Clinical trials: Deep Dental Caries
Deep Carious Lesions
Clinical Performance of Resin Composite Restoration After Dentin Biomodification by Grape Seed Extract in Deep Carious Lesions.
This study will evaluate the clinical and radiographic performance of resin composite restoration after utilized a grape seed extract as dentin biomodification in vital teeth with deep occlusal carious lesions (ICDAS 5-6) after…
- Trial name
- GSE (NCT06780527)
- Testing
- 15% Grape seed extract as dentin pretreatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Primary Dental Caries
Effects of Partical Excavation in One Versus Two Procedures of Primary Deep Caries (PAPRICA)
Background: Deep caries is the most frequent reason for performing root canal treatments. Minimally invasive methods for the treatment of deep carious lesions might therefore be relevant to avoid pulp exposures and consequently…
- Trial name
- PAPRICA (NCT03696498)
- Testing
- Resin restoration (1 step), Resin restoration (2 steps)
- Where
- 11 sites in Denmark, Lithuania and 2 more
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Extremely Deep Caries, Pulpitis
Effectiveness of Pulpotomy vs. Root Canal Treatment in Extremely Deep Caries
Recent clinical trials comparing pulpotomy versus root canal treatment (RCT) have shown promising outcomes; however, the current evidence lacks generalisability to general practitioners.
- Trial name
- NCT07242742
- Testing
- Full Pulpotomy, root canal treatment and intracanal medicament
- Where
- Singapore
- Volunteers
- 93 people
- Sponsor
- National University Hospital, Singapore
Deep Carious Lesions, Caries Class I
A Comparative Study of Different Traditional and Bioactive Indirect Pulp Capping Materials
The protection of the dentin-pulp complex consists of the application of one or more layers of specific material between the restorative material and dental tissue to avoid additional challenge to the pulp tissue caused by…
- Conditions
- Deep Carious Lesions, Caries Class I, Caries Class II
- Trial name
- NCT06707311
- Testing
- patients received calcium hydroxide with glass ionomer restorative material, patients received TheraCal LC with glass ionomer restorative material, patients received bioactive bonding with glass ionomer restorative material
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Caries, Reversible Pulpitis
Management of Deep Carious Lesions in Adults
Dental caries is one of the most prevalent non-communicable disease. However, despite its prevalence there is no consensus on how much caries to remove prior to placing a restoration to achieve optimal outcomes.
- Trial name
- NCT05144711
- Testing
- Selective caries excavation, Non selective caries excavation
- Where
- Jordan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Caries, Dental
Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars
Objective: To assess which is the most efficient pulpotomy medicament on tooth survival in patients with a cariously-exposed vital young permanent molar regarding: absence of postoperative pain, sinus or swelling, internal/…
- Trial name
- NCT03119779
- Testing
- MTA-Anglus, TheraCal
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Partial Removal of Caries Dentines
The aim of this multicenter randomized controlled clinical trial is to evaluate the effectiveness of an alternative treatment for deep caries lesions in Public Health Services.
- Trial name
- PRCD (NCT00887952)
- Testing
- Partial removal of carious dentine, Stepwise excavation
- Where
- 2 sites in Brazil
- Volunteers
- 329 people
- Sponsor
- Federal University of Rio Grande do Sul
Dental Caries
Clinical Comparison of Restorative Materials
Composite resin materials are the first treatment choice in direct restorations due to their good mechanical properties, excellent esthetic properties, conservative preparation, and successful clinical performance.
- Trial name
- NCT06637605
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Deep Dental Caries
Randomized Clinical Trial for Primary Molar Pulpotomy, Biodentine Vs Formocresol-ZOE
This is a RCT that will compare the clinical and radiographic success of pulpotomies on primary molars between the traditional technique (Formocresol/ZOE) and the new technique with Biodentine.
- Trial name
- NCT02201498
- Testing
- Pulpotomies with Formocresol/OZE and Biodentine
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Deep Caries
Deep Marginal Acquisition With Thermacut Bur Vs. Functional Crown Lengthening in Deep Carious Lesions
this clinical trial is conducted to compare between deep marginal acquistion by the means of thermacut bur Vs. functional crown lengthening in exposing deep subgingival interproximal cervical lesions
- Trial name
- NCT06205459
- Testing
- deep marginal acquisition using thermacut bur
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Deep Caries
Multicenter Trial Comparing One-step Partial Caries Removal to Complete Caries Removal for the Treatment of Deep Carious Lesions in Permanent Teeth. (DECAT : DEep CAries Treatment).
This clinical trial is a national multicenter randomized controlled trial performed in parallel groups aiming to validate a treatment that preserves pulp vitality of mature permanent posterior teeth through partial removal of…
- Trial name
- DECAT (NCT02286388)
- Testing
- A one-step partial caries removal procedure for the treatment of deep carious lesions in posterior permanent teeth., A complete caries removal procedure for the treatment of deep carious lesions in posterior permanent teeth., The application of an antibacterial dental adhesive (ClearfilTM SE Protect, Kuraray Dental).
- Where
- 15 sites in France
- Volunteers
- 464 people
- Sponsor
- Hospices Civils de Lyon
Patients With Deep Carious Lesions, Deep Caries Lesion of Pemanent Teeth
A Comparative Clinical Study Assessing Dentin Thickness and Discoloration in Deep Carious Lesions Treated With Biodentine Alone Versus Diode Laser Pre-treatment Followed by Biodentine
This interventional clinical study aims to compare dentin thickness preservation and tooth discoloration in deep carious lesions treated with Biodentine alone versus diode laser pre-treatment followed by Biodentine.
- Conditions
- Patients With Deep Carious Lesions, Deep Caries Lesion of Pemanent Teeth, Deep Carious Lesion
- Trial name
- NCT07358442
- Testing
- Biodentin, Diode laser
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Misr International University
Dental Caries
A Clinical Study of KH001 for Pulp Preservation and Safety in Deep Dentin Caries
The Purpose of this Study is to Evaluate Pulp Preservation and Safety of KH001 in the Administration of Deep Dentin Caries.
- Trial name
- NCT07751016
- Testing
- KH001
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Seoul National University Dental Hospital
Patients With Deep Carious Lesions
Comparative Study Between Biodentine and Mineral Trioxide Aggregate in Direct Pulp Capping
Comparative study between Biodentine and MTA in direct pulp capping of deeply carious teeth.
- Trial name
- NCT02803528
- Testing
- Biodentine, MTA
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Deep Carious Lesions, Reversible Pulpitis
Indirect Pulp Capping With Biodentine and TheraCal LC in Permanent Mature Molars
Management of deep carious lesions in permanent mature molars with reversible pulpitis represents a challenge for clinicians. Vital pulp therapy includes indirect and direct pulp capping, partial pulpotomy and full pulpotomy.
- Conditions
- Deep Carious Lesions, Reversible Pulpitis, Indirect Pulp Capping
- Trial name
- NCT03741816
- Testing
- Indirect pulp capping
- Where
- Spain
- Volunteers
- 212 people
- Sponsor
- University of Valencia
Dental Caries in Children
Partial or Complete Excavation of Deep Caries in Primary Molars
Background: The traditional approach of carious lesions with risk for progression has has been to excavate all infected and demineralised tissue before placement of the restoration.
- Trial name
- PBRN (NCT04614285)
- Testing
- Partial excavation
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Caries
Selective Caries vs Stepwise Caries Removal Technique in Deep Carious Lesions
The aim of this clinical study is to compare and evaluate the Success of Selective Caries vs Stepwise Caries Removal Techniques in treatment of dental caries.
- Trial name
- NCT04375215
- Testing
- Selective caries removal, Stepwise caries removal
- Where
- India
- Volunteers
- 146 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Dental Caries, Reversible Pulpitis
The CAP-1 Trial: Stepwise Excavation Versus One Completed Excavation in Deep Caries
Brief summary Background: A large proportion of dental practice involves the treatment of caries in the permanent dentition. In USA alone tooth related pain is annually responsible for 15 billions days lost through sickness.
- Trial name
- NCT00187837
- Testing
- SW, DCE
- Where
- Denmark
- Volunteers
- 314 people
- Sponsor
- University of Copenhagen
Deep Caries, Dental Caries
Evaluation of Bioactive Giomer Material Versus Nanohybrid Resin Composite in Deep Marginal Elevation
This study will be conducted to evaluate the clinical, radiographic and periodontal performance of bioactive Giomer compared to nanohybrid resin composite restoration in deep subgingival proximal cavities extending below the CEJ…
- Trial name
- NCT06497231
- Testing
- Beautifil II LS, Nanohybrid resin composite material
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Evaluation of the Antibacterial Effect of Laser Diode and Zinc Oxide Nano Particles in Cavity Disinfection
this is a randomized controlled clinical trial, evaluating the antibacterial effect of laser diode and zinc oxide nano-particles when used as cavity disinfectants.Two groups, including 15 patients each, will be randomly allocated…
- Trial name
- NCT03478150
- Testing
- zinc oxide nano-particles, laser diode
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University