Clinical trials: Deep Endometriosis
Endometriosis Related Pain, Quality of Life
Bowel ENDOmetriosis; Evaluation of Diagnostics and Quality of Life
Endometriosis on the bowel is a benign condition that can cause major complaints and severely affect the quality of life of women of fertile age.
- Conditions
- Endometriosis Related Pain, Quality of Life, Pain, Chronic, Bowel Dysfunction
- Trial name
- ENDO (NCT03779256)
- Testing
- 2D transvaginal ultrasound
- Where
- 3 sites in Australia, Austria and 1 more
- Volunteers
- 207 people
- Sponsor
- Oslo University Hospital
Endometriosis
ENDOmetriosis Robotic Assisted Surgery
The purpose of this study is to compare the robot-assisted approach with the laparoscopic approach in terms of reducing the rates of intraoperative and postoperative complications in patients undergoing total hysterectomy for DIE…
- Trial name
- ENDO-RAS (NCT06445179)
- Testing
- Total Laparoscopic Hysterectomy, Ureterolysis
- Where
- 2 sites in France
- Volunteers
- 224 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Deep Infiltrating Endometriosis (DIE), Nerve Sparing Modified Radical Hysterectomy
Uterine Skeletonization for Deep Infiltrative Endometriosis (DIE) Hysterectomy
Endometriosis is characterized by the presence of endometrial glands and stroma outside the uterine cavity, accompanied by chronic inflammation.
- Conditions
- Deep Infiltrating Endometriosis (DIE), Nerve Sparing Modified Radical Hysterectomy, Uterine Skeletonization
- Trial name
- SKELETONDIE (NCT06802900)
- Testing
- Clinical Outcomes and Surgical Insights from Nerve-Sparing Hysterectomy with Uterine Skeletonization for Deep Infiltrative Endometriosis
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Endometriosis
Effect of Anti TNFa Upon Deep Endometriosis Associated Pain
Deep endometriosis associated pain is believed to be caused by inflammation. Anti TNFa has been proved to be an effective treatment for other inflammation related conditions as Crohn's disease Endometriosis is associated with an…
- Trial name
- Infliximab (NCT00604864)
- Testing
- anti TNFa monoclonal antibody - Infliximab
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- KU Leuven
Endometriosis, Parametrium, Surgery
The "Concept" of Parametria in the Treatment of Deep Infiltrating Endometriosis
Background Deep infiltrating endometriosis (DIE) is most commonly located at the uterosacral ligaments, rectovaginal septum, pararectal space and vesicouterine fold.
- Trial name
- NCT04671004
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Deep Infiltrating Endometriosis
Quality of Life and Fertility of Patient With Deep Surgical Endometriosis: a Prospective Cohort
Endometriosis is a common gynaecologic disease affecting 5 to 15% women of reproductive age and up to 40% of infertile women. It is characterized by the presence of active endometrial tissue outside the uterine cavity…
- Trial name
- ENDORAA (NCT03555903)
- Testing
- Endometriosis cohort
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Hospices Civils de Lyon
Deep Endometriosis Stage III, Deep Endometriosis Stage IV
ENDmetriosis and Reserve Ovarienne
Endometriosis is the ectopic implantation of endometrial glands and stroma, and can be ovarian and peritoneal (superficial or deep).
- Trial name
- ENDRO (NCT02400684)
- Testing
- blood samples
- Where
- 2 sites in France
- Volunteers
- 118 people
- Sponsor
- University Hospital, Strasbourg, France
Endometriosis, Endometriosis (Diagnosis)
Deep Endometriosis Affecting the Urogenital Tract: Long-term Outcomes and Impact on Renal Function
Endometriosis is a chronic estrogen-dependent disease characterized by the presence and growth of endometrium-like tissue outside the uterine cavity.
- Conditions
- Endometriosis, Endometriosis (Diagnosis), Urinary Tract Diseases
- Trial name
- RENDO (NCT07776574)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Charles University, Czech Republic
Endometriosis, Rectum
Functional Outcomes of Surgical Management of Deep Endometriosis Infiltrating the Rectum
The purpose of this study is to determine whether performing colorectal resection in deep endometriosis infiltrating the rectum is responsible for a higher rate of postoperative digestive and urinary dysfunction when compared to…
- Trial name
- ENDORE (NCT01291576)
- Testing
- Rectal/colorectal segmental resection, Rectal nodule excision
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Rouen
Endometriosis, Deep Endometriosis
Cohort of the Franco-European Multidisciplinary Institute of Endometriosis
Endometriosis is a chronic benign gynecological condition affecting 5 to 10% of women of reproductive age, often responsible for pelvic pain, digestive symptoms, and infertility, leading to a significant reduction in quality of…
- Conditions
- Endometriosis, Deep Endometriosis, Pelvic Pain
- Trial name
- IFEMEndo (NCT07243587)
- Testing
- OBSERVATIONAL
- Where
- France
- Volunteers
- 15,000 people
- Sponsor
- Clinique Tivoli Ducos
Endometriosis Pelvic
ENDOMED: Evaluation of the Evolution of Endometriosis Lesions on Imaging Under Medical Treatment
Endometriosis is a difficult disease to diagnose because the symptoms are varied, unspecific and inconsistent from one patient to another.
- Trial name
- ENDOMED (NCT05722314)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Endometriosis, Adhesion
New Cross Linked Hyaluronan Gel After Deep Infiltrating Endometriosis Surgery
Hyaluronan, a glycosaminoglycan found in connective tissues and extracellular matrix, has been postulated to reduce postoperative adhesions, because of its unconditioned biological functions at tissue repair but unfortunately it…
- Conditions
- Endometriosis, Adhesion, Quality of Life, Surgery
- Trial name
- HYALOENDOQoL (NCT04023383)
- Testing
- 40 cc HyaRegen NCH gel, 40 cc sterile saline solution
- Volunteers
- 60 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Endometriosis, Bowel Endometriosis
Mesenteric Sparing Surgery in Laparoscopic Colorectal Resection for Endometriosis
Colorectal resection is a standard surgical treatment of bowel deep infiltrating endometriosis (DIE). Nevertheless, concerns about different bowel functional outcomes related to radical surgery versus conservative surgery as…
- Conditions
- Endometriosis, Bowel Endometriosis, Constipation
- Trial name
- IRE-1 (NCT03565848)
- Testing
- Mesenteric vascular and nerve sparing surgery in laparoscopic segmental colorectal resection
- Volunteers
- 50 people
- Sponsor
- Università degli Studi dell'Insubria
Deep Infiltrating Endometriosis (DIE)
A Study to Describe the Efficacy of Diphereline Following Conservative Surgery in Deep Infiltrating Endometriosis (DIE) Patients Over a Period of 24 Months
The purpose of this study is to describe changes in the intensity of specific endometriosis symptoms from baseline pre-surgery to after surgery and subsequent continuous Diphereline (Triptorelin Acetate) treatment for up to 24…
- Trial name
- DIE-NIS (NCT01942369)
- Testing
- Triptorelin Acetate 3.75mg intramuscular injection
- Where
- 18 sites in China
- Volunteers
- 402 people
- Sponsor
- Ipsen
Deep Endometriosis, Surgery
Imaging Comparison for the Preoperative Planning and Diagnosis of DIE: a Multicenter Retrospective Study.
Several centers in Belgium use both transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) for the preoperative diagnosis of deep infiltrating endometriosis (DIE), while other centers rely almost exclusively on TVS.
- Conditions
- Deep Endometriosis, Surgery, Transvaginal Ultrasound, MRI
- Trial name
- NCT06994091
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Ziekenhuis Oost-Limburg
Endometriosis
Preoperative Staging of Endometriosis With MRI
The purpose of the study is to evaluate the value of MRI in preoperative stratification of endometriosis patients needing surgical approach by gynaecologists only or multidisciplinary approach by gynaecologists, urologists or/and…
- Trial name
- IDEAL (NCT01939535)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Deep Endometriosis, Surgery
Surgical TReatment of Women With Deep ENDometriosis
TrEnd trial is aimed to collect data from consecutive patients undergoing segmental sigmoid colon/rectal resection for deep endometriosis.
- Trial name
- TrEnd (NCT06386276)
- Testing
- Colorectal bowel resection
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Casa di Cura Privata 'Malzoni - Villa dei Platani' S.P.A.
Endometriosis
Ultrasonographic Characterization of Parametrial Lesions in Deep Endometriosis: A Diagnostic-Accuracy Study (ULTRA-PARAMETRENDO III)
This is a single-center, prospective diagnostic-accuracy study. All women who will undergo surgery for DE after preoperative ultrasound for six consecutive months will be included.
- Trial name
- NCT06017531
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Deep Infiltrating Endometriosis With or Without Bowel Involvement
Intraoperative Ultrasound in Bowel Deep Endometriosis
This study investigates the use of intraoperative transvaginal (IOTVUS) and/or endorectal ultrasound (IOERUS) in the surgical treatment of bowel deep infiltrating endometriosis (DIE).
- Trial name
- NCT06876376
- Testing
- intraoperative ultrasound for the assessment of bowel deep infiltrating endometriosis
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Fundacion Dexeus
Molecular Markers of Fibrosis of Single Types of Endometriosis and Their Use in Predicting Disease Severity
Molecular Markes of Fibrosis of Endometriosis and Their Use in Predicting Disease Severity
The primary aim of the project is to analyse gene expression in individual types of ectopic endometrium (ovarian endometriosis, peritoneal endometriosis, deep infiltrating endometriosis) and compare it with gene expression in…
- Trial name
- MMF (NCT06020482)
- Testing
- Molecular markes of fibrosis of single types of endometriosis and their use in predicting disease severity
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- General University Hospital, Prague