Clinical trials: Deficiency Disease
Iron Deficiency, Chronic Heart Failure
Effect of Ferric Carboxymaltose on Exercise Capacity in Patients With Iron Deficiency and Chronic Heart Failure
The purpose of this study is to confirm that treatment with IV ferric carboxymaltose improves exercise capacity, physical functioning and quality of life in patients with iron deficiency and chronic heart failure.
- Trial name
- EFFECT-HF (NCT01394562)
- Testing
- Ferinject (ferric carboxymaltose), Standard of Care
- Where
- Netherlands
- Volunteers
- 174 people
- Sponsor
- Vifor Pharma
AIDS, HIV Seropositivity
Investigation of the Psychosocial Factors Responsible for the Late Recourse to HIV Testing Within MSM
The present study will try to investigate and analyze the psycho-social hindrances and levers concerning the recourse to late HIV testing among the MSM population. This study is divided in two parts.
- Trial name
- ReTarD (NCT03661203)
- Testing
- Focus group, Individual interview, online self questionnaire
- Where
- 4 sites in France
- Volunteers
- 1,190 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV/AIDS
Comparison of the Body Roundness Index and A Body Shape Index With Body Fat and Visceral Fat in People Living With HIV.
The study compares the Body Roundness Index (BRI) and the A Body Shape Index (ABSI) with with body fat and visceral fat in people living with HIV.
- Trial name
- NCT07203261
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Queens College, The City University of New York
Infection, Human Immunodeficiency Virus, HIV Infections
Safety and Efficacy Study of GSK2838232 in Human Immunodeficiency Virus (HIV)-1 Infected Adults
GSK2838232 is a novel HIV-1 maturation inhibitor (MI) that is being developed for the treatment of HIV-1 infection in combination with other antiretroviral therapy (ART).
- Trial name
- NCT03045861
- Testing
- GSK2838232, Cobicistat
- Where
- 14 sites in United States, Canada
- Volunteers
- 33 people
- Sponsor
- GlaxoSmithKline
Common Variable Immunodeficiency, Vascular Diseases
Composition and Function of Gut Microbiota in Porto-sinusoidal Vascular Disease Associated With Variable Common Immunodeficiency
This aim of this study is the evaluation of the gut microbiota imbalance occurrence and its characterization in patients with common variable immunodeficiency associated to an enteropathy with or without porto-sinusoidal vascular…
- Trial name
- MI-MVPS (NCT05481554)
- Testing
- Stool sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infection
Drug Interactions Among Anti-HIV Agents
This study examined the interactions of various drugs used to treat HIV infection in order to design larger studies of possible combinations for people who continue to have high viral levels despite combination therapy.
- Trial name
- NCT00001766
- Testing
- Amprenavir, Efavirenz, Abacavir, Nelfinavir, Ritonavir
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
CTLA4 Haploinsufficiency
Neurologic and Immunologic Characteristics of CTLA-4 and LRBA Hereditary Deficiency
CTLA4 and LRBA deficiencies are rare genetic disorders, recently described, and associated with multiple clinical features. It ranges from recurrent infections, auto-immunity, and organ infiltration with lymphocytes.
- Trial name
- NCT05040256
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Urothelial Bladder Cancer, Gastric Adenocarcinoma
Basket Trial Exploring the Efficacy and Safety of the Combination of Niraparib and Dostarlimab
Treatment will consist of a PARP inhibitor (niraparib) monotherapy priming period (cycle 0; 21 days); an anti-PD-1 antibody (Dostarlimab ; TSR-042) will then be added from C1D1 every 21 days in combination for the first 4 cycles…
- Conditions
- Urothelial Bladder Cancer, Gastric Adenocarcinoma, Gastro-oesophageal Adenocarcinoma, Head and Neck Cancer
- Trial name
- NIRADO (NCT04779151)
- Testing
- Dostarlimab, Niraparib
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Primary Immunodeficiency
Safety and Pharmacokinetics of IGSC 20% in Subjects With Primary Immunodeficiency
This study was designed to determine a dose of weekly subcutaneously administered Immune Globulin Subcutaneous (Human), 20% Caprylate/Chromatography Purified (Grifols) (IGSC 20%) that produces steady-state AUC of total IgG that…
- Trial name
- NCT02604810
- Testing
- IGIV-C 10%, IGSC 20%
- Where
- 25 sites in United States, Canada
- Volunteers
- 53 people
- Sponsor
- Grifols Therapeutics LLC
Hereditary Angioedema Types I and II
Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema
The objective of this study is to evaluate the safety and tolerability of a single Subcutaneous (SC) dose of Ecallantide in children and adolescents with Hereditary Angioedema (HAE).
- Trial name
- NCT01832896
- Testing
- Ecallantide subcutaneous dosing
- Where
- United States
- Sponsor
- NYU Langone Health
HIV/AIDS, Hepatitis C
Project I Test: Implementing HIV Testing in Opioid Treatment Programs
This study will test two active evidence-based "practice coaching" (PC) interventions to improve opioid treatment programs' (OTPs') provision and sustained implementation of on-site 1) HIV testing and linkage to care and 2)…
- Conditions
- HIV/AIDS, Hepatitis C, Substance Use Disorders, Opioid-use Disorder
- Trial name
- NCT03135886
- Testing
- Information Control, HIV and HCV Testing Practice Coaching Intervention, HIV Testing Practice Coaching Intervention
- Where
- United States
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Columbia University
Intrauterine Growth Retardation, Low Birth Weight
Effect of Prenatal Nutritional Supplementation on Birth Outcome in Hounde District, Burkina Faso
Low birth weight (LBW; birth weight<2,500g) is the most important determinant of mortality and morbidity in the neonatal period.
- Trial name
- MISAME2 (NCT00909974)
- Testing
- UNIMMAP - multiple micronutrients, Food supplement enriched with multiple micronutrients
- Where
- Burkina Faso
- Volunteers
- 1,302 people
- Sponsor
- Institute of Tropical Medicine, Belgium
HIV Testing, HIV Infections
Near Patient Study of the OraQuick ADVANCE® HIV-1/2 Rapid Antibody Test in Oral Fluid and Fingerstick Whole Blood
Point-of-care (POC) tests for HIV are easy to use, rapid and provide accurate results while the patient is still in-front of a healthcare provider (HCP).
- Trial name
- NCT04810559
- Testing
- OraQuick ADVANCE® HIV-1/2 Rapid Antibody Test
- Where
- 4 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Vitamin D Deficiency, Osteoporosis
Does Vitamin D Alter Bone's Response to Vibration?
Fractures in children are common and the incidence is increasing. They are more common in children who have small, narrow and weak bones.
- Trial name
- NCT02743559
- Testing
- Mechanical Stimulation using whole body vibration
- Where
- United Kingdom
- Sponsor
- Sheffield Children's NHS Foundation Trust
HIV Infections
Use of Amphetamine-type Stimulants & Its Relationship With HIV Incidence and Antiretroviral Adherence Among MSM and TG
There are two stages in the study. In Stage 1, 2000 Thai MSM, MSW and TGW/TGSW will be screened at the Thai Red Cross Anonymous Clinic (TRCAC) or Besides walk-in clients of TRCAC, potential participants could be referred to TRCAC…
- Trial name
- NCT03198962
- Where
- Thailand
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
Cancer Breast, Hypovitaminosis D
Influence of Preoperative Vitamin D Level on Postoperative Pain in Breast Cancer Surgery Patients
Vitamin D deficiency is a general problem that vigorously affects human health . Breast cancer is the most frequently diagnosed life-threatening cancer in women and the leading cause of cancer death among women.Vitamin D…
- Trial name
- NCT06551688
- Testing
- Serum 25(OH)D level
- Where
- Egypt
- Volunteers
- 184 people
- Sponsor
- Fayoum University
Vitamin D Deficiency
Effect of Vitamin D3 and Omega-3FA on Leptin and HbA1C With Vitamin D Deficiency
The Combined effect of Vitamin D3 and Omega-3 supplements on serum leptin and Glycated hemoglobin (Hb A1C) levels in Jordanian people with vitamin D deficiency.
- Trial name
- NCT03735303
- Testing
- VD3 group, omega 3 FA group, VD3 and omega- 3FA group
- Where
- Jordan
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Applied Science Private University
Heart Failure, Iron-deficiency
Beneficial Effects of Vitamin D Combined With Oral Iron Supplementation in Patients With Chronic Heart Failure and Iron Deficiency
The goal of this randomized, controlled, open-label, interventional study is to evaluate whether, in patients with heart failure (HF) and iron deficiency (ID), the administration of vitamin D in combination with sucrosomial iron…
- Conditions
- Heart Failure, Iron-deficiency, Heart Failure, Systolic, Heart Failure NYHA Class II
- Trial name
- VICTORID-HF (NCT05702970)
- Testing
- Sucrosomial iron, Vitamin D, Ferric Carboxymaltose 50 MG/ML
- Volunteers
- 258 people
- Sponsor
- University of Padova
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)
The investigators are doing this research study to look at the relationship between testosterone (the main sex hormone in men) and insulin (the hormone that controls blood sugar levels) in men with Idiopathic Hypogonadotropic…
- Trial name
- NCT03118479
- Testing
- Anastrozole Pill, Testosterone
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
HIV Infections, Lipodystrophy
SHARE: Simple HAART With Abacavir, Reyataz, and Epivir
SHARE: Simple HAART with Abacavir, Reyataz, and Epivir
- Trial name
- NCT00426296
- Testing
- atazanavir (Reyataz), ritonavir (Norvir)
- Where
- United States
- Sponsor
- Clinical Alliance for Research & Education - Infectious Diseases, LLC.
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