Clinical trials: Degenerative Arthritis
Knee Osteoarthritis, Osteoarthritis of the Knee
Postmarketing Multicenter Study of Intra-Articular DIART ONE / EASYGO ONE for Knee Osteoarthritis
This study looked at how safe and effective a hyaluronic acid-based injection (called DIART ONE or EASYGO ONE) is for people with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Osteoarthritis of the Knee, Degenerative Joint Disease
- Trial name
- NCT06927934
- Where
- Ukraine
- Volunteers
- 55 people
- Sponsor
- Yuria-Pharm
Osteoarthritis, Knee
Calypso Knee System Clinical Study, OUS
A study to evaluate the safety and effectiveness of the Calypso Knee System when used in subjects with symptomatic osteoarthritis of the medial compartment of the knee.
- Trial name
- NCT03838978
- Testing
- Calypso Knee System (Implantable Shock Absorber)
- Where
- 5 sites in Belgium, Poland
- Volunteers
- 81 people
- Sponsor
- Moximed
Osteoarthritis, Osteo Arthritis Knee
Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Osteoarthritis
The purpose of this study is to test safety and efficacy of study drug LY3526318 in for the treatment of knee pain due to with osteoarthritis (OA).
- Trial name
- NCT05080660
- Testing
- LY3526318
- Where
- 30 sites in United States, Puerto Rico
- Volunteers
- 160 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis, Knee
An Intervention Study Evaluating the Effects of a Raspberry Leaf Extract in an Osteoarthritic Population.
A double-blind, randomized, placebo-controlled clinical study to evaluate the efficacy of raspberry extract to alleviate symptoms of osteoarthritis in the knee.
- Trial name
- NCT03703024
- Testing
- Raspberry Leaf Extract
- Where
- Ireland
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Knee Osteoarthritis
A Comparative Study on the Safety and Efficacy of the Intra-Articular Injectable Filler ALLOHEAL in Patients With Knee Osteoarthritis
ENDOVISION Co., Ltd. has developed an intra-articular knee injection with sodium polynucleotide, chitosan, and type I collagen as its main components, and aims to demonstrate the non-inferiority of the investigational device…
- Trial name
- ALH-CT-01 (NCT07513415)
- Testing
- ALLOHEAL, Conjuran
- Where
- South Korea
- Volunteers
- 286 people
- Sponsor
- Endovision Co., Ltd.
Knee Osteoarthritis
Total Knee Arthroplasty With Vitamin E Polyethylene
The aim of this observational study is to investigate if there is any difference in survival rate, clinical and radiological results after total knee replacement with vitamin E-blended polyethylene in comparison to conventional…
- Trial name
- NCT05810285
- Testing
- GKS Prime Flex Mobile knee
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- Permedica spa
Osteoarthritis
Uniglide™ Mobile Bearing Unicondylar Knee System vs the Uniglide™ Fixed Bearing Unicondylar Knee System
The purpose of this study is to demonstrate that the Uniglide™ Mobile Bearing Unicondylar Knee System (investigational device)is not inferior when compared to the Uniglide™ Fixed Bearing Unicondylar Knee System (control device…
- Trial name
- MBK (NCT00740376)
- Testing
- Uniglide Mobile Bearing Unicondylar Knee System, Uniglide Fixed Bearing Unicondylar Knee System
- Where
- 6 sites in United States
- Volunteers
- 37 people
- Sponsor
- Corin
Moderate Pain in Knee Osteoarthritis, Severe Pain in Knee Osteoarthritis
A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis
Primary Objective: To explore the effectiveness of different doses of HRS-2129 in the treatment of patients with moderate to severe pain in knee osteoarthritis.
- Trial name
- NCT07351968
- Testing
- HRS-2129 Tablet, Celecoxib capsule
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Osteoarthritis, Osteoarthritis, Knee
A 12-Week Home-Based Electrical Stimulation Program for Strength in Adults With Knee Osteoarthritis
The purpose of this research is to investigate if a 12-week program of stimulation assisted activities can combat disuse atrophy for individuals diagnosed with knee osteoarthritis (KOA).
- Trial name
- NCT05765435
- Testing
- 12-week exercise and walking program, NMES, FES
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cionic, Inc.
Osteoarthritis, Osteoarthritis, Hip
Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Hip
To study the efficacy and safety of Naproxcinod vs. Placebo and Naproxen in the treatment of signs and symptoms of Osteoarthritis.
- Trial name
- NCT00541489
- Testing
- Naproxcinod, Naproxen
- Where
- 48 sites in United States, Canada
- Volunteers
- 800 people
- Sponsor
- NicOx
Symptomatic Osteoarthritis of the Knee
Phase III Study on the Safety and Efficacy of a Single Intra-articular Administration of JTA-004 in Symptomatic Knee Osteoarthritis
Osteoarthritis is a degenerative, chronic, and progressive joint disease considered as the most common joint disorder worldwide. In healthy joints, there is a continuous process of natural breakdown and repair of cartilage.
- Trial name
- JTA-KOA2 (NCT04333160)
- Testing
- JTA-004, Hylan G-F 20
- Where
- 22 sites in Belgium, Czechia and 5 more
- Volunteers
- 746 people
- Sponsor
- Bone Therapeutics S.A
Osteoarthritis, Avascular Necrosis
A Clinical Investigation of the Oxford® Meniscal Unicompartmental Knee System
The purpose of this study is to collect information on complications and survivorship of patients implanted with the Oxford™ Meniscal Unicompartmental Knee System at multiple sites in the United States.
- Trial name
- NCT00578994
- Testing
- Oxford® Meniscal Unicompartmental Knee System
- Where
- 6 sites in United States
- Volunteers
- 388 people
- Sponsor
- Biomet Orthopedics, LLC
Osteoarthritis of Knee
RCT on the Performance and Safety of LightForce® Therapy Lasers on Knee Osteoarthritis Pain Reduction (SPARK)
DJO UK Ltd (ENOVIS) is conducting this study to assess the effectiveness of LightForce® Therapy Lasers on pain reduction in subjects with unilateral or bilateral knee osteoarthritis.
- Trial name
- SPARK (NCT06654739)
- Testing
- Laser therapy + physiotherapy/exercise protocol
- Where
- 7 sites in France, Italy and 1 more
- Volunteers
- 64 people
- Sponsor
- DJO UK Ltd
Proximal Humerus Fracture, Posttraumatic Arthrosis After Humeral Head Fracture
PMCF Study on the Safety, Performance and Clinical Benefits Data of the Anatomical Shoulder 2.0 Fracture System
The study is a multicenter, retrospective and prospective, non-randomized, non-controlled and consecutive series post-market study.
- Conditions
- Proximal Humerus Fracture, Posttraumatic Arthrosis After Humeral Head Fracture, Posttraumatic Necrosis of the Humeral Head
- Trial name
- NCT05351112
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis, Osteoarthritis
A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery
The purpose of this study is to monitor the performance and determine the metal ion release of the DePuy ASR™ System in the treatment of patients with hip joint disease requiring hip resurfacing surgery.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872794
- Testing
- DePuy ASR™ Hip System
- Where
- South Africa
- Volunteers
- 50 people
- Sponsor
- DePuy International
Knee Osteoarthritis
Post-market Study on TrHCROSS® in Knee Osteoarthritis After a Single Injection
Double-blind study assessing the safety and efficacy of TrHCROSS® in knee osteoarthritis, compared to Hyalone®, using scales such as WOMAC, VAS, and KOOS.
- Trial name
- NCT06975631
- Testing
- TrHCROSS®, Hyalone®
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- i+Med S.Coop.
Knee Osteoarthritis
Efficacy and Safety of ELIXCYTE Intra-articular Injection in Subject With Knee Osteoarthritis
This is a Phase III, double-blinded, placebo-controlled, multicenter study to investigate the efficacy and safety of a new study intervention, ELIXCYTE, compared to placebo (normal saline) in subjects with knee osteoarthritis.
- Trial name
- NCT05526001
- Testing
- ELIXCYTE, Saline
- Where
- 4 sites in Taiwan
- Volunteers
- 165 people
- Sponsor
- UnicoCell Biomed CO. LTD
Osteoarthritis, Rheumatoid Arthritis
Cormet Large Diameter Metal on Metal (LDMOM) Total Hip System (G030265)
To demonstrate the safety and efficacy of the Cormet Large Diameter Metal on Metal (LDMOM) Total Hip System using a composite clinical success (CCS) primary endpoint.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Avascular Necrosis
- Trial name
- NCT00867256
- Testing
- Large Diameter Metal on Metal
- Volunteers
- 195 people
- Sponsor
- Corin
Knee Osteoarthritis
Assessment of Patients Quality of Life Treated With Three ARTHRUM H 2% Joint Injections
The reduction of functional limits and disablilities induced by knee osteoarthritis as well as improvement of patients quality of life is a public health need registered amongst the priorities established by the French law of…
- Trial name
- ART-QUALIVIE (NCT02840422)
- Testing
- ARTHRUM H 2%
- Volunteers
- 138 people
- Sponsor
- LCA Pharmaceutical
Healthy
First-in-Human Trial of Anti-ADAMTS-5 Nanobody in Healthy Volunteers
This First-In-Human trial will be conducted in healthy male subjects to explore the safety, tolerability, immunogenicity, pharmacokinetics, and pharmacodynamics of single doses of M6495.
- Trial name
- NCT03224702
- Testing
- M6495
- Where
- Denmark
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany