RAS on Gait in PD Patients With DBS
Participants will be asked to walk along with the metronome beats (RAS) during the participants' stimulation state (ON or OFF) for four minutes for each state.
- Trial name
- NCT05763732
- Testing
- Rhythmic Auditory Stimulation (RAS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Parkinson's Disease and Parkinsonism
Mechanism and Application of DBS in the Treatment of PD
Project name: The mechanism and application of deep brain stimulation in the treatment of Parkinson's disease Objective: To test the hypothesis that electrical stimulation of substantia nigra regulates cognitive dysfunction in…
- Trial name
- NCT06400017
- Testing
- microelectrode stimulation of DBS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Laryngeal Dystonia, Adductor Spastic Dysphonia of Dystonia
Deep Brain Stimulation for Laryngeal Dystonia: From Mechanism to Optimal Application
Deep Brain Stimulation (DBS) is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia…
- Trial name
- NCT05506085
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Indiana University
Obsessive-Compulsive Disorder
Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder
The goal of this clinical trial is to learn if deep brain stimulation (DBS) works to treat refractory obsessive-compulsive disorder (OCD).
- Trial name
- NCT06660225
- Testing
- Medtronic Percept Deep Brain Stimulation Therapy [Therapeutic stimulation]
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nader Pouratian
Deep Brain Stimulation, Parkinson's Disease
EEG Measurements to Capture DBS-induced Electric Potentials
To measure the electric fields induced by DBS (deep brain stimulation) on the scalp and to improve electric field simulations, the investigators will measure EEG (electroencephalography) measurements with high sampling rates…
- Trial name
- NCT07115394
- Testing
- EEG recording
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Autism Spectrum Disorder
Medial Prefrontal Cortex Brain Magnetic Stimulation in Autism
Despite decades of research, no definitive, effective biological treatments exist for core symptoms of Autism Spectrum Disorder (ASD).
- Trial name
- NCT07770451
- Testing
- TMS
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Parkinson Disease
Minimal Electrophysiology and Imaging Enhanced Deep Brain Stimulation
The goal of this study is to learn if Deep Brain Stimulation (DBS) surgery can be streamlined for patients being treated for Parkinson's disease.
- Trial name
- MIXT-DBS (NCT06572150)
- Testing
- Deep Brain Stimulation - Minimal Electrophysiology, Deep Brain Stimulation - Standard
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Nova Scotia Health Authority
Parkinson Disease, Essential Tremor
Clinical Outcomes for Deep Brain Stimulation
The object of this study is to longitudinally collect clinical outcomes of patients receiving deep brain stimulation for movement disorders with the objective of making retrospective comparisons and tracking of risks, benefits…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT03992625
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Washington University School of Medicine