Clinical trials: Defect of Articular Cartilage
Cartilage Injury, Defect of Articular Cartilage
BioPoly RS Knee Registry Study for Cartilage Defect Replacement
Information will be collected on the pre-op and post-op clinical status of patients with focal cartilage defects of the femoral condyles treated with the BioPoly RS Partial Resurfacing Knee Implant, a permanent orthopaedic…
- Conditions
- Cartilage Injury, Defect of Articular Cartilage, Cartilage Damage
- Trial name
- NCT01473199
- Testing
- BioPoly RS Partial Resurfacing Knee Implant
- Where
- 5 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- BioPoly LLC
Knee Chondral or Osteochondral Defect
Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial
Numerous surgical techniques have been developped for the treatment of chondral and osteochondral defects of the knee. Among those techniques autologous chondrocyte transplantation (ACT) was promising but have potential…
- Trial name
- Cartipatch (NCT00560664)
- Testing
- Autologous chondrocytes transplantation, Mosaicoplasty
- Where
- 12 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Brest
Articular Cartilage Disorder of Knee, Cartilage Damage
Human ECM Implanted Within Microfracture Interstices & the Cartilage Defect in the Knee to Regenerate Hyaline Cartilage
HST003 is a human extracellular matrix designed for injection into the subchondral bone following microfracture surgery by an injection into the interstices created by the surgical awl and filling the full defect to help…
- Conditions
- Articular Cartilage Disorder of Knee, Cartilage Damage, Microfractures
- Trial name
- hECM;HST003 (NCT05082831)
- Testing
- microfracture surgery + HST003
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- Histogen
Defect of Articular Cartilage
Protected Versus Early Weight Bearing Post Microfracture Surgery
To test using a randomised control trial, whether conservative rehabilitation and protected weight bearing versus early weight bearing and accelerated rehabilitation affects patient outcomes post microfracture surgery of the knee.
- Trial name
- NCT02542566
- Testing
- Physiotherapy rehabilitation
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Cartilage Defects of the Knee
Long-term Safety and Efficacy of CartiFill After Microfracture Surgery in Knee Cartilage Defects
The purpose of this clinical trial is to evaluate the safety and efficacy of CartiFill implanted at the site of knee joint cartilage defect in a 6-year, long-term, follow-up investigation.
- Trial name
- NCT07621172
- Testing
- CartiFill, Microfracture
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Cellontech Co., Ltd.
Hip Arthroscopy, Articular Cartilage Defect
AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
This is a pilot multi-centre RCT of 40 patients (ages 18-55 years, inclusive) undergoing primary hip arthroscopy with a focal articular cartilage defect of the acetabulum to compare the effect of using autologous matrix-induced…
- Conditions
- Hip Arthroscopy, Articular Cartilage Defect, Microfractures
- Trial name
- REPAIR (NCT05402072)
- Testing
- Autologous matrix-induced chondrogenesis (AMIC)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Cartilage Diseases, Osteoarthritis
Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for articular cartilage defect of knee.
- Trial name
- NCT02291926
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Degeneration Articular Cartilage Knee
Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects
The purpose of this study is to determine whether CARTISTEM, a cell therapeutic product, is safe and effective in the treatment of articular cartilage defects of the knee as a result of ageing, trauma, or degenerative diseases.
- Trial name
- NCT01733186
- Testing
- CARTISTEM®
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Medipost, Inc.
Defect of Articular Cartilage, Osteochondritis Dissecans
Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage Regeneration
The Cartilage Autograft Implantation System (CAIS) is designed as a single surgical treatment of damaged knee cartilage using the subject's own healthy cartilage obtained from a non-weight or low weight-bearing region.
- Trial name
- CAIS (NCT00881023)
- Testing
- Microfracture, Cartilage Autograft Implantation System
- Where
- 29 sites in United States, Canada
- Volunteers
- 75 people
- Sponsor
- DePuy Mitek
Cartilage Disease
Non-interventional Study With NOVOCART® Inject in the Reconstruction of the Knee Cartilage Defects
Retrospective non-interventional study to evaluate safety and efficacy of NOVOCART® Inject in patients with full-thickness cartilage defects in the knee joint.
- Trial name
- RENOVO (NCT02941120)
- Where
- 7 sites in Germany
- Volunteers
- 245 people
- Sponsor
- Tetec AG
Articular Cartilage Lesion of the Femoral Condyle
Efficacy and Safety Study of co.Don Chondrosphere to Treat Cartilage Defects
This is a prospective, phase III, multicenter, open label, randomised clinical trial of co.don chondrosphere®, a three-dimensional autologous chondrocyte transplantation product (ACT3D-CS)compared to the procedure of…
- Trial name
- NCT01222559
- Testing
- co.don chondrosphere®, Microfracture
- Where
- 12 sites in Germany, Poland
- Volunteers
- 102 people
- Sponsor
- co.don AG
Chondral Lesion of the Knee, Meniscal Injuries
Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy
This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or…
- Conditions
- Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
- Trial name
- BMA (NCT06893302)
- Testing
- Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Cartilage Damage, Degenerative Osteoarthritis
UCMSC Transplantation in the Treatment of Cartilage Damage
The purpose of this study is to investigate the efficacy and safety of transplantation of umbilical cord mesenchymal stem cells（UCMSCs） in patient with Knee cartilage damage.
- Trial name
- NCT02776943
- Testing
- umbilical cord mesenchymal stem cells, Hyaluronic acid
- Volunteers
- 20 people
- Sponsor
- South China Research Center for Stem Cell and Regenerative Medicine
Cartilage or Osteochondral Defects in the Knee
COPLA® Cartilage Implant Pilot Clinical Trial
This is a first-in-human clinical, open label, non-randomized, prospective investigation to assess the initial safety and performance of the COPLA® cartilage implant.
- Trial name
- NCT05685316
- Testing
- COPLA® cartilage implant
- Where
- 6 sites in Estonia, Finland and 1 more
- Volunteers
- 20 people
- Sponsor
- Askel Healthcare Ltd
Acetabular Labrum Tear, Femoro Acetabular Impingement
Effect of PRP, PPP, & BMAC on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies
The goal of this clinical trial is to assess the effect of PRP/PPP/BMAC application on functional outcomes after hip arthroscopy to address acetabular labral pathologies. The main questions it aims to answer are: 1.
- Conditions
- Acetabular Labrum Tear, Femoro Acetabular Impingement, Chondral Defect, Bone Marrow Aspirate Concentrate
- Trial name
- PRP; PPP; BMAC (NCT06003101)
- Testing
- Bone marrow aspirate concentrate (BMAC), Control
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Massachusetts General Hospital
Articular Cartilage Defect
Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee
The objective of this trial is to demonstrate superior efficacy and safety of MACI compared with arthroscopic microfracture in the treatment of patients (aged 18 to 55 years) with symptomatic articular cartilage defects of the…
- Trial name
- SUMMIT (NCT00719576)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Microfracture
- Where
- 20 sites in Czechia, France and 5 more
- Volunteers
- 144 people
- Sponsor
- Vericel Corporation
Chondral Defect, Osteochondral Defect
EB-OC for the Treatment of Focal Chondral/Osteochondral Defects in the Knee
EB-OC is a tissue engineered osteochondral tissue graft comprising of a living tissue engineered cartilage layer attaching to a bone scaffold.
- Trial name
- NCT06895889
- Testing
- EB-OC Graft Implantation, Abrasion chondroplasty
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Epibone, Inc.
Defect of Articular Cartilage, Cartilage Injury
Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair
This is a proof-of-concept study to determine the safety and efficacy of a novel device to increase the reparative capacity of the knee.
- Conditions
- Defect of Articular Cartilage, Cartilage Injury, Osteoarthritis, Knee
- Trial name
- AURA (NCT02696876)
- Testing
- Arthroscopic synovial brushing, Microfracture
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University of Leeds
Defect of Articular Cartilage, Degenerative Joint Disease of Ankle and/or Foot
Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle
The objective of this study is to evaluate the efficacy and safety of Chondron (Autologus Chondrocyte) in patients with cartilage defects in their ankle for 18 months
- Conditions
- Defect of Articular Cartilage, Degenerative Joint Disease of Ankle and/or Foot, Ankle (Ligaments); Instability, Familial
- Trial name
- NCT02537067
- Testing
- CHONDRON
- Where
- 2 sites in South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Articular Cartilage Defect
A Study to Compare Two Techniques for Articular Cartilage Repair:ACIC Vs. MCIC
Study Title: A study to compare two articular cartilage repair techniques in the knee joint: Autologous Collagen Induced Chondrogenesis (ACIC) Vs. Mesenchymal Cell Induced Chondrogenesis (MCIC).
- Trial name
- NCT01984450
- Testing
- ACIC, MCIC, implant with a collagen + fibrin gel mixture
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Shetty-Kim Research Foundation