Clinical trials: Defect, Congenital Heart
Duchenne Muscular Dystrophy, Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy
Duchenne Muscular Dystrophy Heart Study
Retrospective cohort study including patients with genetically proven Duchenne muscular dystrophy, diagnosed from January 1993 to March 2020.
- Trial name
- DMD-HS (NCT03443115)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Hôpital Cochin
Heart Failure, Coronary Artery Disease
COVID-19 Testing in Underserved and Vulnerable Populations
As part of National Institutes of Health Rapid Acceleration of Diagnostics-Underserved Populations (RADx-UP) program, the goal of the RADxUP study is to develop, test, and evaluate a rapid, scalable capacity building project to…
- Conditions
- Heart Failure, Coronary Artery Disease, Cancer, Chronic Kidney Diseases
- Trial name
- NCT05315908
- Testing
- Community outreach method
- Where
- United States
- Volunteers
- 9,120 people
- Sponsor
- Jesse Nodora
Congenital Heart Disease
Copeptin- Relevance as a Perioperative Marker in Pediatric Cardiac Surgery
This study evaluates the relevance of Copeptin in children with congenital heart disease undergoing cardiac surgery with the need of cardiopulmonary bypass. Three blood samples are taken of each patient.
- Trial name
- NCT03316508
- Where
- Austria
- Volunteers
- 81 people
- Sponsor
- Claudia Herbst
Aortic Stenosis
Loss of Y Chromosome in Aortic Stenosis
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body.
- Trial name
- NCT06595407
- Testing
- Blood analysis for loss-of-Y chromosome
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Congenital Heart Disease
Impact of a Cardiac and Mental Health Rehab Program on Well-Being and Fitness in Young Adults With Fontan Circulation: A Randomized Trial
Helping Young Adults With Fontan Circulation Feel Better and Stay Active What is the study about? This study looked at how a special program could help young adults with Fontan circulation feel better mentally and physically.
- Trial name
- (NCTXXXXXXXX) (NCT06844149)
- Testing
- CPR; (Cardiac and Psychosocial Rehabilitation) with Cardiac Rehabilitation, CR; Home-Based Cardiac Rehabilitation, Usual Care
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Samsung Medical Center
Bleeding, Surgery
Trial of PCC Versus FFP in Patients Undergoing Heart Surgery
The PROPHESY trial is a single centre pilot trial investigating Fresh Frozen Plasma (FFP) or Prothrombin Complex Concentrate (PCC) treatment for patients who are bleeding during cardiac surgery, and who are NOT receiving a…
- Conditions
- Bleeding, Surgery, Transfusion
- Trial name
- PROPHESY (NCT03715348)
- Testing
- Prothrombin Complex Concentrate (PCC), Fresh Frozen Plasma
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Queen Mary University of London
Acyanotic Congenital Heart Disease, Cyanotic Congenital Heart Disease
Plasma Metanephrines in Patients With Cyanotic and Acyanotic Congenital Heart Disease
The aim of our study is to compare plasma metanephrines in patients with cyanotic and acyanotic congenital heart disease and possible association with chronic hypoxic stress.
- Conditions
- Acyanotic Congenital Heart Disease, Cyanotic Congenital Heart Disease, Pheochromocytoma, Paraganglioma
- Trial name
- NCT04891081
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Heterozygous Familial Hypercholesterolemia, Coronary Artery Disease
Efficacy and Safety Study of ISIS 301012 (Mipomersen) as Add-on in Familial Hypercholesterolemic Patients With Coronary Artery Disease
The purpose of this study is to determine whether mipomersen safely and effectively lowers low-density lipoprotein cholesterol (LDL-C) in patients with Heterozygous Familial Hypercholesterolemia (HeFH) and coronary artery disease…
- Trial name
- RADICHOL II (NCT00706849)
- Testing
- mipomersen sodium
- Where
- 48 sites in United States, Canada
- Volunteers
- 124 people
- Sponsor
- Kastle Therapeutics, LLC
Arteriovenous Fistula, Arteriovenous Graft
Access Creation for Hemodialysis: Association With Structural Changes of the Heart
The purpose of this study is to determine if the creation of a fistula or a graft plays a role in the development of heart disease for patients undergoing hemodialysis
- Conditions
- Arteriovenous Fistula, Arteriovenous Graft, Left Ventricular Hypertrophy, Brain Natriuretic Peptide
- Trial name
- NCT00368147
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Ottawa Hospital Research Institute
Pulmonary Hypertension
Study of Inhaled Iloprost for the Treatment of Pulmonary Hypertension After Repair of Congenital Heart Disease
The objective of this study was to assess the efficacy and appropriate dose of iloprost for inhalation in the treatment of postoperative pulmonary hypertension in children with congenital heart defects.
- Trial name
- NCT01320878
- Testing
- iloprost nebuliser solution, distilled water
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Coarctation of the Aorta
Large Diameter Advanta™ V12 Covered Stent Trial for Coarctation of the Aorta
This study is designed as a prospective, multicenter, non-randomized, single arm study to assess the safety and effectiveness of the Large Diameter Advanta™ V12 Covered Stent for stent implantation in coarctations of the aorta.
- Trial name
- NCT00978952
- Testing
- Large Diameter Advanta™ V12 Covered Stent
- Where
- 9 sites in Australia, Brazil and 5 more
- Volunteers
- 70 people
- Sponsor
- Atrium Medical Corporation
Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1
Troriluzole in Adult Participants With Spinocerebellar Ataxia
The purpose of this study is to compare the efficacy of Troriluzole (200 mg once daily) versus placebo after 48 weeks of treatment in subjects with spinocerebellar ataxia (SCA).
- Conditions
- Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3
- Trial name
- NCT03701399
- Testing
- troriluzole
- Where
- 23 sites in United States, China
- Volunteers
- 299 people
- Sponsor
- Biohaven Pharmaceuticals, Inc.
Congestive Heart Failure, Asthma
Remote Monitoring of High-Risk Patients With Chronic Cardiopulmonary Diseases
In this project, Institute of Bioengineering \& Bioimaging (IBB), A*STAR would like to collaborate with Massachusetts General Hospital to aggregate patient data and to further develop its software algorithm using machine learning…
- Conditions
- Congestive Heart Failure, Asthma, Chronic Obstructive Pulmonary Disease, Cystic Fibrosis
- Trial name
- NCT04825067
- Testing
- Respiratory Sensor measurements
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Institute of Bioengineering and Bioimaging (IBB)
Neurodevelopmental Abnormality, Congenital Heart Disease
The Swiss Neurodevelopmental Outcome Registry for Children With CHD
Introduction: Congenital heart disease (CHD) is the most frequent birth defect. As survival has significantly improved, attention has turned to neurodevelopmental outcomes of children undergoing heart surgery in early infancy.
- Conditions
- Neurodevelopmental Abnormality, Congenital Heart Disease, Cardiac Disease, Intensive Care Neurological Disorder
- Trial name
- SwissORCHID (NCT05996211)
- Where
- 3 sites in Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University Children's Hospital, Zurich
Heart Defects, Congenital, Heart Failure, Congestive
Trial of Angiotensin Converting Enzyme Inhibition in Infants With Single Ventricle--Pediatric Heart Network
This study will evaluate the efficacy and safety of administering an angiotensin converting enzyme inhibitor (ACE-I) (enalapril) to infants with a functional single ventricle.
- Trial name
- ISV (NCT00113087)
- Testing
- Enalapril
- Where
- 9 sites in United States, Canada
- Volunteers
- 230 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Congenital Heart Disease
Real-time 3-Dimensional Echocardiography for Assessment of Cardiac Function and Congenital Heart Disease
The propose of this study is to generate normative data of the tree-dimensional echocardiographic(3-DE) measurements for cardiac structure and function in a large cohort of normal infants, children,and adolescents.
- Trial name
- 3DE-CHD (NCT01300221)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Drexel University
Mitral Valve Insufficiency, Heart Failure
Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure
Mitral regurgitation (MR), also known as mitral insufficiency, is a condition in which the heart's mitral valve, located between two of the heart's main chambers, does not firmly shut, allowing blood to leak backwards within the…
- Trial name
- SMMART-HF (NCT00608140)
- Testing
- Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT)
- Where
- 9 sites in United States, Canada
- Volunteers
- 2 people
- Sponsor
- Duke University
Arrhythmogenic Cardiomyopathy, PKP2-ACM
A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM
An observational study to assess real-world patient characteristics and clinical course of disease in participants with PKP2-ACM.
- Conditions
- Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
- Trial name
- SNAPSHOT- PKP2 (NCT06976606)
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Lexeo Therapeutics
POX Range of Healthy Newborns at Different Altitudes, POX Threshold for Screening Major CHD in Neonates
POX Range and the Threshold for Screening Major CHD in Neonates at Different Altitudes
major CHD (Congenital Heart Disease) screening by POX (pulse oximetry) in sea-level areas is not fit for low, medium and high altitude areas, but the normal range of pulse oximetry at different altitude areas has not been studied…
- Trial name
- NCT04238104
- Testing
- no intervention
- Where
- 8 sites in China
- Volunteers
- 2,200 people
- Sponsor
- Children's Hospital of Fudan University
Congenital Heart Disease, Single Ventricle
Diffuse Myocardial Fibrosis in Fontan Patients
The purpose of this protocol is to measure the relaxation of the heart in subjects with single ventricles who have undergone the surgical Fontan procedure.
- Conditions
- Congenital Heart Disease, Single Ventricle, Myocardial Fibrosis
- Trial name
- NCT01929174
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Oregon Health and Science University
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