Clinical trials: Degenerative Arthritis
Osteoarthritis, Pain
A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers
A First-in-Human, Double-blind, Randomized, Placebo-controlled, Single Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics/Pharmacodynamics of iN1011-N17 after Oral Administration in Healthy Volunteers.
- Conditions
- Osteoarthritis, Pain, Post Herpetic Neuralgia, Neuropathic Pain
- Trial name
- NCT05496205
- Testing
- iN1011-N17
- Where
- Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- iN Therapeutics Co., Ltd.
TKA, Knee Osteoarthritis
Wearable Electrogoniometry-Based Telerehabilitation After Total Knee Arthroplasty
This study evaluated a wearable electrogoniometry-based telerehabilitation system designed to support recovery after total knee arthroplasty.
- Trial name
- NCT07779122
- Testing
- Wearable Electrogoniometry-Based Telerehabilitation System, Standard Home-Based Rehabilitation Program
- Where
- Chile
- Volunteers
- 82 people
- Sponsor
- University of Chile
Osteoarthritis
Chinese Herbal Fumigation With Acupuncture for the Knee Osteoarthritis
To evaluate the effect of fumigation in conjunction with acupuncture for knee osteoarthritis, participators were collected from acupuncture and Chinese traumatology clinic at Linsen Chinese Medicine and Kunming Branch, Taipei…
- Trial name
- NCT03659370
- Testing
- Fumigation, Acupuncture
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Taipei City Hospital
Osteoarthritis, Knee
Effect of Transcutaneous Electrostimulation (TENS) on Pain and Physical Function in Patients With Knee Osteoarthritis
The proposed study is a multi-center, randomized, double blind (patient and assessor), sham controlled clinical trial using a parallel 2 group design recruiting 220 patients of at least 18 years of age.
- Trial name
- ETRELKA (NCT01875042)
- Testing
- TENS
- Where
- Switzerland
- Volunteers
- 220 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Knee Arthritis, Knee Osteoarthritis
Gold Factor on Knee Joint Health and Function
The purpose of this clinical study was to determine whether gold nanoparticles (AuNP) supplement holds clinical value in improving joint health, function, and quality of life for arthritis patients.
- Conditions
- Knee Arthritis, Knee Osteoarthritis, Knee Pain Chronic, Knee Discomfort
- Trial name
- NCT05347602
- Testing
- Gold Factor (Gold Nanoparticles, AuNPs)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- 4Life Research, LLC
Arthrosis of Hand
DIGItal Cohort Osteoarthritis Design
Introduction Osteoarthritis is a chronic disease characterized by a progressive degradation of articular cartilage. Hand OA involves symptomatically more than 1 million of subjects in France (i.e., painful or with functional…
- Trial name
- DIGICOD (NCT01831570)
- Testing
- GENETIC and radiographs
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hand Osteoarthritis
Pulsed Radiofrequency Therapy for Hand OsteoArthritis Pain
Different types of pain may be present in patients with hand osteoarthritis, including nociceptive pain and non-nociceptive pain. This makes adequate pain treatment difficult, and thus new treatment options are needed.
- Trial name
- PROAP (NCT05217979)
- Testing
- Transcutaneous pulsed radiofrequency
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
BC Study of G7 Cup and Compatible Femoral Stems
A prospective , observational, multi-centre, cohort study of the G7™ Acetabular System used with compatible femoral stems in patients with degenerative disease of the hip. The study will be enrolled onto Beyond Compliance.
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis
- Trial name
- NCT03456622
- Where
- United Kingdom
- Volunteers
- 230 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2)
The knee osteoarthritis is a frequent degenerative condition that mainly affects subjects over 60, population often weakened by numerous comorbidities and concomitant treatments, justifying the development of new therapies.
- Trial name
- PANDORA2 (NCT05978180)
- Testing
- Medical Device : HO-1, Medical Device : HS-3, Medical Device : SINOVIAL® ONE
- Where
- 35 sites in France, Monaco
- Volunteers
- 252 people
- Sponsor
- Labrha
Knee Pain Chronic
Genicular RFT vs Phenol Management in Patients With Knee Osteoarthritis
The aim of this study was to compare the efficacy of phenol and radiofrequency ablation for genicular nerve neurolysis in severe knee pain.
- Trial name
- NCT05908942
- Testing
- Nerve ablation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Diskapi Teaching and Research Hospital
Shoulder Disease, Shoulder Impingement
Cross-sectorial Use of Patient-Reported Outcomes in Chronic Degenerative Shoulder Conditions
This research project aims to test if systematic (extensive) use of patient-reported outcomes across treatment boundaries can 1.
- Conditions
- Shoulder Disease, Shoulder Impingement, Shoulder Osteoarthritis, Shoulder Frozen
- Trial name
- C-PRO (NCT06435494)
- Testing
- Systematic use of patient reported outcome measures in clinical work with the patients
- Where
- 6 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Osteoarthritis, Knee
Proximal Tibial Open Wedge Osteotomy. A Clinical Prospective, Randomized RSA-trial.
In the treatment of osteoarthritis of the medial compartment of the knee, Open wedge high tibial osteotomy is a good choice of treatment for the young and active patient.
- Trial name
- NCT00319280
- Testing
- bonesubstitution (Calcibon, Iliac Crest Bonegraft, control)
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Osteoarthritis, Knee
A Study Comparing Viscosupplementation and Corticosteroid Injections for Knee Osteoarthritis
Do differences exist between patients who receive a single intra-articular injection of corticosteroid versus patients who receive a single intra-articular injection of hyaluronic acid for the treatment of knee osteoarthritis at…
- Trial name
- NCT01132677
- Testing
- Hylan G-F 20 (Synvisc One), Methylprednisolone (Corticosteroid)
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- LifeMark Health
Knee Osteoarthritis
Placebo Response of Different Types of Sham Acupuncture for Knee Osteoarthritis
This study aims to conduct a randomized controlled trial to investigate the difference in clinical efficacy and blinding effect between real acupuncture and various sham acupuncture techniques.
- Trial name
- PSAKOA (NCT06675981)
- Testing
- Real Acupuncture, Non-acupuncture at real-acupoint, Shallow acupuncture at real-acupoint
- Where
- 2 sites in China
- Volunteers
- 150 people
- Sponsor
- West China Hospital
Knee Osteoarthritis
A Study of Alendronate Sodium Vitamin D3 Tablets on Knee Osteoarthritis
The purpose of this study is to evaluate the effect of alendronate sodium vitamin D3 tablets compared with placebo on the improvement of joint structure and joint pain in participants with knee osteoarthritis.
- Trial name
- NCT04739592
- Testing
- alendronate sodium vitamin D3 tablets
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Osteoarthritis Knees Both
The Synergistic Effects of Intra-articular Hyaluronic Acid and Platelet-rich Plasma Injections on Knee Osteoarthritis
Although intra-articular knee injection with platelet-rich plasma (PRP) may have better outcomes than using hyaluronic acid (HA) for people with knee osteoarthritis (OA), it is expensive to use PRP.
- Trial name
- HAPRP (NCT04443166)
- Testing
- A platelet-rich plasma (PRP)+ hyaluronic acid (HA) program
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University WanFang Hospital
Osteoarthritis
Transcatheter Arterial Micro-Embolization (TAME) Using Nexsphere-F in Patients With Chronic Pain in Elbow or Wrist
In patients with chronic elbow or wrist pain, the pain is controlled by conventional conservative therapy The pain reduction effect of Nexsphere-F embolization in patients who need additional treatment It is intended to…
- Trial name
- NCT06207851
- Testing
- Transcatheter Arterial Micro-Embolization
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Next Biomedical Co., Ltd.
Mild Knee Osteoarthritis
Efficacy of Omija (Schisandra Chinensis) Extract in Subjects With Knee Osteoarthritis
Knee osteoarthritis (KO) is a common arthropathy and a leading cause of disability in elderly adults. Schizandra chinensis(Omija) has been known to have five predominant tastes: salty, sweet, sour, astringent, and bitter.
- Trial name
- NCT01472822
- Testing
- Omija extract.
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Arthritis of the Hip
Polarstem Versus Corail; a Comparison of Micromotion and Periprosthetic Bone Remodelling of Two Femoral Stems
A randomised controlled trial comparing a recently introduced femoral stem with an established stem for total hip arthroplasty (THA). 60 patients will be randomised into one of the two groups 1.
- Trial name
- NCT05815953
- Testing
- Polarstem, Corail
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Helse-Bergen HF
Postoperative Pain
Comparison of the Efficacy of PENG Block in Combination With LFCN Block and Wound Infiltration
The ultrasound-guided approach for the blockade of articular branches of femoral and obturator nerves, pericapsular nerve group (PENG) block, is an effective method for postoperative analgesia in hip surgeries.
- Trial name
- NCT04681222
- Testing
- LFCN, Wound infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Derince Training and Research Hospital